Signatures of protective memory immune responses during hepatitis C virus reinfection

Gastroenterology

Volumn 147, Issue 4, 2014, Pages 870-881.e8

  Abdel Hakeem, Mohamed S ^a,b,c   Bédard, Nathalie ^a   Murphy, Donald ^d   Bruneau, Julie ^a,c   Shoukry, Naglaa H ^a,c  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b CAIRO UNIVERSITY   (Egypt)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d INSTITUT NATIONAL DE SANTÉ PUBLIQUE DU QUÉBEC   (Canada)

Author keywords

Cytokines; Immune; Immunity; Infection; Protective; Regulation; Viral

Indexed keywords

CD27 ANTIGEN; CYTOCHROME P450 2B4; EPITOPE; GAMMA INTERFERON; HEPATITIS C ANTIBODY; HLA ANTIGEN CLASS 1; INTERLEUKIN 2; INTERLEUKIN 7 RECEPTOR; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; PROGRAMMED DEATH 1 LIGAND 1; TUMOR NECROSIS FACTOR ALPHA; VIRUS RNA; BIOLOGICAL MARKER; INTERLEUKIN 7 RECEPTOR ALPHA; PDCD1 PROTEIN, HUMAN; PROGRAMMED DEATH 1 RECEPTOR; VIRUS ANTIGEN;

ADULT; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIGEN RECOGNITION; ARTICLE; BLOOD SAMPLING; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; EFFECTOR CELL; FEMALE; FOLLOW UP; GENOTYPE; HEPATITIS C; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL MEMORY; INTERFERON PRODUCTION; LONGITUDINAL STUDY; LYMPHOCYTE PROLIFERATION; MALE; MEMORY T LYMPHOCYTE; MIDDLE AGED; PERSISTENT VIRUS INFECTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REINFECTION; T LYMPHOCYTE ACTIVATION; VIRAL CLEARANCE; VIRUS ISOLATION; VIRUS LOAD; BLOOD; CANADA; CELL PROLIFERATION; GENETICS; HEPACIVIRUS; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; SECONDARY PREVENTION; TIME; VIROLOGY;

ANTIGENS, VIRAL; BIOLOGICAL MARKERS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; EPITOPES, T-LYMPHOCYTE; HEPACIVIRUS; HEPATITIS C; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; PHENOTYPE; PROGRAMMED CELL DEATH 1 RECEPTOR; QUEBEC; RNA, VIRAL; SECONDARY PREVENTION; TIME FACTORS;

EID: 84921680487     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.07.005     Document Type: Article

References (33)

