High titre of antiglutamic acid decarboxylase autoantibody is a strong predictor of the development of thyroid autoimmunity in patients with type 1 diabetes and latent autoimmune diabetes in adults

Clinical Endocrinology

Volumn 74, Issue 5, 2011, Pages 587-592

  Jin, Ping ^a   Huang, Gan ^a   Lin, Jian ^a   Yang, Lin ^a   Xiang, Bin ^a   Zhou, Weidong ^a   Zhou, ZhiGuang ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; C PEPTIDE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLUTAMATE DECARBOXYLASE ANTIBODY; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; THYROGLOBULIN ANTIBODY; THYROID PEROXIDASE ANTIBODY;

ADOLESCENT; ADULT; ANTIBODY TITER; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNE THYROID DISEASE; CHILD; DISEASE ASSOCIATION; FEMALE; GENOTYPE; HAPLOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LATENT AUTOIMMUNE DIABETES IN ADULT; MAJOR CLINICAL STUDY; MALE; PREDICTION; PREDICTOR VARIABLE; PRIORITY JOURNAL; RISK FACTOR; SCHOOL CHILD;

ADOLESCENT; ADULT; ANTIGENS, CD; AUTOANTIBODIES; AUTOIMMUNITY; CHILD; DIABETES MELLITUS, TYPE 1; FEMALE; GENOTYPE; GLUTAMATE DECARBOXYLASE; HLA-DQ ANTIGENS; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; THYROIDITIS, AUTOIMMUNE; YOUNG ADULT;

EID: 79953738087     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2011.03976.x     Document Type: Article

References (33)

