The sky is the limit: Adhering to antiretroviral therapy and HIV self-management from the perspectives of adolescents living with HIV and their adult caregivers

Journal of the International AIDS Society

Volumn 18, Issue 1, 2015, Pages

  Denison, Julie A ^a,b   Banda, Harry ^a   Dennis, Alexis C ^a   Packer, Catherine ^a   Nyambe, Namakau ^a   Stalter, Randy M ^a   Mwansa, Jonathan K ^c   Katayamoyo, Patrick ^a   McCarraher, Donna R ^a  

^a FAMILY HEALTH INTERNATIONAL   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c Department of Paediatric Surgery   (Zambia)

Author keywords

Adherence; Adolescents; Antiretroviral therapy; Caregivers; HIV; Qualitative; Sub Saharan Africa; Youth; Zambia

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ADOLESCENT; ADOLESCENT DISEASE; ADULT; ANTIVIRAL THERAPY; ARTICLE; CAREGIVER; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEALTH BELIEF; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTERVIEW; MALE; MEDICATION COMPLIANCE; PATIENT COMPLIANCE; PRIORITY JOURNAL; SELF CARE; SPIRITUAL HEALING; SUPPORT GROUP; ZAMBIA; HIV INFECTIONS; SOCIAL STIGMA;

ADOLESCENT; ADULT; CAREGIVERS; FEMALE; HIV INFECTIONS; HUMANS; MALE; MEDICATION ADHERENCE; SELF CARE; SOCIAL STIGMA;

EID: 84920982504     PISSN: None     EISSN: 17582652     Source Type: Journal    
DOI: 10.7448/IAS.18.1.19358     Document Type: Article

References (43)

