Lack of association between polymorphisms in genes MTHFR and MDR1 with risk of childhood acute lymphoblastic leukemia

Asian Pacific Journal of Cancer Prevention

Volumn 15, Issue 22, 2014, Pages 9707-9711

  Kreile, Madara ^a,b   Rots, Dmitrijs ^a   Piekuse, Linda ^a   Cebura, Elizabete ^b   Grutupa, Marika ^b   Kovalova, Zhanna ^a,b   Lace, Baiba ^c  

^a RIGA STRADINS UNIVERSITY   (Latvia)

^b CHILDREN'S CLINICAL UNIVERSITY HOSPITAL   (Latvia)

^c LATVIAN BIOMEDICAL RESEARCH AND STUDY CENTRE   (Latvia)

Author keywords

Childhood cases; Lymphoblastic leukemia; MDR1; MTHFR; Polymorphisms

Indexed keywords

ABCB1 PROTEIN, HUMAN; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MTHFR PROTEIN, HUMAN; MULTIDRUG RESISTANCE PROTEIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; CANCER STAGING; CASE CONTROL STUDY; CHILD; COMPARATIVE STUDY; FEMALE; FOLLOW UP; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HUMAN; INFANT; MALE; PATHOLOGY; PRESCHOOL CHILD; PROGNOSIS; RISK FACTOR;

ADOLESCENT; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FEMALE; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INFANT; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); NEOPLASM STAGING; P-GLYCOPROTEINS; POLYMORPHISM, GENETIC; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS; RISK FACTORS;

EID: 84921525665     PISSN: 15137368     EISSN: None     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.22.9707     Document Type: Article

References (37)

