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Volumn 29, Issue 1, 2015, Pages 10-20

Pharmacology and mechanisms of action of new oral anticoagulants

Author keywords

Anticoagulant; Apixaban; Dabigatran; Edoxaban; Heparin; Pharmacology; Rivaroxaban

Indexed keywords

ANTICOAGULANT AGENT; ANTIVITAMIN K; APIXABAN; DABIGATRAN; EDOXABAN; ENOXAPARIN; HEPARIN; PLACEBO; RIVAROXABAN; WARFARIN;

EID: 84921065018     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/fcp.12091     Document Type: Review
Times cited : (35)

References (55)
  • 1
    • 45949099359 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty
    • Eriksson B.I., Borris L.C., Friedman R.J. et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty. N. Engl. J. Med. (2008) 26 2765-2775.
    • (2008) N. Engl. J. Med. , vol.26 , pp. 2765-2775
    • Eriksson, B.I.1    Borris, L.C.2    Friedman, R.J.3
  • 2
    • 45949103416 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty
    • Lassen M.R., Ageno W., Borris L.C. et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N. Engl. J. Med. (2008) 26 2776-2786.
    • (2008) N. Engl. J. Med. , vol.26 , pp. 2776-2786
    • Lassen, M.R.1    Ageno, W.2    Borris, L.C.3
  • 3
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • Connolly S.J., Ezekowitz M.D., Yusuf S., et al. Dabigatran versus warfarin in patients with atrial fibrillation. N. Engl. J. Med. (2009) 12 1139-1151.
    • (2009) N. Engl. J. Med. , vol.12 , pp. 1139-1151
    • Connolly, S.J.1    Ezekowitz, M.D.2    Yusuf, S.3
  • 4
    • 79952301326 scopus 로고    scopus 로고
    • Apixaban in patients with atrial fibrillation
    • Connolly S.J., Eikelboom J., Joyner C., et al. Apixaban in patients with atrial fibrillation. N. Engl. J. Med. (2011) 9 806-817.
    • (2011) N. Engl. J. Med. , vol.9 , pp. 806-817
    • Connolly, S.J.1    Eikelboom, J.2    Joyner, C.3
  • 5
    • 80052592404 scopus 로고    scopus 로고
    • Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    • Patel M.R., Mahaffey K.W., Garg J., et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N. Engl. J. Med. (2011) 10 883-891.
    • (2011) N. Engl. J. Med. , vol.10 , pp. 883-891
    • Patel, M.R.1    Mahaffey, K.W.2    Garg, J.3
  • 6
    • 80052825103 scopus 로고    scopus 로고
    • Apixaban versus warfarin in patients with atrial fibrillation
    • Granger C.B., Alexander J.H., McMurray J.J.V., et al. Apixaban versus warfarin in patients with atrial fibrillation. N. Engl. J. Med. (2011) 11 981-992.
    • (2011) N. Engl. J. Med. , vol.11 , pp. 981-992
    • Granger, C.B.1    Alexander, J.H.2    McMurray, J.J.V.3
  • 7
    • 84888362796 scopus 로고    scopus 로고
    • Edoxaban versus warfarin in patients with atrial fibrillation
    • Giugliano R.P., Ruff C.T., Braunwald E., et al. Edoxaban versus warfarin in patients with atrial fibrillation. N. Engl. J. Med. (2013) 22 2093-2104.
    • (2013) N. Engl. J. Med. , vol.22 , pp. 2093-2104
    • Giugliano, R.P.1    Ruff, C.T.2    Braunwald, E.3
  • 8
    • 78650619315 scopus 로고    scopus 로고
    • Oral rivaroxaban for symptomatic venous thromboembolism
    • EINSTEIN Investigators, Bauersachs R., Berkowitz S.D., Brenner B. et al. Oral rivaroxaban for symptomatic venous thromboembolism. N. Engl. J. Med. (2010) 26 2499-2510.
