CTLA-4 gene polymorphism contributes to the genetic risk for latent autoimmune diabetes in adults

Annals of the New York Academy of Sciences

Volumn 958, Issue , 2002, Pages 337-340

  Cosentino, Anna ^a   Gambelunghe, Giovanni ^b   Tortoioli, Cristina ^a   Falorni, Alberto ^a,c  

^a UNIVERSITY OF PERUGIA   (Italy)

^b KAROLINSKA INSTITUTE   (Sweden)

^c Dipto Med Int Sci Endocr M   (Italy)

Author keywords

Autoimmunity; CTLA 4 gene; Genetic association; Islet autoantibodies; Type 1 diabetes

Indexed keywords

AUTOANTIBODY; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HLA DQ ANTIGEN; HLA DR ANTIGEN;

ADULT; AGED; ALLELE; AUTOIMMUNE DISEASE; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HAPLOTYPE; HETEROZYGOSITY; HIGH RISK POPULATION; HOMOZYGOSITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE;

EID: 0036268774     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb03000.x     Document Type: Conference Paper

References (8)

1. The role of major histocompatibility complex in insulin-dependent diabetes mellitus
2. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
3. The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes
4. Latent autoimmune diabetes mellitus in adults (LADA): The role of antibodies to glutamic acid decarboxylase in diagnosis and prediction of insulin dependency
5. Increased risk for endocrine autoimmunity in type 2 diabetic patients with GAD65 autoantibodies
6. Two distinct MICA gene markers discriminate major autoimmune diabetes types
7. Autoantibody recognition of COOH-terminal epitopes of GAD65 marks the risk for insulin requirement in adult-onset diabetes mellitus
8. Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphism in multiple ethnic groups