1. Alpman A, Ozkinay F, Tekgul H, et al (2010). Multidrug resistance 1 (MDR1) gene polymorphisms in childhood drug-resistant epilepsy. J Child Neurol, 25, 1485-90.
2. Ayaz G, Batar B, Kanigur G, et al (2013). The association of MDR1 C3435T and G2677T/A polymorphisms with plasma platelet-activating factor levels and coronary artery disease risk in Turkish population. Gene, 527, 301-5.
3. Bektas-Kayhan K, Kucukhuseyin O, Karagoz G, et al (2012). Is the MDR1 C3435T polymorphism responsible for oral mucositis in children with acute lymphoblastic leukemia? Asian Pac J Cancer Prev, 13, 5251-5.
4. Bhojwani D, Howard SC, Pui CH (2009). High-risk childhood acute lymphoblastic leukemia. Clin Lymphoma Myeloma, 9, 222-30.
5. Chokkalingam AP, Metayer C, Scelo GA, et al (2012). Variation in xenobiotic transport and metabolism genes, household chemical exposures, and risk of childhood acute lymphoblastic leukemia. Cancer Causes Control, 23, 1367-75.
6. Giovannetti E, Ugrasena DG, Supriyadi E, et al (2008). Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia. Leuk Res, 32, 19-24.
7. Gorniak P, Pastorczak A, Zalewska-Szewczyk B, et al (2014). Polymorphism in IKZF1 gene affects age at onset of childhood acute lymphoblastic leukemia. Leuk Lymphoma, 55, 2174-8.
8. Hanson NQ, Aras O, Yang F, Tsai MY (2001). C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: incidence and effect of combined genotypes on plasma fasting and post-methionine load homocysteine in vascular disease. Clin Chem, 47, 661-6.
9. Hattori H, Suminoe A, Wada M, et al (2007). Regulatory polymorphisms of multidrug resistance 1 (MDR1) gene are associated with the development of childhood acute lymphoblastic leukemia. Leuk Res, 31, 1633-40.
10. Healy J, Richer C, Bourgey M, Kritikou EA, Sinnett D (2010). Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia. Haematologica, 95, 1608-11.
11. Inaba H, Greaves M, Mullighan CG (2013). Acute lymphoblastic leukaemia. Lancet, 381, 1943-55.
12. Jain M, Pandey P, Tiwary NK, Jain S (2012). MTHFR C677T polymorphism is associated with hyperlipidemia in women with polycystic ovary syndrome. J Hum Reprod Sci, 5, 52-6.
13. Jamroziak K, Robak T (2008). Do polymorphisms in ABC transporter genes influence risk of childhood acute lymphoblastic leukemia? Leuk Res, 32, 1173-5.
14. Jiang Y, Hou J, Zhang Q, et al (2013). The MTHFR C677T polymorphism and risk of acute lymphoblastic leukemia: an updated meta-analysis based on 37 case-control studies. Asian Pac J Cancer Prev, 14, 6357-62.
15. John SW, Weitzner G, Rozen R, Scriver CR (1991). A rapid procedure for extracting genomic DNA from leukocytes. Nucleic Acids Res, 19, 408.
16. Kim YO, Kim MK, Woo YJ, et al (2006). Single nucleotide polymorphisms in the multidrug resistance 1 gene in Korean epileptics. Seizure, 15, 67-72.
17. Kimura Y, Selmi C, Leung PS, et al (2005). Genetic polymorphisms influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis. Hepatology, 41, 55-63.
18. Leal-Ugarte E, Gutierrez-Angulo M, Macias-Gomez NM, et al (2008). MDR1 C3435T polymorphism in Mexican children with acute lymphoblastic leukemia and in healthy individuals. Hum Biol, 80, 449-55.
19. Li X, Liao Q, Zhang S, Chen M (2014). Association of methylenetetrahytrofolate reductase (MTHFR) C677T and A1298C polymorphisms with the susceptibility of childhood acute lymphoblastic leukaemia (ALL) in Chinese population. Eur J Med Res, 19, 5.
20. Lightfoot TJ, Johnston WT, Painter D, et al (2010). Genetic variation in the folate metabolic pathway and risk of childhood leukemia. Blood, 115, 3923-9.
21. Lupo PJ, Nousome D, Kamdar KY, Okcu MF, Scheurer ME (2012). A case-parent triad assessment of folate metabolic genes and the risk of childhood acute lymphoblastic leukemia. Cancer Causes Control, 23, 1797-803.
22. Nousome D, Lupo PJ, Okcu MF, Scheurer ME (2013). Maternal and offspring xenobiotic metabolism haplotypes and the risk of childhood acute lymphoblastic leukemia. Leuk Res, 37, 531-5.
23. Purcell S, Neale B, Todd-Brown K, et al (2007). PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet, 81, 559-75.
24. Rao DN, Anuradha C, Vishnupriya S, et al (2010). Association of an MDR1 gene (C3435T) polymorphism with acute leukemia in India. Asian Pac J Cancer Prev, 11, 1063-6.
25. Ren YQ, Han JQ, Cao JB, Li SX, Fan GR (2012). Association of MDR1 gene polymorphisms with susceptibility to hepatocellular carcinoma in the Chinese population. Asian Pac J Cancer Prev, 13, 5451-4.
26. Safarinejad MR, Shafiei N, Safarinejad S (2012). Methylenetetrahydrofolate reductase (MTHFR) gene C677T, A1298C and G1793A polymorphisms: association with risk for clear cell renal cell carcinoma and tumour behaviour in men. Clin Oncol (R Coll Radiol), 24, 269-81.
27. Semsei AF, Erdelyi DJ, Ungvari I, et al (2008). Association of some rare haplotypes and genotype combinations in the MDR1 gene with childhood acute lymphoblastic leukaemia. Leuk Res, 32, 1214-20.
28. Tharnprisan P, Khiewyoo J, Sripraya P, Wiangnon S (2013). Relapse-free rate with childhood acute lymphoblastic leukemia treated under the thai national protocol. Asian Pac J Cancer Prev, 14, 1127-30.
29. Urayama KY, Wiencke JK, Buffler PA, et al (2007). MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomarkers Prev, 16, 1172-7.
30. Wang H, Wang J, Zhao L, Liu X, Mi W (2012). Methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia-evidence from an updated meta-analysis including 35 studies. BMC Med Genet, 13, 77.
31. Wang J, Wang B, Bi J, Li K, Di J (2012). MDR1 gene C3435T polymorphism and cancer risk: a meta-analysis of 34 case-control studies. J Cancer Res Clin Oncol, 138, 979-89.
32. Wang LH, Song YB, Zheng WL, Jiang L, Ma WL (2013). The association between polymorphisms in the MDR1 gene and risk of cancer: a systematic review and pooled analysis of 52 case-control studies. Cancer Cell Int, 13, 46.
33. Wu DD, Zhang JX, Li J, Dong WG (2014). Lack of association of the MDR1 C3435T polymorphism with susceptibility to gastric cancer and peptic ulcer: a systemic review and meta-analysis. Asian Pac J Cancer Prev, 15, 3021-7.
34. Yan J, Yin M, Dreyer ZE, et al (2012). A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children. Pediatr Blood Cancer, 58, 513-8.
35. Yan Y, Liang H, Xie L, et al (2014). Association of MDR1 G2677T polymorphism and leukemia risk: evidence from a meta-analysis. Tumour Biol, 35, 2191-7.
36. Zhai X, Wang H, Zhu X, et al (2012). Gene polymorphisms of ABC transporters are associated with clinical outcomes in children with acute lymphoblastic leukemia. Arch Med Sci, 8, 659-71.
37. Zintzaras E, Doxani C, Rodopoulou P, et al (2012). Variants of the MTHFR gene and susceptibility to acute lymphoblastic leukemia in children: a synthesis of genetic association studies. Cancer Epidemiol, 36, 169-76.