Modulation of antioxidant enzymes and inflammatory cytokines: Possible mechanism of anti-diabetic effect of ginger extracts

African Journal of Biomedical Research

Volumn 14, Issue 3, 2011, Pages 195-202

  Morakinyo, A O ^a   Akindele, A J ^a   Ahmed, Z ^b  

^a UNIVERSITY OF LAGOS   (Nigeria)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

Antioxidants; Diabetes; Ginger; Lipid peroxidation; TNF a

Indexed keywords

ALCOHOL; CATALASE; GINGER EXTRACT; GLUCOSE; GLUTATHIONE; MALONALDEHYDE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME REGULATION; GLUCOSE BLOOD LEVEL; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; SOLVENT EFFECT;

EID: 84877973430     PISSN: 11195096     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Aebi H. (1984). Catalase in vitro. Methods Enzymology 105:121-126.
2. Akhani SP, Vishwakarma SL, Golyal RK. (2004). Antidiabetic activity of Zingiber officinale in streptozotocininduced type I diabetic rats. Journal of Pharmacy and Pharmacology 56:101-105.
3. Al-Amin ZM, Thomson M, Al-Qattan KK, Peltonen-Shalaby R., Ali M. (2006). Anti-diabetic and hypolipidemic properties of ginger (Zingiber officinale) in streptozotocin induced diabetic rats. British Journal of Nutrition 96:660-666.
4. Alli BH, Gerald B, Tanira MO, Nemmar A. (2008). Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food and Chemical Toxicology 46: 409-420
5. Bashan N, Kovsan J, Kachko I, Ovadia H, Rudich A. (2009). Positive and negative regulation of insulin signaling by reactive oxygen and nitrogen species. Physiological Review 89, 27-71.
6. Droge W. (2002). Free radicals in the physiological control of cell function. Physiological Review 82, 47-95.
7. Feinstein R, Kanety H, Papa MZ, Lunenfeld B, Karasik A. (1993). Tumor necrosis factor-a suppress insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. Journal of Biological Chemistry 268, 26055-26058.
8. Grzanna R, Lindmark L, Frondoza CG. (2005). Ginger - an herbal medicinal product with broad anti-inflammatory actions. Journal of Medicinal Food 8, 125-132.
9. Ahmed Z, Chishti MZ, Johri RK, Bhagat A, Gupta KK, Ram G. (2009). Antihyperglycemic and antidyslipidemic activity of aqueous extract of Dioscorea Bulbifera tubers. Diabetologia Croatica 38, 63-72.
10. Kakkar R, Kalra J, Mantha SV, Prasad K. (1995). Lipid peroxidation and activity of antioxidant enzymes in diabetic rats. Molecular and Cell Biochemistry 151, 113-9.
11. Ko JK, Leung CC. (2010). Ginger extract and polaprezinc exert gastroprotective actions by antioxidant and growth factor modulating effects in rats. Journal of Gastroenterology and Hepatology 25, 1861-68.
12. Krastanov SA, Stoyanova A, Denev P, Gargova S. (2007). Antioxidant activities of a ginger extract (Zingiber officinale). Food Chemistry 102: 764-770.
13. Maechler P, Jornot L, Wollheim CB. (1999). Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells. Journal of Biological Chemistry 274, 27905-27913.
14. Maritim AC, Sanders RA, Watkins JB. (2003). Diabetes, oxidative stress, and antioxidants: a review. Journal of Biochemistry and Molecular Toxicology 17, 24-38.
15. Morakinyo AO, Achema PU, Adegoke OA. (2010). Effect of Zingiber officinale (Ginger) on sodium arsenite-induced reproductive toxicity in male rats. African Journal of Biomedical Research 13: 39-45.
16. Morakinyo AO, Iranloye, B.O, Daramola, AO, Adegoke, OA. (2011). Antifertility effect of calcium channel blockers on male rats: association with oxidative stress. Advances in Medical Sciences 56, 1-8.
17. NIH (1985). Guide for the Use of Laboratory Animals DHHS, PHS. NIH Publication No. 85-23 (1985 Revised).
18. Ojewole JA. (2006). Analgesic, anti-inflammatory and hypoglycemic effects of ethanol extract of Zingiber officinale (Roscoe) rhizomes (Zingiberaceae) in mice and rats. Phytotherapy Research 20:764-772.
19. Penna SC, Medeiros MV, Aimbire FS, Faria-Neto, HC, Sertie, JA, Lopes-Martins, RA. (2003). Anti-inflammatory effect of the hydro-alcoholic extract of Zingiber officinale rhizomes on rat paw and skin edema. Phytomedicine 10: 381-385.
20. Perez-Matute P, Zulet MA, Martinez JA. (2009). Reactive species and diabetes: counteracting oxidative stress to improve health. Current Opinion in Pharmacology 9, 771-779.
21. Qiang X, Satoh J, Sagara M, Fukuzawa M, Masuda T, Sakata Y, Muto G, Muto Y, Takahashi K, Toyota T. (1998). Inhibitory effect of troglitazone on diabetic neuropathy in streptozotozin-induced diabetic rats. Diabetologia 41, 1321-6.
22. Raji Y, Udoh US, Oluwadara OO, Akinsomisoye OS, Awobajo O, Adeshoga K. (2002). Anti-inflammatory and analgesic properties of the rhizome extract of Zingiber officinale. African Journal of Biomedical Research 5: 121-124.
23. Sahebkar A. (2011). Potential efficacy of ginger as antural supplement for non-alcohilic fatty liver disease. World Journal of Gastroenterology 17, 271-72.
24. Sun M, Zigman S. (1978). An improved spectrophotometric assay for superoxide dismutase based on ephinephrine autoxidation. Anal of Biochemistry 90, 81-89.
25. Thomson M, Al-Qattan KK, Al-Sawan SM, Alnaqeeb MA, Khan I, Ali M. (2002). The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. Prostaglandins, Leukotrienes and Essential Fatty Acid 67: 475-478.
26. Uchiyama M, Mihara M. (1978). Determination of malonaldehyde precursor in tissues by thiobarbituris acid test. Anal of Biochemistry 86, 271-278.
27. Ueno Y, Kizaki M, Nakagiri R, Kamiya T, Sumi H, Osawa T. (2002). Dietary glutathione protects rats from diabetic nephropathy and neuropathy. Journal of Nutrition 132, 897-900.
28. Van Dooran R, Liejdekker CM, Handerson PT. (1978). Synergistic effects of phorone on the hepatotoxicity of bromobenzene and paracetamol in mice. Toxicology 11: 225-233.
29. Wiernsperger NF. (2003). Oxidative stress as a therapeutic target in diabetes: revisiting the controversy. Diabetes and Metabolism 29, 579-85.