1. UNAIDS. Global report: UNAIDS report on the global AIDS epidemic 2013. Geneva: UNAIDS; 2013.
2. WHO. HIV and adolescents: Guidance for HIV testing and counselling and care for adolescents living with HIV. Geneva: WHO; 2013.
3. Gilliam PP, Ellen JM, Leonard L, Kinsman S, Jevitt CM, Straub DM. Transition of adolescents with HIV to adult care: Characteristics and current practices of the adolescent trials network for HIV/AIDS interventions. J Assoc Nurses AIDS Care. 2011; 22: 283-94.
4. Chakraborty R, Van Dyke RB, Flynn PM, Aldrovandi GM, Chadwick EG, Cooper ER, et al. Transitioning HIV-infected youth into adult health care. Pediatrics. 2013; 132: 192-7.
5. Siu GE, Bakeera-Kitaka S, Kennedy CE, Dhabangi A, Kambugu A. HIV serostatus disclosure and lived experiences of adolescents at the Transition Clinic of the Infectious Diseases Clinic in Kampala, Uganda: A qualitative study. AIDS Care. 2012; 24: 606-11.
6. Mburu G, Hodgson I, Teltschik A, Ram M, Haamujompa C, Bajpai D, et al. Rights-based services for adolescents living with HIV: Adolescent self-efficacy and implications for health systems in Zambia. Reprod Health Matters. 2013; 21: 176-85.
7. Mburu G, Hodgson I, Kalibala S, Haamujompa C, Cataldo F, Lowenthal ED, et al. Adolescent HIV disclosure in Zambia: Barriers, facilitators and outcomes. J Int AIDS Soc. 2014; 17: 18866.
8. Mellins CA, Malee KM. Understanding the mental health of youth living with perinatal HIV infection: Lessons learned and current challenges. J Int AIDS Soc. 2013; 16: 18593.
9. Parker L, Maman S, Pettifor A, Chalachala J, Edmonds A, Golin C, et al. Adaptation of a US evidence-based positive prevention intervention for youth living with HIV/AIDS in Kinshasa, Democratic Republic of the Congo. Eval Program Plann. 2013; 36(1): 124-35.
10. Sawyer SM, Drew S, Yeo MS, Britto MT. Adolescents with a chronic condition: Challenges living, challenges treating. Lancet. 2007; 369: 1481-9.
11. Birungi H, Mugisha JF, Obare F, Nyombi JK. Sexual behavior and desires among adolescents perinatally infected with human immunodeficiency virus in Uganda: Implications for programming. J Adolesc Health. 2009; 44: 184-7.
12. Obare F, van der Kwaak A, Birungi H. Factors associated with unintended pregnancy, poor birth outcomes and post-partum contraceptive use among HIV-positive female adolescents in Kenya. BMC Women's Health. 2012; 12: 34.
13. Bakeera-Kitaka S, Nabukeera-Barungi N, Nöstlinger C, Addy K, Colebunders R. Sexual risk reduction needs of adolescents living with HIV in a clinical care setting. AIDS Care. 2008; 20: 426-33.
14. Nachega JB, Hislop M, Nguyen H, Dowdy DW, Chaisson RE, Regensberg L, et al. Antiretroviral therapy adherence, virologic and immunologic outcomes in adolescents compared with adults in southern Africa. J Acquir Immune Defic Syndr. 2009; 51: 65.
15. Wiens MO, MacLeod S, Musiime V, Ssenyonga M, Kizza R, Bakeera-Kitaka S, et al. Adherence to antiretroviral therapy in HIV-positive adolescents in Uganda assessed by multiple methods: A prospective cohort study. Pediatr Drugs. 2012; 14: 331-5.
16. Lowenthal ED, Bakeera-Kitaka S, Marukutira T, Chapman J, Goldrath K, Ferrand RA. Perinatally acquired HIV infection in adolescents from sub-Saharan Africa: A review of emerging challenges. Lancet Infect Dis. 2014; 14(7): 627-39.
17. Mavhu W, Berwick J, Chirawu P, Makamba M, Copas A, Dirawo J, et al. Enhancing psychosocial support for HIV positive adolescents in Harare, Zimbabwe. PLoS One. 2013; 8: E70254.
18. Vreeman RC, Wiehe SE, Pearce EC, Nyandiko WM. A systematic review of pediatric adherence to antiretroviral therapy in low-and middle-income countries. Pediatr Infect Dis J. 2008; 27: 686-91.
19. Vandenhoudt H, Miller KS, Ochura J, Wyckoff SC, Obong'o CO, Otwoma NJ, et al. Evaluation of a US evidence-based parenting intervention in rural western Kenya: From parents matter! To families matter!. AIDS Educ Prev. 2010; 22: 328-43.
20. Poulsen MN, Vandenhoudt H, Wyckoff SC, Obong'o CO, Ochura J, Njika G, et al. Cultural adaptation of a US evidence-based parenting intervention for rural Western Kenya: From parents matter! To families matter!. AIDS Educ Prev. 2010; 22: 273-85.
21. Bhana A, McKay MM, Mellins C, Petersen I, Bell C. Family-based HIV prevention and intervention services for youth living in poverty-affected contexts: The CHAMP model of collaborative, evidence-informed programme development. J Int AIDS Soc. 2010; 13: S8.
