메뉴 건너뛰기




Volumn 11, Issue 1, 2015, Pages 1-4

Exceptional responders: In search of the science behind the miracle cancer cures

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DULANERMIN; EVEROLIMUS; HISTONE DEACETYLASE INHIBITOR; IRINOTECAN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; NEW DRUG; RAPAMYCIN; SORAFENIB; SUNITINIB; TEMSIROLIMUS; VORINOSTAT;

EID: 84921028558     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.14.204     Document Type: Review
Times cited : (13)

References (17)
  • 1
    • 84883006303 scopus 로고    scopus 로고
    • Accelerated approval and breakthrough therapy designation: Oncology drug development on speed?
    • Yao JC, Meric-Bernstam F, Lee JJ, Eckhardt SG. Accelerated approval and breakthrough therapy designation: oncology drug development on speed? Clin. Cancer Res. 19(16), 4305-4308 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , Issue.16 , pp. 4305-4308
    • Yao, J.C.1    Meric-Bernstam, F.2    Lee, J.J.3    Eckhardt, S.G.4
  • 2
    • 84905850596 scopus 로고    scopus 로고
    • National Cancer Institute's Precision Medicine Initiatives for the new National Clinical Trials Network
    • Abrams J, Conley B, Mooney M et al. National Cancer Institute's Precision Medicine Initiatives for the new National Clinical Trials Network. Am. Soc. Clin. Oncol. Educ. Book 2014, 71-76 (2014).
    • (2014) Am. Soc. Clin. Oncol. Educ. Book , vol.2014 , pp. 71-76
    • Abrams, J.1    Conley, B.2    Mooney, M.3
  • 3
    • 84901829381 scopus 로고    scopus 로고
    • Learning from exceptional drug responders
    • Mullard A. Learning from exceptional drug responders. Nat. Rev. Drug Discov. 13(6), 401-402 (2014).
    • (2014) Nat. Rev. Drug Discov. , vol.13 , Issue.6 , pp. 401-402
    • Mullard, A.1
  • 4
    • 84887462642 scopus 로고    scopus 로고
    • 'N of 1' case reports in the era of whole-genome sequencing
    • Brannon AR, Sawyers CL. 'N of 1' case reports in the era of whole-genome sequencing. J. Clin. Invest. 123(11), 4568-4570 (2013).
    • (2013) J. Clin. Invest. , vol.123 , Issue.11 , pp. 4568-4570
    • Brannon, A.R.1    Sawyers, C.L.2
  • 5
    • 84893823864 scopus 로고    scopus 로고
    • A novel immunomodulatory molecularly targeted strategy for refractory Hodgkin's lymphoma
    • Subbiah V, Brown RE, McGuire MF et al. A novel immunomodulatory molecularly targeted strategy for refractory Hodgkin's lymphoma. Oncotarget 5(1), 95-102 (2014).
    • (2014) Oncotarget , vol.5 , Issue.1 , pp. 95-102
    • Subbiah, V.1    Brown, R.E.2    McGuire, M.F.3
  • 6
    • 84867333656 scopus 로고    scopus 로고
    • Genome sequencing identifies a basis for everolimus sensitivity
    • Iyer G, Hanrahan AJ, Milowsky MI et al. Genome sequencing identifies a basis for everolimus sensitivity. Science 338(6104), 221 (2012).
    • (2012) Science , vol.338 , Issue.6104 , pp. 221
    • Iyer, G.1    Hanrahan, A.J.2    Milowsky, M.I.3
  • 7
    • 84892379425 scopus 로고    scopus 로고
    • Targeted therapy by combined inhibition of the RAF and mTOR kinases in malignant spindle cell neoplasm harboring the KIAA1549-BRAF fusion protein
    • Subbiah V, Westin SN, Wang K et al. Targeted therapy by combined inhibition of the RAF and mTOR kinases in malignant spindle cell neoplasm harboring the KIAA1549-BRAF fusion protein. J. Hematol. Oncol. 7(1), 8 (2014).
    • (2014) J. Hematol. Oncol. , vol.7 , Issue.1 , pp. 8
    • Subbiah, V.1    Westin, S.N.2    Wang, K.3
  • 8
    • 84899680978 scopus 로고    scopus 로고
    • Activating mTOR mutations in a patient with an extraordinary response on a Phase i trial of everolimus and pazopanib
    • Wagle N, Grabiner BC, Van Allen EM et al. Activating mTOR mutations in a patient with an extraordinary response on a Phase I trial of everolimus and pazopanib. Cancer Discov. 4(5), 546-553 (2014).
    • (2014) Cancer Discov. , vol.4 , Issue.5 , pp. 546-553
    • Wagle, N.1    Grabiner, B.C.2    Van Allen, E.M.3
  • 9
    • 84906903083 scopus 로고    scopus 로고
    • Synthetic lethality in ATM-deficient RAD50-mutant tumors underlie outlier response to cancer therapy
    • Al-Ahmadie H, Iyer G, Hohl M et al. Synthetic lethality in ATM-deficient RAD50-mutant tumors underlie outlier response to cancer therapy. Cancer Discov. 4(9), 1014-1021 (2014).
