NRSF/REST regulates the mTOR signaling pathway in oral cancer cells

Oncology Reports

Volumn 33, Issue 3, 2015, Pages 1459-1464

  Cho, Eugene ^a   Moon, Sung Min ^a   Park, Bo Ram ^a   Kim, Do Kyung ^a   Lee, Byung Kwon ^b   Kim, Chun Sung ^a  

^a Chosun University   (South Korea)

^b UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Apoptosis; Human oral squamous cell carcinoma; MTOR signaling; NRSF REST

Indexed keywords

DNA; MAMMALIAN TARGET OF RAPAMYCIN; NEURON RESTRICTIVE SILENCER FACTOR; REPRESSOR ELEMENT 1 SILENCING TRANSCRIPTION FACTOR; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ELF 1; TRANSCRIPTION FACTOR ELF 4E; TRANSCRIPTION FACTOR ELF 4G; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; DNA BINDING PROTEIN; EIF4EBP1 PROTEIN, HUMAN; ELF4 PROTEIN, HUMAN; MTOR PROTEIN, HUMAN; PHOSPHOPROTEIN; RE1-SILENCING TRANSCRIPTION FACTOR; REPRESSOR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER SURVIVAL; CELL VIABILITY; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; DEACETYLATION; DNA FRAGMENTATION; HUMAN; HUMAN CELL; KERATINOCYTE; MOUTH CANCER; MOUTH SQUAMOUS CELL CARCINOMA; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; BIOSYNTHESIS; CELL SURVIVAL; GENETICS; METABOLISM; MOUTH TUMOR; PATHOLOGY; PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL SURVIVAL; DNA FRAGMENTATION; DNA-BINDING PROTEINS; HUMANS; MOUTH NEOPLASMS; PHOSPHOPROTEINS; PHOSPHORYLATION; REPRESSOR PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS;

EID: 84921628341     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3675     Document Type: Article

References (34)

