Platelets are associated with xenograft tumor growth and the clinical malignancy of ovarian cancer through an angiogenesis-dependent mechanism

Molecular Medicine Reports

Volumn 11, Issue 4, 2015, Pages 2449-2458

  Yuan, Lei ^a   Liu, Xishi ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Angiogenesis dependent mechanism; Ovarian cancer; Platelets; Xenograft tumor growth

Indexed keywords

CA 125 ANTIGEN; CD31 ANTIGEN; CRK ASSOCIATED SUBSTRATE PROTEIN; D DIMER; FIBRINOGEN RECEPTOR; FOCAL ADHESION KINASE; GLYCOPROTEIN IIB; HIRUDIN; PROTEIN LYSINE 6 OXIDASE; RECOMBINANT THROMBOPOIETIN; VASCULOTROPIN; ANTITHROMBIN; HIRUDIN DERIVATIVE;

ANCHORAGE INDEPENDENT GROWTH; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER PROGNOSIS; CANCER SURVIVAL; CELL ADHESION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; IN VIVO STUDY; MOUSE; NONHUMAN; OVARY CANCER; PHENOTYPE; SURVIVAL RATE; THROMBIN TIME; THROMBOCYTE; THROMBOCYTE COUNT; THROMBOCYTOPOIESIS; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; TUMOR INVASION; TUMOR VOLUME; TUMOR XENOGRAFT; ANIMAL; BLOOD CLOTTING; CANCER STAGING; DISEASE MODEL; DRUG EFFECTS; METABOLISM; MORTALITY; NEOVASCULARIZATION (PATHOLOGY); OVARIAN NEOPLASMS; PATHOLOGY; PROGNOSIS; THROMBOPHILIA; THROMBOSIS; TUMOR CELL LINE; XENOGRAFT;

MUS;

ANIMALS; ANTITHROMBINS; BLOOD COAGULATION; BLOOD PLATELETS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; FEMALE; HETEROGRAFTS; HIRUDINS; HUMANS; MICE; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; OVARIAN NEOPLASMS; PROGNOSIS; THROMBOPHILIA; THROMBOSIS; TUMOR BURDEN;

EID: 84921324652     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.3082     Document Type: Article

References (43)

