Excretion of antimicrobials used to treat methicillin-resistant Staphylococcus aureus infections during lactation: Safety in breastfeeding infants

Pharmacotherapy

Volumn 29, Issue 9, 2009, Pages 1103-1109

  Mitrano, Jennifer A ^a,b   Spooner, Linda M ^a   Belliveau, Paul ^a  

^a MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^b School of Pharmacy   (United States)

Author keywords

Antibiotics; Breast milk; Breastfeeding; Infant exposure; Lactation; Methicillin resistant Staphylococcus aureus; MRSA

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; CLINDAMYCIN; COTRIMOXAZOLE; DALFOPRISTIN PLUS QUINUPRISTIN; DAPTOMYCIN; DOXYCYCLINE; GENTAMICIN; LINEZOLID; MINOCYCLINE; RIFAMPICIN; TETRACYCLINE; TETRACYCLINE DERIVATIVE; TIGECYCLINE; VANCOMYCIN;

ABDOMINAL INFECTION; ACNE; ANTIMICROBIAL ACTIVITY; BONE GROWTH; BREAST FEEDING; BREAST MILK; CHILD CARE; CLINICAL RESEARCH; CLINICAL TRIAL; CLOSTRIDIUM DIFFICILE INFECTION; COMMUNITY ACQUIRED PNEUMONIA; DATA BASE; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DIFFUSION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG INDICATION; DRUG MANUFACTURE; DRUG SAFETY; DRUG TISSUE LEVEL; ENDOCARDITIS; ENDOMETRIAL DISEASE; ENTEROCOCCAL INFECTION; FEEDING DISORDER; HEMATOCHEZIA; HEMOLYTIC ANEMIA; HUMAN; INFECTION RISK; JAUNDICE; KERNICTERUS; LACTATION; MATERNAL PLASMA; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MULTIDRUG RESISTANT TUBERCULOSIS; NONHUMAN; PATIENT MONITORING; PRESCRIPTION; REVIEW; SIDE EFFECT; SKIN INFECTION; SOFT TISSUE INFECTION; STAPHYLOCOCCUS INFECTION; STREPTOCOCCUS INFECTION; TOOTH DISCOLORATION;

ANTI-BACTERIAL AGENTS; BREAST FEEDING; CLINICAL TRIALS AS TOPIC; FEMALE; HUMANS; INFANT; LACTATION; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 69249154737     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.29.9.1103     Document Type: Review

References (39)

