Nasal contribution to exhaled nitric oxide during exhalation against resistance or during breath holding

Thorax

Volumn 52, Issue 6, 1997, Pages 540-544

  Kharitonov, Sergei A ^a   Barnes, Peter J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Asthma; Nitric oxide; Upper respiratory tract

Indexed keywords

NITRIC OXIDE;

ARTICLE; ASTHMA; DIAGNOSTIC VALUE; EXPIRED AIR; HUMAN; NORMAL HUMAN; NOSE AIRFLOW; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; TIDAL VOLUME;

EID: 0030818690     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.52.6.540     Document Type: Article

References (25)

1. Gustafsson LE, Leone AM, Persson M, Wiklund NP, Moncada S. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea-pigs and humans. Biochem Biophys Res Commun 1991;181:852-57.
2. Borland C, Cox Y, Higenbottam T. Measurement of exhaled nitric oxide in man. Thorax 1993;48:1160-2.
3. Leone AM, Gustaisson LE, Francis PL, Persson MG, Wiklund NP, Moncada S. Nitric oxide in exhaled breath in humans: direct GC-MS confirmation. Biochem Biophys Res Commun 1994;201:883-7.
4. Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J 1993; 6:1268-70.
5. Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shinebourne E, Barnes PJ. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 1994;343:133-5.
6. Persson MG, Zetterstrom O, Argenius V, Ihre E, Gustafsson LE. Single-breath oxide measurements in asthmatic patients and smokers. Lancet 1994;343:146-7.
7. Robbins RA, Floreani AA, von Essen SG, Sissin JH, Hill GE, Rubinstein I, et al. Measurement of exhaled nitric oxide by three different techniques. Am J Respir Crit Care Med 1996;153:1631-5.
8. Kharitonov SA, Wells AU, O'Connor BJ, Hansell DM, Cole PJ, Barnes PJ. Elevated levels of exhaled nitric oxide in bronchiectasis. Am J Respir Crit Care Med 1995;151: 1889-93.
9. Kharitonov SA, Yates D, Barnes PJ. Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections. Eur Respir J 1995;8:295-7.
10. Barnes PJ. Nitric oxide and airway disease. Ann Med 1995; 27:389-93.
11. Barnes PJ, Kharitnnov SA. Exhaled nitric oxide: a new lung function test. Thorax 1996; 51:218-20.
12. Yates DH, Kharitonov SA, Robbins RA, Thomas PS, Barnes PJ. Effect of a nitric oxide synthase inhibitor and a glucocorticosteroid on exhaled nitric oxide. Am J Respir Crit Care Med 1995;152:892-6.
13. Kharitonov SA, Yates DH, Barnes PJ. Regular inhaled budesonide decreases nitric oxide concentration in the exhaled air of asthmatic patients. Am J Respir Crit Care Med 1996;153:454-7.
14. Kharitonov SA, Yates DH, Chung KF, Barnes PJ. Changes in the dose of inhaled steroid affect exhaled nitric oxide levels in asthmatic patients. Eur J Respir Dis 1996;9: 196-201.
15. Persson MG, Wiklund NP, Gustafsson LE. Endogenous nitric oxide in single exhalation, and the change during exercise. Am Rev Respir Dis 1993;148:1210-4.
16. Gerlach H, Rossaint R, Pappert D, Knorr M, Falke KJ. Autoinhalation of nitric oxide after endogenous synthesis in nasopharynx. Lancet 1994;343:518-9.
17. Lundberg JON, Weitzberg E, Nordvall SL, Kuylenstierna R, Lundberg JM, Alving K. Primarily nasal origin of exhaled nitric oxide and absence in Kartagener's syndrome. Eur Respir J 1994;8:1501-4.
18. Kharitonov SA, Rajakulasingam K, O'Connor BJ, Durham SR, Barnes PJ. Nasal nitric oxide is increased in patients with asthma and allergic rhinitis and may be modulated by nasal glucocorticoids. J Allergy Clin Immunol 1997;99: 58-64.
19. Kharitonov S, Chung KF, Evans DJ, O'Connor BJ, Barnes PJ. Increased exhaled nitric oxide in asthma is derived from the lower respiratory tract. Am J Respir Crit Care Med 1996;153:1773-80.
20. Massaro AF, Mehta S, Lilly CM, Kobzik L, Reilly JJ, Drazen JM. Elevated nitric oxide concentrations in isolated lower airway gas of asthmatic subjects. Am J Respir Crit Care Med 1996;153:1510-4.
21. Cremona G, Higenbottam T, Takao M, Hall L, Bower EA. Exhaled nitric oxide in isolated pig lungs. J Appl Physiol 1995;78:59-63.
22. Kimberley B, Nejadnik B, Giraud GD, Holden WH. Nasal contribution to exhaled nitric oxide at rest and during breath holding in humans. Am J Respir Crit Care Med 1996;153:829-36.
23. Schilling J, Holzer P, Guggenbach M, Gyurech D, Marathia K, Geroulanos S. Reduced endogenous nitric oxide in the exhaled air of smokers and hypertensioners. Eur Respir J 1994;7:467-71.
24. Massaro AF, Gaston B, Kita D, Fanta C, Stamler J, Drazen JM. Expired nitric oxide levels during treatment for acute asthma. Am J Respir Crit Care Med 1995;152:800-3.
25. Sehedin U, Frostell C, Persson MG, Jakobsson J, Anderssson G, Gustafsson LE. Contribution from upper and lower airways to exhaled endogenous nitric oxide in humans. Acta Anaesthesiol Scand 1995;39:327-32.