22. Kim S-H, Gerver SM, Fidler S,Ward H. Adherence to antiretroviral therapy in adolescents living with HIV: Systematic review and meta-analysis. AIDS. 2014; 28: 1945-56.
23. van Cutsem G, Knight L, Kerschberger B, Malavazzi C, Ford N, Boulle A. ART for youth and adolescents in Khayelitsha. AIDS 2010 - XVIII International AIDS Conference July 18-23, 2010. Vienna, Austria; 2010.
24. Mutevedzi PC, Lessells RJ, Rodger AJ, Newell M-L. Association of age with mortality and virological and immunological response to antiretroviral therapy in rural South African adults. PLoS One. 2011; 6: E21795.
25. Evans D, Menezes C, Mahomed K, Macdonald P, Untiedt S, Levin L, et al. Treatment outcomes of HIV-infected adolescents attending public-sector HIV clinics across Gauteng and Mpumalanga, South Africa. AIDS Res Hum Retrovir. 2013; 29: 892-900.
26. Nglazi MD, Kranzer K, Holele P, Kaplan R, Mark D, Jaspan H, et al. Treatment outcomes in HIV-infected adolescents attending a community-based antiretroviral therapy clinic in South Africa. BMC Infect Dis. 2012; 12: 21.
27. Richter L, Beyrer C, Kippax S, Heidari S. Visioning services for children affected by HIV and AIDS through a family lens. J Int AIDS Soc. 2010; 13: I1.
28. Richter LM, Sherr L, Adato M, Belsey M, Chandan U, Desmond C, et al. Strengthening families to support children affected by HIV and AIDS. AIDS Care. 2009; 21: 3-12.
29. Rotheram-Borus MJ, Swendeman D, Lee SJ, Li L, Amani B, Nartey M. Interventions for families affected by HIV. Transl Behav Med. 2011; 1: 313-26.
30. Kirk S, Beatty S, Callery P, Gellatly J, Milnes L, Pryjmachuk S. The effectiveness of self-care support interventions for children and young people with long-term conditions: A systematic review. Child Care Health Dev. 2013; 39(3): 305-24.
31. Modi AC, Pai AL, Hommel KA, Hood KK, Cortina S, Hilliard ME, et al. Pediatric self-management: A framework for research, practice, and policy. Pediatrics. 2012; 129: E473-85.
32. American Academy of Pediatrics, American Academy of Family Physicians, American College of Physicians-American Society of Internal Medicine. A consensus statement on health care transitions for young adults with special health care needs. Pediatrics. 2002; 110: 1304-6.
33. Salema NEM, Elliott RA, Glazebrook C. A systematic review of adherenceenhancing interventions in adolescents taking long-term medicines. J Adolesc Health. 2011; 49: 455-66.
34. Rapoff MA. Adherence to pediatric medical regimens. Boston, MA: Springer; 2010.
35. Thurman TR, Jarabi B, Rice J. Caring for the caregiver: Evaluation of support groups for guardians of orphans and vulnerable children in Kenya. AIDS Care. 2012; 24: 811-9.
36. Miles MB, Huberman AM. Qualitative data analysis: An expanded sourcebook. Thousand Oaks: Sage; 1994.
37. Hirnschall G, Harries AD, Easterbrook PJ, Doherty MC, Ball A. The next generation of the World Health Organization's global antiretroviral guidance. J Int AIDS Soc. 2013; 16: 18757.
38. Hodgson I, Ross J, Haamujompa C, Gitau-Mburu D. Living as an adolescent with HIV in Zambia-lived experiences, sexual health and reproductive needs. AIDS Care. 2012; 24: 1204-10.
39. Sivapalasingam S, Mendillo M, Ahmed A, Mwamzuka M, Said S, Marshed F, et al. The importance of caregivers in the outcome of pediatric HIV management, Mombasa, Kenya. AIDS Care. 2014; 26: 425-33.
40. Williams PL, Storm D, Montepiedra G, Nichols S, Kammerer B, Sirois PA, et al. Predictors of adherence to antiretroviral medications in children and adolescents with HIV infection. Pediatrics. 2006; 118: E1745-57.
41. Naar-King S, Montepiedra G, Garvie P, Kammerer B, Malee K, Sirois PA, et al. Social ecological predictors of longitudinal HIV treatment adherence in youth with perinatally acquired HIV. J Pediatr Psychol. 2013; 38: 664-74.
42. Buchanan AL, Montepiedra G, Sirois PA, Kammerer B, Garvie PA, Storm DS, et al. Barriers to medication adherence in HIV-infected children and youth based on self- And caregiver report. Pediatrics. 2012; 129: E1244-51.
43. Mburu G, Ram M, Skovdal M, Bitira D, Hodgson I, Mwai G, et al. Resisting and challenging stigma in Uganda: The role of support groups of people living with HIV. J Int AIDS Soc. 2013; 16 3 (Suppl 2): 18636.