    • (2010) N. Engl. J. Med. , vol.26 , pp. 2499-2510
    • Bauersachs, R.1    Berkowitz, S.D.2    Brenner, B.3
  • 9
    • 84859385808 scopus 로고    scopus 로고
    • Oral rivaroxaban for the treatment of symptomatic pulmonary embolism
    • EINSTEIN-PE Investigators, Büller H.R., Prins M.H., Lensin A.W.A. et al. Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. N. Engl. J. Med. (2012) 14 1287-1297.
    • (2012) N. Engl. J. Med. , vol.14 , pp. 1287-1297
    • Büller, H.R.1    Prins, M.H.2    Lensin, A.W.A.3
  • 10
    • 84873596181 scopus 로고    scopus 로고
    • Apixaban for extended treatment of venous thromboembolism
    • Agnelli G., Buller H.R., Cohen A., et al. Apixaban for extended treatment of venous thromboembolism. N. Engl. J. Med. (2013) 8 699-708.
    • (2013) N. Engl. J. Med. , vol.8 , pp. 699-708
    • Agnelli, G.1    Buller, H.R.2    Cohen, A.3
  • 11
    • 84885618705 scopus 로고    scopus 로고
    • Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism
    • Hokusai-VTE Investigators
    • Hokusai-VTE Investigators, Büller H.R., Décousus H., Grosso M.A. et al. Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism. N. Engl. J. Med. (2013) 15 1406-1415.
    • (2013) N. Engl. J. Med. , vol.15 , pp. 1406-1415
    • Büller, H.R.1    Décousus, H.2    Grosso, M.A.3
  • 12
    • 84862907587 scopus 로고    scopus 로고
    • Rivaroxaban in patients with a recent acute coronary syndrome
    • Mega J.L., Braunwald E., Wiviott S.D., et al. Rivaroxaban in patients with a recent acute coronary syndrome. N. Engl. J. Med. (2012) 1 9-19.
    • (2012) N. Engl. J. Med. , vol.1 , pp. 9-19
    • Mega, J.L.1    Braunwald, E.2    Wiviott, S.D.3
  • 13
    • 0035871772 scopus 로고    scopus 로고
    • Prothrombin protects factor Xa in the prothrombinase complex from inhibition by the heparin-antithrombin complex
    • Rezaie A.R. Prothrombin protects factor Xa in the prothrombinase complex from inhibition by the heparin-antithrombin complex. Blood (2001) 8 2308-2313.
    • (2001) Blood , vol.8 , pp. 2308-2313
    • Rezaie, A.R.1
  • 14
    • 29144518504 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939-an oral, direct Factor Xa inhibitor-after multiple dosing in healthy male subjects
    • Kubitza D., Becka M., Wensing G., Voith B., Zuehlsdorf M. Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939-an oral, direct Factor Xa inhibitor-after multiple dosing in healthy male subjects. Eur. J. Clin. Pharmacol. (2005) 12 873-880.
    • (2005) Eur. J. Clin. Pharmacol. , vol.12 , pp. 873-880
    • Kubitza, D.1    Becka, M.2    Wensing, G.3    Voith, B.4    Zuehlsdorf, M.5
  • 15
    • 22844442726 scopus 로고    scopus 로고
    • In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939 - an oral, direct Factor Xa inhibitor
    • Perzborn E., Strassburger J., Wilmen A., et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939 - an oral, direct Factor Xa inhibitor. J. Thromb. Haemost. (2005) 3 514-521.
    • (2005) J. Thromb. Haemost. , vol.3 , pp. 514-521
    • Perzborn, E.1    Strassburger, J.2    Wilmen, A.3
  • 16
    • 33748779231 scopus 로고    scopus 로고
    • Effect of BAY 59-7939- a novel, oral, direct Factor Xa inhibitor-on clot-bound Factor Xa activity in vitro
    • Abstract P1104.
    • Depasse F., Busson J., Mnich J. et al. Effect of BAY 59-7939- a novel, oral, direct Factor Xa inhibitor-on clot-bound Factor Xa activity in vitro. J. Thromb. Haemost. (2005) 3 Abstract P1104.
