Amplification strategies using electrochemiluminescence biosensors for the detection of DNA, bioactive molecules and cancer biomarkers

TrAC - Trends in Analytical Chemistry

Volumn 65, Issue , 2015, Pages 137-150

  Ding, Caifeng ^a   Zhang, Wei ^a   Wang, Wei ^a   Chen, Yaoyao ^a   Li, Xaoqian ^a  

^a QINGDAO UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Bioactive molecule; Bioassay; Cancer biomarker; Cell; DNA; Electrochemiluminescence; Nanoparticle; Protein; Signal amplification; Single nucleotide polymorphism

Indexed keywords

BIOASSAY; BIOMARKERS; CELLS; DISEASES; DNA; MOLECULES; NANOPARTICLES; NUCLEOTIDES; PROTEINS; SIGNAL DETECTION; SIGNAL PROCESSING;

BIOACTIVE MOLECULES; CANCER BIOMARKERS; ELECTROCHEMILUMINESCENCE; SIGNAL AMPLIFICATIONS; SINGLE NUCLEOTIDE POLYMORPHISMS;

BIOSENSORS;

DNA; GOLD NANOPARTICLE; NANOMATERIAL; TUMOR MARKER;

BIOACTIVE MOLECULE; BIOASSAY; BIOSENSOR; CANCER CELL; CHEMICAL ANALYSIS; CHEMOLUMINESCENCE; DNA DETERMINATION; DNA SEQUENCE; ELECTROCHEMICAL DETECTION; ELECTROCHEMILUMINESCENCE; GENE AMPLIFICATION; HUMAN; IMMUNOSENSOR; MOLECULE; NONHUMAN; PROTEIN ANALYSIS; REVIEW; SIGNAL PROCESSING; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84921047769     PISSN: 01659936     EISSN: 18793142     Source Type: Journal    
DOI: 10.1016/j.trac.2014.10.015     Document Type: Review

References (112)

1. Hu L.Z., Xu G.B. Applications and trends in electrochemiluminescence. Chem. Soc. Rev 2010, 39:3275-3304.
2. Shen M., Rodriguez-Lopez J., Huang J., Liu Q., Zhu X.H., Bard A.J. Electrochemistry and electrogenerated chemiluminescence of dithienylbenzothiadiazole derivative. Differential reactivity of donor and acceptor groups and simulations of radical cation-anion and dication-radical anion annihilations. J. Am. Chem. Soc 2010, 132:13453-13641.
3. Zheng L.Y., Chi Y.W., Dong Y.Q., Lin J.P., Wang B.B. Electrochemiluminescence of water-soluble carbon nanocrystals released electrochemically from Graphite. J. Am. Chem. Soc 2009, 131:4564-4565.
4. Bertoncello P., Forster R.J. Nanostructured materials for electrochemiluminescence (ECL)-based detection methods: recent advances and future perspectives. Biosens. Bioelectron 2009, 24:3191-3200.
5. Yu J.G., Fan F.R.F., Pan S.L., Lynch V.M., Omer K.M., Bard A.J. Spontaneous formation and electrogenerated chemiluminescence of Tris(bipyridine) Ru(II) derivative nanobelts. J. Am. Chem. Soc 2008, 130:7196-7197.
6. Chang Y.L., Palacios R.E., Fan F.R.F., Bard A.J., Barbara P.F. Electrogenerated chemiluminescence of single conjugated polymer nanoparticles. J. Am. Chem. Soc 2008, 130:8906-8907.
7. Guo Z.H., Dong S.J. Electrogenerated chemiluminescence from Ru(Bpy)32 + ion-exchanged in carbon nanotube/perfluorosulfonated ionomer composite films. Anal. Chem 2004, 76:2683-2688.
8. Mark M.R. Electrochemiluminescence (ECL). Chem. Rev 2004, 104:3003-3036.
9. Visco R.E., Chandross E.A. Electroluminescence in solutions of aromatic hydrocarbons. J. Am. Chem. Soc 1964, 86:5350-5351.
10. Santhanam K.S., Bard A.J. Chemiluminescence of electrogenerated 9,10-diphenylanthracene anion radical. J. Am. Chem. Soc 1965, 87:139-140.
