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Volumn 14, Issue 2, 2015, Pages 335-342

Tigecycline: A critical safety review

Author keywords

Adverse reactions; Drugs interactions; Safety evaluation; Tigecycline

Indexed keywords

CONTRACEPTIVE AGENT; CYCLOSPORIN; DIGOXIN; TIGECYCLINE; WARFARIN; ANTIINFECTIVE AGENT; MINOCYCLINE;

EID: 84921416194     PISSN: 14740338     EISSN: 1744764X     Source Type: Journal    
DOI: 10.1517/14740338.2015.997206     Document Type: Review
Times cited : (75)

References (52)
  • 1
    • 84897918505 scopus 로고    scopus 로고
    • Ready for a world without antibiotics? The pensières antibiotic resistance call to action
    • Carlet J, Jarlier V, Harbarth S, et al. Ready for a world without antibiotics? The pensières antibiotic resistance call to action. Antimicrob Resist Infect Control 2012;1(1):11
    • (2012) Antimicrob Resist Infect Control , vol.1 , Issue.1 , pp. 11
    • Carlet, J.1    Jarlier, V.2    Harbarth, S.3
  • 2
    • 0347357817 scopus 로고    scopus 로고
    • Oritavancin and tigecycline: Investigational antimicrobials for multidrug-resistant bacteria
    • Guay DR. Oritavancin and tigecycline: investigational antimicrobials for multidrug-resistant bacteria. Pharmacotherapy 2004;24(1):58-68
    • (2004) Pharmacotherapy , vol.24 , Issue.1 , pp. 58-68
    • Guay, D.R.1
  • 4
    • 84921397315 scopus 로고    scopus 로고
    • Increased Risk of Death With Tygacil (Tigecycline) Compared to Other Antibiotics used to Treat Similar Infections
    • Available from: [Last accessed 10 March 2014]
    • Increased Risk of Death With Tygacil (Tigecycline) Compared to Other Antibiotics used to Treat Similar Infections. FDA drug safety and availability. FDA/center for drug evaluation and research. 2010. Available from: http://www.fda.gov/Drugs/DrugSafety/ucm224370.htm [Last accessed 10 March 2014]
    • (2010) FDA Drug Safety and Availability. FDA/center for Drug Evaluation and Research
  • 5
    • 84921397314 scopus 로고    scopus 로고
    • FDA Warns of Increased Risk of Death With IV Antibacterial Tygacil (Tigecycline) and Approves new Boxed Warning
    • Available from: [Last accessed 10 March 2014]
    • FDA Warns of Increased Risk of Death With IV Antibacterial Tygacil (Tigecycline) and Approves new Boxed Warning. FDA drug safety communication. FDA/center for drug evaluation and research. 2013. Available from: http://www.fda.gov/drugs/drugsafety/ucm369580.htm [Last accessed 10 March 2014]
    • (2013) FDA Drug Safety Communication. FDA/center for Drug Evaluation and Research
  • 7
    • 11244353707 scopus 로고    scopus 로고
    • Pharmacokinetics of tigecycline after single and multiple doses in healthy subjects
    • Muralidharan G, Micalizzi M, Speth J, et al. Pharmacokinetics of tigecycline after single and multiple doses in healthy subjects. Antimicrob Agents Chemother 2005;49:220-9
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 220-229
    • Muralidharan, G.1    Micalizzi, M.2    Speth, J.3
  • 8
    • 28044443844 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, safety and tolerability of tigecycline
    • Rello J. Pharmacokinetics, pharmacodynamics, safety and tolerability of tigecycline. J Chemother 2005;17(Suppl 1):12-22
    • (2005) J Chemother , vol.17 , pp. 12-22
    • Rello, J.1
  • 9
    • 78650811738 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of a single intravenous dose of the antibiotic tigecycline in patients with cirrhosis