    • (2014) Cancer Discov. , vol.4 , Issue.9 , pp. 1014-1021
    • Al-Ahmadie, H.1    Iyer, G.2    Hohl, M.3
  • 10
    • 79953742425 scopus 로고    scopus 로고
    • Targeted morphoproteomic profiling of Ewing's sarcoma treated with insulin-like growth factor 1 receptor (IGF1R) inhibitors: Response/resistance signatures
    • Subbiah V, Naing A, Brown RE et al. Targeted morphoproteomic profiling of Ewing's sarcoma treated with insulin-like growth factor 1 receptor (IGF1R) inhibitors: response/resistance signatures. PLoS ONE 6(4), e18424 (2011).
    • (2011) PLoS ONE , vol.6 , Issue.4 , pp. e18424
    • Subbiah, V.1    Naing, A.2    Brown, R.E.3
  • 11
    • 84905915756 scopus 로고    scopus 로고
    • Novel secondary somatic mutations in Ewing's sarcoma and desmoplastic small round cell tumors
    • Jiang Y, Subbiah V, Janku F et al. Novel secondary somatic mutations in Ewing's sarcoma and desmoplastic small round cell tumors. PLoS ONE 9(8), e93676 (2014).
    • (2014) PLoS ONE , vol.9 , Issue.8 , pp. e93676
    • Jiang, Y.1    Subbiah, V.2    Janku, F.3
  • 12
    • 84880823765 scopus 로고    scopus 로고
    • Germline PTPRD mutations in Ewing sarcoma: Biologic and clinical implications
    • Jiang Y, Janku F, Subbiah V et al. Germline PTPRD mutations in Ewing sarcoma: biologic and clinical implications. Oncotarget 4(6), 884-889 (2013).
    • (2013) Oncotarget , vol.4 , Issue.6 , pp. 884-889
    • Jiang, Y.1    Janku, F.2    Subbiah, V.3
  • 13
    • 84869206991 scopus 로고    scopus 로고
    • Targeting the apoptotic pathway in chondrosarcoma using recombinant human Apo2L/TRAIL (dulanermin), a dual proapoptotic receptor (DR4/DR5) agonist
    • Subbiah V, Brown RE, Buryanek J et al. Targeting the apoptotic pathway in chondrosarcoma using recombinant human Apo2L/TRAIL (dulanermin), a dual proapoptotic receptor (DR4/DR5) agonist. Mol. Cancer Ther. 11(11), 2541-2546 (2012).
    • (2012) Mol. Cancer Ther. , vol.11 , Issue.11 , pp. 2541-2546
    • Subbiah, V.1    Brown, R.E.2    Buryanek, J.3
  • 14
    • 79960860865 scopus 로고    scopus 로고
    • Preclinical and clinical activity of sunitinib in patients with cisplatin-refractory or multiply relapsed germ cell tumors: A Canadian Urologic Oncology Group/German Testicular Cancer Study Group cooperative study
    • Oechsle K, Honecker F, Cheng T et al. Preclinical and clinical activity of sunitinib in patients with cisplatin-refractory or multiply relapsed germ cell tumors: a Canadian Urologic Oncology Group/German Testicular Cancer Study Group cooperative study. Ann. Oncol. 22(12), 2654-2660 (2011).
    • (2011) Ann. Oncol. , vol.22 , Issue.12 , pp. 2654-2660
    • Oechsle, K.1    Honecker, F.2    Cheng, T.3
  • 15
    • 77956621875 scopus 로고    scopus 로고
    • Phase II trial of sunitinib in patients with relapsed or refractory germ cell tumors
    • Feldman DR, Turkula S, Ginsberg MS et al. Phase II trial of sunitinib in patients with relapsed or refractory germ cell tumors. Invest. New Drugs 28(4), 523-528 (2010).
    • (2010) Invest. New Drugs , vol.28 , Issue.4 , pp. 523-528
    • Feldman, D.R.1    Turkula, S.2    Ginsberg, M.S.3
  • 16
    • 84908288657 scopus 로고    scopus 로고
    • Next generation sequencing analysis of platinum refractory advanced germ cell tumor sensitive to sunitinib (Sutent®) a VEGFR2/PDGFRss/c-kit/FLT3/RET/CSF1R inhibitor in a Phase II trial
    • Subbiah V, Meric-Bernstam F, Mills GB et al. Next generation sequencing analysis of platinum refractory advanced germ cell tumor sensitive to sunitinib (Sutent®) a VEGFR2/PDGFRss/c-kit/FLT3/RET/CSF1R inhibitor in a Phase II trial. J. Hematol. Oncol. 7(1), 52 (2014).
    • (2014) J. Hematol. Oncol. , vol.7 , Issue.1 , pp. 52
    • Subbiah, V.1    Meric-Bernstam, F.2    Mills, G.B.3
  • 17
    • 84921024765 scopus 로고    scopus 로고
    • Cancer centers zero in on exceptional responders
    • Sheridan C. Cancer centers zero in on exceptional responders. Nat. Biotechnol. 32(8), 703-704 (2014).
    • (2014) Nat. Biotechnol. , vol.32 , Issue.8 , pp. 703-704
    • Sheridan, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.