    • (2005) J. Thromb. Haemost. , vol.3
    • Depasse, F.1    Busson, J.2    Mnich, J.3
  • 17
    • 35848929515 scopus 로고    scopus 로고
    • Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa
    • Pinto D.J.P., Orwat M.J., Koch S., et al. Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4, 5, 6, 7-tetrahydro-1H-pyrazolo[3, 4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa. J. Med. Chem. (2007) 22 5339-5356.
    • (2007) J. Med. Chem. , vol.22 , pp. 5339-5356
    • Pinto, D.J.P.1    Orwat, M.J.2    Koch, S.3
  • 18
    • 33748763511 scopus 로고    scopus 로고
    • The oral, direct factor Xa inhibitor BAY 59-7939 does not cross-react with antiheparin/ PF4 (heparin-induced thrombocytopenia) antibodies
    • Abstract P1883.
    • Walenga J.M., Hoppensteadt D., Iqbal O. et al. The oral, direct factor Xa inhibitor BAY 59-7939 does not cross-react with antiheparin/ PF4 (heparin-induced thrombocytopenia) antibodies. Blood (American Society of Hematology Annual Meeting Abstracts) (2005) 11 Abstract P1883.
    • (2005) Blood (American Society of Hematology Annual Meeting Abstracts) , vol.11
    • Walenga, J.M.1    Hoppensteadt, D.2    Iqbal, O.3
  • 19
    • 53849123533 scopus 로고    scopus 로고
    • A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: the Einstein-DVT Dose-Ranging Study
    • Buller H.R., Lensing A.W.A., Prins M.H., et al. A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: the Einstein-DVT Dose-Ranging Study. Blood (2008) 6 2242-2247.
    • (2008) Blood , vol.6 , pp. 2242-2247
    • Buller, H.R.1    Lensing, A.W.A.2    Prins, M.H.3
  • 20
    • 33746795675 scopus 로고    scopus 로고
    • Effects of single-dose BAY 59-7939 - an oral, direct Factor Xa inhibitor - in subjects with extreme body weight
    • Abstract P1872.
    • Kubitza D., Becka M., Zuehlsdorf M., Mueck W. Effects of single-dose BAY 59-7939 - an oral, direct Factor Xa inhibitor - in subjects with extreme body weight. Blood (2005) 106 Abstract P1872.
    • (2005) Blood , vol.106
    • Kubitza, D.1    Becka, M.2    Zuehlsdorf, M.3    Mueck, W.4
  • 21
    • 33846448135 scopus 로고    scopus 로고
    • Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects
    • Kubitza D., Becka M., Zuehlsdorf M., Mueck W. Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects. J. Clin. Pharmacol. (2007) 2 218-226.
    • (2007) J. Clin. Pharmacol. , vol.2 , pp. 218-226
    • Kubitza, D.1    Becka, M.2    Zuehlsdorf, M.3    Mueck, W.4
  • 22
    • 33645779998 scopus 로고    scopus 로고
    • Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in healthy subjects
    • Kubitza D., Becka M., Zuehlsdorf M., Mueck W. Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in healthy subjects. J. Clin. Pharmacol. (2006) 5 549-558.
    • (2006) J. Clin. Pharmacol. , vol.5 , pp. 549-558
    • Kubitza, D.1    Becka, M.2    Zuehlsdorf, M.3    Mueck, W.4
  • 23
    • 84921062811 scopus 로고    scopus 로고
    • Daily Med, Current Medication Information, Apixaban [accessed 26 June 2014].
    • Daily Med, Current Medication Information, Apixaban http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e9481622-7cc6-418a-acb6-c5450daae9b0 [accessed 26 June 2014].
  • 24
    • 84869109465 scopus 로고    scopus 로고
    • Pharmacokinetics, biotransformation, and mass balance of edoxaban, a selective, direct factor Xa inhibitor, in humans
    • Bathala M.S., Masumoto H., Oguma T., He L., Lowrie C., Mendell J. Pharmacokinetics, biotransformation, and mass balance of edoxaban, a selective, direct factor Xa inhibitor, in humans. Drug Metab. Dispos. (2012) 12 2250-2255.
