Embryo selection using metabolomics

Methods in Molecular Biology

Volumn 1154, Issue , 2014, Pages 533-540

  Sakkas, D ^a  

^a NONE

Author keywords

Algorithm; Embryo selection; Embryo viability; Metabolomics; Near infra red spectrometry

Indexed keywords

ARTICLE; EMBRYO CULTURE; EMBRYO SELECTION; EMBRYO TRANSFER; FETAL WELL BEING; GLUCOSE TRANSPORT; HUMAN; INFERTILITY THERAPY; METABOLISM; METABOLOMICS; MULTIPLE EMBRYO TRANSFER; NEAR INFRARED SPECTROSCOPY; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL; ANIMAL EMBRYO; BLASTOCYST; CULTURE MEDIUM; FERTILIZATION IN VITRO; GENETICS; MOLECULAR BIOLOGY; NIDATION; PROCEDURES;

CULTURE MEDIUM;

BLASTOCYST; CULTURE MEDIA; EMBRYO CULTURE TECHNIQUES; EMBRYO IMPLANTATION; EMBRYO TRANSFER; EMBRYO, MAMMALIAN; FERTILIZATION IN VITRO; HUMANS; METABOLOMICS; MOLECULAR BIOLOGY;

EID: 84921437779     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-0659-8_24     Document Type: Article

References (35)

