Protection of retina by mini-αA in NaIO3-induced retinal pigment epithelium degeneration mice

International Journal of Molecular Sciences

Volumn 16, Issue 1, 2015, Pages 1644-1656

  Zhang, Jinglin ^a   Zhao, Xiujuan ^a   Cai, Yu ^a   Li, Yonghao ^a   Yu, Xiling ^a   Lu, Lin ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Cell apoptosis; Mini ; NaIO3 induced retinal pigment epithelium

Indexed keywords

ALPHA CRYSTALLIN; CASPASE 3; MESSENGER RNA; SODIUM IODATE; X BOX BINDING PROTEIN 1; IODATE; PEPTIDE; PROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL VIABILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; MALE; MOUSE; MTT ASSAY; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RETINA PIGMENT DEGENERATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CELL LINE; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; MOLECULAR GENETICS; PATHOLOGY; RETINA; RETINAL DEGENERATION; RETINAL PIGMENT EPITHELIUM;

ANIMALIA; MUS;

ALPHA-CRYSTALLIN A CHAIN; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CELL LINE; HUMANS; IODATES; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTECTIVE AGENTS; RETINA; RETINAL DEGENERATION; RETINAL PIGMENT EPITHELIUM;

EID: 84921287289     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms16011644     Document Type: Article

References (31)