11. Bertolino C., Sweeney M.M., Tobin J., ONeill B., Sheehan M.M., Coluccia S., et al. A monolithic silicon based integrated signal generation and detection system for monitoring DNA hybridization. Biosens. Bioelectron 2005, 21:565-573.
12. Zhan W., Bard A.J. Electrogenerated chemiluminescence. 83. Immunoassay of human C-reactive protein by using Ru(bpy)32+-encapsulated liposomes as labels. Anal. Chem 2007, 79:459-463.
13. Ryoji K., Kumi A., Kohei N., Dai K., Osamu N. Development of electrogenerated chemiluminescence-based enzyme linked immunosorbent assay for Sub-pM detection. Anal. Chem 2010, 82:1692-1697.
14. Liu X., Ju H.X. Coreactant enhanced anodic electrochemiluminescence of CdTe quantum dots at low potential for sensitive biosensing amplified by enzymatic cycle. Anal. Chem 2008, 80:5377-5382.
15. Rivera V.R., Gamez F.J., Keener W.K., Poli M.A. Rapid detection of Clostridium botulinum toxins A, B, E, and F in clinical samples, selected food matrices, and buffer using paramagnetic bead-based electrochemiluminescence detection. Anal. Biochem 2006, 353:248-256.
16. Chen X.M., Su B.Y., Song X.H., Chen Q.A., Chen X., Wang X.R. Recent advances in electrochemiluminescent enzyme biosensors. TrAC-Trends Anal. Chem 2011, 33:665-676.
17. Yin X.B. Functional nucleic acids for electrochemical and electrochemiluminescent sensing applications. TrAC-Trends Anal. Chem 2012, 33:81-94.
18. Huang B.M., Zhou X.B., Xue Z.H., Lu X.Q. Electrochemiluminescence quenching of tris(2,2'-bipyridyl)ruthenium. TrAC-Trends Anal. Chem 2013, 51:107-116.
19. Li J., Wang E.K. Applications of Tris (2, 2'-bipyridyl) ruthenium(II) in Electrochemiluminescence. Chem. Rec 2012, 12:177-187.
20. Guo L.H., Fu F.F., Chen G.N. Capillary electrophoresis with electrochemiluminescence detection: fundamental theory, apparatus, and applications, Chen. Anal. Bioanal. Chem 2011, 399:3323-3343.
21. Hill C.M., Clayton D.A., Pan S.L. Combined optical and electrochemical methods for studying electrochemistry at the single molecule and single particle level: recent progress and perspectives. Phys. Chem. Chem. Phys 2013, 15:20797-20807.
22. Muzyka K. Current trends in the development of the electrochemiluminescent Immunosensors. Biosens. Bioelectron 2014, 54:393-407.
23. Huang H.P., Li J.J., Zhu J.J. Electrochemiluminescence based on quantum dots and their analytical application. Anal. Methods 2011, 3:33-42.
24. Richter M.M. Electrochemiluminescence (ECL). Chem. Rev 2004, 104:3003-3036.
25. Li J., Jia X.F., Wang E. Electrochemiluminescence of ruthenium complex and its application in biosensors. Spectrosc. Prop. Inorg. Organomet. Compd 2013, 44:1-27.
26. Deng S.Y., Ju H.X. Electrogenerated chemiluminescence of nanomaterials for bioanalysis. Analyst 2013, 138:43-61.
27. Lei J.P., Ju H.X. Fundamentals and bioanalytical applications of functional quantum dots as electrogenerated emitters of chemiluminescence. TrAC-Trends Anal. Chem 2011, 30:1351-1359.
28. Lisdat F., Schäfer D., Kapp A. Quantum dots on electrodes - new tools for bioelectroanalysis. Anal. Bioanal. Chem 2013, 405:3739-3752.
29. Rampazzo E., Bonacchi S., Genovese D., Juris R., Marcaccio M., Montalti M., et al. Nanoparticles in metal complexes-based electrogenerated chemiluminescence for highly sensitive applications. Chem. Rev 2012, 256:1664-1681.