    • (2012) Drug Metab. Dispos. , vol.12 , pp. 2250-2255
    • Bathala, M.S.1    Masumoto, H.2    Oguma, T.3    He, L.4    Lowrie, C.5    Mendell, J.6
  • 25
    • 84921062810 scopus 로고    scopus 로고
    • Xarelto summary of product characteristics. [accessed 26 June 2014].
    • Bayer Schering Pharma AG. Xarelto summary of product characteristics. http://www.xarelto.com/html/downloads/2013-05_XRL_SPC_final_low.pdf [accessed 26 June 2014].
  • 26
    • 84921062809 scopus 로고    scopus 로고
    • Daily Med, Current Medication Information, Dabigatran Etexilate Mesylate, [accessed 26 June 2014].
    • Daily Med, Current Medication Information, Dabigatran Etexilate Mesylate, http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ba74e3cd-b06f-4145-b284-5fd6b84ff3c9 [accessed 26 June 2014].
  • 27
    • 84884512133 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with mechanical heart valves
    • Eikelboom J.W., Connolly S.J., Brueckmann M., et al. Dabigatran versus warfarin in patients with mechanical heart valves. N. Engl. J. Med. (2013) 13 1206-1214.
    • (2013) N. Engl. J. Med. , vol.13 , pp. 1206-1214
    • Eikelboom, J.W.1    Connolly, S.J.2    Brueckmann, M.3
  • 28
    • 84857021520 scopus 로고    scopus 로고
    • Dabigatran association with higher risk of acute coronary events: meta-analysis of noninferiority randomized controlled trials
    • Uchino K., Hernandez A.V. Dabigatran association with higher risk of acute coronary events: meta-analysis of noninferiority randomized controlled trials. Arch. Intern. Med. (2012) 5 397-402.
    • (2012) Arch. Intern. Med. , vol.5 , pp. 397-402
    • Uchino, K.1    Hernandez, A.V.2
  • 29
    • 80052162121 scopus 로고    scopus 로고
    • Apixaban with antiplatelet therapy after acute coronary syndrome
    • Alexander J.H., Lopes R.D., James S., et al. Apixaban with antiplatelet therapy after acute coronary syndrome. N. Engl. J. Med. (2011) 8 699-708.
    • (2011) N. Engl. J. Med. , vol.8 , pp. 699-708
    • Alexander, J.H.1    Lopes, R.D.2    James, S.3
  • 30
    • 84879589989 scopus 로고    scopus 로고
    • Stroke prevention in atrial fibrillation: understanding the new oral anticoagulants dabigatran, rivaroxaban, and apixaban
    • Ru San T., Chan M.Y.Y., Wee Siong T. et al. Stroke prevention in atrial fibrillation: understanding the new oral anticoagulants dabigatran, rivaroxaban, and apixaban. Thrombosis (2012) 108983.
    • (2012) Thrombosis , pp. 108983
    • Ru San, T.1    Chan, M.Y.Y.2    Wee Siong, T.3
  • 31
    • 78751637313 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation: an analysis of patients undergoing cardioversion
    • Nagarakanti R., Ezekowitz M.D., Oldgren J., et al. Dabigatran versus warfarin in patients with atrial fibrillation: an analysis of patients undergoing cardioversion. Circulation (2011) 2 131-136.
    • (2011) Circulation , vol.2 , pp. 131-136
    • Nagarakanti, R.1    Ezekowitz, M.D.2    Oldgren, J.3
  • 32
    • 84877276344 scopus 로고    scopus 로고
    • Outcomes after cardioversion and atrial fibrillation ablation in patients treated with rivaroxaban and warfarin in the ROCKET AF trial
    • Piccini J.P., Stevens S.R., Lokhnygina Y., et al. Outcomes after cardioversion and atrial fibrillation ablation in patients treated with rivaroxaban and warfarin in the ROCKET AF trial. J. Am. Coll. Cardiol. (2013) 19 1998-2006.