    • Korth-Bradley JM, Baird-Bellaire SJ, Patat AA, et al. Pharmacokinetics and safety of a single intravenous dose of the antibiotic tigecycline in patients with cirrhosis. J Clin Pharmacol 2011;51:93-101
    • (2011) J Clin Pharmacol , vol.51 , pp. 93-101
    • Korth-Bradley, J.M.1    Baird-Bellaire, S.J.2    Patat, A.A.3
  • 10
    • 0032918653 scopus 로고    scopus 로고
    • In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936)
    • Petersen PJ, Jacobus NV, Weiss WJ, et al. In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936). Antimicrob Agents Chemother 1999;43:738-44
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 738-744
    • Petersen, P.J.1    Jacobus, N.V.2    Weiss, W.J.3
  • 11
    • 84455169913 scopus 로고    scopus 로고
    • Pharmacokinetics-pharmacodynamics of tigecycline in patients with community-acquired pneumonia
    • Rubino CM, Bhavnani SM, Forrest A, et al. Pharmacokinetics-pharmacodynamics of tigecycline in patients with community-acquired pneumonia. Antimicrob Agents Chemother 2012;56:130-6
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 130-136
    • Rubino, C.M.1    Bhavnani, S.M.2    Forrest, A.3
  • 12
    • 0033843634 scopus 로고    scopus 로고
    • In vitro activity of GAR-936 against chlamydia pneumoniae and chlamydia trachomatis
    • Roblin PM, Hammerschlag MR. In vitro activity of GAR-936 against chlamydia pneumoniae and chlamydia trachomatis. Int J Antimicrob Agents 2000;16:61-3
    • (2000) Int J Antimicrob Agents , vol.16 , pp. 61-63
    • Roblin, P.M.1    Hammerschlag, M.R.2
  • 13
    • 84896978278 scopus 로고    scopus 로고
    • Tigecycline activity when tested against bacterial strains from united states medical centers: Variation in potency and spectrum since approval for clinical use (2006-2012)
    • Sader HS, Farrell DJ, Flamm RK, et al. Tigecycline activity when tested against bacterial strains from united states medical centers: variation in potency and spectrum since approval for clinical use (2006-2012). Antimicrob Agents Chemother 2014;doi: 10.1128/AAC.02684-13
    • (2014) Antimicrob Agents Chemother
    • Sader, H.S.1    Farrell, D.J.2    Flamm, R.K.3
  • 14
    • 23844479577 scopus 로고    scopus 로고
    • Tigecycline 300 cSSSI Study Group. The efficacy and safety of tigecycline in the treatment of skin and skin-structure infections: Results of 2 double-blind phase 3 comparison studies with vancomycin-aztreonam
    • Ellis-Grosse EJ, Babinchak T, Dartois N, et al. Tigecycline 300 cSSSI Study Group. The efficacy and safety of tigecycline in the treatment of skin and skin-structure infections: results of 2 double-blind phase 3 comparison studies with vancomycin-aztreonam. Clin Infect Dis 2005;41(Suppl 5):S341-53
    • (2005) Clin Infect Dis , vol.41 , pp. S341-S353
    • Ellis-Grosse, E.J.1    Babinchak, T.2    Dartois, N.3
  • 15
    • 23844486729 scopus 로고    scopus 로고
    • The efficacy and safety of tigecycline for the treatment of complicated intra-abdominal infections: Analysis of pooled clinical trial data
    • Babinchak T, Ellis-Grosse E, Dartois N, et al. Tigecycline 301 Study Group. The efficacy and safety of tigecycline for the treatment of complicated intra-abdominal infections: analysis of pooled clinical trial data. Clin Infect Dis 2005;41(Suppl 5):S354-67
    • (2005) Clin Infect Dis , vol.41 , pp. S354-S367