30. Gan X.X., Yuan R., Chai Y.Q., Yuan Y.L., Cao Y.L., Liao Y.H., et al. 3,4,9,10-Perylenetetracarboxylic dianhydride functionalized graphene sheet as labels for ultrasensitive electrochemiluminescent detection of thrombin. Anal. Chim. Acta 2012, 726:67-72.
31. Li Y., Qi H.L., Gao Q., Zhang C.X. Label-free and sensitive electrogenerated chemiluminescence aptasensor for the determination of lysozyme. Biosens. Bioelectron 2011, 26:2733-2736.
32. Hu L.Z., Bian Z., Li H.J., Han S., Yuan Y.L., Gao L.X., et al. [Ru(bpy)2dppz]2 + electrochemiluminescence switch and its applications for DNA interaction study and label-free ATP aptasensor. Anal. Chem 2009, 81:9807-9811.
33. Liu D.Y., Xin Y.Y., He X.W., Yin X.B. A sensitive, non-damaging electrochemiluminescent aptasensor via a low potential approach at DNA-modified gold electrodes. Analyst 2011, 136:479-485.
34. Cousino M.A., Jarbawi T.B., Halsall H.B., Heineman W.R. Peer reviewed: pushing down the limits of detection: molecular needles in a haystack how low can analytical chemistry go?. Anal. Chem 1997, 69:544-549.
35. Kitano H. Systems biology: a brief overview. Science 2002, 295:1662-1664.
36. Perfezou M., Turner A., Merkoçi A. Cancer detection using nanoparticle-based sensors. Chem. Soc. Rev 2012, 41:2606-2622.
37. Smith J.C., Lambert J.P., Elisma F., Figeys D. Proteomics in 2005/2006: developments, applications and challenges. Anal. Chem 2007, 79:4325-4343.
38. Wilson M.S., Nie W.Y. Multiplex measurement of seven tumor markers using an electrochemical protein chip. Anal. Chem 2006, 78:6476-6483.
39. Du D., Zou Z.X., Shin Y., Wang J., Wu H., Engelhard M.H., et al. Sensitive immunosensor for cancer biomarker based on dual signal amplification strategy of graphene sheets and multienzyme functionalized carbon nanospheres. Anal. Chem 2010, 82:2989-2995.
40. Risch N., Merikangas K. The future of genetic studies of complex human Diseases. Science 1996, 273:1516-1517.
41. McCarthy J.J., Hilfiker R. The use of single-nucleotide polymorphism maps in pharmacogenomics. Nat. Biotechnol 2000, 18:505-508.
42. Yin X.B., Xin Y.Y., Zhao Y. Label-free electrochemiluminescent aptasensor with attomolar mass LODs based on a Ru(phen)32+-double-strand DNA composite film electrode. Anal. Chem 2009, 81:9299-9305.
43. Jiang J., Chai Y., Cui H. The electrogenerated chemiluminescence detection of IS6110 of Mycobacterium tuberculosis based on a luminol functionalized gold nanoprobe. RSC Adv 2011, 1:247-254.
44. Yu X.X., Chai Y., Jiang J., Cui H. Sensitive ECL sensor for sequence-specific DNA from Mycobacterium tuberculosis based on N-(aminobutyl)-N-ethylisoluminol functionalized gold nanoparticles labeling. J. Photoch. Photobio. A 2012, 241:45-51.
45. Yao C.Y., Xiang Y., Deng K. Sensitive and specific HBV genomic DNA detection using RCA-based QCM biosensor. Sens. Actuators B 2013, 181:382-387.
46. Jiang D.N., Liu F., Liu C.H., Liu L.L., Li Y., Pu X.Y. Induction of an electrochemiluminescence sensor for DNA detection of Clostridium perfringens based on rolling circle amplification. Anal. Methods 2014, 6:1558-1562.
47. Long Y., Zhou X.M., Xing D. Sensitive and isothermal electrochemiluminescence gene-sensing of Listeria monocytogenes with hyperbranching rolling circle amplification technology. Biosens. Bioelectron 2011, 26:2897-2904.