1. Hersh AL, Chambers HF, Maselli JH, Gonzales R. National trends in ambulatory visits and antibiotic prescribing for skin and soft-tissue infections. Arch Intern Med 2008;168(14): 1585-1591
2. Abrahamian FM, Shroff SD. Use of routine wound cultures to evaluate cutaneous abscesses for community-associated methicillin-resistant Staphylococcus aureus. Ann Emerg Med 2007;50(1):66-67
3. Chung AM, Reed MD, Blumer JL. Antibiotics and breastfeeding: a critical review of the literature. Paediatr Drugs 2002;4(12):817-837 (Pubitemid 36005727)
4. Gleghorn T, Housholder GT. Anti-infective drug therapy: implications for the lactating mother and nursing infant. J Dent Hyg 1995;69(3):130-135
5. Chin KG, Mactal-Haaf C, McPherson CE. Use of anti-infective agents during lactation, part 1: beta-lactam antibiotics, vancomycin, quinupristin- dalfopristin, and linezolid. J Hum Lact 2000;16(4):351-358
6. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr 2004;80(5):S189-98.
7. Pfizer Inc. Cleocin phosphate (clindamycin injection, USP, and clindamycin injection in 5% dextrose) package insert. New York, NY; 2005.
8. Hale TW. Medications and mothers' milk. Amarillo, TX: Pharmasoft, 2004:11.
9. American Academy of Pediatrics Committee on Drugs. The transfer of drugs and other chemicals into human milk. Pediatrics 2001;108;776-789
10. World Health Organization. Breastfeeding and maternal medication. Recommendations for drugs in the eleventh WHO model list of essential drugs. Geneva, Switzerland: World Health Organization, 2002.
11. Cubist Pharmaceuticals, Inc. Cubicin (daptomycin for injection) package insert. Lexington, MA; 2007.
12. Pfizer Inc. Zyvox (linezolid) injection, tablets, and oral suspension package insert. New York, NY; 2007.
13. Monarch Pharmaceuticals Inc. Synercid I.V. (quinupristin and dalfopristin for injection) package insert. Bristol, TN; 2003.
14. Bearden DT. Clinical pharmacokinetics of quinupristin/dalfopristin. Clin Pharmacokinet 2004;43(4):239-252
15. MicroMedex. Rifampin: DrugDex evaluation. Available from http://www.thomsonhc.com/home/dispatch. Accessed January 30, 2009.
16. Agwuh KN, MacGowan A. Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J Antimicrob Chemother. 2006;58(2):256-265 (Pubitemid 44294934)
17. Wyeth Pharmaceuticals Inc. Tygacil (tigecycline) for injection package insert. Philadelphia, PA; 2007.
18. Monarch Pharmaceuticals Inc. Septra tablets, Septra DS (double strength tablets), Septra suspension, Septra grape suspension (trimethoprim and sulfamethoxazole) package insert. Bristol, TN; 2007.
19. Eli Lilly and Company. Vancocin HCl capsules (vancomycin hydrochloride capsules, USP) package insert. Indianapolis, IN; 2000.
20. Pfizer Inc. Cleocin HCl (clindamycin hydrochloride capsules, USP) package insert. New York, NY; 2007.
21. Stéen B, Rane A. Clindamycin passage into human milk. Br J Clin Pharmacol 1982;13(5):661-664
22. Smith JA, Morgan JR, Rachlis AR, Papsin FR. Clindamycin in human breast milk [letter]. Can Med Assoc J 1975;112:806.
23. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol 1984;5:57-60.
24. Fulton B, Moore LL. Antiinfectives in breastmilk, part III: antituberculars, quinolones and urinary germicides. J Hum Lact 1993;9:43-46
25. Mann CF. Clindamycin and breast-feeding. Pediatrics 1980;66(6):1030-1031
26. Buitrago MI, Crompton JA, Bertolami S, North DS, Nathan RA. Extremely low excretion of daptomycin into breast milk of a nursing mother with methicillin-resistant Staphylococcus aureus pelvic inflammatory disease. Pharmacotherapy 2009;29(3):347-351
27. Tran JH, Montakantikul P. The safety of antituberculosis medications during breastfeeding. J Hum Lact 1998;14(4): 337-340
28. Vorherr H. Drug excretion in breast milk. Postgrad Med 1974;56(4):97-104.
29. Snider DE, Powell KE. Should women taking antituberculosis drugs breast-feed? Arch Intern Med 1984;144:589-590
30. Chin KG, McPherson CE, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation, part 2: aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact 2001;17(1):54-65. (Pubitemid 33669822)
31. Ressel G. AAP updates statements for transfer of drugs and other chemicals into breast milk. Am Fam Physician 2002;65(5):979-980 (Pubitemid 34212527)
32. Hendles L, Trask PA. Tetracycline and lactation. J Am Dent Assoc 1983;107:12, 14.
33. Nahum GG, Uhl K, Kennedy DL. Antibiotic use in pregnancy and lactation: what is and is not known about teratogenic and toxic risks. Obstet Gynecol 2006;107(5):1120-1138 (Pubitemid 43755551)
34. Basler RS. Black galactorrhea as a consequence of minocycline and phenothiazine therapy. Arch Dermatol 1985;121(3):417-418
35. Hunt MJ, Salisbury EL, Grace J, Armati R. Black breast milk due to minocycline therapy. Br J Dermatol 1996;134(5):943-944 (Pubitemid 26150295)
36. Kaiser J, McPherson V, Kaufman L, Huber T. Clinical inquiries: which UTI therapies are safe and effective in breastfeeding? J Fam Pract 2007;56(3):225-228
37. Miller RD, Salter AJ. The passage of trimethoprim/ sulfamethoxazole into breast milk and its significance. Proceedings of the 8th international congress of chemotherapy, Athens. Hellenic Soc Chemother 1974;1:687-691
38. Ito S, Blajchman A, Stephenson M, Eliopoulos D, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol 1993;168:1393-1399 (Pubitemid 23153278)
39. Reyes MP, Ostrea EM Jr, Cabinian AE, et al. Vancomycin during pregnancy: does it cause hearing loss or nephrotoxicity in the infant? Am J Obstet Gynecol 1989;161:977-981