Genetic variants of STAT4 are associated with ankylosing spondylitis susceptibility and severity in a chinese han population

International Journal of Clinical and Experimental Medicine

Volumn 7, Issue 12, 2014, Pages 5877-5881

  Liu, Zhixiang ^a   Zhang, Peisen ^a   Dong, Jie ^a  

^a WEIFANG MEDICAL UNIVERSITY   (China)

Author keywords

Ankylosing spondylitis; Chinese Han population; Gene polymorphism; STAT4

Indexed keywords

STAT4 PROTEIN;

ADULT; ALLELE; ANKYLOSING SPONDYLITIS; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; GENETIC VARIABILITY; GENOTYPE; HAN CHINESE; HUMAN; MAJOR CLINICAL STUDY; MALE; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84921441821     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Braun J and Sieper J. Ankylosing spondylitis. Lancet 2007; 369: 1379-1390.
2. Australo-Anglo-American Spondyloarthritis C, Reveille JD, Sims AM, Danoy P, Evans DM, Leo P, Pointon JJ, Jin R, Zhou X, Bradbury LA, Ap-pleton LH, Davis JC, Diekman L, Doan T, Do-wling A, Duan R, Duncan EL, Farrar C, Hadler J, Harvey D, Karaderi T, Mogg R, Pomeroy E, Pry-ce K, Taylor J, Savage L, Deloukas P, Kumanduri V, Peltonen L, Ring SM, Whittaker P, Glazov E, Thomas GP, Maksymowych WP, Inman RD, Wa-rd MM, Stone MA, Weisman MH, Wordsworth BP and Brown MA. Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nat Genet 2010; 42: 123-127.
3. Ng SC, Liao Z, Yu DT, Chan ES, Zhao L and Gu J. Epidemiology of spondyloarthritis in the People’s Republic of China: review of the literature and commentary. Semin Arthritis Rheum 2007; 37: 39-47.
4. Feldtkeller E, Khan MA, van der Heijde D, van der Linden S and Braun J. Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis. Rheumatol Int 2003; 23: 61-66.
5. Brown MA, Laval SH, Brophy S and Calin A. Recurrence risk modelling of the genetic susceptibility to ankylosing spondylitis. Ann Rhe-um Dis 2000; 59: 883-886.
6. Brown MA, Kennedy LG, MacGregor AJ, Darke C, Duncan E, Shatford JL, Taylor A, Calin A and Wordsworth P. Susceptibility to ankylosing spo-ndylitis in twins: the role of genes, HLA, and the environment. Arthritis Rheum 1997; 40: 1823-1828.
7. Brewerton DA, Hart FD, Nicholls A, Caffrey M, James DC and Sturrock RD. Ankylosing spondylitis and HL-A 27. Lancet 1973; 1: 904-907.
8. Khan MA and Ball EJ. Genetic aspects of ankylosing spondylitis. Best Pract Res Clin Rheu-matol 2002; 16: 675-690.
9. Frucht DM, Aringer M, Galon J, Danning C, Br-own M, Fan S, Centola M, Wu CY, Yamada N, El Gabalawy H and O’Shea JJ. Stat4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1-mediated inflammation. J Immunol 2000; 164: 4659-4664.
10. Mathur AN, Chang HC, Zisoulis DG, Stritesky GL, Yu Q, O'Malley JT, Kapur R, Levy DE, Kansas GS and Kaplan MH. Stat3 and Stat4 direct development of IL-17-secreting Th cells. J Im-munol 2007; 178: 4901-4907.
11. Watford WT, Hissong BD, Bream JH, Kanno Y, Muul L and O'Shea JJ. Signaling by IL-12 and IL-23 and the immunoregulatory roles of ST-AT4. Immunol Rev 2004; 202: 139-156.
12. Zhao Y, Liu X, Liu X, Su Y, Li Y, Zhang X, Zhu L, Wang S, Wang T, Jiang Q, Liu X, Li X, Huang C, Jia R, Lu X, Guo J and Li Z. Association of STAT4 gene polymorphism with increased susceptibility of rheumatoid arthritis in a northern Chinese Han subpopulation. Int J Rheum Dis 2013; 16: 178-184.
13. Tong G, Zhang X, Tong W and Liu Y. Association between polymorphism in STAT4 gene and risk of rheumatoid arthritis: a meta-analysis. Hum Immunol 2013; 74: 586-592.
14. Mohamed RH, Pasha HF and El-Shahawy EE. Influence of TRAF1/C5 and STAT4 genes polymorphisms on susceptibility and severity of rheumatoid arthritis in Egyptian population. Cell Immunol 2012; 273: 67-72.
15. Zervou MI, Sidiropoulos P, Petraki E, Vazgiou-rakis V, Krasoudaki E, Raptopoulou A, Kritikos H, Choustoulaki E, Boumpas DT and Gouliel-mos GN. Association of a TRAF1 and a STAT4 gene polymorphism with increased risk for rheumatoid arthritis in a genetically homogeneous population. Hum Immunol 2008; 69: 567-571.
16. Orozco G, Alizadeh BZ, Delgado-Vega AM, Gon-zalez-Gay MA, Balsa A, Pascual-Salcedo D, Fer-nandez-Gutierrez B, Gonzalez-Escribano MF, Petersson IF, van Riel PL, Barrera P, Coenen MJ, Radstake TR, van Leeuwen MA, Wijmenga C, Koeleman BP, Alarcon-Riquelme M and Mar-tin J. Association of STAT4 with rheumatoid arthritis: a replication study in three European populations. Arthritis Rheum 2008; 58: 1974-1980.
17. van der Linden S, Valkenburg HA and Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum 1984; 27: 361-368.
18. Braun J, Golder W, Bollow M, Sieper J and van der Heijde D. Imaging and scoring in ankylosing spondylitis. Clin Exp Rheumatol 2002; 20: S178-184.
19. Walsh PS, Metzger DA and Higuchi R. Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. Biotechniques 1991; 10: 506-513.
20. Miossec P. Interleukin-17 in fashion, at last: ten years after its description, its cellular sou-rce has been identified. Arthritis Rheum 2007; 56: 2111-2115.
21. Sigurdsson S, Nordmark G, Garnier S, Grund-berg E, Kwan T, Nilsson O, Eloranta ML, Gunna-rsson I, Svenungsson E, Sturfelt G, Bengtsson AA, Jonsen A, Truedsson L, Rantapaa-Dahlqvist S, Eriksson C, Alm G, Goring HH, Pastinen T, Syvanen AC and Ronnblom L. A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5. Hum Mol Genet 2008; 17: 2868-2876.
22. Kariuki SN, Kirou KA, MacDermott EJ, Barillas-Arias L, Crow MK and Niewold TB. Cutting ed-ge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo. J Immunol 2009; 182: 34-38.
23. Abelson AK, Delgado-Vega AM, Kozyrev SV, Sanchez E, Velazquez-Cruz R, Eriksson N, Woj-cik J, Linga Reddy MV, Lima G, D’Alfonso S, Migliaresi S, Baca V,Orozco L, Witte T, Ortego-Cen-teno N, group A, Abderrahim H, Pons-Estel BA, Gutierrez C, Suarez A, Gonzalez-Escribano MF, Martin J and Alarcon-Riquelme ME. STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk. Ann Rheum Dis 2009; 68: 1746-1753.