48. Liu T., Chen X., Hong C.Y., Xu X.P., Yang H.H. Label-free and ultrasensitive electrochemiluminescence detection of microRNA based on long-range self-assembled DNA nanostructures. Microchim. Acta 2014, 181:7-8.
49. Chen Y., Xu J., Su J., Xiang Y., Yuan R., Chai Y.Q. In situ hybridization chain reaction amplification for universal and highly sensitive electrochemiluminescent detection of DNA. Anal. Chem 2012, 84:7750-7755.
50. Zhou J., Lu Q., Tong Y., Wei W., Liu S. Detection of DNA damage by using hairpin molecular beacon probes and graphene oxide. Talanta 2012, 99:625-630.
51. Wei W., Zhou J., Li H., Yin L., Pu Y., Liu S. Fabrication of CdTe at SiO2 nanoprobes for sensitive electrogenerated chemiluminescence detection of DNA damage. Analyst 2013, 138:3253-3258.
52. Chen Y., Yang M.L., Xiang Y., Yuan R., Chai Y.Q. Ligase chain reaction amplification for sensitive electrochemiluminescent detection of single nucleotide, polymorphisms. Anal. Chim. Acta 2013, 796:1-6.
53. Zhou H., Liu J., Xu J.J., Chen H.Y. Ultrasensitive DNA detection based on Au nanoparticles and isothermal circular double-assisted electrochemiluminescence signal amplification. Chem. Commun 2011, 47:8358-8360.
54. Zhou H., Liu J., Xu J.J., Chen H.Y. Highly sensitive electrochemiluminescence detection of single-nucleotide polymorphisms based on isothermal cycle-assisted triple-stem probe with dual-nanoparticle label. Anal. Chem 2011, 83:8320-8328.
55. Wang G.F., Huang H., Wang B.J., Zhang X.J., Wang L. A supersandwich multienzyme DNA label based electrochemical immunosensor. Chem. Commun 2011, 48:720-722.
56. Zhang B., Liu B.Q., Tang D.P., Niessner R.H., Chen G.N. DNA-based hybridization chain reaction for amplified bioelectronic signal and ultrasensitive detection of proteins. Anal. Chem 2012, 84:5392-5399.
57. Xu J., Wu J., Zong C., Ju H.X., Yan F. Manganese porphyrin-dsDNA complex: a mimicking enzyme for highly efficient bioanalysis. Anal. Chem 2013, 85:3374-3379.
58. Guo Y.S., Jia X.P., Zhang S.S. DNA cycle amplification device on magnetic microbeads for determination of thrombin based on graphene oxide enhancing signal-on electrochemiluminescence. Chem. Commun 2011, 47:725-727.
59. Jie G.F., Yuan J.X. Novel magnetic Fe3O4 at CdSe composite quantum dot-based electrochemiluminescence detection of thrombin by a multiple DNA cycle amplification strategy. Anal. Chem 2012, 84:2811-2817.
60. Zhao M., Zhuo Y., Chai Y.Q., Xiang Y., Liao N., Gui G.F., et al. Dual signal amplification strategy for the fabrication of an ultrasensitive electrochemiluminescenct aptasensor. Analyst 2013, 138:6639-6644.
61. Xiao L.J., Chai Y.Q., Yuan R., Cao Y.L., Wang H.J., Bai L.J. Amplified electrochemiluminescence of luminal based on hybridization chain reaction and in situ generate co-reactant for highly sensitive immunoassay. Talanta 2013, 115:577-582.
62. Tang J., Tang D.P., Li Q.F., Su B.L., Qiu B., Chen G.N. Sensitive electrochemical immunoassay of carcinoembryonic antigen with signal dual-amplification using glucose oxidase and an artificial catalase. Anal. Chim. Acta 2011, 697:16-22.
63. Wang H.J., Yuan R., Chai Y.Q., Niu H., Cao Y.L., Liu H.J. Bi-enzyme synergetic catalysis to in situ generate coreactant of peroxydisulfate solution for ultrasensitive electrochemiluminescence immunoassay. Biosens. Bioelectron 2012, 37:6-10.
64. Wang F.A., Elbaz J., Orbach R., Magen N., Willner I. Amplified analysis of DNA by the autonomous assembly of polymers consisting of DNAzyme wires. J. Am. Chem. Soc 2011, 133:17149-17151.
