Enhancement of DNA vaccine efficacy by intracellular targeting strategies

Methods in Molecular Biology

Volumn 1143, Issue , 2014, Pages 33-59

  Freitas, Elisabete Borges ^a   Henriques, Ana Margarida ^a   Fevereiro, Miguel ^a   Prazeres, Duarte Miguel ^a   Monteiro, Gabriel Amaro ^a  

^a NONE

Author keywords

Antigenic protein; DNA vaccines; E1A; ELISA; Flow cytometry; LAMP; MHC; Neuraminidase; RT PCR; Targeting sequences

Indexed keywords

ANTIBODY; DNA VACCINE; MESSENGER RNA; PLASMID DNA; VIRUS SIALIDASE; ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; CHO CELL LINE; DRUG EFFICACY; ENDOPLASMIC RETICULUM; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FEMALE; FLOW CYTOMETRY; LEGHORN CHICKEN; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; VACCINATION; ANIMAL; CHICKEN; CRICETULUS; GENE EXPRESSION REGULATION; GENETICS; HAMSTER; IMMUNOLOGY; PLASMID;

ANIMALS; ANTIGENS; CHICKENS; CHO CELLS; CRICETINAE; CRICETULUS; GENE EXPRESSION REGULATION; PLASMIDS; VACCINES, DNA;

EID: 84921304581     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-0410-5_4     Document Type: Article

References (22)

1. Williams JA, Carnes AE, Hodgson CP (2009) Plasmid DNA vaccine vector design: impact on efficacy, safety and upstream production. Biotechnol Adv 27(4):353–370
2. Carvalho JA, Prazeres DM, Monteiro GA (2009) Bringing DNA vaccines closer to commercial use. IDrugs 12:642–647
3. Henriques AM, Fevereiro M, Prazeres DM et al (2007) Development of a candidate DNA vaccine against Maedi-Visna virus. Vet Immunol Immunopathol 119(3–4):222–232
4. Carvalho JA, Azzoni AR, Prazeres DM et al (2010) Comparative analysis of antigentargeting sequences used in DNA vaccines. Mol Biotechnol 44(3):204–212
5. Berhane S, Areste C, Ablack JN et al (2011) Adenovirus E1A interacts directly with, and regulates the level of expression of, the immunoproteasome component MECL1. Virology 421(2):149–158
6. Qiu JT, Liu B, Tian C et al (2000) Enhancement of primary and secondary cellular immune responses against human immunodeficiency virus type 1 gag by using DNA expression vectors that target gag antigen to the secretory pathway. J Virol 74(13):5997–6005
7. Ruff AL, Guarnieri FG, Staveley-O’Carroll K et al (1997) The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein traffi cking pathway. J Biol Chem 272(13): 8671–8678
8. Persson H, Jornvall H, Zabielski J (1980) Multiple mRNA species for the precursor to an adenovirus-encoded glycoprotein: Identification and structure of the signal sequence. Proc Natl Acad Sci U S A 77(11):6349–6353
9. Leifert JA, Rodriguez-Carreno MP, Rodriguez F et al (2004) Targeting plasmid-encoded proteins to the antigen presentation pathways. Immunol Rev 199:40–53
10. Liang R, van den Hurk JV, Zheng C et al (2005) Immunization with plasmid DNA encoding a truncated, secreted form of the bovine viral diarrhea virus E2 protein elicits strong humoral and cellular immune responses. Vaccine 23(45):5252–5262
11. Braulke T, Bonifacino JS (2009) Sorting of lysosomal proteins. Biochim Biophys Acta 1793(4):605–614
12. Storni T, Kundig TM, Senti G et al (2005) Immunity in response to particulate antigendelivery systems. Adv Drug Deliv Rev 57(3): 333–355
13. Wiesel M, Oxenius A (2012) From crucial to negligible: functional CD8(+) T-cell responses and their dependence on CD4(+) T-cell help. Eur J Immunol 42(5):1080–1088
14. Kaur M, Rai A, Bhatnagar R (2009) Rabies DNA vaccine: no impact of MHC class I and class II targeting sequences on immune response and protection against lethal challenge. Vaccine 27(15):2128–2137
15. Villadangos J, Schnorrer P (2007) Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo. Nat Rev Immunol 7:543–555
16. Kutzler MA, Weiner DB (2008) DNA vaccines: ready for prime time? Nat Rev Genet 9(10):776–788
17. Azzoni AR, Ribeiro SC, Monteiro GA et al (2007) The impact of polyadenylation signals on plasmid nuclease-resistance and transgene expression. J Gene Med 9(5):392–402
18. Gil JB (2011) Development of DNA vaccines prototypes against avian infl uenza viruses. Master thesis
19. Carapuça E, Azzoni AR, Prazeres DM et al (2007) Time-course determination of plasmid content in eukaryotic and prokaryotic cells using Real-Time PCR. Mol Biotechnol 37:120–126
20. Bridge SH, Sharpe SA, Dennis MJ et al (2011) Heterologous prime-boost-boost immunisation of Chinese cynomolgus macaques using DNA and recombinant poxvirus vectors expressing HIV-1 virus-like particles. Virol J 8:429
21. Freitas EB (2012) DNA vaccines against avian infl uenza virus: enhancing immune response by protein targeting. Master thesis
22. Kamps B, Hoffmann C, Preiser W (2006) Infl uenza Report. Flying Publisher, Wuppertal