Interactions between nano-TiO2 and the oral cavity: Impact of nanomaterial surface hydrophilicity/hydrophobicity

Journal of Hazardous Materials

Volumn 286, Issue , 2015, Pages 298-305

  Teubl, Birgit J ^a   Schimpel, Christa ^a   Leitinger, Gerd ^b,c   Bauer, Bettina ^a   Fröhlich, Eleonore ^b,c   Zimmer, Andreas ^a,c   Roblegg, Eva ^a,c  

^a UNIVERSITY OF GRAZ   (Austria)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c BIOTECHMED GRAZ   (Austria)

Author keywords

Hydrophilicity hydrophobicity; Intracellular distribution; Oral cavity; Titanium dioxide nanoparticles; Toxicity

Indexed keywords

CELL MEMBRANES; CYTOLOGY; HYDROPHILICITY; HYDROPHOBICITY; LIGHT SCATTERING; MITOCHONDRIA; NANOPARTICLES; OXIDE MINERALS; OXIDES; TITANIUM; TOXICITY;

INTRACELLULAR DISTRIBUTION; INTRACELLULAR PARTICLES; MITOCHONDRIAL MEMBRANE POTENTIAL; ORAL CAVITY; PARTICLE CHARACTERIZATION; REACTIVE OXYGEN SPECIES; SURFACE HYDROPHILICITY; TITANIUM DIOXIDE NANOPARTICLES;

TITANIUM DIOXIDE;

MUCIN; REACTIVE OXYGEN METABOLITE; SALIVA SUBSTITUTE; TITANIUM DIOXIDE NANOPARTICLE; NANOPARTICLE; TITANIUM; TITANIUM DIOXIDE;

HYDROPHOBICITY; MUCUS; NANOTECHNOLOGY; ORAL HEALTH; TITANIUM; TOXICITY;

ANIMAL CELL; APOPTOSIS; ARTICLE; BASEMENT MEMBRANE; BINDING AFFINITY; CELL MEMBRANE; CELL STRESS; CELL VIABILITY; CHEEK MUCOSA; CONNECTIVE TISSUE; CONTROLLED STUDY; CYTOTOXICITY; DISPERSION; DYNAMIC LIGHT SCATTERING; ENDOSOME; ENERGY FILTERED TRANSMISSION ELECTRON MICROSCOPY; GENE MUTATION; GENOTOXICITY; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; IONIC STRENGTH; LASER DIFFRACTION; LIGHT SCATTERING; LYSOSOME; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUTH CAVITY; MUTAGEN TESTING; NONHUMAN; POINT MUTATION; SALIVA; SQUAMOUS EPITHELIUM; SURFACE PROPERTY; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMICAL PHENOMENA; CHEMISTRY; CRICETULUS; DRUG EFFECTS; IN VITRO STUDY; METABOLISM; MOUTH MUCOSA; PARTICLE SIZE; PERMEABILITY; PIG; ULTRASTRUCTURE;

ANIMALS; CELL LINE; CELL SURVIVAL; CRICETULUS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IN VITRO TECHNIQUES; LYSOSOMES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MOUTH MUCOSA; NANOPARTICLES; PARTICLE SIZE; PERMEABILITY; REACTIVE OXYGEN SPECIES; SURFACE PROPERTIES; SWINE; TITANIUM;

EID: 84920997606     PISSN: 03043894     EISSN: 18733336     Source Type: Journal    
DOI: 10.1016/j.jhazmat.2014.12.064     Document Type: Article

References (49)