    • (2013) J. Am. Coll. Cardiol. , vol.19 , pp. 1998-2006
    • Piccini, J.P.1    Stevens, S.R.2    Lokhnygina, Y.3
  • 33
    • 84896506763 scopus 로고    scopus 로고
    • Efficacy and safety of apixaban in patients after cardioversion for atrial fibrillation: insights from the ARISTOTLE Trial (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation)
    • Flaker G., Lopes R.D., Al-Khatib S.M., et al. Efficacy and safety of apixaban in patients after cardioversion for atrial fibrillation: insights from the ARISTOTLE Trial (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation). J. Am. Coll. Cardiol. (2014) 11 1082-1087.
    • (2014) J. Am. Coll. Cardiol. , vol.11 , pp. 1082-1087
    • Flaker, G.1    Lopes, R.D.2    Al-Khatib, S.M.3
  • 34
    • 84880280696 scopus 로고    scopus 로고
    • EHRA practical guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation: executive summary
    • Heidbuchel H., Verhamme P., Alings M., et al. EHRA practical guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation: executive summary. Eur. Heart J. (2013) 27 2094-2106.
    • (2013) Eur. Heart J. , vol.27 , pp. 2094-2106
    • Heidbuchel, H.1    Verhamme, P.2    Alings, M.3
  • 35
    • 84899547365 scopus 로고    scopus 로고
    • Rationale and design of the eXplore the efficacy and safety of once-daily oral rivaroxaban for the prevention of cardiovascular events in patients with nonvalvular atrial fibrillation scheduled for cardioversion trial: a comparison of oral rivaroxaban once daily with dose-adjusted vitamin K antagonists in patients with nonvalvular atrial fibrillation undergoing elective cardioversion
    • Ezekowitz M.D., Cappato R., Klein A.L., et al. Rationale and design of the eXplore the efficacy and safety of once-daily oral rivaroxaban for the prevention of cardiovascular events in patients with nonvalvular atrial fibrillation scheduled for cardioversion trial: a comparison of oral rivaroxaban once daily with dose-adjusted vitamin K antagonists in patients with nonvalvular atrial fibrillation undergoing elective cardioversion. Am. Heart J. (2014) 5 646-652.
    • (2014) Am. Heart J. , vol.5 , pp. 646-652
    • Ezekowitz, M.D.1    Cappato, R.2    Klein, A.L.3
  • 36
    • 84878260361 scopus 로고    scopus 로고
    • Recommendations for the emergency management of complications associated with the new direct oral anticoagulants (DOACs), apixaban, dabigatran and rivaroxaban
    • Steiner T., Böhm M., Dichgans M., et al. Recommendations for the emergency management of complications associated with the new direct oral anticoagulants (DOACs), apixaban, dabigatran and rivaroxaban. Clin. Res. Cardiol. (2013) 6 399-412.
    • (2013) Clin. Res. Cardiol. , vol.6 , pp. 399-412
    • Steiner, T.1    Böhm, M.2    Dichgans, M.3
  • 37
    • 25844525489 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor
    • Kubitza D., Becka M., Voith B., Zuehlsdorf M., Wensing G. Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor. Clin. Pharmacol. Ther. (2005) 4 412-421.
    • (2005) Clin. Pharmacol. Ther. , vol.4 , pp. 412-421
    • Kubitza, D.1    Becka, M.2    Voith, B.3    Zuehlsdorf, M.4    Wensing, G.5
  • 38
    • 34250166525 scopus 로고    scopus 로고
    • Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban-an oral, direct factor xa inhibitor-in healthy subjects
    • Mueck W., Becka M., Kubitza D., Voith B., Zuehlsdorf M. Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban-an oral, direct factor xa inhibitor-in healthy subjects. Int. J. Clin. Pharmacol. Ther. (2007) 6 335-344.