65. Willner I., Shlyahovsky B., Zayats M., Willner B. DNAzymes for sensing, nanobiotechnology and logic gate applications. Chem. Soc. Rev 2008, 37:1153-1165.
66. Cai Y., Li N., Kong D.M., Shen H.X. Fluorogenic substrate screening for G-quadruplex DNAzyme-based sensors. Biosens. Bioelectron 2013, 49:312-317.
67. Travascio P., Witting P.K., Mauk A.G., Sen D. The peroxidase activity of a hemin-DNA oligonucleotide complex: free radical damage to specific guanine bases of the DNA. J. Am. Chem. Soc 2001, 123:1337-1348.
68. Chinnapen D.J.F., Sen D. Hemin-stimulated docking of cytochrome c to a hemin-DNA aptamer complex. Biochemistry 2002, 41:5202-5212.
69. Xiao Y., Pavlov V., Niazov T., Dishon A., Kotler M., Willner I. Catalytic beacons for the detection of DNA and telomerase activity. J. Am. Chem. Soc 2004, 126:7430-7431.
70. Zhuo Y., Ma M.N., Chai Y.Q., Zhao M., Yuan R. Amplified electrochemiluminescent aptasensor using mimicking bi-enzyme nanocomplexes as signal enhancement. Anal. Chim. Acta 2014, 809:47-53.
71. Duan R., Zhou X., Xing D. Electrochemiluminescence biobarcode method based on cysteamine-gold nanoparticle conjugates. Anal. Chem 2010, 82:3099-3103.
72. Pinijsuwan S., Rijiravanich P., Somasundrum M., Surareung-chai W. Sub-femtomolar electrochemical detection of DNA hybridization based on latex/gold nanoparticle-assisted signal amplification. Anal. Chem 2008, 80:6779-6784.
73. Jie G., Zhang J., Wang D., Cheng C., Chen H.Y., Zhu J.J. Electrochemiluminescence immunosensor based on CdSe nanocomposites. Anal. Chem 2008, 80:4033-4039.
74. Jie G.F., Liu P., Wang L., Zhang S.S. Electrochemiluminescence immunosensor based on nanocomposite film of CdS quantum dots-carbon nanotubes combined with gold nanoparticles-chitosan. Electrochem. Commun 2010, 12:22-26.
75. Wu Y.F., Shi H.Y., Yuan L.A., Liu S.Q. A novel electrochemiluminescence immunosensor via polymerization-assisted amplification. Chem. Commun 2010, 46:7763-7765.
76. Zhang Y., Ge S.G., Wang S.W., Yan M., Yu J.H., Song X.R., et al. Magnetic beads-based electrochemiluminescence immunosensor for determination of cancer markers using quantum dot functionalized PtRu alloys as labels. Analyst 2012, 137:2176-2182.
77. Liu F., Zhang Y., Ge S.G., Lu J.J., Yu J.H., Song R., et al. Magnetic graphene nanosheets based electrochemiluminescence immunoassay of cancer biomarker using CdTe quantum dots coated silica nanospheres as labels. Talanta 2012, 99:512-519.
78. Zhang Y., Dai W.J., Liu F., Li L., Li M., Ge S.G., et al. Ultrasensitive electrochemiluminescent immunosensor based on dual signal amplification strategy of gold nanoparticles-dotted graphene composites and CdTe quantum dots coated silica nanoparticles. Anal. Bioanal. Chem 2013, 405:4921-4929.
79. Zhang Y., Li L., Yang H.M., Ding Y.N., Su M., Zhu J.T., et al. Gold-silver nanocomposite-functionalized graphene sensing platform for an electrochemiluminescent immunoassay of a tumor marker. RSC Adv 2013, 3:14701-14709.
80. Liu W.Y., Zhang Y., Ge S.G., Song X.R., Huang J.D., Yan M., et al. Core-shell Fe3O4-Au magnetic nanoparticles based nonenzymatic ultrasensitive electrochemiluminescence immunosensor using quantum dots functionalized graphene sheet as labels. Anal. Chim. Acta 2013, 770:132-139.
