Effects of inhibiting secretion of mesenchymal stem cells originated interleukin-6 on oxygen glucose deprivation injured PC12 cells

Journal of Shanghai Jiaotong University (Medical Science)

Volumn 34, Issue 10, 2014, Pages

  He, Mu Lan ^a   Liu, Jing Jing ^a   Gu, Yan ^a   Li, Ting Yu ^a   Chen, Jie ^a  

^a CHILDREN S HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Anti apoptosis; Interleukin 6; Mesenchymal stem cells; Nerve injury; Oxygen glucose deprivation; STAT3

Indexed keywords

GLUCOSE; OXYGEN;

ANIMAL CELL; ARTICLE; CELL DAMAGE; MESENCHYMAL STEM CELL; NONHUMAN; PC12 CELL LINE; RAT;

EID: 84921533437     PISSN: 16748115     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1674-8115.2014.10.004     Document Type: Article

References (12)

1. Gong M, Bi Y, Jiang W, et al. Immortalized mesenchymal stem cells: an alternative to primary mesenchymal stem cells in neuronal differentiation and neuroregeneration associated studies[J]. J Biomed Sci, 2011, 18(1): 87.
2. Zhang Y, Yang Y, Bi Y, et al. Mesenchymal stromal cell neuroprotection of hydrogen peroxide-challenged pheochromocytoma cells through reducing apoptosis and releasing cytokines[J]. Cytotherapy, 2012, 14(8): 954-966.
3. Scheller J, Chalaris A, Schmidt-Arras D, et al. The pro-and anti-inflammatory properties of the cytokine interleukin-6[J]. Biochim Biophys Acta, 2011, 1813(5): 878-888.
4. Parr AM, Tator CH, Keating A, et al. Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury[J]. Bone Marrow Transplant, 2007, 40(7): 609-619.
5. Liu Y, Zhang X, Dai Y, et al. Effects of bone marrow mesenchymal stem cells on learning and memory functional recovery in neonatal rats with hypoxic-ischemic brain damage[J]. Zhonghua Er Ke Za Zhi, 2008, 46(9): 648-653.
6. Zhang R, Liu Y, Yan K, et al. Anti-inflammatory and immunomodulatory mechanisms of mesenchymal stem cell transplantation in experimental traumatic brain injury[J]. J Neuroinflammation, 2013, 10(1): 106.
7. Walker PA, Harting MT, Jimenez F, et al. Direct intrathecal implantation of mesenchymal stromal cells leads to enhanced neuroprotection via an nfkappab-mediated increase in interleukin-6 production[J]. Stem Cells Dev, 2010, 19 (6): 867-876.
8. Winter CD, Pringle AK, Clough GF, et al. Raised parenchymal interleukin-6 levels correlate with improved outcome after traumatic brain injury[J]. Brain, 2004, 127(Pt 2): 315-320.
9. Penkowa M, Giralt M, Lago N, et al. Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury[J]. Exp Neurol, 2003, 181(2): 130-148.
10. Jung JE, Kim GS, Chan PH, et al. Neuroprotection by interleukin-6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in ischemic stroke[J]. Stroke, 2011, 42(12): 3574-3579.
11. Yamashita T, Sawamoto K, Suzuki S, et al. Blockade of interleukin-6 signaling aggravates ischemic cerebral damage in mice: possible involvement of stat3 activation in the protection of neurons[J]. J Neuronchem, 2005, 94(2): 459-468.
12. Liu Z, Qiu YH, Li B, et al. Neuroprotection of interleukin-6 against NMDA-induced apoptosis and its signal-transduction mechanisms[J]. Neurotox Res, 2011, 19(3): 484-495.