Prediagnostic transcriptomic markers of Chronic lymphocytic leukemia reveal perturbations 10 years before diagnosis

Annals of Oncology

Volumn 25, Issue 5, 2014, Pages 1065-1072

  Chadeau Hyam, M ^a   Vermeulen, R C H ^b,c   Hebels, D G A J ^d   Castagne R ^a   Campanella, G ^a   Portengen, L ^b   Kelly, R S ^a   Bergdahl, I A ^e,f   Melin, B ^g   Hallmans, G ^e   Palli, D ^h   Krogh, V ⁱ   Tumino, R ^j   Sacerdote, C ^k   Panico, S ^l   de Kok, T M C M ^d   Smith, M T ^m   Kleinjans, J C S ^d   Vineis, P ^a,k   Kyrtopoulos, S A ⁿ   Georgiadis, P ^f   Botsivali, M ^f   Papadopoulou, C ^f   Chatziioannou, A ^f   Valavanis, I ^f   Gottschalk, R ^f   van Leeuwen, D ^f   Timmermans, L ^f   Keun, H C ^f   Athersuch, T J ^f   Lenner, P ^f   Bendinelli, B ^f   Stephanou, E G ^f   Myridakis, A ^f   Kogevinas, M ^f   Saberi Hosnijeh, F ^f   Fazzo, L ^f   de Santis, M ^f   Comba, P ^f   Kiviranta, H ^f   Rantakokko, P ^f   Airaksinen, R ^f   Ruokojarvi, P ^f   Gilthorpe, M S ^f   Fleming, S ^f   Fleming, T ^f   Tu, Y K ^f   Jonsson, B ^f   Lundh, T ^f   Chien, K L ^f   Chen, W J ^f   Lee, W C ^f   Hsiao, C K ^f   Kuo, P H ^f   Hung, H ^f   Liao, S F ^f   more..

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d MAASTRICHT UNIVERSITY   (Netherlands)

^e Nutritional Research

^f Department of Public Health and Clinical Medicine ^*

^g UMEÅ UNIVERSITY   (Sweden)

^h ISPO Cancer Prevention and Research Institute   (Italy)

ⁱ NATIONAL CANCER INSTITUTE   (Italy)

^j Ragusa Cancer Registry Azienda Ospedaliera Civile MP Arezzo

^k Human Genetics Foundation

^l UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^m UNIVERSITY OF CALIFORNIA   (United States)

ⁿ INSTITUTE OF BIOLOGY   (Greece)

more..

Author keywords

chronic lymphocytic leukemia; epidemiology; lymphoma; mRNA analyses; prospective cohort

Indexed keywords

TRANSCRIPTOME; TUMOR MARKER;

ADULT; AGED; BIOLOGICAL MODEL; BLOOD; CASE CONTROL STUDY; FEMALE; GENETICS; HUMAN; HUMAN GENOME; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; PRINCIPAL COMPONENT ANALYSIS; PROSPECTIVE STUDY;

ADULT; AGED; CASE-CONTROL STUDIES; FEMALE; GENOME, HUMAN; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; MODELS, GENETIC; PRINCIPAL COMPONENT ANALYSIS; PROSPECTIVE STUDIES; TRANSCRIPTOME; TUMOR MARKERS, BIOLOGICAL;

EID: 84921433441     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdu056     Document Type: Article

References (23)