81. Xu S.J., Liu Y., Wang T.H., Li J.H. Positive potential operation of a cathodic electrogenerated chemiluminescence immunosensor based on luminol and graphene for cancer biomarker detection. Anal. Chem 2011, 83:3817-3823.
82. Mao L., Yuan R., Chai Y.Q., Zhuo Y., Jiang W. Potential controlling highly-efficient catalysis of wheat-like silver particles for electrochemiluminescence immunosensor labeled by nano-Pt at Ru and multi-sites biotin/streptavidin affinity. Analyst 2011, 136:1450-1455.
83. Wang G.J., Jin F., Dai N., Zhong Z.Y., Qing Y., Li M.X., et al. Signal-enhanced electrochemiluminescence immunosensor based on synergistic catalysis of nicotinamide adenine dinucleotide hydride and silver nanoparticles. Anal. Biochem 2012, 422:7-13.
84. Liao N., Zhuo Y., Chai Y.Q., Xiang Y., Han J., Yuan R. Reagentless electrochemiluminescent detection of protein biomarker using graphene-based magnetic nanoprobes and poly-l-lysine as co-reactant. Biosens. Bioelectron 2013, 45:189-194.
85. Xiao L.J., Chai Y.Q., Yuan R., Wang H.J., Bai L.J. Highly enhanced electrochemiluminescence based on pseudo triple-enzyme cascade catalysis and generation of co-reactant for thrombin detection. Analyst 2014, 139:1030-1036.
86. Wang J., Han H.Y., Jiang X.C., Huang L., Chen L.N., Li N. Quantum dot-based near-infrared electrochemiluminescent immunosensor with gold nanoparticle-graphene nanosheet hybrids and silica nanospheres double-assisted signal amplification. Anal. Chem 2012, 84:4893-4899.
87. Wang H.Y., Gong W., Tan Z.A., Yin X.X., Wang L. Label-free bifunctional electrochemiluminescence aptasensor for detection of adenosine and lysozyme. Electrochim. Acta 2012, 76:416-423.
88. Wang J., Zhao W.W., Zhou H., Xu J.J., Chen H.Y. Amplified electrochemiluminescence detection of DNA-binding protein based on the synergy effect of electron and energy transfer between CdS nanocrystals and gold nanoparticles. Biosens. Bioelectron 2013, 41:615-620.
89. Jie G.F., Zhang J., Jie G.X., Wang L. A novel quantum dot nanocluster as versatile probe for electrochemiluminescence and electrochemical assays of DNA and cancer cells. Biosens. Bioelectron 2014, 52:69-75.
90. Jie G.F., Wang L., Yuan J.X., Zhang S.S. Versatile electrochemiluminescence assays for cancer cells based on dendrimer/CdSe-ZnS-quantum dot nanoclusters. Anal. Chem 2011, 83:3873-3880.
91. Yu F.L., Li G., Mao C.M. An electrochemiluminescence aptasensor for tumor cells assay based on signal amplification of Ru(II) covalently doped silica nanoparticles. Electrochem. Commun 2011, 13:1244-1247.
92. Li C.X., Lin J., Guo Y.S., Zhang S.S. A novel electrochemiluminescent reagent of cyclometalated iridium complex-based DNA biosensor and its application in cancer cell detection. Chem. Commun 2011, 47:4442-4444.
93. Ding C.F., Ge Y., Zhang S.S. Electrochemical and electrochemiluminescence determination of cancer cells based on aptamers and magnetic beads. Chem. Eur. J. 2010, 16:10707-10714.
94. Ding C.F., Wei S., Liu H.T. Electrochemiluminescent determination of cancer cells based on aptamers, nanoparticles, and magnetic beads. Chem. Eur. J. 2012, 18:7263-7268.
95. Jie G.F., Yuan J.X., Zhang J. Quantum dots-based multifunctional dendritic superstructure for amplified electrochemiluminescence detection of ATP. Biosens. Bioelectron 2012, 31:69-76.
96. Zhou X.M., Su Q., Xing D. An electrochemiluminescent assay for high sensitive detection of mercury (II) based on isothermal rolling circular amplification. Anal. Chim. Acta 2012, 713:45-49.