1. J. Grebely, M. Prins, and M. Hellard Hepatitis C virus clearance, reinfection, and persistence, with insights from studies of injecting drug users: towards a vaccine Lancet Infect Dis 12 2012 408 414
2. C.M. Walker Adaptive immunity to the hepatitis C virus Adv Virus Res 78 2010 43 86
3. A. Takaki, M. Wiese, and G. Maertens Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C Nat Med 6 2000 578 582
4. N.H. Shoukry, A. Grakoui, and M. Houghton Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection J Exp Med 197 2003 1645 1655
5. M.S. Abdel-Hakeem, and N.H. Shoukry Protective immunity against hepatitis C: many shades of grey Front Immunol 2014 5
6. A. Grakoui, N.H. Shoukry, and D.J. Woollard HCV persistence and immune evasion in the absence of memory T cell help Science 302 2003 659 662
7. S.H. Mehta, A. Cox, and D.R. Hoover Protection against persistence of hepatitis C Lancet 359 2002 1478 1483
8. W.O. Osburn, B.E. Fisher, and K.A. Dowd Spontaneous control of primary hepatitis C virus infection and immunity against persistent reinfection Gastroenterology 138 2010 315 324
9. D.G. Murphy, B. Willems, and M. Deschenes Use of sequence analysis of the NS5B region for routine genotyping of hepatitis C virus with reference to C/E1 and 5′ untranslated region sequences J Clin Microbiol 45 2007 1102 1112
10. G. Badr, N. Bedard, and M.S. Abdel-Hakeem Early interferon therapy for hepatitis C virus infection rescues polyfunctional, long-lived CD8+ memory T cells J Virol 82 2008 10017 10031
11. M. Roederer, J.L. Nozzi, and M.C. Nason SPICE: exploration and analysis of post-cytometric complex multivariate datasets Cytometry A 79 2011 167 174
12. J. Grebely, M.D. Morris, and T.M. Rice Cohort profile: the International Collaboration of Incident HIV and Hepatitis C in Injecting Cohorts (InC3) Study Int J Epidemiol 42 2013 1649 1659
13. H. Kared, T. Fabre, and N. Bedard Galectin-9 and IL-21 mediate cross-regulation between Th17 and Treg cells during acute hepatitis C PLoS Pathog 9 2013 e1003422
14. J. Bruneau, E. Roy, and N. Arruda The rising prevalence of prescription opioid injection and its association with hepatitis C incidence among street-drug users Addiction 107 2012 1318 1327
15. S.M. Kaech, J.T. Tan, and E.J. Wherry Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells Nat Immunol 4 2003 1191 1198
16. M.S. Abdel-Hakeem, N. Bedard, and G. Badr Comparison of immune restoration in early versus late alpha interferon therapy against hepatitis C virus J Virol 84 2010 10429 10435
17. S. Urbani, B. Amadei, and E. Cariani The impairment of CD8 responses limits the selection of escape mutations in acute hepatitis C virus infection J Immunol 175 2005 7519 7529
18. V. Kasprowicz, Y.H. Kang, and M. Lucas Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution J Virol 84 2010 1656 1663
19. G.M. Lauer, E. Barnes, and M. Lucas High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection Gastroenterology 127 2004 924 936
20. S. Smyk-Pearson, I.A. Tester, and D. Lezotte Differential antigenic hierarchy associated with spontaneous recovery from hepatitis C virus infection: implications for vaccine design J Infect Dis 194 2006 454 463
21. F. Lechner, D.K. Wong, and P.R. Dunbar Analysis of successful immune responses in persons infected with hepatitis C virus J Exp Med 191 2000 1499 1512
22. R. Thimme, D. Oldach, and K.M. Chang Determinants of viral clearance and persistence during acute hepatitis C virus infection J Exp Med 194 2001 1395 1406
23. S.H. Park, E.C. Shin, and S. Capone Successful vaccination induces multifunctional memory T-cell precursors associated with early control of hepatitis C virus Gastroenterology 143 2012 1048 1060 e4
24. J.R. Almeida, D.A. Price, and L. Papagno Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover J Exp Med 204 2007 2473 2485
25. D. Meyer-Olson, N.H. Shoukry, and K.W. Brady Limited T cell receptor diversity of HCV-specific T cell responses is associated with CTL escape J Exp Med 200 2004 307 319
26. M.C. Iglesias, J.R. Almeida, and S. Fastenackels Escape from highly effective public CD8+ T-cell clonotypes by HIV Blood 118 2011 2138 2149
27. K. Ladell, M. Hashimoto, M.C. Iglesias, and P.G. Wilmann A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells Immunity 38 2013 425 436
28. S.H. Park, N.S. Veerapu, and E.C. Shin Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection Nat Med 19 2013 1638 1642
29. D.G. Murphy, B. Willems, and M. Deschenes Use of sequence analysis of the NS5B region for routine genotyping of hepatitis C virus with reference to C/E1 and 5′ untranslated region sequences J Clin Microbiol 45 2007 1102 1112
30. S. Pelletier, C. Drouin, and N. Bedard Increased degranulation of natural killer cells during acute HCV correlates with the magnitude of virus-specific T cell responses J Hepatol 53 2010 805 816
31. G. Badr, N. Bedard, and M.S. Abdel-Hakeem Early interferon therapy for hepatitis C virus infection rescues polyfunctional, long-lived CD8+ memory T cells J Virol 82 2008 10017 10031
32. M. Roederer, J.L. Nozzi, and M.C. Nason SPICE: exploration and analysis of post-cytometric complex multivariate datasets Cytometry A 79 2011 167 174
33. M.S. Abdel-Hakeem, N. Bedard, and G. Badr Comparison of immune restoration in early versus late alpha interferon therapy against hepatitis C virus J Virol 84 2010 10429 10435