One-pot two-step radiosynthesis of a new 18F-labeled thiol reactive prosthetic group and its conjugate for insulinoma imaging

Molecular Pharmaceutics

Volumn 11, Issue 11, 2014, Pages 3875-3884

  Yue, Xuyi ^a   Yan, Xuefeng ^a,b   Wu, Chenxi ^a,c   Niu, Gang ^a   Ma, Ying ^a   Jacobson, Orit ^a   Shen, Baozhong ^b   Kiesewetter, Dale O ^a   Chen, Xiaoyuan ^a  

^a NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

fluorine 18; insulinoma imaging; thiol reactive prosthetic group

Indexed keywords

6 FLUORONICOTINIC ACID 2,3,5,6 TETRAFLUOROPHENYL N (2 AMINOETHYL)MALEIMIDE TRIFLUOROACETIC ACID F 18; EXENDIN 4; FLUORINE 18; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; MALEIMIDE DERIVATIVE; N [2 (2,5 DIOXO 2,5 DIHYDRO 1H PYRROL 1 YL)ETHYL] 6 FLUORONICOTINAMIDE CYSTEINE 40 EXENDIN 4 F 18; N [2 (2,5 DIOXO 2,5 DIHYDRO 1H PYRROL 1 YL)ETHYL] 6 FLUORONICOTINAMIDE F 18; THIOL; TRACER; TRIFLUOROACETIC ACID; TRIMETHYLAMMONIUM SALT DERIVATIVE; UNCLASSIFIED DRUG; FLUORINE; GLP1R PROTEIN, MOUSE; GLUCAGON RECEPTOR; N-(2-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1-YL)ETHYL)-6-FLUORONICOTINAMIDE; NICOTINAMIDE; SUCCINIMIDE DERIVATIVE; THIOL DERIVATIVE;

AMIDATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INSULINOMA; ISOTOPE LABELING; MOUSE; NONHUMAN; NUCLEOPHILICITY; ONE POT SYNTHESIS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; RADIOCHEMISTRY; RAT; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DISEASE MODEL; IC50; METABOLISM; SCINTISCANNING; SYNTHESIS; TEMPERATURE; THIN LAYER CHROMATOGRAPHY; TISSUE DISTRIBUTION; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CHROMATOGRAPHY, THIN LAYER; DISEASE MODELS, ANIMAL; FEMALE; FLUORINE RADIOISOTOPES; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; INHIBITORY CONCENTRATION 50; INSULINOMA; MICE; MICE, INBRED BALB C; NIACINAMIDE; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, GLUCAGON; SUCCINIMIDES; SULFHYDRYL COMPOUNDS; TEMPERATURE; TISSUE DISTRIBUTION;

EID: 84921481990     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp5001857     Document Type: Article

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