1. Weetman, A.P., &, McGregor, A.M., (1994) Autoimmune thyroid disease: further developments in our understanding. Endocrine Reviews, 15, 788-830.
2. Barker, J.M., Yu, J., Yu, L., et al. (2005) Autoantibody "subspecificity" in type 1 diabetes: risk for organ-specific autoimmunity clusters in distinct groups. Diabetes Care, 28, 850-856.
3. Glastras, S.J., Craig, M.E., Verge, C.F., et al. (2005) The role of autoimmunity at diagnosis of type 1 diabetes in the development of thyroid and celiac disease and microvascular complications. Diabetes Care, 28, 2170-2175. (Pubitemid 41242463)
4. Umpierrez, G.E., Latif, K.A., Murphy, M.B., et al. (2003) Thyroid dysfunction in patients with type 1 diabetes: a longitudinal study. Diabetes Care, 26, 1181-1185. (Pubitemid 36929269)
5. Kordonouri, O., Klinghammer, A., Lang, E.B., et al. (2002) Thyroid autoimmunity in children and adolescents with type 1 diabetes: a multicenter survey. Diabetes Care, 25, 1346-1350. (Pubitemid 41071144)
6. Huang, W., Connor, E., Rosa, T.D., et al. (1996) Although DR3-DQB1*0201 may be associated with multiple component diseases of the autoimmune polyglandular syndromes, the human leukocyte antigen DR4-DQB1*0302 haplotype is implicated only in β-cell autoimmunity. Journal of Clinical Endocrinology and Metabolism, 81, 2559-2563. (Pubitemid 26240278)
7. Hashimoto, K., Maruyama, H., Nishiyama, M., et al. (2005) Susceptibility alleles and haplotypes of human leukocyte antigen DRB1, DQA1, and DQB1 in autoimmune polyglandular syndrome type III in Japanese population. Hormone Research, 64, 253-260. (Pubitemid 41636330)
8. Ueda, H., Howson, J.M., Esposito, L., et al. (2003) Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature, 423, 506-511. (Pubitemid 36648570)
9. Mochizuki, M., Amemiya, S., Kobayashi, K., et al. (2003) Association of the CTLA-4 gene 49 A/G polymorphism with type 1 diabetes and autoimmune thyroid disease in Japanese children. Diabetes Care, 26, 843-847. (Pubitemid 36929353)
10. Takara, M., Komiya, I., Kinjo, Y., et al. (2000) Association of CTLA-4 gene A/G polymorphism in Japanese type 1 diabetic patients with younger age of onset and autoimmune thyroid disease. Diabetes Care, 23, 975-978. (Pubitemid 30480026)
11. Ikegami, H., Awata, T., Kawasaki, E., et al. (2006) The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in Japan. Journal of Clinical Endocrinology and Metabolism, 91, 1087-1092. (Pubitemid 43357785)
12. Djilali-Saiah, I., Larger, E., Harfouch-Hammoud, E., et al. (1998) No major role for the CTLA-4 gene in the association of autoimmune thyroid disease with IDDM. Diabetes, 47, 125-127. (Pubitemid 28030818)
13. Tuomi, T., Groop, L.C., Zimmet, P.Z., et al. (1993) Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease. Diabetes, 42, 359-362. (Pubitemid 23045043)
14. Fourlanos, S., Dotta, F., Greenbaum, C.J., et al. (2005) Latent autoimmune diabetes in adults (LADA) should be less latent. Diabetologia, 48, 2206-2212. (Pubitemid 41618908)
15. Turner, R., Stratton, I., Horton, V., et al. (1997) UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group. Lancet, 350, 1288-1293. (Pubitemid 28036638)
16. Kuera, P., Novakova, D., Behanova, M., et al. (2003) Gliadin, endomysial and thyroid antibodies in patients with latent autoimmune diabetes of adults (LADA). Clinical and Experimental Immunology, 133, 139-143. (Pubitemid 36791952)
17. Gambelunghe, G., Forini, F., Laureti, S., et al. (2000) Increased risk for endocrine autoimmunity in Italian type 2 diabetic patients with GAD65 autoantibodies. Clinical Endocrinology (Oxford), 52, 565-573. (Pubitemid 30337081)
18. Takeda, H., Kawasaki, E., Shimizu, I., et al. (2002) Ehime study. Clinical, autoimmune, and genetic characteristics of adult-onset diabetic patients with GAD autoantibodies in Japan (Ehime study). Diabetes Care, 25, 995-1001. (Pubitemid 41110484)
19. Buzzetti, R., Di Pietro, S., Giaccari, A., et al. (2007) Non Insulin Requiring Autoimmune Diabetes Study Group. High titer of autoantibodies to GAD identifies a specific phenotype of adult-onset autoimmune diabetes. Diabetes Care, 30, 932-938. (Pubitemid 46556589)
20. Jin, P., Xiang, B., Lin, J., et al. (2009) Association of CTLA-4 +49A/G and CT60 gene polymorphism with type 1 diabetes and thyroid autoimmunity. Zhonghua Yi Xue Za Zhi (National Medical Journal of China), 89, 1246-1249.
21. Li, X., Zhou, Z.G., Huang, G., et al. (2004) Optimal cutoff point of glutamate decarboxylase antibody titers in differentiating two subtypes of adult-onset latent autoimmune diabetes. Annals of the New York Academy of Sciences, 1037, 122-126. (Pubitemid 40299753)
22. Wang, J.P., Zhou, Z.G., Lin, J., et al. (2007) Islet autoantibodies are associated with HLA-DQ genotypes in Han Chinese patients with type 1 diabetes and their relatives. Tissue Antigens, 70, 369-375. (Pubitemid 47537397)
23. Zalloua, P.A., Abchee, A., Shbaklo, H., et al. (2004) Patients with early onset of type 1 diabetes have significantly higher GG genotype at position 49 of the CTLA-4 gene. Human Immunology, 65, 719-724. (Pubitemid 39061169)
24. Downie-Doyle, S., Bayat, N., Rischmueller, M., et al. (2006) Influence of CTLA4 haplotypes on susceptibility and some extraglandular manifestations in primary Sjogren's syndrome. Arthritis and Rheumatism, 54, 2434-2440. (Pubitemid 44205003)
25. De Block, C.E., De Leeuw, I.H., Van Gaal, L.F., et al. (1999) High prevalence of manifestations of gastric autoimmunity in parietal cell antibody-positive type 1 (insulin-dependent) diabetic patients. The Belgian Diabetes Registry. The Journal of Clinical Endocrinology and Metabolism, 84, 4062-4067. (Pubitemid 30644195)
26. Holl, R.W., Bohm, B., Loos, U., et al. (1999) Thyroid autoimmunity in children and adolescents with type 1 diabetes mellitus. Hormone Research, 52, 113-118. (Pubitemid 30128713)
27. Chikuba, N., Akazawa, S., Yamaguchi, Y., et al. (1995) Immunogenetic heterogeneity in type 1 (insulin-dependent) diabetes among Japanese-class II antigen and autoimmune thyroid disease. Diabetes Research and Clinical Practice, 27, 31-37.
28. Chuang, L.M., Wu, H.P., Chang, C.C., et al. (1996) HLA DRB1/DQA1/DQB1 haplotype determines thyroid autoimmunity in patients with insulin-dependent diabetes mellitus. Clinical Endocrinology (Oxford), 45, 631-636.
29. Howson, J.M., Dunger, D.B., Nutland, S., et al. (2007) A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene. Diabetologia, 50, 741-746. (Pubitemid 46355837)
30. Kawasaki, E., Takino, H., Yano, M., et al. (1994) Autoantibodies to glutamic acid decarboxylase in patients with IDDM and autoimmune thyroid disease. Diabetes, 43, 80-86.
31. Mohn, A., Di Michele, S., Di Luzio, R., et al. (2002) The effect of subclinical hypothyroidism on metabolic control in children and adolescents with Type 1 diabetes mellitus. Diabetic Medicine, 19, 70-73. (Pubitemid 34146640)
32. Chase, H.P., Garg, S.K., Cockerham, R.S., et al. (1990) Thyroid hormone replacement and growth of children with subclinical hypothyroidism and diabetes. Diabetic Medicine, 7, 299-303. (Pubitemid 20145975)
33. American Diabetes Association (2008) Standards of medical care in diabetes-2008. Diabetes Care, 31 (Suppl. 1), S12-S54.