    • Babinchak, T.1    Ellis-Grosse, E.2    Dartois, N.3
  • 16
    • 45549109768 scopus 로고    scopus 로고
    • Integrated results of 2 Phase III studies comparing tigecycline and levofloxacin in community-acquired pneumonia
    • Tanaseanu C, Bergallo C, Teglia O, et al. Integrated results of 2 Phase III studies comparing tigecycline and levofloxacin in community-acquired pneumonia. Diagn Microbiol Infect Dis 2008;61:329-38
    • (2008) Diagn Microbiol Infect Dis , vol.61 , pp. 329-338
    • Tanaseanu, C.1    Bergallo, C.2    Teglia, O.3
  • 17
    • 77956576770 scopus 로고    scopus 로고
    • Comparison of tigecycline with imipenem/cilastatin for the treatment of hospital-acquired pneumonia
    • Freire AT, Melnyk V, Kim MJ, et al. Comparison of tigecycline with imipenem/cilastatin for the treatment of hospital-acquired pneumonia. Diagn Microbiol Infect Dis 2010;68:140-51
    • (2010) Diagn Microbiol Infect Dis , vol.68 , pp. 140-151
    • Freire, A.T.1    Melnyk, V.2    Kim, M.J.3
  • 18
    • 33845309674 scopus 로고    scopus 로고
    • Four cases of invasive methicillin-resistant staphylococcus aureus (MRSA) infections treated with tigecycline
    • Munoz-Price LS, Lolans K, Quinn JP. Four cases of invasive methicillin-resistant staphylococcus aureus (MRSA) infections treated with tigecycline. Scand J Infect Dis 2006;38:1081-4
    • (2006) Scand J Infect Dis , vol.38 , pp. 1081-1084
    • Munoz-Price, L.S.1    Lolans, K.2    Quinn, J.P.3
  • 19
    • 84866072596 scopus 로고    scopus 로고
    • Predictors of mortality in bloodstream infections caused by klebsiella pneumoniae carbapenemase-producing K. Pneumoniae: Importance of combination therapy
    • Tumbarello M, Viale P, Viscoli C, et al. Predictors of mortality in bloodstream infections caused by klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy. Clin Infect Dis 2012;55:943-50
    • (2012) Clin Infect Dis , vol.55 , pp. 943-950
    • Tumbarello, M.1    Viale, P.2    Viscoli, C.3
  • 20
    • 80052702897 scopus 로고    scopus 로고
    • Vancomycin-resistant enterococcus faecium (VRE) bacteremia in infective endocarditis successfully treated with combination daptomycin and tigecycline
    • Polidori M, Nuccorini A, Tascini C, et al. Vancomycin-resistant enterococcus faecium (VRE) bacteremia in infective endocarditis successfully treated with combination daptomycin and tigecycline. J Chemother Florence Italy 2011;23:240-1
    • (2011) J Chemother Florence Italy , vol.23 , pp. 240-241
    • Polidori, M.1    Nuccorini, A.2    Tascini, C.3
  • 21
    • 79952118615 scopus 로고    scopus 로고
    • Brucellosis in a patient with end-stage liver disease undergoing liver transplantation: Successful treatment with tigecycline
    • Cocchi S, Bisi L, Codeluppi M, et al. Brucellosis in a patient with end-stage liver disease undergoing liver transplantation: successful treatment with tigecycline. Liver Transpl 2010;16:1215-16
    • (2010) Liver Transpl , vol.16 , pp. 1215-1216
    • Cocchi, S.1    Bisi, L.2    Codeluppi, M.3
  • 22
    • 77952243515 scopus 로고    scopus 로고
    • Primary retroperitoneal abscesses due to rhodococcus equi in a patient with severe nephrotic syndrome: Successful antibiotic treatment with linezolid and tigecycline
    • Russo G, Lichtner M, Carnevalini M, et al. Primary retroperitoneal abscesses due to rhodococcus equi in a patient with severe nephrotic syndrome: successful antibiotic treatment with linezolid and tigecycline. Int J Infect Dis 2010;14:e533-5