1. Chong JA, Tapia-Ramírez J, Kim S, Toledo-Aral JJ, Zheng Y, Boutros MC, Altshuller YM, Frohman MA, Kraner SD and Mandel G: REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 80:949-957, 1995.
2. Schoenherr CJ and Anderson DJ: The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science 267:1360-1363, 1995.
3. Jones FS and Meech R: Knockout of REST/NRSF shows that the protein is a potent repressor of neuronally expressed genes in non-neural tissues. Bioessays 21:372-376, 1999.
4. Palm K, Belluardo N, Metsis M and Timmusk T: Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene. J Neurosci 18:1280-1296, 1998.
5. Lunyak VV, Burgess R, Prefontaine GG, Nelson C, Sze SH, Chenoweth J, Schwartz P, Pevzner PA, Glass C, Mandel G and Rosenfeld MG: Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Science 298:1747-1752, 2002.
6. Ballas N and Mandel G: The many faces of REST oversee epigenetic programming of neuronal genes. Curr Opin Neurobiol 15:500-506, 2005.
7. Tapia-Ramírez J, Eggen BJ, Peral-Rubio MJ, Toledo-Aral JJ and Mandel G: A single zinc finger motif in the silencing factor REST represses the neural-specific type II sodium channel promoter. Proc Natl Acad Sci USA 94:1177-1182, 1997.
8. Thiel G, Lietz M and Cramer M: Biological activity and modular structure of RE-1-silencing transcription factor (REST), a repressor of neuronal genes. J Biol Chem 273:26891-26899, 1998.
9. Bruce AW, Donaldson IJ, Wood IC, Yerbury SA, Sadowski MI, Chapman M, Göttgens B and Buckley NJ: Genome-wide analysis of repressor element 1 silencing transcription factor/neuronrestrictive silencing factor (REST/NRSF) target genes. Proc Natl Acad Sci USA 101:10458-10463, 2004.
10. Naruse Y, Aoki T, Kojima T and Mori N: Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes. Proc Natl Acad Sci USA 96:13691-13696, 1999.
11. Grimes JA, Nielsen SJ, Battaglioli E, Miska EA, Speh JC, Berry DL, Atouf F, Holdener BC, Mandel G and Kouzarides T: The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex. J Biol Chem 275:9461-9467, 2000.
12. Roopra A, Sharling L, Wood IC, Briggs T, Bachfischer U, Paquette AJ and Buckley NJ: Transcriptional repression by neuron-restrictive silencer factor is mediated via the Sin3-histone deacetylase complex. Mol Cell Biol 20:2147-2157, 2000.
13. Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ, Federoff HJ, Rose DW, Rosenfeld MG, Brehm P and Mandel G: Regulation of neuronal traits by a novel transcriptional complex. Neuron 31:353-365, 2001.
14. You A, Tong JK, Grozinger CM and Schreiber SL: CoREST is an integral component of the CoREST-human histone deacetylase complex. Proc Natl Acad Sci USA 98:1454-1458, 2001.
15. Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L and Elledge SJ: A genetic screen for candidate tumor suppressors identifies REST. Cell 121:837-848, 2005.
16. Lawinger P, Venugopal R, Guo ZS, Immaneni A, Sengupta D, Lu W, Rastelli L, Marin Dias Carneiro A, Levin V, Fuller GN, Echelard Y and Majumder S: The neuronal repressor REST/NRSF is an essential regulator in medulloblastoma cells. Nat Med 6:826-831, 2000.
17. Su X, Kameoka S, Lentz S and Majumder S: Activation of REST/NRSF target genes in neural stem cells is sufficient to cause neuronal differentiation. Mol Cell Biol 24:8018-8025, 2004.
18. Fuller GN, Su X, Price RE, Cohen ZR, Lang FF, Sawaya R and Majumder S: Many human medulloblastoma tumors overexpress repressor element-1 silencing transcription (REST)/neuron-restrictive silencer factor, which can be functionally countered by REST-VP16. Mol Cancer Ther 4:343-349, 2005.
19. Immaneni A, Lawinger P, Zhao Z, Lu W, Rastelli L, Morris JH and Majumder S: REST-VP16 activates multiple neuronal differentiation genes in human NT2 cells. Nucleic Acids Res 28:3403-3410, 2000.
20. Su X, Gopalakrishnan V, Stearns D, Aldape K, Lang FF, Fuller G, Snyder E, Eberhart CG and Majumder S: Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation. Mol Cell Biol 26:1666-1678, 2006.
21. Nishimura E, Sasaki K, Maruyama K, Tsukada T and Yamaguchi K: Decrease in neuron-restrictive silencer factor (NRSF) mRNA levels during differentiation of cultured neuroblastoma cells. Neurosci Lett 211:101-104, 1996.
22. Higashino K, Narita T, Taga T, Ohta S and Takeuchi Y: Malignant rhabdoid tumor shows a unique neural differentiation as distinct from neuroblastoma. Cancer Sci 94:37-42, 2003.
23. Shi Z and Stack MS: Molecules of cell adhesion and extracellular matrix proteolysis in oral squamous cell carcinoma. Histol Histopathol 25:917-932, 2010.
24. Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 55:74-108, 2005.
25. Kim CS, Hwang CK, Song KY, Choi HS, Kimdo K, Law PY, Wei LN and Loh HH: Novel function of neuron-restrictive silencer factor (NRSF) for posttranscriptional regulation. Biochim Biophys Acta 1783:1835-1846, 2008.
26. Mamane Y, Petroulakis E, LeBacquer O and Sonenberg N: mTOR, translation initiation and cancer. Oncogene 25:6416-6422, 2006.
27. Laplante M and Sabatini D: mTOR signaling in growth control and disease. Cell 149:274-293, 2012.
28. Palm K, Metsis M and Timmusk T: Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat. Brain Res Mol Brain Res 72:30-39, 1999.
29. Coulson JM, Edgson JL, Woll PJ and Quinn JP: A splice variant of the neuron-restrictive silencer factor repressor is expressed in small cell lung cancer: a potential role in derepression of neuroendocrine genes and a useful clinical marker. Cancer Res 60:1840-1844, 2000.
30. Tawadros T, Martin D, Abderrahmani A, Leisinger HJ, Waeber G and Haefliger JA: IB1/JIP-1 controls JNK activation and increased during prostatic LNCaP cells neuroendocrine differentiation. Cell Signal 17:929-939, 2005.
31. Lv H, Pan G, Zheng G, Wu X, Ren H, Liu Y and Wen J: Expression and functions of the repressor element 1 (RE-1)-silencing transcription factor (REST) in breast cancer. J Cell Biochem 110:968-974, 2010.
32. Hay N and Sonenberg N: Upstream and downstream of mTOR. Genes Dev 18:1926-1945, 2004.
33. Yuan R, Kay A, Berg WJ and Lebwohl D: Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy. J Hematol Oncol 2:45, 2009.
34. Yellen P, Saqcena M, Salloum D, Feng J, Preda A, Xu L, Rodrik-Outmezguine L and Foster DA: High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1. Cell Cycle 22:3948-3956, 2011.