    • (2007) Int. J. Clin. Pharmacol. Ther. , vol.6 , pp. 335-344
    • Mueck, W.1    Becka, M.2    Kubitza, D.3    Voith, B.4    Zuehlsdorf, M.5
  • 39
    • 78149492327 scopus 로고    scopus 로고
    • An optimised, rapid chromogenic assay, specific for measuring direct factor Xa inhibitors (rivaroxaban) in plasma
    • Samama M.M., Amiral J., Guinet C., Perzborn E., Depasse F. An optimised, rapid chromogenic assay, specific for measuring direct factor Xa inhibitors (rivaroxaban) in plasma. Thromb. Haemost. (2010) 5 1078-1079.
    • (2010) Thromb. Haemost. , vol.5 , pp. 1078-1079
    • Samama, M.M.1    Amiral, J.2    Guinet, C.3    Perzborn, E.4    Depasse, F.5
  • 40
    • 84856632988 scopus 로고    scopus 로고
    • Evaluation of the anti-factor Xa chromogenic assay for the measurement of rivaroxaban plasma concentrations using calibrators and controls
    • Samama M.M., Contant G., Spiro T.E., et al. Evaluation of the anti-factor Xa chromogenic assay for the measurement of rivaroxaban plasma concentrations using calibrators and controls. Thromb. Haemost. (2012) 2 379-387.
    • (2012) Thromb. Haemost. , vol.2 , pp. 379-387
    • Samama, M.M.1    Contant, G.2    Spiro, T.E.3
  • 41
    • 78649736882 scopus 로고    scopus 로고
    • Clinical laboratory measurement of direct factor Xa inhibitors: anti-Xa assay is preferable to prothrombin time assay
    • Barrett Y.C., Wang Z., Frost C., Shenker A. Clinical laboratory measurement of direct factor Xa inhibitors: anti-Xa assay is preferable to prothrombin time assay. Thromb. Haemost. (2010) 6 1263-1271.
    • (2010) Thromb. Haemost. , vol.6 , pp. 1263-1271
    • Barrett, Y.C.1    Wang, Z.2    Frost, C.3    Shenker, A.4
  • 42
    • 84859937545 scopus 로고    scopus 로고
    • Reversal of antithrombotic agents
    • Bauer K.A. Reversal of antithrombotic agents. Am. J. Hematol. (2012) 87(Suppl 1) S119-S126.
    • (2012) Am. J. Hematol. , vol.87 , pp. S119-S126
    • Bauer, K.A.1
  • 43
    • 84878460192 scopus 로고    scopus 로고
    • A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa
    • Lu G., DeGuzman F.R., Hollenbach S.J., et al. A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nat. Med. (2013) 4 446-451.
    • (2013) Nat. Med. , vol.4 , pp. 446-451
    • Lu, G.1    DeGuzman, F.R.2    Hollenbach, S.J.3
  • 44
    • 84874251027 scopus 로고    scopus 로고
    • Acute management of bleeding in patients on novel oral anticoagulants
    • Siegal D.M., Crowther M.A. Acute management of bleeding in patients on novel oral anticoagulants. Eur. Heart J. (2013) 7 489-498b.
    • (2013) Eur. Heart J. , vol.7 , pp. 489-498b
    • Siegal, D.M.1    Crowther, M.A.2
  • 45
    • 80053571188 scopus 로고    scopus 로고
    • Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects
    • Eerenberg E.S., Kamphuisen P.W., Sijpkens M.K., Meijers J.C., Buller H.R., Levi M. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation (2011) 14 1573-1579.
    • (2011) Circulation , vol.14 , pp. 1573-1579
    • Eerenberg, E.S.1    Kamphuisen, P.W.2    Sijpkens, M.K.3    Meijers, J.C.4    Buller, H.R.5    Levi, M.6
  • 46
    • 84864370719 scopus 로고    scopus 로고
    • Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers
    • Marlu R., Hodaj E., Paris A., et al. Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers. Thromb. Haemost. (2012) 2 217-224.
