Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes

Biomaterials

Volumn 44, Issue , 2015, Pages 55-70

  Gutowski, Stacie M ^a   Shoemaker, James T ^a   Templeman, Kellie L ^a,b   Wei, Yang ^c   Latour, Robert A ^c   Bellamkonda, Ravi V ^a   LaPlaca, Michelle C ^a   García, Andrés J ^a,b  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^c Clemson University   (United States)

Author keywords

Astrocyte; Electrode; Hydrogel; Inflammation; Neural cell; Peptide

Indexed keywords

BRAIN COMPUTER INTERFACE; CELL ADHESION; CELL DEATH; COATED WIRE ELECTRODES; COATINGS; ELECTRIC WELDING; ELECTRODES; GENE EXPRESSION; HYDROGELS; NEURONS; PATHOLOGY; PEPTIDES; POLYETHYLENE GLYCOLS; TISSUE REGENERATION;

ANTI-INFLAMMATORY AGENTS; ASTROCYTE; BRAIN MACHINE INTERFACE; GENE EXPRESSION ANALYSIS; INFLAMMATION; INFLAMMATORY CELL MARKERS; NEURAL CELLS; POLY(ETHYLENE GLYCOL) HYDROGEL;

TISSUE;

BRAIN DERIVED GROWTH FACTOR; CELL MARKER; CHONDROITIN SULFATE; CILIARY NEUROTROPHIC FACTOR; COLLAGENASE 3; GAMMA INTERFERON; GELATINASE A; GELATINASE B; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCOSAMINOGLYCAN; IMMUNOGLOBULIN G; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROGOL; MALEIMIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; NERVE GROWTH FACTOR; PROTEINASE; AUTACOID; BIOCOMPATIBLE COATED MATERIAL; HYDROGEL; LIPOPOLYSACCHARIDE; MACROGOL DERIVATIVE; MALEIMIDE DERIVATIVE; PEPTIDE HYDROLASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN NERVE CELL; CELL ADHESION; CELL SPREADING; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG RELEASE; ELECTRODE IMPLANT; ELECTRODE IMPLANTATION; ENZYME DEGRADATION; GENE EXPRESSION; GLIA CELL; HYDROGEL; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATION; INFLAMMATORY INFILTRATE; MACROGLIA; MALE; MATERIAL COATING; MICROARRAY ANALYSIS; MICROGLIA; NEURAL ELECTRODE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STIMULUS RESPONSE; TISSUE REACTION; AMINO ACID SEQUENCE; ANIMAL; ASTROCYTE; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; MOLECULAR GENETICS; NERVE CELL; PATHOLOGY; SPRAGUE DAWLEY RAT; SURFACE PROPERTY;

AMINO ACID SEQUENCE; ANIMALS; ASTROCYTES; BLOOD-BRAIN BARRIER; CELL ADHESION; CELL SURVIVAL; CELLS, CULTURED; CHONDROITIN SULFATES; COATED MATERIALS, BIOCOMPATIBLE; ELECTRODES, IMPLANTED; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; HYDROGEL; IMMUNOGLOBULIN G; INFLAMMATION MEDIATORS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; LIPOPOLYSACCHARIDES; MALE; MALEIMIDES; MICROGLIA; MOLECULAR SEQUENCE DATA; NEURONS; PEPTIDE HYDROLASES; POLYETHYLENE GLYCOLS; RATS, SPRAGUE-DAWLEY; SURFACE PROPERTIES;

EID: 84921263213     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.12.009     Document Type: Article

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