    • (2010) Int J Infect Dis , vol.14 , pp. e533-e535
    • Russo, G.1    Lichtner, M.2    Carnevalini, M.3
  • 23
    • 84887259304 scopus 로고    scopus 로고
    • European society of clinical microbiology and infectious diseases: Update of the treatment guidance document for clostridium difficile infection
    • Debast SB, Bauer MP, Kuijper EJ, et al. European society of clinical microbiology and infectious diseases: update of the treatment guidance document for clostridium difficile infection. Clin Microbiol Infect 2014;20:1-26
    • (2014) Clin Microbiol Infect , vol.20 , pp. 1-26
    • Debast, S.B.1    Bauer, M.P.2    Kuijper, E.J.3
  • 24
    • 67651115783 scopus 로고    scopus 로고
    • Tigecycline use in cancer patients with serious infections: A report on 110 cases from a single institution
    • Chemaly RF, Hanmod SS, Jiang Y, et al. Tigecycline use in cancer patients with serious infections: a report on 110 cases from a single institution. Medicine (Baltimore) 2009;88:211-20
    • (2009) Medicine (Baltimore) , vol.88 , pp. 211-220
    • Chemaly, R.F.1    Hanmod, S.S.2    Jiang, Y.3
  • 25
    • 32644443249 scopus 로고    scopus 로고
    • In vitro antibacterial activities of tigecycline in combination with other antimicrobial agents determined by chequerboard and time-kill kinetic analysis
    • Petersen PJ, Labthavikul P, Jones CH, et al. In vitro antibacterial activities of tigecycline in combination with other antimicrobial agents determined by chequerboard and time-kill kinetic analysis. J Antimicrob Chemother 2006;57:573-6
    • (2006) J Antimicrob Chemother , vol.57 , pp. 573-576
    • Petersen, P.J.1    Labthavikul, P.2    Jones, C.H.3
  • 26
    • 38349176291 scopus 로고    scopus 로고
    • In vitro activities of tigecycline combined with other antimicrobials against multiresistant gram-positive and gram-negative pathogens
    • Vouillamoz J, Moreillon P, Giddey M, et al. In vitro activities of tigecycline combined with other antimicrobials against multiresistant gram-positive and gram-negative pathogens. J Antimicrob Chemother 2008;61:371-4
    • (2008) J Antimicrob Chemother , vol.61 , pp. 371-374
    • Vouillamoz, J.1    Moreillon, P.2    Giddey, M.3
  • 27
    • 67349159744 scopus 로고    scopus 로고
    • Tigecycline in combination with other antimicrobials: A review of in vitro, animal and case report studies
    • Entenza JM, Moreillon P. Tigecycline in combination with other antimicrobials: a review of in vitro, animal and case report studies. Int J Antimicrob Agents 2009;34:8.e1-9
    • (2009) Int J Antimicrob Agents , vol.34 , pp. 8.e1-8.e9
    • Entenza, J.M.1    Moreillon, P.2
  • 28
    • 45749156422 scopus 로고    scopus 로고
    • Evaluation of a potential tigecycline-warfarin drug interaction
    • Zimmerman JJ, Raible DG, Harper DM, et al. Evaluation of a potential tigecycline-warfarin drug interaction. Pharmacotherapy 2008;28:895-905
    • (2008) Pharmacotherapy , vol.28 , pp. 895-905
    • Zimmerman, J.J.1    Raible, D.G.2    Harper, D.M.3
  • 29
    • 34249812684 scopus 로고    scopus 로고
    • Absence of an interaction between tigecycline and digoxin in healthy men
    • Zimmerman JJ, Harper DM, Matschke K, et al. Absence of an interaction between tigecycline and digoxin in healthy men. Pharmacotherapy 2007;27:835-44
    • (2007) Pharmacotherapy , vol.27 , pp. 835-844