1. Steptoe PC, Edwards RG (1978) Birth after the reimplantation of a human embryo [letter]. Lancet 2(8085): 366.
2. Trounson A, Mohr L (1983) Human pregnancy following cryopreservation, thawing and transfer of an eight-cell embryo. Nature 305(5936): 707-709.
3. Lutjen P, Trounson A, Leeton J, Findlay J, Wood C, Renou P (1984) The establishment and maintenance of pregnancy using in vitro fertilization and embryo donation in a patient with primary ovarian failure. Nature 307(5947): 174-175.
4. Society for Assisted Reproduction Technology (SART) 2009 data. https://www. sartcorsonl i n e. c o m/r p t C S R_P u b l i c M u l t Ye a r. aspx?ClinicPKID=0.
5. De MJ, Goossens V, Bhattacharya S, Castilla JA, Ferraretti AP, Korsak V et al (2010) Assisted reproductive technology in Europe, 2006: results generated from European registers by ESHRE. Hum Reprod 25(8): 1851-1862.
6. Adashi EY, Barri PN, Berkowitz R, Braude P, Bryan E, Carr J et al (2003) Infertility therapyassociated multiple pregnancies (births): an ongoing epidemic. Reprod Biomed Online 7(5): 515-542.
7. Ledger WL, Anumba D, Marlow N, Thomas CM, Wilson EC (2006) The costs to the NHS of multiple births after IVF treatment in the UK. BJOG 113(1): 21-25.
8. Cummins J, Breen T, Harrison K, Shaw J, Wilson L, Hennessey J (1986) A formula for scoring human embryo growth rates in in vitro fertilization: its value in predicting pregnancy and in comparison with visual estimates of embryo quality. J In Vitro Fert Embryo Transf 3: 284-295.
9. Edwards R, Fishel S, Cohen J (1984) Factors influencing the success of in vitro fertilization for alleviating human infertility. J In Vitro Fert Embryo Transf 1: 3-23.
10. De Neubourg D, Gerris J (2003) Single embryo transfer-state of the art. Reprod Biomed Online 7(6): 615-622.
11. Sakkas D, Gardner DK (2004) Evaluation of embryo quality. In: Gardner DK, Weissman A, Howles C, Shoham Z (eds) Assisted reproduction technology laboratory and clinical perspectives, 2nd edn. Martin Dunitz Press, London, pp 211-234.
12. Sakkas D, Gardner DK (2005) Noninvasive methods to assess embryo quality. Curr Opin Obstet Gynecol 17(3): 283-288.
13. Gardner DK, Surrey E, Minjarez D, Leitz A, Stevens J, Schoolcraft WB (2004) Single blastocyst transfer: a prospective randomized trial. Fertil Steril 81(3): 551-555.
14. Inge GB, Brinsden PR, Elder KT (2005) Oocyte number per live birth in IVF: were Steptoe and Edwards less wasteful? Hum Reprod 20(3): 588-592.
15. Patrizio P, Sakkas D (2009) From oocyte to baby: a clinical evaluation of the biological effi-ciency of in vitro fertilization. Fertil Steril 91(4): 1061-1066.
16. Renard JP, Philippon A, Menezo Y (1980) In-vitro uptake of glucose by bovine blastocysts. J Reprod Fertil 58(1): 161-164.
17. Gardner DK, Leese HJ (1987) Assessment of embryo viability prior to transfer by the noninvasive measurement of glucose uptake. J Exp Zool 242(1): 103-105.
18. Lane M, Gardner DK (1996) Selection of viable mouse blastocysts prior to transfer using a metabolic criterion. Hum Reprod 11(9): 1975-1978.
19. Botros L, Sakkas D, Seli E (2008) Metabolomics and its application for non-invasive embryo assessment in IVF. Mol Hum Reprod 14(12): 679-690.
20. Oliver SG, Winson MK, Kell DB, Baganz F (1998) Systematic functional analysis of the yeast genome. Trends Biotechnol 16(9): 373-378.
21. Ellis DI, Goodacre R (2006) Metabolic fingerprinting in disease diagnosis: biomedical applications of infrared and Raman spectroscopy. Analyst 131(8): 875-885.
22. Seli E, Sakkas D, Scott R, Kwok SH, Rosendahl S, Burns DH (2007) Non-invasive metabolomic profiling of embryo culture media using Raman and near infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Fertil Steril 88(5): 1350-1357.
23. Katz-Jaffe MG, Schoolcraft WB, Gardner DK (2006) Analysis of protein expression (secretome) by human and mouse preimplantation embryos. Fertil Steril 86(3): 678-685.
24. Katz-Jaffe MG, Gardner DK, Schoolcraft WB (2006) Proteomic analysis of individual human embryos to identify novel biomarkers of development and viability. Fertil Steril 85(1): 101-107.
25. Scott R, Seli E, Miller K, Sakkas D, Scott K, Burns DH (2008) Noninvasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential: a prospective blinded pilot study. Fertil Steril 90(1): 77-83.
26. Seli E, Vergouw CG, Morita H, Botros L, Roos P, Lambalk CB et al (2010) Noninvasive metabolomic profiling as an adjunct to morphology for noninvasive embryo assessment in women undergoing single embryo transfer. Fertil Steril 94(2): 535-542.
27. Ahlstrom A, Wikland M, Rogberg L, Barnett JS, Tucker M, Hardarson T (2011) Crossvalidation and predictive value of near-infrared spectroscopy algorithms for day-5 blastocyst transfer. Reprod Biomed Online 22(5): 477-484.
28. Vergouw CG, Botros LL, Roos P, Lens JW, Schats R, Hompes PG et al (2008) Metabolomic profiling by near-infrared spectroscopy as a tool to assess embryo viability: a novel, non-invasive method for embryo selection. Hum Reprod 23(7): 1499-1504.
29. Seli E, Bruce C, Botros L, Henson M, Roos P, Judge K et al (2011) Receiver operating characteristic (ROC) analysis of day 5 morphology grading and metabolomic Viability Score on predicting implantation outcome. J Assist Reprod Genet 28(2): 137-144.
30. Hardarson T, Ahlstrom A, Rogberg L, Botros L, Hillensjo T, Westlander G et al (2012) Noninvasive metabolomic profiling of Day 2 and 5 embryo culture media: a prospective randomized trial. Hum Reprod 27: 89-96.
31. Blake DA, Farquhar CM, Johnson N, Proctor M (2007) Cleavage stage versus blastocyst stage embryo transfer in assisted conception. Cochrane Database Syst Rev (4): CD002118.
32. Vergouw CG. Metabolomic profiling of culture media by NIR spectroscopy as an adjunct to morphology for selection of a single Day 3 embryo to transfer: a double blind randomised trial (unpublished data).
33. Sfontouris IA, Lainas GT, Sakkas D, Zorzovilis IZ, Petsas GK, Lainas TG (2013) Non-invasive metabolomic analysis using a commercial NIR instrument for embryo selection. J Hum Reprod Sci 6(2): 133-139.
34. Mastenbroek S, Twisk M, van Echten-Arends J, Sikkema-Raddatz B, Korevaar JC, Verhoeve HR et al (2007) In vitro fertilization with preimplantation genetic screening. N Engl J Med 357(1): 9-17.
35. Wells D, Alfarawati S, Fragouli E (2008) Use of comprehensive chromosomal screening for embryo assessment: microarrays and CGH. Mol Hum Reprod 14(12): 703-710.