1. Felding-Habermann B, Habermann R, Saldivar E and Ruggeri ZM: Role of beta3 integrins in melanoma cell adhesion to activated platelets under flow. J Biol Chem 271: 5892-5900, 1996.
2. Borsig L, Wong R, Feramisco J, et al: Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis. Proc Natl Acad Sci USA 98: 3352-3357, 2001.
3. Labelle M, Begum S and Hynes RO: Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 20: 576-590, 2011.
4. Buergy D, Wenz F, Groden C and Brockmann MA: Tumor-platelet interaction in solid tumors. Int J Cancer 130: 2747-2760, 2012.
5. Rao AK and Rao DA: Platelets signal and tumors take off. Blood 120: 4667-4668, 2012.
6. Douglas VK, Tallman MS, Cripe LD and Peterson LC: Thrombopoietin administered during induction chemotherapy to patients with acute myeloid leukemia induces transient morphologic changes that may resemble chronic myeloproliferative disorders. Am J Clin Path 117: 844-850, 2002.
7. Stone RL, Nick AM, McNeish IA, et al: Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med 366: 610-618, 2012.
8. Wang-Tilz Y, Tilz C, Wang B, Tilz GP and Stefan H: Influence of lamotrigine and topiramate on MDR1 expression in difficult-to-treat temporal lobe epilepsy. Epilepsia 47: 233-239, 2006.
9. Ma S, Liu X, Geng JG and Guo SW: Increased SLIT immunoreactivity as a biomarker for recurrence in endometrial carcinoma. Am J Obstet Gynecol 202: 68 e61-e68, e11, 2010.
10. Feng W, Madajka M, Kerr BA, et al: A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing. Blood 117: 3893-3902, 2011.
11. Manetta A, Satyaswaroop PG, Hamilton T, et al: Radio imaging of human ovarian carcinoma xenograft in nude mice. Gynecol Oncol 28: 292-299, 1987
12. Holmes CE, Levis JE and Ornstein DL: Activated platelets enhance ovarian cancer cell invasion in a cellular model of metastasis. Clin Exp Metastasis 26: 653-661, 2009
13. Trikha M, Zhou Z, Timar J, et al: Multiple roles for platelet GPIIb/IIIa and alphavbeta3 integrins in tumor growth, angiogenesis, and metastasis. Cancer Res 62: 2824-2833, 2002.
14. Dardik R, Savion N, Kaufmann Y and Varon D: Thrombin promotes platelet-mediated melanoma cell adhesion to endothelial cells under flow conditions: role of platelet glycoproteins P-selectin and GPIIb-IIIA. Br J Cancer 77: 2069-2075, 1998.
15. Matsui H, Harada I and Sawada Y: Src, p130Cas, and Mechanotransduction in Cancer Cells. Genes Cancer 3: 394-401, 2012.
16. Nick AM, Stone RL, Armaiz-Pena G, et al: Silencing of p130cas in ovarian carcinoma: a novel mechanism for tumor cell death. J Natl Cancer Inst. 103: 1596-1612, 2011.
17. Sawada Y, Tamada M, Dubin-Thaler BJ, et al: Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell 127: 1015-1026, 2006.
18. Zhang P, Guo A, Possemato A, et al: Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14. Oncogene 32: 2087-2095, 2013.
19. Chatzizacharias NA, Kouraklis GP and Theocharis SE: Clinical significance of FAK expression in human neoplasia. Histol Histopathol 23: 629-650, 2008.
20. Goel HL and Mercurio AM: VEGF targets the tumour cell. Nat Rev Cancer 13: 871-882, 2013.
21. Hanahan D and Weinberg RA: Hallmarks of cancer: the next generation. Cell 144: 646-674, 2011.
22. Prow D and Vadhan-Raj S: Thrombopoietin: biology and potential clinical applications. Oncology (Williston Park) 12: 1597-1604, 1607-1598; discussion 1611-1594, 1998.
23. Dardik R, Kaufmann Y, Savion N, et al: Platelets mediate tumor cell adhesion to the subendothelium under flow conditions: involvement of platelet GPIIb-IIIa and tumor cell alpha(v) integrins. Int J Cancer 70: 201-207, 1997
24. Konstantopoulos K and Thomas SN: Cancer cells in transit: the vascular interactions of tumor cells. Annu Rev Biomed Eng 11: 177-202, 2009
25. McCarty OJ, Mousa SA, Bray PF and Konstantopoulos K: Immobilized platelets support human colon carcinoma cell tethering, rolling, and firm adhesion under dynamic flow conditions. Blood 96: 1789-1797, 2000.
26. Ay C, Dunkler D, Pirker R, et al: High D-dimer levels are associated with poor prognosis in cancer patients. Haematologica 97 1158-1164, 2012.
27. Dirix LY, Salgado R, Weytjens R, et al: Plasma fibrin D-dimer levels correlate with tumour volume, progression rate and survival in patients with metastatic breast cancer. Br J Cancer 86: 389-395, 2002.
28. Zigler M, Kamiya T, Brantley EC, Villares GJ and Bar-Eli M: PAR-1 and thrombin: the ties that bind the microenvironment to melanoma metastasis. Cancer Res 71: 6561-6566, 2011.
29. Cowell LN, Graham JD, Bouton AH, Clarke CL and O'Neill GM: Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway. Oncogene 25: 7597-7607, 2006
30. McLean GW, Carragher NO, Avizienyte E, et al: The role of focal-adhesion kinase in cancer - a new therapeutic opportunity. Nat Rev Cancer 5: 505-515, 2005
31. Ward KK, Tancioni I, Lawson C, et al: Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression. Clin Exp Metastasis 30: 579-594, 2013.
32. Chen XL, Nam JO, Jean C, et al: VEGF-induced vascular permeability is mediated by FAK. Dev Cell. 22: 146-157, 2012.
33. Erler JT, Bennewith KL, Nicolau M, et al: Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440: 1222-1226, 2006
34. Kirschmann DA, Seftor EA, Fong SF, et al: A molecular role for lysyl oxidase in breast cancer invasion. Cancer Res 62: 4478-4483, 2002.
35. Baker AM, Bird D, Lang G, Cox TR and Erler JT: Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK. Oncogene 32: 1863-1868, 2013.
36. Baker AM, Cox TR, Bird D, et al: The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer. J Natl Cancer Inst 103: 407-424, 2011.
37. Lapointe J, Li C, Higgins J P, et al: Gene expression profiling identifies clinically relevant subtypes of prostate cancer. Proc Natl Acad Sci USA 101: 811-816, 2004.
38. Battegay EJ, Rupp J, Iruela-Arispe L, Sage EH and Pech M: PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors. J Cell Biol 125: 917-928, 1994.
39. Anglesio MS, George J, Kulbe H, et al: IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer. Clin Cancer Res 17: 2538-2548, 2011.
40. Harker LA, Marzec UM, Kelly AB, et al: Prevention of thrombocytopenia and neutropenia in a nonhuman primate model of marrow suppressive chemotherapy by combining pegylated recombinant human megakaryocyte growth and development factor and recombinant human granulocyte colony-stimulating factor. Blood 89: 155-165, 1997.
41. Grossmann A, Lenox J, Ren H P, et al: Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice. Exp Hematol 24: 1238-1246, 1996.
42. Bergmeier W, Piffath CL, Goerge T, et al: The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis. Proc Natl Acad Sci USA 103: 16900-16905, 2006.
43. Cho MS, Bottsford-Miller J, Vasquez HG, et al: Platelets increase the proliferation of ovarian cancer cells. Blood 120: 4869-4872, 2012.