    • Zimmerman, J.J.1    Harper, D.M.2    Matschke, K.3
  • 30
    • 57849104346 scopus 로고    scopus 로고
    • High serum concentrations of cyclosporin related to administration of tigecycline
    • Stumpf AN, Schmidt C, Hiddemann W, et al. High serum concentrations of cyclosporin related to administration of tigecycline. Eur J Clin Pharmacol 2009;65:101-3
    • (2009) Eur J Clin Pharmacol , vol.65 , pp. 101-103
    • Stumpf, A.N.1    Schmidt, C.2    Hiddemann, W.3
  • 31
    • 69249154737 scopus 로고    scopus 로고
    • Excretion of antimicrobials used to treat methicillin-resistant staphylococcus aureus infections during lactation: Safety in breastfeeding infants
    • Mitrano JA, Spooner LM, Belliveau P. Excretion of antimicrobials used to treat methicillin-resistant staphylococcus aureus infections during lactation: safety in breastfeeding infants. Pharmacotherapy 2009;29:1103-9
    • (2009) Pharmacotherapy , vol.29 , pp. 1103-1109
    • Mitrano, J.A.1    Spooner, L.M.2    Belliveau, P.3
  • 32
    • 84879355663 scopus 로고    scopus 로고
    • Safety and tolerability of tigecycline for the treatment of complicated skin and soft-tissue and intra-abdominal infections: An analysis based on five european observational studies
    • Guirao X, García MS, Bassetti M, et al. Safety and tolerability of tigecycline for the treatment of complicated skin and soft-tissue and intra-abdominal infections: an analysis based on five european observational studies. J Antimicrob Chemother 2013;68:ii37-44
    • (2013) J Antimicrob Chemother , vol.68 , pp. ii37-ii44
    • Guirao, X.1    García, M.S.2    Bassetti, M.3
  • 33
    • 84861894709 scopus 로고    scopus 로고
    • Adverse event profile of tigecycline: Data mining of the public version of the US FDA adverse event reporting system
    • Kadoyama K, Sakaeda T, Tamon A, et al. Adverse event profile of tigecycline: data mining of the public version of the US FDA adverse event reporting system. Biol Pharm Bull 2012;35:967-70
    • (2012) Biol Pharm Bull , vol.35 , pp. 967-970
    • Kadoyama, K.1    Sakaeda, T.2    Tamon, A.3
  • 35
    • 79952784586 scopus 로고    scopus 로고
    • Extreme alkaline phosphatase elevation associated with tigecycline
    • Bonilla MF, Avery RK, Rehm SJ, et al. Extreme alkaline phosphatase elevation associated with tigecycline. J Antimicrob Chemother 2011;66:952-3
    • (2011) J Antimicrob Chemother , vol.66 , pp. 952-953
    • Bonilla, M.F.1    Avery, R.K.2    Rehm, S.J.3
  • 37
    • 84856754658 scopus 로고    scopus 로고
    • Pharmacokinetics and safety profile of tigecycline in children aged 8 to 11 years with selected serious infections: A multicenter, open-label, ascending-dose study
    • Purdy J, Jouve S, Yan JL, et al. Pharmacokinetics and safety profile of tigecycline in children aged 8 to 11 years with selected serious infections: a multicenter, open-label, ascending-dose study. Clin Ther 2012;34:496-507
    • (2012) Clin Ther , vol.34 , pp. 496-507
    • Purdy, J.1    Jouve, S.2    Yan, J.L.3
  • 38
    • 84871819819 scopus 로고    scopus 로고
    • Neutrophils engraftment delay during tigecycline treatment in 2 bone marrow-transplanted patients
    • Maximova N, Zanon D, Verzegnassi F, et al. Neutrophils engraftment delay during tigecycline treatment in 2 bone marrow-transplanted patients. J Pediatr Hematol Oncol 2013;35:e33-7
    • (2013) J Pediatr Hematol Oncol , vol.35 , pp. e33-e37
