Effect of ginger (Zingiber officinale) on heavy menstrual bleeding: A placebo-controlled, randomized clinical trial

Phytotherapy Research

Volumn 29, Issue 1, 2015, Pages 114-119

  Kashefi, Farzaneh ^a   Khajehei, Marjan ^b   Alavinia, Mohammad ^c   Golmakani, Ebrahim ^d   Asili, Javad ^d  

^a IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b CURTIN UNIVERSITY   (Australia)

^c NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Ginger; Heavy menstrual bleeding; Herbal medicine

Indexed keywords

GINGER EXTRACT; PLACEBO; MICROCAPSULE; POWDER;

ABDOMINAL PAIN; ADOLESCENT; ADULT; ARTICLE; CLINICAL ASSESSMENT; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG CAPSULE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FLATULENCE; FOLLOW UP; HEARTBURN; HIGH SCHOOL; HUMAN; MAJOR CLINICAL STUDY; MENORRHAGIA; MENSTRUAL CYCLE; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; TREATMENT OUTCOME; CHEMISTRY; GINGER; MICROCAPSULE; PHYTOTHERAPY; POWDER;

ZINGIBER OFFICINALE;

ADOLESCENT; CAPSULES; DOUBLE-BLIND METHOD; FEMALE; GINGER; HUMANS; MENORRHAGIA; PHYTOTHERAPY; POWDERS;

EID: 84920984359     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5235     Document Type: Article

References (27)

1. Casablanca Y. 2008. Management of Dysfunctional Uterine Bleeding. Obstet Gynecol Clin North Am 35: 219-234.
2. Catalano R, Wilson M, Boddy S, Jabbour H. 2011. Comprehensive expression analysis of prostanoid enzymes and receptors in the human endometrium across the menstrual cycle. Mol Hum Reprod 17: 182-192.
3. Cihangir U, Ebru A, Murat E, Levent Y. 2013. Mechanism of action of the levonorgestrel-releasing intrauterine system in the treatment of heavy menstrual bleeding. Int J Gynaecol Obstet 123: 146-149.
4. Funk J, Frye J, Wright L, Timmermann B. 2012. Effects of Ginger (Zingiber officialis L) on Inflammation-Induced Bone Loss. FASEB J 26: 263-265.
5. Glazerman LR. 2013. Endometrial ablation as a treatment for heavy menstrual bleeding. Surg Technol Int 23: 137-141.
6. Hall P, Maclachlan N, Thorn N, Nudd MW, Taylor CG, Garrioch DB. 1987. Control of menorrhagia by the cyclo-oxygenase inhibitors naproxen sodium and mefenamic acid. Br J Obstet Gynaecol 94: 554-558.
7. Han Y, Song C, Koh W, et al. 2013. Anti-inflammatory effects of the Zingiber officinale roscoe constituent 12-dehydrogingerdione in lipopolysaccharide-stimulated Raw 264.7 cells. Phytother Res 27: 1200-1205.
8. Heliovaara-Peippo S, Hurskainen R, Teperi J, et al. 2013. Quality of life and costs of levonorgestrel-releasing intrauterine system or hysterectomy in the treatment of menorrhagia: a 10-year randomized controlled trial. Am J Obstet Gynecol 209: 535 e531-535 e514.
9. Higham J, O'Brien P, Shaw R. 1990. Assesment of menstruel blood loss using a pictorial chart. Br J Obstet Gynaecol 97: 734-739.
10. Jensen J, Parke S, Mellinger U, Machlitt A, Fraser I. 2011. Effective Treatment of Heavy Menstrual Bleeding With Estradiol Valerate and Dienogest: A Randomized Controlled Trial. Obstet Gynecol 117: 777-787.
11. Kashefi F, Khajehei M, Cher MT, Alavinia M, Asili J. 2014. Comparison of the Effect of Ginger and Zinc Sulfate on Primary Dysmenorrhea: A Placebo-Controlled Randomized Trial. Pain Manag Nurs. pii: S1524-9042(13)00118-5. doi: 10.1016/j.pmn.2013.09.001. [Epub ahead of print]
12. Kottarapat J, Vijayastelter L, Ramadasan K. 2013. Antioxidant, Anti-inflammatory and Antinociceptive Activities of Essential Oil from Ginger. Indian J Physiol Pharmacol 57: 51-62.
13. Kumar S, Saxena K, Singh U, Saxena R. 2013. Anti-inflamtory action of ginger: A critical review in anemia of inflamtion and its future aspects. Intl J Trad Herb Med 1: 16-20.
14. Lethaby A, Duckitt K, Farquhar C, 2013. Non-steroidal antiinflammatory drugs for heavy menstrual bleeding. Cochrane Database of Systematic Reviews 1:CD000400 doi: 10.1002/14651858.CD000400.pub3.
15. Li F, Nitteranon V, Tang X, et al. 2012. In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin. Food Chem 135: 332-337.
16. Livdans-Forret A, Harvey P, Larkin-Thier S. 2007. Menorrhagia: A synopsis ofmanagement focusing on herbal and nutritional supplements and chiropractic. J Can Chiropr Assoc 51: 235-246.
17. Lukes A, Moore K, Muse K, et al. 2010. Tranexamic Acid Treatment for Heavy Menstrual Bleeding: A Randomized Controlled Trial. Obstet Gynecol 116: 865-875.
18. Magon N, Chauhan M, Goel P, et al. 2013. Levonorgestrel intrauterine system: Current role in management of heavy menstrual bleeding. J Midlife Health 4: 8-15.
19. Marx W, Ried K, McCarthy A, et al. 2013. Ginger - mechanismof action in chemotherapy-induced nausea and vomiting: a review. Crit Rev Food Sci Nutr 71(4): 245-254. doi: 10.1111/nure.12016
20. Morakinyo A, Akindele A, Ahmed Z. 2011. Modulation of Antioxidant Enzymes and Inflammatory Cytokines: Possible Mechanism of Anti-diabetic Effect of Ginger Extracts. African Journal of Biomedical Research 14: 195-202.
21. Ozgoli G, Goli M, Moattar F. 2009. Comparison of Effects of Ginger, Mefenamic Acid, and Ibuprofen on Pain in Women with Primary Dysmenorrhea. The J Altern Complement Med 15: 129-132.
22. Philipp CS, Faiz A, Dowling N, et al. 2005. Age and the Prevalence of Bleeding Disorders in Women with Menorrhagia. Obstet Gynecol 105: 61-66.
23. Pizzorno J, Murray M. 2006. Textbook of Natural Medicine. Churchill livingstone Elsevier, St. Louis, MO.
24. Reid PC, Virtanen-Kari S. 2005. Randomised comparative trial of the levonorgestrel intrauterine system and mefenamic acid for the treatment of idiopathic menorrhagia: a multiple analysis using total menstrual fluid loss, menstrual blood loss and pictorial blood loss assessment charts. BJOG: An International Journal of Obstetrics & Gynaecology 112: 1121-1125.
25. Shimoda H, Shan S, Tanaka J, et al. 2010. Anti-Inflammatory Properties of Red Ginger (Zingiber officinale var. Rubra) Extract and Suppression of Nitric Oxide Production by Its Constituents. J Med Food 13: 156-162.
26. Steenkamp V, 2003. Traditional herbal remedies used by South African women for gynaecological complaints. J Ethnopharmacol 86: 97-108.
27. Vuori-Holopainen E, Makipernaa A, Tiitinen A, 2013. Menorrhagia in adolescents: Normal or a sign of underlying medical condition? Duodecim 129: 2613-2620.