1. Ingolia, T.D.; Craig, E.A. Four small Drosophila heat shock proteins are related to each other and to mammalian alpha-crystallin. Proc. Natl. Acad. Sci. USA 1982, 79, 2360–2364.
2. Kato, K.; Shinohara, H.; Kurobe, N.; Goto, S.; inaguma, Y.; Ohshima, K. Immunoreactive alpha A crystallin in rat non-lenticular tissues detected with a sensitive immunoassay method. Biochim. Biophys. Acta 1991, 1080, 173–180.
3. Sakaguchi, H.; Miyagi, M.; Darrow, R.M.; Crabb, J.S.; Hollyfield, J.G.; Organisciak, D.T.; Crabb, J.W. Intense light exposure changes the crystallin content in retina. Exp. Eye Res.2003, 76, 131–133.
4. Vazquez-Chona, F.; Song, B.K.; Geisert, E.J. Temporal changes in gene expression after injury in the rat retina. Investig. Ophthalmol. Vis. Sci. 2004, 45, 2737–2746.
5. Steele, M.R.; Inman, D.M.; Calkins, D.J.; Horner, P.J.; Vetter, M.L. Microarray analysis of retinal gene expression in the DBA/2J model of glaucoma. Investig. Ophthalmol. Vis. Sci. 2006, 47, 977–985.
6. Zhou, P.; Ye, H.-F.; Jiang, Y.-X.; Yang, J.; Zhu, X.-J.; Sun, X.-H.; Luo, Y.; Dou, G.-R.; Wang, Y.-S.; Lu, Y. αA crystallin may protect against geographic atrophy-meta-analysis of cataract vs. cataract surgery for geographic atrophy and experimental studies. PLoS One 2012, 7, e43173.
7. Pasupuleti, N.; Matsuyama, S.; Voss O.; Doseff, A.I.; Song, K.; Danielpour, D.; Nagaraj, R.H. The anti-apoptotic function of human alphaA-crystallin is directly related to its chaperone activity. Cell Death Dis.2010, 1, e31.
8. Bhattacharyya, J.; Sharma, K.K. Conformational specificity of mini-alphaA-crystallin as a molecular chaperone. J. Pept. Res. 2001, 57, 428–434.
9. Sreekumar, P.G.; Chothe, P.; Sharma K.K.; Baid, R.; Kompella, U.; Spee, C.; Kannan, N.; Manh, C.; Ryan, S.J.; Ganapathy, V., et al. Antiapoptotic properties of alpha-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells. Investig. Ophthalmol. Vis. Sci. 2013, 54, 2787–2798.
10. Chen, C.; Cano, M.; Wang, J.J.; Li, J.; Huang, C.; Yu, Q.; Herbert, T.P.; Handa, J.T.; Zhang, S.X. Role of unfolded protein response dysregulation in oxidative injury of retinal pigment epithelial cells. Antioxid. Redox Signal. 2014, 20, 2091–2106.
11. Kiuchi, K.; Yoshizawa, K.; Shikata, N.; Moriguchi, K.; Tsubura, A. Morphologic characteristics of retinal degeneration induced by sodium iodate in mice. Curr. Eye Res. 2002, 25, 373–379.
12. Machalinska, A.; Lubinski, W.; Klos, P.; Kawa, M.; Baumert, B.; Penkala, K.; Grzegrzolka, R.; Karczewicz, D.; Wiszniewska, B.; Machalinski, B. Sodium iodate selectively injuries the posterior pole of the retina in a dose-dependent manner: Morphological and electrophysiological study. Neurochem. Res.2010, 35, 1819–1827.
13. Mizota, A.; Adachi-Usami, E. Functional recovery of retina after sodium iodate injection in mice. Vis. Res. 1997, 37, 1859–1865.
14. Machalinska, A.; Klos, P.; Baumert, B.; Baskiewicz, M.; Kawa, M.; Rudnicki, M.; Lubinski, W.; Wiszniewska, B.; Karczewicz, D.; Machalinski, B. Stem Cells are mobilized from the bone marrow into the peripheral circulation in response to retinal pigment epithelium damage—A pathophysiological attempt to induce endogenous regeneration. Curr. Eye Res. 2011, 36, 663–672.
15. Redfern, W.S.; Storey, S.; Tse, K.; Hussain, Q.; Maung, K.P.; Valentin, J.-P.; Ahmed, G.; Bigley, A.; Heathcote, D.; McKay, J.S. Evaluation of a convenient method of assessing rodent visual function in safety pharmacology studies: Effects of sodium iodate on visual acuity and retinal morphology in albino and pigmented rats and mice. J. Pharmacol. Toxicol. Methods 2011, 63, 102–114.
16. Enzmann, V.; Row, B.W.; Yamauchi, Y.; Kheirandish, L.; Gozal, D.; Kaplan, H.J.; McCall, M.A. Behavioral and anatomical abnormalities in a sodium iodate-induced model of retinal pigment epithelium degeneration. Exp. Eye Res.2006, 82, 441–448.
17. Machalinska, A.; Kawa, M.P.; Pius-Sadowska, E.; Roginska, D.; Klos, P.; Baumert, B.; Wiszniewska, B.; Machalinski, B. Endogenous regeneration of damaged retinal pigment epithelium following low dose sodium iodate administration: An insight into the role of glial cells in retinal repair. Exp. Eye Res. 2013, 112, 68–78.
18. Hariri, S.; Tam, M.C.; Lee, D.; Hileeto, D.; Moayed, A.A.; Bizheva, K. Noninvasive imaging of the early effect of sodium iodate toxicity in a rat model of outer retina degeneration with spectral domain optical coherence tomography. J. Biomed. Opt. 2013, 18, 26017.
19. Zhu, Y.-T.; Deng, X.-G.; Gao, Y.; He, M.-F.; Li, N. Pathological and SOD, CAT changes in rats with retinal injuries induced by Sodium iodate. Chin. J. Pathophysiol. 2010, 9, 048.(In Chinese)
20. Zhang, T.; Zhang, N.; Baehr, W.; Fu, Y. Cone opsin determines the time course of cone photoreceptor degeneration in Leber congenital amaurosis. Proc. Natl. Acad. Sci. USA 2011, 108, 8879–8884.
21. Mendes, C.S.; Levet, C.; Chatelain, G.; Dourlen, P.; Fouillet, A.; Dichtel-Danjoy, M.-L.; Gambis, A.; Ryoo, H.D.; Steller, H.; Mollereau, B. ER stress protects from retinal degeneration. EMBO J. 2009, 28, 1296–1307.
22. Farrar, G.J.; Palfi, A.; O’Reilly, M. Gene therapeutic approaches for dominant retinopathies. Curr. Gene. Ther. 2010, 10, 381–388.
23. Tanaka, Y.; Kume, S.; Kitada, M.; Kanasaki, K.; Uzu, T.; Maegawa, H.; Koya, D. Autophagy as a therapeutic target in diabetic nephropathy. Exp. Diabetes Res. 2012, 2012, 628978.
24. Ron, D.; Walter, P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 2007, 8, 519–529.
25. Hummasti, S.; Hotamisligil, G.S. Endoplasmic reticulum stress and inflammation in obesity and diabetes. Circ. Res. 2010, 107, 579–591.
26. Rutkowski, D.T.; Kaufman, R.J. That which does not kill me makes me stronger: Adapting to chronic ER stress. Trends Biochem. Sci. 2007, 32, 469–476.
27. Kroemer, G.; Marino, G.; Levine B. Autophagy and the integrated stress response. Mol. Cell 2010, 40, 280–293.
28. Rao, N.A.; Saraswathy, S.; Wu, G.S; Katselis, G.S.; Wawrousek, E.F.; Bhat, S. Elevated retina-specific expression of the small heat shock protein, alphaA-crystallin, is associated with photoreceptor protection in experimental uveitis. Investig. Ophthalmol. Vis. Sci. 2008, 49, 1161–1171.
29. Bahk, S.C.; Jang, J.U.; Choi, C.U.; Lee, S.-H.; Park, Z.-Y.; Yang, J.-Y.; Kim, J.-D.; Yang, Y.-S.; Chung, H.-T. Post-translational modification of crystallins in vitreous body from experimental autoimmune uveitis of rats. J. Proteome Res. 2007, 6, 3891–3898.
30. Kannan, R.; Sreekumar, P.G.; Hinton, D.R. Novel roles for alpha-crystallins in retinal function and disease. Prog. Retin. Eye Res. 2012, 31, 576–604.
31. Sun, T.Z.; Fu, X.B.; Yao, Y.M.; Yang, Y.H.; Chen, W.; Zhao, Z.L.; Sun, X.Q. An ideal way of intravenous medication administration in male rats. Shi Yan Dong Wu Ke Xue Yu Guan Li 2002, 19, 46. (In Chinese)