Rapid reversal of severe lactic acidosis after thiamine administration in critically ill adults: A report of 3 cases

Nutrition in Clinical Practice

Volumn 30, Issue 1, 2015, Pages 104-110

  Giacalone, Marilù ^a   Martinelli, Rita ^b   Abramo, Antonio ^b   Rubino, Antonio ^c   Pavoni, Vittorio ^d   Iacconi, Pietro ^a   Giunta, Francesco ^a   Forfori, Francesco ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY HOSPITAL OF PISA   (Italy)

^c PAPWORTH HOSPITAL   (United Kingdom)

^d CAREGGI UNIVERSITY HOSPITAL   (Italy)

Author keywords

critical illness; lactic acidosis; parenteral nutrition; thiamine; thiamine deficiency; thiamine pyrophosphate

Indexed keywords

CREATININE; LACTIC ACID; MAGNESIUM SULFATE; THIAMINE;

ACID BASE BALANCE; ACUTE PANCREATITIS; ADULT; AGED; ALCOHOLISM; ALKALOSIS; ARTERIAL GAS; ARTERIAL PH; ARTICLE; ATAXIA; BIPOLAR DISORDER; CASE REPORT; COLON CANCER; CONSCIOUSNESS DISORDER; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CRITICALLY ILL PATIENT; DISEASE SEVERITY; DYSPHAGIA; ENERGY METABOLISM; ENTERIC FEEDING; FEMALE; FOOD INTAKE; GASTROINTESTINAL TRACT FUNCTION; GENERALIZED EDEMA; GLASGOW COMA SCALE; HEMICOLECTOMY; HEMODYNAMIC PARAMETERS; HOSPITAL PATIENT; HUMAN; HYPOREFLEXIA; HYPOTENSION; INTESTINE OBSTRUCTION; KIDNEY DYSFUNCTION; LACTIC ACIDOSIS; LETHARGY; MALABSORPTION; METABOLIC ACIDOSIS; NEUROLOGIC DISEASE; NUTRITIONAL STATUS; NYSTAGMUS; OPHTHALMOPLEGIA; PARENTERAL NUTRITION; PARTIAL GASTRECTOMY; POSTOPERATIVE PERIOD; ROUX Y ANASTOMOSIS; SECOND CANCER; STOMACH CANCER; TACHYCARDIA; TACHYPNEA; THIAMINE DEFICIENCY; URINE VOLUME; WERNICKE ENCEPHALOPATHY; ACIDOSIS, LACTIC; ADVERSE EFFECTS; BLOOD; COMPLICATION; CRITICAL ILLNESS; INTRAVENOUS DRUG ADMINISTRATION; NERVOUS SYSTEM DISEASES; PROCEDURES; SHOCK; TREATMENT OUTCOME;

ACIDOSIS, LACTIC; ADMINISTRATION, INTRAVENOUS; ADULT; AGED; CRITICAL ILLNESS; FEMALE; HUMANS; NERVOUS SYSTEM DISEASES; PARENTERAL NUTRITION; SHOCK; THIAMINE; THIAMINE DEFICIENCY; TREATMENT OUTCOME;

EID: 84921450580     PISSN: 08845336     EISSN: 19412452     Source Type: Journal    
DOI: 10.1177/0884533614561790     Document Type: Article

References (28)