1. Khan, A.E., Gallo, V., Linseisen, J., et al. Diabetes and the risk of non-Hodgkin's lymphoma and multiple myeloma in the European Prospective Investigation into Cancer and Nutrition. Haematologica 93 (2008), 842–850.
2. Clarke, C.A., Glaser, S.L., Dorfman, R.F., et al. Expert review of non-Hodgkin's lymphomas in a population-based cancer registry: reliability of diagnosis and subtype classifications. Cancer Epidemiol Biomarkers Prev 13 (2004), 138–143.
3. Nieters, A., Rohrmann, S., Becker, N., et al. Smoking and lymphoma risk in the European Prospective Investigation into Cancer and nutrition. Am J Epidemiol 167 (2008), 1081–1089.
4. Levy, H., Wang, X., Kaldunski, M., et al. Transcriptional signatures as a disease-specific and predictive inflammatory biomarker for type 1 diabetes. Genes Immun 13 (2012), 593–604.
5. Alizadeh, A.A., Eisen, M.B., Davis, R.E., et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403 (2000), 503–511.
6. Fekete, T., Raso, E., Pete, I., et al. Meta-analysis of gene expression profiles associated with histological classification and survival in 829 ovarian cancer samples. Int J Cancer 131 (2012), 95–105.
7. van 't Veer, L.J., Dai, H.Y., van de Vijver, M.J., et al. Expression profiling predicts outcome in breast cancer. Breast Cancer Res 5 (2003), 57–58.
8. Vineis, P., Perera, F., Molecular epidemiology and biomarkers in etiologic cancer research: the new in light of the old. Cancer Epidemiol Biomarkers Prev 16 (2007), 1954–1965.
9. Lund, E., Plancade, S., Transcriptional output in a prospective design conditionally on follow-up and exposure: the multistage model of cancer. Int J Mol Epidemiol Genet 3 (2012), 107–114.
10. Palli, D., Berrino, F., Vineis, P., et al. A molecular epidemiology project on diet and cancer: the EPIC-Italy prospective study. Design and baseline characteristics of participants. Tumori 89 (2003), 586–593.
11. Hallmans, G., Agren, A., Johansson, G., et al. Cardiovascular disease and diabetes in the Northern Sweden Health and Disease Study Cohort—evaluation of risk factors and their interactions. Scand J Public Health Suppl 61 (2003), 18–24.
12. Fritz, A., Percy, C., Jack, A., et al. International Classification of Diseases for Oncology, 3rd edition (ICD-O-3). 2000, World Health Organization, Geneva, Switzerland.
13. Hebels, D.G.A.J., Georgiadis, P., Keun, H.C., et al. Performance in omics analyses of blood samples in long-term storage: opportunities for the exploitation of existing biobanks in environmental health research. Environ Health Perspect 121 (2013), 480–487.
14. McHale, C.M., Zhang, L.P., Lan, Q., et al. Global gene expression profiling of a population exposed to a range of benzene levels. Environ Health Perspect 119 (2011), 628–634.
15. Franceschi, S., Lise, M., Trepo, C., et al. Infection with hepatitis B and C viruses and risk of lymphoid malignancies in the European Prospective Investigation into Cancer and nutrition (EPIC). Cancer Epidemiol Biomarkers Prev 20 (2011), 208–214.
16. van Veldhoven, C.M., Khan, A.E., Teucher, B., et al. Physical activity and lymphoid neoplasms in the European Prospective Investigation into Cancer and nutrition (EPIC). Eur J Cancer 47 (2011), 748–760.
17. Morton, L.M., Turner, J.J., Cerhan, J.R., et al. Pro-posed classification of lymphoid neoplasms for epidemiologic research from the Pathology Working Group of the International Lymphoma Epidemiology Consortium (InterLymph). Blood 110 (2007), 695–708.
18. Jelinek, D.F., Tschumper, R.C., Stolovitzky, G.A., et al. Identification of a global gene expression signature of B-chronic lymphocytic leukemia. Mol Cancer Res 1 (2003), 346–361.
19. Mahadevan, D., Choi, J., Cooke, L., et al. Gene expression and serum cytokine profiling of low stage CLL identify WNT/PCP, Flt-3L/Flt-3 and CXCL9/CXCR3 as regulators of cell proliferation, survival and migration. Hum Genomics Proteomics, 2009, 2009, 453634.
20. Landgren, O., Albitar, M., Ma, W.L., et al. B-Cell clones as early markers for chronic lymphocytic leukemia. N Engl J Med 360 (2009), 659–667.
21. Mowery, Y.M., Lanasa, M.C., Clinical aspects of monoclonal B-cell lymphocytosis. Cancer Control 19 (2012), 8–17.
22. Lanasa, M.C., Allgood, S.D., Slager, S.L., et al. Immunophenotypic and gene expression analysis of monoclonal B-cell lymphocytosis shows biologic characteristics associated with good prognosis CLL. Leukemia 25 (2011), 1459–1466.
23. López, C., Delgado, J., Costa, D., et al. Clonal evolution in chronic lymphocytic leukemia: analysis of correlations with IGHV mutational status, NOTCH1 mutations and clinical significance. Genes Chromosomes Cancer 52 (2013), 920–927.