Astragalus polysaccharides can regulate cytokine and P-glycoprotein expression in H22 tumor-bearing mice

World Journal of Gastroenterology

Volumn 18, Issue 47, 2012, Pages 7079-7086

  Tian, Qing E ^a,b   Li, Huan De ^a   Yan, Miao ^a   Cai, Hua Lin ^a   Tan, Qin You ^a   Zhang, Wen Yuan ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b Xiangtan Central Hospital   (China)

Author keywords

Adjunct anticancer; Astragalus polysaccharides; Cytokines; P glycoprotein; Tumor inhibition rate

Indexed keywords

DOXORUBICIN; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 2; INTERLEUKIN 6; MULTIDRUG RESISTANCE PROTEIN; POLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN; THYMUS; WESTERN BLOTTING;

EID: 84873886349     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v18.i47.7079     Document Type: Article

References (36)

1. Moving cancer up the global health agenda. Lancet 2010; 375: 2051
2. Kawahara N, Masui T, Roh JK, Hao XS, Hill D, Akaza H. What should we do to raise awareness on the issue of cancer in the global health agenda? Jpn J Clin Oncol 2010; 40 Suppl 1: i82-i85
3. Urruticoechea A, Alemany R, Balart J, Villanueva A, Viñals F, Capellá G. Recent advances in cancer therapy: an overview. Curr Pharm Des 2010; 16: 3-10
4. Kelloff GJ. Perspectives on cancer chemoprevention research and drug development. Adv Cancer Res 2000; 78: 199-334
5. Choi CH. ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal. Cancer Cell Int 2005; 5: 30
6. Nobili S, Landini I, Giglioni B, Mini E. Pharmacological strategies for overcoming multidrug resistance. Curr Drug Targets 2006; 7: 861-879
7. Wong R, Sagar CM, Sagar SM. Integration of Chinese medicine into supportive cancer care: a modern role for an ancient tradition. Cancer Treat Rev 2001; 27: 235-246
8. Qi F, Li A, Inagaki Y, Gao J, Li J, Kokudo N, Li XK, Tang W. Chinese herbal medicines as adjuvant treatment during chemoor radio-therapy for cancer. Biosci Trends 2010; 4: 297-307
9. Ruan WJ, Lai MD, Zhou JG. Anticancer effects of Chinese herbal medicine, science or myth? J Zhejiang Univ Sci B 2006; 7: 1006-1014
10. Konkimalla VB, Efferth T. Evidence-based Chinese medicine for cancer therapy. J Ethnopharmacol 2008; 116: 207-210
11. Ji DB, Ye J, Jiang YM, Qian BW. Anti-tumor effect of Liqi, a traditional Chinese medicine prescription, in tumor bearing mice. BMC Complement Altern Med 2009; 9: 20
12. Astragalus membranaceus. Monograph. Altern Med Rev 2003; 8: 72-77
13. Na D, Liu FN, Miao ZF, Du ZM, Xu HM. Astragalus extract inhibits destruction of gastric cancer cells to mesothelial cells by anti-apoptosis. World J Gastroenterol 2009; 15: 570-577
14. Rittenhouse JR, Lui PD, Lau BH. Chinese medicinal herbs reverse macrophage suppression induced by urological tumors. J Urol 1991; 146: 486-490
15. Ma XQ, Shi Q, Duan JA, Dong TT, Tsim KW. Chemical analysis of Radix Astragali (Huangqi) in China: a comparison with its adulterants and seasonal variations. J Agric Food Chem 2002; 50: 4861-4866
16. Shao BM, Xu W, Dai H, Tu P, Li Z, Gao XM. A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Biochem Biophys Res Commun 2004; 320: 1103-1111
17. Li J, Bao Y, Lam W, Li W, Lu F, Zhu X, Liu J, Wang H. Immunoregulatory and anti-tumor effects of polysaccharopeptide and Astragalus polysaccharides on tumor-bearing mice. Immunopharmacol Immunotoxicol 2008; 30: 771-782
