Direct enantioselective conjugate addition of carboxylic acids with chiral lithium amides as traceless auxiliaries

Journal of the American Chemical Society

Volumn 137, Issue 2, 2015, Pages 656-659

  Lu, Ping ^a   Jackson, Jeffrey J ^a   Eickhoff, John A ^a   Zakarian, Armen ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITION REACTIONS; AMIDES; CARBON; CARBOXYLIC ACIDS;

CARBON-HETEROATOM BONDS; CARBOXYL GROUPS; ENANTIOSELECTIVE CONJUGATE ADDITION; ENANTIOSELECTIVE MICHAEL ADDITION; ENANTIOSELECTIVE TOTAL SYNTHESIS; FUNCTIONALIZATIONS; MICHAEL ADDITIONS; SYNTHETIC METHODS;

ENANTIOSELECTIVITY;

AMIDE; CARBOXYLIC ACID; INDOLEACETIC ACID DERIVATIVE; LITHIUM DERIVATIVE; PHENYLACETIC ACID; PIPERIDINE DERIVATIVE; LITHIUM;

ALKYLATION; ARTICLE; ASYMMETRIC SYNTHESIS; CARBON NUCLEAR MAGNETIC RESONANCE; CHIRALITY; CONJUGATE; CRYSTALLIZATION; CURTIUS REARRANGEMENT; DENSITY FUNCTIONAL THEORY; DIASTEREOISOMER; ENANTIOMER; ENANTIOSELECTIVITY; LITHIUM NUCLEAR MAGNETIC RESONANCE; MICHAEL ADDITION; NITROGEN NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; SYNTHESIS; X RAY CRYSTALLOGRAPHY; CATALYSIS; CHEMISTRY; ENZYME SPECIFICITY; STEREOISOMERISM;

AMIDES; CARBOXYLIC ACIDS; CATALYSIS; LITHIUM; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 84921483420     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja512213c     Document Type: Article

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