Procalcitonin in early rule-in/rule-out of sepsis in SIRS patients admitted to a medical ward

Clinical Chemistry and Laboratory Medicine

Volumn 52, Issue 10, 2014, Pages 1473-1478

  Fiotti, Nicola ^b   Mearelli, Filippo ^a,b   Ruscio, Maurizio ^c   Altamura, Nicola ^b   Vinci, Pierandrea ^b   Fernandes, Giovanni ^b   De Nardo, Margherita ^b   Lombardi, Jacopo ^b   Mamolo, Lorenza ^b   Chendi, Enrico ^b   Breglia, Andrea ^b   Peretti, Alberto ^b   Peric, Daniele ^b   Orso, Daniele ^b   Pivetti, Giulia ^b   Biolo, Gianni ^b  

^a UNIVERSITY OF TRIESTE   (Italy)

^b Morfologiche e Tecnologiche   (Italy)

^c S ANTONIO HOSPITAL   (Italy)

Author keywords

Cut off; Diagnosis; Medical ward; Procalcitonin; Sepsis

Indexed keywords

PROCALCITONIN; CALCITONIN; PROTEIN PRECURSOR;

AGED; ANALYTIC METHOD; ANTIMICROBIAL THERAPY; AREA UNDER THE CURVE; ARTICLE; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; HOSPITAL ADMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; SEPSIS; SURVIVAL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; WARD; BLOOD; TIME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CALCITONIN; FEMALE; HUMANS; MALE; PATIENT ADMISSION; PROGNOSIS; PROTEIN PRECURSORS; SEPSIS; TIME FACTORS;

EID: 84921328098     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm-2014-0196     Document Type: Article

References (17)

1. Stiermaier T, Herkner H, Tobudic S, Burgmann K, Staudinger T, Schellongowski P, et al. Incidence and long-term outcome of sepsis on general wards and in an ICU at the General Hospital of Vienna: an observational cohort study. Wien Klin Wochenschr 2013;125:302-8.
2. Ramírez P, Ferrer M, Martí V, Reyes S, Martínez R, Menéndez R, et al. Inflammatory biomarkers and prediction for intensive care unit admission in severe community-acquired pneumonia. Crit Care Med 2011;39:2211-7.
3. Iapichino G, Corbella D, Minelli C, Mills GH, Artigas A, Edbooke DL, et al. Reasons for refusal of admission to intensive care and impact on mortality. Intensive Care Med 2010;36: 1772-9.
4. Instruction Manual (version 4.0us) article number: 825.050: Immunofluorescent assay for the determination of PCT (procalcitonin) in human serum and plasma. BRAHMS PCT sensitive KRYPTOR 2008 (Hennigsdorf, Germany).
5. Caruhel P, Mazier C, Kunde J, Morgenthaler NG, Darbouret B. Homogeneous time-resolved fluoroimmunoassay for the measurement of midregional proadrenomedullin in plasma on the fully automated system B.R.A.H.M.S. KRYPTOR. Clin Biochem 2009;42:725-8.
6. Mearelli F, Fiotti N, Altamura N, Zanetti M, Fernandes G, Burekovic I, et al. Heterogeneous models for an early discrimination between sepsis and non-infective SIRS in medical ward patients: a pilot study. Intern Emerg Med 2014. doi: 10.1007/ s11739-013-1031-x. [Epub ahead of print 22 Dec 2013].
7. Bone RC, Balk RA, Cerra FB, Dellinger RD, Fein AM, Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/ Society of Critical Care Medicine. Chest 1992;101:1644-55.
8. Angeletti S, Battistoni F, Fioravanti M, Bernardini S, Dicuonzo G. Procalcitonin and mid-regional pro-adrenomedullin test combination in sepsis diagnosis. Clin Chem Lab Med 2013;51:1059-67.
9. Al Shuaibi M, Bahu R, Chaftari AM, Al Wohoush I, Shomali W, Jiang Y, et al. Pro-adrenomedullin as a novel biomarker for predicting infections and response to antimicrobials in febrile patients with hematologic malignancies. Clin Infect Dis 2013;56:943-50.
10. Adib-Conquy M, Cavaillon JM. Stress molecules in sepsis and systemic inflammatory response syndrome. FEBS Letters 2007;581:3723-33.
11. Harbarth S, Holeckova K, Froidevaux C, Pittet D, Ricou B, Grau GE, et al. Diagnostic value of procalcitonin, interleukin-6 and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med 2001;164:396-402.
12. Selberg O, Hecker H, Martin M, Klos A, Bautsch W, Köhl J. Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin-6. Crit Care Med 2000;28:2793-8.
13. Cinel I, Opal SM. Molecular biology of inflammation and sepsis: a primer. Crit Care Med 2009;37:291-304.
14. Matwiyoff GN, Prahl JD, Miller RJ, Carmichael JJ, Amundson DE, Seda G, et al. Immune regulation of procalcitonin: a biomarker and mediator of infection. Inflamm Res 2012;61:401-9.
15. Schiopu A, Hedblad B, Engström G, Struck J, Morgenthaler NG, Melander O. Plasma procalcitonin and the risk of cardiovascular events and death: a prospective population-based study. J Intern Med 2012;272:484-91.
16. Castelli GP, Pognani C, Meisner M, Stuani A, Bellomi D, Sgarbi L. Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction. Crit Care 2004;8:R234-40.
17. Suprin CA, Camus C, Gaoucin A, LeTulzo Y, Levaoue S, Feuillu A, et al. Procalcitonin: a valuable indicator of infection in a medical ICU? Intensive Care Med 2000;26:1232-8.