97. Yuan Y.L., Wei S.Q., Liu G.P., Xie S.B., Chai Y.Q., Yuan R. Ultrasensitive electrochemiluminescent aptasensor for ochratoxin A detection with the loop-mediated isothermal amplification. Anal. Chim. Acta 2014, 811:70-75.
98. Ding S.N., Xu J.J., Shan D., Gao B.H., Yang H.X., Sun Y.M., et al. Electrochromic response and electrochemiluminescence of CdS nanocrystals thin film in aqueous solution. Electrochem. Commun 2010, 12:713-716.
99. Delaney J.L., Hogan C.F., Tian J., Shen W. Electrogenerated chemiluminescence detection in paper-based microfluidic sensors. Anal. Chem 2011, 83:1300-1306.
100. Hvastkovs E.G., So M., Krishnan S., Bajrami B., Tarun M., Jansson I., et al. Electrochemiluminescent arrays for cytochrome P450-activated genotoxicity screening. DNA damage from benzo[a]pyrene metabolites. Anal. Chem 2007, 79:1897-1906.
101. Krishnan S., Hvastkovs E.G., Bajrami B., Choudhary D., Schenkman J.B., Rusling J.F. Synergistic metabolic toxicity screening using microsome/DNA electrochemiluminescent arrays and nanoreactors. Anal. Chem 2008, 80:5279-5285.
102. Pan S.M., Zhao L.L., Schenkman J.B., Rusling J.F. Evaluation of electrochemiluminescent metabolic toxicity screening arrays using a multiple compound set. Anal. Chem 2011, 83:2754-2760.
103. Sardesai N.P., Barron J.C., Rusling J.F. Carbon nanotube microwell array for sensitive electrochemiluminescent detection of cancer biomarker proteins. Anal. Chem 2011, 83:6698-6703.
104. Venkatanarayanana A., Crowleya K., Lestini E., Keyesa T.E., Rusling J.F., Forster R.J. High sensitivity carbon nanotube based electrochemiluminescence sensor array. Biosens. Bioelectron 2012, 31:233-239.
105. Lin Z.J., Chen X.M., Jia T.T., Wang X.D., Xie Z.X., Oyama M., et al. Fabrication of a colorimetric electrochemiluminescence sensor. Anal. Chem 2009, 81:830-833.
106. Dolci L.S., Zanarini S., Ciana L.D., Paolucci F., Roda A. Development of a new device for ultrasensitive electrochemiluminescence microscopy imaging. Anal. Chem 2009, 81:6234-6241.
107. Milutinovic M., Suraniti E., Studer V., Mano N., Manojlovic D., Sojic N. Photopatterning of ultrathin electrochemiluminescent redox hydrogel films. Chem. Commun 2011, 47:9125-9127.
108. Deiss F., LaFratta C.N., Symer M., Blicharz T.M., Sojic N., Walt D.R. Multiplexed sandwich immunoassays using electrochemiluminescence imaging resolved at the single bead level. J. Am. Chem. Soc 2009, 131:6088-6089.
109. Guo S., Fabian O., Chang Y.L., Chen J.T., Lackowski W.M., Barbara P.F. Electrogenerated chemiluminescence of conjugated polymer films from patterned electrodes. J. Am. Chem. Soc 2011, 133:11994-12000.
110. Shi C.G., Shan X., Pan Z.Q., Xu J.J., Lu C., Bao N., et al. Quantum Dot (QD)-modified carbon tape electrodes for reproducible electrochemiluminescence (ECL) emission on a paper-based platform. Anal. Chem 2012, 84:3033-3038.
111. Wu M.S., Shi H.W., He L.J., Xu J.J., Chen H.Y. Microchip device with 64-site electrode array for multiplexed immunoassay of cell surface antigens based on electrochemiluminescence resonance energy transfer. Anal. Chem 2012, 84:4207-4213.
112. Wu M.S., Qian Q.G., Xu J.J., Chen H.Y. Sensitive electrochemiluminescence detection of c-Myc mRNA in breast cancer cells on a wireless bipolar electrode. Anal. Chem 2012, 84:5407-5414.