    • Maximova, N.1    Zanon, D.2    Verzegnassi, F.3
  • 39
    • 54049131288 scopus 로고    scopus 로고
    • Efficacy and safety of tigecycline compared with vancomycin or linezolid for treatment of serious infections with methicillin-resistant staphylococcus aureus or vancomycin-resistant enterococci: A Phase 3, multicentre, double-blind, randomized study
    • Florescu I, Beuran M, Dimov R, et al. Efficacy and safety of tigecycline compared with vancomycin or linezolid for treatment of serious infections with methicillin-resistant staphylococcus aureus or vancomycin-resistant enterococci: a Phase 3, multicentre, double-blind, randomized study. J Antimicrob Chemother 2008;62(Suppl 1):i17-28
    • (2008) J Antimicrob Chemother , vol.62 , pp. i17-i28
    • Florescu, I.1    Beuran, M.2    Dimov, R.3
  • 40
    • 79952325057 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of the effectiveness and safety of tigecycline for treatment of infectious disease
    • Cai Y, Wang R, Liang B, et al. Systematic review and meta-analysis of the effectiveness and safety of tigecycline for treatment of infectious disease. Antimicrob Agents Chemother 2011;55:1162-72
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 1162-1172
    • Cai, Y.1    Wang, R.2    Liang, B.3
  • 41
    • 82455187892 scopus 로고    scopus 로고
    • Efficacy and safety of tigecycline for the treatment of infectious diseases: A meta-analysis
    • Tastina E, Haidich AB, Kokkali S, et al. Efficacy and safety of tigecycline for the treatment of infectious diseases: a meta-analysis. Lancet Infect Dis 2011;11:834-44
    • (2011) Lancet Infect Dis , vol.11 , pp. 834-844
    • Tastina, E.1    Haidich, A.B.2    Kokkali, S.3
  • 42
    • 80051692552 scopus 로고    scopus 로고
    • Efficacy and safety of tigecycline: A systematic review and meta-analysis
    • Yahav D, Lador A, Paul M, et al. Efficacy and safety of tigecycline: a systematic review and meta-analysis. J Antimicrob Chemother 2011;66:1963-71
    • (2011) J Antimicrob Chemother , vol.66 , pp. 1963-1971
    • Yahav, D.1    Lador, A.2    Paul, M.3
  • 43
    • 84861505966 scopus 로고    scopus 로고
    • Excess deaths associated with tigecycline after approval based on noninferiority trials
    • Prasad P, Sun J, Danner RL, et al. Excess deaths associated with tigecycline after approval based on noninferiority trials. Clin Infect Dis 2012;54:1699-709
    • (2012) Clin Infect Dis , vol.54 , pp. 1699-1709
    • Prasad, P.1    Sun, J.2    Danner, R.L.3
  • 44
    • 84861016339 scopus 로고    scopus 로고
    • Effectiveness and safety of tigecycline: Focus on use for approved indications
    • Vardakas KZ, Rafailidis PI, Falagas ME. Effectiveness and safety of tigecycline: focus on use for approved indications. Clin Infect Dis 2012;54:1672-4
    • (2012) Clin Infect Dis , vol.54 , pp. 1672-1674
    • Vardakas, K.Z.1    Rafailidis, P.I.2    Falagas, M.E.3
  • 45
    • 84876285875 scopus 로고    scopus 로고
    • All-cause mortality imbalance in the tigecycline Phase III and IV clinical trials
    • McGovern PC, Wible M, El-Tahtawy A, et al. All-cause mortality imbalance in the tigecycline Phase III and IV clinical trials. Int J Antimicrob Agents 2013;41:463-7
    • (2013) Int J Antimicrob Agents , vol.41 , pp. 463-467
    • McGovern, P.C.1    Wible, M.2    El-Tahtawy, A.3
  • 46
    • 73649099901 scopus 로고    scopus 로고