    • (2012) Thromb. Haemost. , vol.2 , pp. 217-224
    • Marlu, R.1    Hodaj, E.2    Paris, A.3
  • 47
    • 84875926001 scopus 로고    scopus 로고
    • Effective elimination of dabigatran by haemodialysis. A phase I single-centre study in patients with end-stage renal disease
    • Khadzhynov D., Wagner F., Formella S., et al. Effective elimination of dabigatran by haemodialysis. A phase I single-centre study in patients with end-stage renal disease. Thromb. Haemost. (2013) 4 596-605.
    • (2013) Thromb. Haemost. , vol.4 , pp. 596-605
    • Khadzhynov, D.1    Wagner, F.2    Formella, S.3
  • 49
    • 77953168824 scopus 로고    scopus 로고
    • Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity
    • Van Ryn J., Stangier J., Haertter S., et al. Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity. Thromb. Haemost. (2010) 6 1116-1127.
    • (2010) Thromb. Haemost. , vol.6 , pp. 1116-1127
    • Van Ryn, J.1    Stangier, J.2    Haertter, S.3
  • 50
    • 84878290471 scopus 로고    scopus 로고
    • Betrixaban compared with warfarin in patients with atrial fibrillation: results of a phase 2 randomized dose-ranging study (EXPLORE-Xa) Eur
    • Connolly S.J., Eikelboom J., Dorian P., et al. Betrixaban compared with warfarin in patients with atrial fibrillation: results of a phase 2 randomized dose-ranging study (EXPLORE-Xa) Eur. Heart J. (2013) 34 1498-1505.
    • (2013) Heart J. , vol.34 , pp. 1498-1505
    • Connolly, S.J.1    Eikelboom, J.2    Dorian, P.3
  • 51
    • 84921062808 scopus 로고    scopus 로고
    • Daily Med, Current Medication Information, Rivaroxaban, [accessed 26 June 2014].
    • Daily Med, Current Medication Information, Rivaroxaban, http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=10db92f9-2300-4a80-836b-673e1ae91610 [accessed 26 June 2014].
  • 52
    • 77953787643 scopus 로고    scopus 로고
    • Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers
    • Ogata K., Mendell-Harary J., Tachibana M., et al. Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers. J. Clin. Pharmacol. (2010) 50 743-753.
    • (2010) J. Clin. Pharmacol. , vol.50 , pp. 743-753
    • Ogata, K.1    Mendell-Harary, J.2    Tachibana, M.3
  • 53
    • 84858335249 scopus 로고    scopus 로고
    • In vitro study of the anticoagulant effects of edoxaban and its effect on thrombin generation in comparison to fondaparinux
    • Samama M.M., Mendell J., Guinet C., Le Flem L., Kunitada S. In vitro study of the anticoagulant effects of edoxaban and its effect on thrombin generation in comparison to fondaparinux. Thromb. Res. (2012) 4 77-82.
    • (2012) Thromb. Res. , vol.4 , pp. 77-82
    • Samama, M.M.1    Mendell, J.2    Guinet, C.3    Le Flem, L.4    Kunitada, S.5
  • 54
    • 84856631805 scopus 로고    scopus 로고
    • Reversal of anticoagulant effects of edoxaban, an oral, direct factor Xa inhibitor, with haemostatic agents
    • Fukuda T., Honda Y., Kamisato C., Morishima Y., Shibano T. Reversal of anticoagulant effects of edoxaban, an oral, direct factor Xa inhibitor, with haemostatic agents. Thromb. Haemost. (2012) 2 253-259.
    • (2012) Thromb. Haemost. , vol.2 , pp. 253-259
    • Fukuda, T.1    Honda, Y.2    Kamisato, C.3    Morishima, Y.4    Shibano, T.5
  • 55
    • 84921062807 scopus 로고    scopus 로고
    • Summary of product characteristics, Rivaroxaban. [accessed 26 June 2014].
    • European Medecines Agency, Summary of product characteristics, Rivaroxaban. http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000944/human_med_001155.jsp%26mid=WC0b01ac058001d124 [accessed 26 June 2014].


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