Dehydroabietic acid reverses TNF-α-induced the activation of FOXO1 and suppression of TGF-β1/Smad signaling in human adult dermal fibroblasts

International Journal of Clinical and Experimental Pathology

Volumn 7, Issue 12, 2014, Pages 8616-8626

  Wang, Xiao Wei ^a   Yu, Yong ^a   Gu, Lei ^b  

^a ZHONGSHAN HOSPITAL OF FUDAN UNIVERSITY   (China)

^b TONGJI HOSPITAL OF TONGJI UNIVERSITY   (China)

Author keywords

Dehydroabietic acid; Diabetes; Forkhead box o1; Transforming growth factor 1; Tumor necrosis factor ; Wound healing

Indexed keywords

ABIETANE DERIVATIVE; DEHYDROABIETIC ACID; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ADULT; APOPTOSIS; CELL CULTURE; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECTS; FIBROBLAST; HUMAN; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKIN; WESTERN BLOTTING; WOUND HEALING;

ADULT; APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DITERPENES, ABIETANE; FIBROBLASTS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKIN; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA; WOUND HEALING;

EID: 84921455389     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Singh N, Armstrong DG, Lipsky BA. Preventing foot ulcers in patients with diabetes. JAMA 2005; 293: 217-228.
2. Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev 2003; 83: 835-870.
3. Zhang Q, Fong CC, Yu WK, Chen Y, Wei F, Koon CM, Lau KM, Leung PC, Lau CB, Fung KP, Yang M. Herbal formula Astragali Radix and Reh-manniae Radix exerted wound healing effect on human skin fibroblast cell line Hs27. Ph-ytomedicine 2012; 20: 9-16.
4. Arancibia R, Oyarzún A, Silva D, Tobar N, Martínez J, Smith PC. Tumor necrosis factor-a inhibits transforming growth factor-β-stimu-lated myofibroblastic differentiation and extracellular matrix production in human gingival fibroblasts. J Periodontol 2013; 84: 683-693.
5. Desta T, Li J, Chino T, Graves DT. Altered fibroblast proliferation and apoptosis in diabetic gingival wounds. J Dent Res 2010; 89: 609-614.
6. Xu F, Zhang C, Graves DT. Abnormal cell responses and role of TNF-α in impaired diabetic wound healing. Biomed Res Int 2013; 2013: 754802.
7. Siqueira MF, Li J, Chehab L, Desta T, Chino T, Krothpali N, Behl Y, Alikhani M, Yang J, Braasch C, Graves DT. Impaired wound healing in mo-use models of diabetes is mediated by TNF-α dysregulation and associated with enhanced activation of forkhead box O1 (FOXO1). Dia-betologia 2010; 53: 378-388.
8. Falanga V. Wound healing and its impairment in the diabetic foot. Lancet 2005; 366: 1736-1743.
9. Kaiser GC, Polk DB. Tumor necrosis factor a regulates proliferation in a mouse intestinal cell line. Gastroenterology 1997; 112: 1231-1240.
10. Hasnan J, Yusof MI, Damitri TD, Faridah AR, Adenan AS, Norbaini TH. Relationship between apoptotic markers (Bax and bcl-2) and biochemical markers in type 2 diabetes mellitus. Singap Med J 2010; 51: 50-55.
11. Hinz B. Formation and function of the myofi -broblast during tissue repair. J Invest Dermatol 2007; 127: 526-537.
12. Al-Mulla F, Leibovich SJ, Francis IM, Bitar MS. Impaired TGF-β signaling and a defect in resolution of inflammation contribute to delayed wound healing in a female rat model of type 2 diabetes. Mol Biosyst 2011; 7: 3006-3020.
13. Goldberg MT, Han YP, Yan C, Shaw MC, Garner WL. TNF-αlpha suppresses alpha-smooth muscle actin expression in human dermal fi bro-blasts: An implication for abnormal wound he-aling. J Invest Dermatol 2007; 127: 2645-2655.
14. Kang MS, Hirai S, Goto T, Kuroyanagi K, Lee JY, Uemura T, Ezaki Y, Takahashi N, Kawada T. De-hydroabietic acid, aphytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation. Biochem Bio-phys Res Commun 2008; 369: 333-338.
15. Kang MS, Hirai S, Goto T, Kuroyanagi K, Kim YI, Ohyama K, Uemura T, Lee JY, Sakamoto T, Ez-aki Y, Yu R, Takahashi N, Kawada T. Dehydro-abietic acid, a diterpene, improves diabetes and hyperlipidemia in obese diabetic KK-Ay mice. Biofactors 2009; 35: 442-448.
16. Burlacu A. Regulation of apoptosis by Bcl-2 family proteins. J Cell Mol Med 2003; 7: 249-257.
17. Dvir-Ginzberg M, Gagarina V, Lee EJ, Booth R, Gabay O, Hall DJ. Tumor necrosis factor alpha-mediated cleavage and inactivation of sirt1 in human osteoarthritic chondrocytes. Arthritis Rheumatol 2011; 63: 2363-2373.
18. Wang W, Yan C, Zhang J, Lin R, Lin Q, Yang L, Ren F, Zhang J, Ji M, Li Y. SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of Fo-xO1. Apoptosis 2013; 18: 689-701.
19. Huang HJ, Tindall DJ. Dynamic FoxO transcription factors. J Cell Sci 2007; 120: 2479-2487.
20. Serini G, Bochaton-Piallat ML, Ropraz P, Geinoz A, Borsi L, Zardi L, Gabbiani G. The fi bronectin domain ED-A is crucial for myofi broblastic phenotype induction by transforming growth factor-beta1. J Cell Biol 1998; 142: 873-881.