    • Safety and efficacy of intravenous tigecycline in subjects with secondary bacteremia: Pooled results from 8 Phase III clinical trials
    • Gardiner D, Dukart G, Cooper A, et al. Safety and efficacy of intravenous tigecycline in subjects with secondary bacteremia: pooled results from 8 Phase III clinical trials. Clin Infect Dis 2010;50:229-38
    • (2010) Clin Infect Dis , vol.50 , pp. 229-238
    • Gardiner, D.1    Dukart, G.2    Cooper, A.3
  • 47
    • 84858673076 scopus 로고    scopus 로고
    • More about the safety of tigecycline for the treatment of infectious diseases: The role of superinfection rates
    • Martín-Gandul C, García-Cabrera E, Castillo-Ojeda E, et al. More about the safety of tigecycline for the treatment of infectious diseases: the role of superinfection rates. J Antimicrob Chemother 2012;67:1048-9
    • (2012) J Antimicrob Chemother , vol.67 , pp. 1048-1049
    • Martín-Gandul, C.1    García-Cabrera, E.2    Castillo-Ojeda, E.3
  • 48
    • 84902539127 scopus 로고    scopus 로고
    • Effectiveness and safety of high-dose tigecycline-containing regimens for the treatment of severe bacterial infections
    • Falagas ME, Vardakas KZ, Tsiveriotis KP, et al. Effectiveness and safety of high-dose tigecycline-containing regimens for the treatment of severe bacterial infections. Int J Antimicrob Agents 2014;44(1):1-7
    • (2014) Int J Antimicrob Agents , vol.44 , Issue.1 , pp. 1-7
    • Falagas, M.E.1    Vardakas, K.Z.2    Tsiveriotis, K.P.3
  • 49
    • 79960490810 scopus 로고    scopus 로고
    • Prospective, non-interventional, multi-centre trial of tigecycline in the treatment of severely ill patients with complicated infections: New insights into clinical results and treatment practice
    • Eckmann C, Heizmann WR, Leitner E, et al. Prospective, non-interventional, multi-centre trial of tigecycline in the treatment of severely ill patients with complicated infections: new insights into clinical results and treatment practice. Chemotherapy 2011;57:275-84
    • (2011) Chemotherapy , vol.57 , pp. 275-284
    • Eckmann, C.1    Heizmann, W.R.2    Leitner, E.3
  • 50
    • 84861503205 scopus 로고    scopus 로고
    • Editorial commentary: Asking the right questions: Morbidity, mortality, and measuring what's important in unbiased evaluations of antimicrobials
    • Powers JH. Editorial commentary: asking the right questions: morbidity, mortality, and measuring what's important in unbiased evaluations of antimicrobials. Clin Infect Dis 2012;54:1710-13
    • (2012) Clin Infect Dis , vol.54 , pp. 1710-1713
    • Powers, J.H.1
  • 51
    • 67349135277 scopus 로고    scopus 로고
    • Tigecycline possibly underdosed for the treatment of pneumonia: A pharmacokinetic viewpoint
    • Burkhardt O, Rauch K, Kaever V, et al. Tigecycline possibly underdosed for the treatment of pneumonia: a pharmacokinetic viewpoint. Int J Antimicrob Agents 2009;34:101-2
    • (2009) Int J Antimicrob Agents , vol.34 , pp. 101-102
    • Burkhardt, O.1    Rauch, K.2    Kaever, V.3
  • 52
    • 84863979284 scopus 로고    scopus 로고
    • Imbalanced mortality evidence for tigecycline: 2011, the year of the meta-analysis
    • Verde PE, Curcio D. Imbalanced mortality evidence for tigecycline: 2011, the year of the meta-analysis. Clin Infect Dis 2012;55:471-2
    • (2012) Clin Infect Dis , vol.55 , pp. 471-472
    • Verde, P.E.1    Curcio, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.