18. Liu X, Yang Y, Zhang X, Xu S, He S, Huang W, Roberts MS. Compound Astragalus and Salvia miltiorrhiza extract inhibits cell invasion by modulating transforming growth factorbeta/Smad in HepG2 cell. J Gastroenterol Hepatol 2010; 25: 420-426
19. Zhao LH, Ma ZX, Zhu J, Yu XH, Weng DP. Characterization of polysaccharide from Astragalus radix as the macrophage stimulator. Cell Immunol 2011; 271: 329-334
20. Tin MM, Cho CH, Chan K, James AE, Ko JK. Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft. Carcinogenesis 2007; 28: 1347-1355
21. Zee-Cheng RK. Shi-quan-da-bu-tang (ten significant tonic decoction), SQT. A potent Chinese biological response modifer in cancer immunotherapy, potentiation and detoxifcation of anticancer drugs. Methods Find Exp Clin Pharmacol 1992; 14: 725-736
22. Cui R, He J, Wang B, Zhang F, Chen G, Yin S, Shen H. Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats. Cancer Chemother Pharmacol 2003; 51: 75-80
23. Wang J, Ito H, Shimura K. Enhancing effect of antitumor polysaccharide from Astragalus or Radix hedysarum on C3 cleavage production of macrophages in mice. Jpn J Pharmacol 1989; 51: 432-434
24. Guo L, Bai SP, Zhao L, Wang XH. Astragalus polysaccharide injection integrated with vinorelbine and cisplatin for patients with advanced non-small cell lung cancer: effects on quality of life and survival. Med Oncol 2012; 29: 1656-1662
25. Liu XN, Zhang CY, Jin XD, Li YZ, Zheng XZ, Li L. Inhibitory effect of schisandrin B on gastric cancer cells in vitro. World J Gastroenterol 2007; 13: 6506-6511
26. Xiaoguang C, Hongyan L, Xiaohong L, Zhaodi F, Yan L, Lihua T, Rui H. Cancer chemopreventive and therapeutic activities of red ginseng. J Ethnopharmacol 1998; 60: 71-78
27. Gao L, Chen L, Fei XH, Qiu HY, Zhou H, Wang JM. STI571 combined with vincristine greatly suppressed the tumor formation of multidrug-resistant K562 cells in a human-nude mice xenograft model. Chin Med J (Engl) 2006; 119: 911-918
28. Jin Y, Li J, Rong LF, Li YH, Guo L, Xu SY. Anti-hepatocarcinoma effects of 5-fuorouracil encapsulated by galactosylceramide liposomes in vivo and in vitro. World J Gastroenterol 2005; 11: 2643-2646
29. Chen H, Takahashi S, Imamura M, Okutani E, Zhang ZG, Chayama K, Chen BA. Earthworm fbrinolytic enzyme: antitumor activity on human hepatoma cells in vitro and in vivo. Chin Med J (Engl) 2007; 120: 898-904
30. Mi Y, Lou L. ZD6474 reverses multidrug resistance by directly inhibiting the function of P-glycoprotein. Br J Cancer 2007; 97: 934-940
31. Liu Z, Stevenson GD, Barrett HH, Furenlid LR, Wilson DW, Kastis GA, Bettan M, Woolfenden JM. Imaging recognition of inhibition of multidrug resistance in human breast cancer xenografts using 99mTc-labeled sestamibi and tetrofosmin. Nucl Med Biol 2005; 32: 573-583
32. Ding L, Chen XP, Zhang ZW, Jing K, Zhang WG. Human multi-drug resistant hepatocellular carcinoma induced in nude mice by B-ultrasonographically-directed orthotopic implantation: a new experimental model. Hepatobiliary Pancreat Dis Int 2007; 6: 393-398
33. Cassetta L, Cassol E, Poli G. Macrophage polarization in health and disease. Scientifc World J 2011; 11: 2391-2402
34. Dizdarevic S, Peters AM. Imaging of multidrug resistance in cancer. Cancer Imaging 2011; 11: 1-8
35. Goda K, Bacsó Z, Szabó G. Multidrug resistance through the spectacle of P-glycoprotein. Curr Cancer Drug Targets 2009; 9: 281-297
36. Mayur YC, Peters GJ, Prasad VV, Lemo C, Sathish NK. Design of new drug molecules to be used in reversing multidrug resistance in cancer cells. Curr Cancer Drug Targets 2009; 9: 298-306