1. Baan R., Straif K., Grosse Y., Secretan B., El Ghissassi F., Cogliano V. Carcinogenicity of carbon black, titanium dioxide, and talc. Lancet Oncol. 2006, 7:295-296.
2. U.S.F.a.D. Administration, Listing of color additives exempt from certification in: Title 21 - Food and Drugs, Code of Federal Regulations 73.575, U.S., 1996.
3. Fröhlich E., Roblegg E. Models for oral uptake of nanoparticles in consumer products. Toxicology 2012, 291:10-17.
4. Wertz P.W., Squier C.A. Cellular and molecular basis of barrier function in oral epithelium. Crit. Rev. Ther. Drug Carrier Syst. 1991, 8:237-269.
5. Roblegg E., Fröhlich E., Meindl C., Teubl B., Zaversky M., Zimmer A. Evaluation of a physiological in vitro system to study the transport of nanoparticles through the buccal mucosa. Nanotoxicology 2012, 6:399-413.
6. Teubl B.J., Meindl C., Eitzlmayr A., Zimmer A., Fröhlich E., Roblegg E. In-vitro permeability of neutral polystyrene particles via buccal mucosa. Small 2012, 9:457-466.
7. 2 nanoparticle uptake. Nanotoxicology 2014, 1-9.
8. Watson S.S., Beydoun D., Scott J.A., Amal R. The effect of preparation method on the photoactivity of crystalline titanium dioxide particles. Chem. Eng. J. 2003, 95:213-220.
9. 2 nanotoxicity. J. Nanopart. Res. 2009, 11:1361-1374.
10. Carlotti M.E., Ugazio E., Sapino S., Fenoglio I., Greco G., Fubini B. Role of particle coating in controlling skin damage photoinduced by titania nanoparticles. Free Radical Res. 2009, 43:312-322.
11. 2. Chem. Braz. 1993, 29:503-506.
12. Florence A.T., Hillery A.M., Hussain N., Jani P.U. Nanoparticles as carriers for oral peptide absorption: studies on particle uptake and fate. J. Control. Release 1995, 36:39-46.
13. Qiao R., Roberts A.P., Mount A.S., Klaine S.J., Ke P.C. Translocation of c60 and its derivatives across a lipid bilayer. Nano Lett. 2007, 7:614-619.
14. Li Y., Chen X., Gu N. Computational investigation of interaction between nanoparticles and membranes: hydrophobic/hydrophilic effect. J. Phys. Chem. B 2008, 112:16647-16653.
15. Hackenberg S., Friehs G., Froelich K., Ginzkey C., Koehler C., Scherzed A., Burghartz M., Hagen R., Kleinsasser N. Intracellular distribution, geno- and cytotoxic effects of nanosized titanium dioxide particles in the anatase crystal phase on human nasal mucosa cells. Toxicol. Lett. 2010, 195:9-14.
16. Karlsson H.L., Gustafsson J., Cronholm P., Möller L. Size-dependent toxicity of metal oxide particles - a comparison between nano- and micrometer size. Toxicol. Lett. 2009, 188:112-118.
17. Bykov V.L. [The tissue and cell defense mechanisms of the oral mucosa]. Morfologiia 1996, 110:14-24.
18. Braun J. Titanium dioxide - a review. J. Coat.Technol. 1997, 69:59-72.
19. Weir A., Westerhoff P., Fabricius L., Hristovski K., von Goetz N. Titanium dioxide nanoparticles in food and personal care products. Environ. Sci. Technol. 2012, 46:2242-2250.
20. Lesch C.A., Squier C.A., Cruchley A., Williams D.M., Speight P. The permeability of human oral mucosa and skin to water. J. Dent. Res. 1989, 68:1345-1349.
21. Gurr J.R., Wang A.S., Chen C.H., Jan K.Y. Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. Toxicology 2005, 213:66-73.
22. Veranth J.M., Kaser E.G., Veranth M.M., Koch M., Yost G.S. Cytokine responses of human lung cells (BEAS-2B) treated with micron-sized and nanoparticles of metal oxides compared to soil dusts, part. Fibre Toxicol. 2007, 4:2.
23. Chen H.-W., Su S.-F., Chien C.-T., Lin W.-H., Yu S.-L., Chou C.-C., Chen J.J.W., Yang P.-C. Titanium dioxide nanoparticles induce emphysema-like lung injury in mice. FASEB J. 2006, 20:2393-2395.
24. De Haar C., Hassing I., Bol M., Bleumink R., Pieters R. Ultrafine but not fine particulate matter causes airway inflammation and allergic airway sensitization to co-administered antigen in mice. Clin. Exp. Allergy 2006, 36:1469-1479.
25. Grassian V.H., O'Shaughnessy T., Adamcakova-Dodd A., Pettibone J.M., Thorne P.S. Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5nm. Environ. Health Perspect. 2007, 115:397-402.