1. Cruickshank AM, Telfer ABM, Shenkin A. Thiamine deficiency in the critically ill. Intensive Care Med. 1988 ; 14: 384-387
2. Donnino MW, Carney E, Cocchi MN, et al. Thiamine deficiency in critically patients with sepsis. J Crit Care. 2010 ; 25: 576-581
3. Seear M, Lockitch G, Jakobson B, Quigley G, MacNab A. Thiamin, riboflavin, and pyridoxine deficiencies in a population of critically ill children. J Pediatr. 1992 ; 121: 533-538
4. Manzanares W, Hardy G. Thiamine supplementation in the critically ill. Curr Opin Clin Nutr Metab Care. 2011 ; 14: 610-617
5. Francini-Pesenti F, Brocadello F, Manara R, Santelli L, Laroni A, Caregaro L. Wernicke's syndrome during parenteral feeding: not an unusual complication. Nutrition. 2009 ; 25: 142-146
6. Sequeira Lopes da Silva JT, Almaraz Velarde R, Olgado Ferrero F, et al. Wernicke's encephalopathy induced by total parenteral nutrition. Nutr Hosp. 2010 ; 25: 1034-1036
7. Sánchez Rodríguez T, García Marín A, Camarero Mulas C, Sanz Sánchez M, Turégano Fuentes F. Wernicke's encephalopathy after gastrectomy due to thiamine deficiency. Rev Esp Enferm Dig. 2009 ; 101: 296-302
8. Fernández Suárez FE, Hernández Bujedo M, Varela Rodríguez L, Fernández Miranda A, García Arango B, Miyar Villarica MC. Beriberi tras una esofaguectomía. Rev Esp Anestesiol Reanim. 2002 ; 49: 541-544
9. Sechi G, Serra A. Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management. Lancet Neurol. 2007 ; 6: 442-455
10. Gascón-Bayarri J, Campdelacreu J, Garcìa-Carreira MC, et al. Wernicke's encephalopathy in non-alcoholic patients: a series of 8 cases. Neurologìa. 2011 ; 26: 540-547
11. Fei JQ, Zhong C, Jin L, et al. Clinical characteristics and MR imaging features of nonalcoholic Wernicke encephalopathy. Am J Neuroradiol. 2008 ; 29: 164-169
12. Seligmann H, Halkin H, Rauchfleisch S, et al. Thiamine deficiency in patients with congestive heart failure receiving long-term furosemide therapy: a pilot study. Am J Med. 1991 ; 91: 151-155
13. Dyckner T, Ek B, Nyhlin H, Wester PO. Aggravation of thiamine deficiency by magnesium depletion: a case report. Acta Med Scand. 1985 ; 218: 129-131
14. McLean J, Manchip S. Wernicke's encephalopathy induced by magnesium depletion. Lancet. 1999 ; 353: 1768
15. Vanek VW, Borum P, Buchman A, et al. A.S.P.E.N. Position paper: recommendations for changes in commercially available parenteral multivitamin and multi-trace element products. Nutr Clin Pract. 2012 ; 27: 440-491
16. Lactic acidosis traced to thiamine deficiency related to nationwide shortage of multivitamins for total parenteral nutrition. MMWR Morb Mortal Wkly Rep. 1997 ; 46: 523-528
17. Romanski SA, McMahon MM. Metabolic acidosis and thiamine deficiency. Mayo Clin Proc. 1999 ; 74: 259-263
18. Hahn JS, Berquist W, Alcorn DM, Chamberlain L, Bass D. Wernicke encephalopathy and beriberi during total parenteral nutrition attributable to multivitamin infusion shortage. Pediatrics. 1998 ; 101: E10
19. Clinical guidelines for the use of parenteral and enteral nutrition in adult and pediatric patients. J Parenter Enteral Nutr. 2009 ; 33: 255-259
20. Singer P, Berger MM, Van Der Berghe G, Biolo G, Calder P, Forbes A. ESPEN guidelines on parenteral nutrition: intensive care. Clin Nutr. 2009 ; 28: 387-400
21. American Hospital Association. AHA survey on drug shortages. Available at: www.aha.org/content/11/drugshortagesurvey.pdf. Accessed March 3, 2014.
22. American Society for Parenteral and Enteral Nutrition. Drug shortages update. Available at: http://www.nutritioncare.org/Professional-Resources/Drug-Shortages-Update/. Accessed March 4, 2014.
23. Rufa A, Rosini F, Cerase A, et al. Wernicke encephalopathy after gastrointestinal surgery for cancer: causes of diagnostic failure or delay. Int J Neurosci. 2011 ; 121: 201-208
24. Hazell AS, Butterworth RF. Update of cell damage mechanisms in thiamine deficiency: focus on oxidative stress, excitotoxicity and inflammation. Alcohol Alcoholism. 2009 ; 44: 141-147
25. Kitamura K, Takahashi T, Tanaka H, et al. Two cases of thiamine deficiency-induced lactic acidosis during total parenteral nutrition. Tohoku J Exp Med. 1993 ; 171: 129-133
26. Rieck J, Halkin H, Almog S, et al. Urinary loss of thiamine is increased by low doses of furosemide in healthy volunteers. J Lab Clin Med. 1999 ; 134: 238-243
27. Zenuk C, Healey J, Donnelly J, Vaillancourt R, Almalki Y, Smith S. Thiamine deficiency in congestive heart failure patients receiving long term furosemide therapy. Can J Clin Pharmacol. 2003 ; 10: 184-188
28. Galvin R, Bråthen G, Ivashynka A, Hillbom M, Tanasescu R, Leone MA. EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy. Eur J Neurol. 2010 ; 17: 1408-1418