HGAL localization to cell membrane regulates B-cell receptor signaling

Blood

Volumn 125, Issue 4, 2015, Pages 649-657

  Lu, Xiaoqing ^a   Sicard, Renaud ^b   Jiang, Xiaoyu ^a   Stockus, Jessica N ^c   McNamara, George ^c   Abdulreda, Midhat ^b   Moy, Vincent T ^b   Landgraf, Ralf ^b   Lossos, Izidore S ^a,b  

^a UNIVERSITY OF MIAMI   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MIAMI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CHEMOATTRACTANT; HUMAN GERMINAL CENTER ASSOCIATED LYMPHOMA PROTEIN; MEMBRANE PROTEIN; PROTEIN KINASE SYK; UNCLASSIFIED DRUG; ACTIN; CHEMOTACTIC FACTOR; GCET2 PROTEIN, HUMAN; LYMPHOCYTE ANTIGEN RECEPTOR; MYOSIN II; PROTEIN TYROSINE KINASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA PROTEIN, MOUSE; SIGNAL PEPTIDE; TUMOR PROTEIN;

ARTICLE; CELL MEMBRANE; CELL MOTILITY; CONTROLLED STUDY; CYTOPLASM; HEK293 CELL LINE; HUMAN; HUMAN CELL; LIPID RAFT; MYRISTYLATION; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; B LYMPHOCYTE; CELL MOTION; CYTOLOGY; GENETICS; HELA CELL LINE; IMMUNOLOGY; LIPOYLATION; METABOLISM; PHYSIOLOGY; PROTEIN TRANSPORT;

ACTINS; B-LYMPHOCYTES; CELL MOVEMENT; CHEMOTACTIC FACTORS; CYTOPLASM; HELA CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOYLATION; MEMBRANE MICRODOMAINS; MYOSIN TYPE II; NEOPLASM PROTEINS; PROTEIN TRANSPORT; PROTEIN-TYROSINE KINASES; PROTEOLYSIS; RECEPTORS, ANTIGEN, B-CELL; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 84921502858     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-04-571331     Document Type: Article

References (28)

1. Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [see comments]. Nature. 2000;403(6769):503-511.
2. Lossos IS, Alizadeh AA, Rajapaksa R, Tibshirani R, Levy R. HGAL is a novel interleukin-4-inducible gene that strongly predicts survival in diffuse large B-cell lymphoma. Blood. 2003;101(2):433-440.
3. Natkunam Y, Hsi ED, Aoun P, et al. Expression of the human germinal center-associated lymphoma (HGAL) protein identifies a subset of classic Hodgkin lymphoma of germinal center derivation and improved survival. Blood. 2007;109(1):298-305.
4. Azambuja D, Lossos IS, Biasoli I, et al. Human germinal center-associated lymphoma protein expression is associated with improved failurefree survival in Brazilian patients with classical Hodgkin lymphoma. Leuk Lymphoma. 2009;50(11):1830-1836.
5. Baecklund E, Natkunam Y, Backlin C, et al. Expression of the human germinal-centreassociated lymphoma protein in diffuse large B-cell lymphomas in patients with rheumatoid arthritis. Br J Haematol. 2008;141(1):69-72.
6. Schenten D, Egert A, Pasparakis M, Rajewsky K. M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice. Blood. 2006;107(12):4849-4856.
7. Romero-Camarero I, Jiang X, Natkunam Y, et al. Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation. Nat Commun. 2013;4:1338.
8. Lu X, Chen J, Malumbres R, Cubedo Gil E, Helfman DM, Lossos IS. HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration. Blood. 2007;110(13):4268-4277.
9. Lu X, Kazmierczak K, Jiang X, et al. Germinal center-specific protein human germinal center associated lymphoma directly interacts with both myosin and actin and increases the binding of myosin to actin. FEBS J. 2011;278(11):1922-1931.
10. Jiang X, Lu X, McNamara G, et al. HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway. Blood. 2010;116(24):5217-5227.
11. Natkunam Y, Lossos IS, Taidi B, et al. Expression of the human germinal center-associated lymphoma (HGAL) protein, a new marker of germinal center B-cell derivation. Blood. 2005;105(10):3979-3986.
12. Nadolski MJ, Linder ME. Protein lipidation. FEBS J. 2007;274(20):5202-5210.
13. Linder ME, Deschenes RJ. Palmitoylation: policing protein stability and traffic. Nat Rev Mol Cell Biol. 2007;8(1):74-84.
14. Prior IA, Harding A, Yan J, Sluimer J, Parton RG, Hancock JF. GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Nat Cell Biol. 2001;3(4):368-375.
15. Dagan LN, Jiang X, Bhatt S, Cubedo E, Rajewsky K, Lossos IS. miR-155 regulates HGAL expression and increases lymphoma cell motility. Blood. 2012;119(2):513-520.
16. Barlow AL, Macleod A, Noppen S, Sanderson J, Guérin CJ. Colocalization analysis in fluorescence micrographs: verification of a more accurate calculation of pearson's correlation coefficient. Microsc Microanal. 2010;16(6):710-724.
17. Abdulreda MH, Rodriguez-Diaz R, Berggren P-O, Caicedo A. Three-dimensional colocalization analysis in immunostained sections of human pancreas. Protocol Exchange. September 19, 2011; doi:10.1038/protex.2011.258.
18. Jaczewska J, Abdulreda MH, Yau CY, et al. TNF-α and IFN-γ promote lymphocyte adhesion to endothelial junctional regions facilitating transendothelial migration. J Leukoc Biol. 2014;95(2):265-274.
19. Rodriguez-Diaz R, Abdulreda MH, Formoso AL, et al. Innervation patterns of autonomic axons in the human endocrine pancreas. Cell Metab. 2011;14(1):45-54.
20. Pan Z, Shen Y, Ge B, Du C, McKeithan T, Chan WC. Studies of a germinal centre B-cell expressed gene, GCET2, suggest its role as a membrane associated adapter protein. Br J Haematol. 2007;137(6):578-590.
21. Kurosaki T, Hikida M. Tyrosine kinases and their substrates in B lymphocytes. Immunol Rev. 2009;228(1):132-148.
22. Cheng PC, Dykstra ML, Mitchell RN, Pierce SK. A role for lipid rafts in B cell antigen receptor signaling and antigen targeting. J Exp Med. 1999;190(11):1549-1560.
23. Gupta N, DeFranco AL. Lipid rafts and B cell signaling. Semin Cell Dev Biol. 2007;18(5):616-626.
24. Gupta N, DeFranco AL. Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation. Mol Biol Cell. 2003;14(2):432-444.
25. Le Roux D, Lankar D, Yuseff MI, et al. Sykdependent actin dynamics regulate endocytic trafficking and processing of antigens internalized through the B-cell receptor. Mol Biol Cell. 2007;18(9):3451-3462.
26. Treanor B, Depoil D, Gonzalez-Granja A, et al. The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor. Immunity. 2010;32(2):187-199.
27. Brown BK, Song W. The actin cytoskeleton is required for the trafficking of the B cell antigen receptor to the late endosomes. Traffic. 2001;2(6):414-427.
28. Hao S, August A. Actin depolymerization transduces the strength of B-cell receptor stimulation. Mol Biol Cell. 2005;16(5):2275-2284.