A chemically cross-linked knottin dimer binds integrins with picomolar affinity and inhibits tumor cell migration and proliferation

Journal of the American Chemical Society

Volumn 137, Issue 1, 2015, Pages 6-9

  Kim, Jun W ^a   Cochran, Frank V ^a   Cochran, Jennifer R ^a  

^a Stanford University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; CELLS; CROSSLINKING; CYTOLOGY; DIMERIZATION; FUNCTIONAL GROUPS; GLYCOPROTEINS; MONOMERS; TUMORS;

BINDING AFFINITIES; INTEGRIN BINDING; INTEGRIN INHIBITORS; INTEGRIN TARGETING; MOLECULAR TOPOLOGIES; NON NATURAL AMINO ACIDS; PICOMOLAR BINDING; TUMOR CELL MIGRATION;

DIMERS;

CILENGITIDE; DIMER; FUNCTIONAL GROUP; INTEGRIN; KNOTTIN; MONOMER; OXIME; PEPTIDOMIMETIC AGENT; CROSS LINKING REAGENT;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; CONJUGATION; CONTROLLED STUDY; CROSS LINKING; DIMERIZATION; HUMAN; HUMAN CELL; IC50; MIGRATION; PROTEIN BINDING; TUMOR CELL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CELL MOTION; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; MOLECULAR MODEL; NEOPLASM; PATHOLOGY; PROTEIN MULTIMERIZATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

BINDING SITES; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CROSS-LINKING REAGENTS; CYSTINE-KNOT MINIPROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INTEGRINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEOPLASMS; PROTEIN MULTIMERIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84921030306     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja508416e     Document Type: Article

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