26. Oberdörster G., Ferin J., Lehnert B.E. Correlation between particle size, in vivo particle persistence, and lung injury. Environ. Health Perspect. 1994, 5:173-179.
27. Shukla R., Bansal V., Chaudhary M., Basu A., Bhonde R.R., Sastry M. Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overview. Langmuir 2005, 21:10644-10654.
28. R.H. Müller, Surface Hydrophobicity-Determination by Rose Bengal (RB) Adsorption Methods, in: Colloidal Carriers for Controlled Drug Delivery and Targeting, CRC, Press, Stuttgart, 1991, pp. 99-109.
29. 2-DNA nanoconjugate stability. Small 2009, 5:1318-1325.
30. Jacobsen J., van Deurs M., Rassing M.R. TR146 cells grown on filters as a model for human buccal epithelium: I. Morphology, growth, barrier properties, and permeability. Int. J. Pharm. 1995, 125:165-184.
31. 2-adrenoceptor antagonists. Comparison to human, monkey and porcine buccal mucosa. Int. J. Pharm. 2000, 194:155-167.
32. Buch K., Peters T., Nawroth T., Sänger M., Schmidberger H., Langguth P. Determination of cell survival after irradiation via clonogenic assay versus multiple MTT assay - a comparative study. Radiat. Oncol. 2012, 7:1-6.
33. 2 nanoparticles on Ls-174-t human colon carcinoma cells. World J. Gastroenterol. 2004, 10:3191-3193.
34. Dekker J., Rossen J.W.A., Büller H.A., Einerhand A.W.C. The MUC family: an obituary. Trends Biochem. Sci. 2002, 27:126-131.
35. Thornton D.J., Carlstedt I., Howard M., Devine P.L., Price M.R., Sheehan J.K. Respiratory mucins: identification of core proteins and glycoforms. Biochem. J. 1996, 316:967-975.
36. Van Klinken B.J., Dekker J., Buller H.A., Einerhand A.W. Mucin gene structure and expression: protection vs. adhesion. J. Am. Physiol. Gastrointest. Liver Physiol. 1995, 269:G613-G627.
37. Lehr C.M. From sticky stuff to sweet receptors - achievements, limits and novel approaches to bioadhesion. Eur. J. Drug Metab. Pharmacokinet. 1996, 21:139-148.
38. Jung T., Kamm W., Breitenbach A., Kaiserling E., Xiao J.X., Kissel T. Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake?. Eur. J. Pharm. Biopharm. 2000, 50:147-160.
39. Fröhlich E., Meindl C., Roblegg E., Ebner B., Absenger M., Pieber T. Action of polystyrene nanoparticles of different sizes on lysosomal function and integrity part. Fibre Toxicol. 2012, 9:26.
40. Geiser M., Rothen-Rutishauser B., Kapp N., Schurch S., Kreyling W., Schulz H., Semmler M., Im Hof V., Heyder J., Gehr P. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ. Health Perspect. 2005, 113:1555-1560.
41. Verma A., Uzun O., Hu Y., Hu Y., Han H.-S., Watson N., Chen S., Irvine D.J., Stellacci F. Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles. Nat. Mater. 2008, 7:588-595.
42. Leroueil P.R., Hong S., Mecke A., Baker J.R., Orr B.G., Banaszak Holl M.M. Nanoparticle Interaction with Biological Membranes: Does Nanotechnology Present a Janus Face?, Acc. Chem. Res . 2007, 40:335-342.
43. 2: Role of the specific surface area and of surface methylation of the particles. Toxicol. Appl. Pharmacol. 2007, 222:141-151.
44. Stearns R.C., Paulauskis J.D., Godleski J.J. Endocytosis of ultrafine particles by A549 cells. Am. J. Respir. Cell Mol. Biol. 2001, 24:108-115.
45. Kokoszka J.E., Coskun P., Esposito L.A., Wallace D.C. Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:2278-2283.
46. Nel A., Xia T., Mädler L., Li N. Toxic potential of materials at the nanolevel. Science 2006, 311:622-627.
47. Pallardó F.V., Lloret A., Lebel M., d'Ischia M., Cogger V.C., Le Couteur D.G., Gadaleta M.N., Castello G., Pagano G. Mitochondrial dysfunction in some oxidative stress-related genetic diseases: ataxia-telangiectasia, down syndrome, Fanconi anaemia and Werner syndrome. Biogerontology 2010, 11:401-419.
48. Green D.R., Reed J.C. Mitochondria and apoptosis. Science 1998, 281:1309-1312.
49. Kroemer G., Dallaporta B., Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu. Rev. Physiol. 1998, 60:619-642.