The importance of caregivers in the outcome of pediatric HIV management, Mombasa, Kenya

AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV

Volumn 26, Issue 4, 2014, Pages 425-433

  Sivapalasingam, Sumathi ^a   Mendillo, Megan ^a   Ahmed, Aabid ^b   Mwamzuka, Musa ^b   Said, Swale ^b   Marshed, Fatma ^b   Abdulaziz, Farhad Luhar ^b   Fajans, Mark ^a   Holzman, Robert ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Bomu Medical Centre   (Kenya)

Author keywords

Adherence; Africa; HIV treatment; Pediatrics; Resource limited settings

Indexed keywords

ABACAVIR; COTRIMOXAZOLE; EFAVIRENZ; LAMIVUDINE; LOPINAVIR PLUS RITONAVIR; NEVIRAPINE; ZIDOVUDINE;

ANTIVIRAL THERAPY; ARTICLE; CAREGIVER; CHILD; CHILDHOOD MORTALITY; COHORT ANALYSIS; CONTROLLED STUDY; DRUG TREATMENT FAILURE; FEMALE; HOSPITAL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; KENYA; MAJOR CLINICAL STUDY; MALE; MEDICATION COMPLIANCE; NEWBORN; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; PRESCHOOL CHILD; PRIORITY JOURNAL; RELATIVE; SCHOOL CHILD; TREATMENT OUTCOME; VIROLOGY;

ADOLESCENT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CAREGIVERS; CD4 LYMPHOCYTE COUNT; CHILD; CHILD, PRESCHOOL; DISEASE PROGRESSION; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; INFANT; INFANT, NEWBORN; KENYA; LOGISTIC MODELS; MALE; MULTIVARIATE ANALYSIS; PATIENT COMPLIANCE; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; VIRAL LOAD;

EID: 84892608563     PISSN: 09540121     EISSN: 13600451     Source Type: Journal    
DOI: 10.1080/09540121.2013.841829     Document Type: Article

References (36)

1. Bolton-Moore, C., Mubiana-Mbewe, M., Cantrell, R. A., Chintu, N., Stringer, E. M., Chi, B. H., ... Stringer, J. S. A. (2007). Clinical outcomes and CD4 cell response in children receiving antiretroviral therapy at primary health care facilities in Zambia. JAMA, 298(16), 1888-1899. doi: 10.1001/jama.298.16.1888
2. Chi, B. H., Cantrell, R. A., Zulu, I., Mulenga, L. B., Levy, J. W., Tambatamba, B. C., ... Stringer, J. S. (2009). Adherence to first-line antiretroviral therapy affects nonvirologic outcomes among patients on treatment for more than 12 months in Lusaka, Zambia. International Journal of Epidemiology, 38(3), 746-756. doi:10.1093/ije/dyp004
3. Chintu, C., Bhat, G. J., Walker, A. S., Mulenga, V., Sinyinza, F., Lishimpi, K., ... CHAP Trial Team. (2004). Cotrimoxazole as prophylaxis against opportunistic infections in HIV-infected Zambian children (CHAP): A doubleblind randomised placebo-controlled trial. Lancet, 364, 1865-1871. doi:10.1016/S0140-6736(04)17442-4
4. Ciaranello, A. L., Chang, Y., Margulis, A. V., Bernstein, A., Bassett, I. V., Losina, E., & Walensky, R. P. (2009). Effectiveness of pediatric antiretroviral therapy in resource-limited settings: A systematic review and metaanalysis. Clinical Infectious Diseases, 49(12), 1915-1927. doi:10.1086/648079
5. Davies, M.-A., Boulle, A., Fakir, T., Nuttall, J., & Eley, B. (2008). Adherence to antiretroviral therapy in young children in Cape Town, South Africa, measured by medication return and caregiver self-report: A prospective cohort study. BMC Pediatrics, 8(1), 34. doi:10.1186/1471-2431-8-34
6. De Beaudrap, P., Rouet, F., Fassinou, P., Kouakoussui, A., Mercier, S., Ecochard, R., & Msellati, P. (2008). CD4 cell response before and after HAART initiation according to viral load and growth indicators in HIV-1-infected children in Abidjan, Cote d'Ivoire. Journal of Acquired Immune Deficiency Syndromes, 49(1), 70-76. doi:10.1097/QAI. 0b013e3181831847
7. Farley, J., Hines, S., Musk, A., Ferrus, S., & Tepper, V. (2003). Assessment of adherence to antiviral therapy in HIVinfected children using the Medication Event Monitoring System, pharmacy refill, provider assessment, caregiver self-report, and appointment keeping. Journal of Acquired Immune Deficiency Syndromes, 33(2), 211-218. doi:10.1097/00126334-200306010-00016
8. Fassinou, P., Elenga, N., Rouet, F., Laguide, R., Kouakoussui, K. A., Timite, M., ... Msellati, P. (2004). Highly active antiretroviral therapies among HIV-1-infected children in Abidjan, Cote d'Ivoire. AIDS, 18(14), 1905-1913. doi:10.1097/00002030-200409240-00006
9. Giacomet, V., Albano, F., Starace, F., Franciscis, A., Giaquinto, C., Gattinara, G. C., ... Guarino, A. (2003). Adherence to antiretroviral therapy and its determinants in children with human immunodeficiency virus infection: A multicentre, national study. Acta Paediatrica, 92(12), 1398-1402. doi:10.1111/j.1651-2227.2003.tb00822.x
10. Giannattasio, A., Albano, F., Giacomet, V., & Guarino, A. (2009). The changing pattern of adherence to antiretroviral therapy assessed at two time points, 12 months apart, in a cohort of HIV-infected children. Expert Opinion Pharmacotherapy, 10(17), 2773-2778. doi:10.1517/1465656090 3376178
11. Goldman, J. D., Cantrell, R. A., Mulenga, L. B., Tambatamba, B. C., Reid, S. E., Levy, J. W., ... Chi, B. H. (2008). Simple adherence assessments to predict virologic failure among HIV-infected adults with discordant immunologic and clinical responses to antiretroviral therapy. AIDS Research Human Retroviruses, 24(8), 1031-1035. doi:10.1089/aid.2008.0035
12. Jaspan, H. B., Berrisford, A. E., & Boulle, A. M. (2008). Twoyear outcomes of children on non-nucleoside reverse transcriptase inhibitor and protease inhibitor regimens in a South African pediatric antiretroviral program. Pediatric Infectious Disease Journal, 27(11), 993-998. doi:10.1097/INF. 0b013e31817acf7b
13. Jennings, C., Fiscus, S. A., Crowe, S. M., Danilovic, A. D., Morack, R. J., Scianna, S., ... Bremer, J. W. (2005). Comparison of two human immunodeficiency virus (HIV) RNA surrogate assays to the standard HIV RNA assay. Journal of Clinical Microbiology, 43(12), 5950-5956. doi:10.1128/JCM.43.12. 5950-5956.2005
14. Katko, E., Johnson, G. M., Fowler, S. L., Turner, R. B. (2001). Assessment of adherence with medications in human immunodeficiency virus-infected children. Pediatric Infectious Disease Journal, 20(12), 1174-1176. doi:10.1097/00006454-200112000-00017
15. Kekitiinwa, A., Lee, K. J., Walker, A. S., Maganda, A., Doerholt, K., Kitaka, S. B., ... Gibb, D. M. (2008). Differences in factors associated with initial growth, CD4, and viral load responses to ART in HIV-infected children in Kampala, Uganda, and the United Kingdom/Ireland. Journal of Acquired Immune Deficiency Syndromes, 49(4), 384-392. doi:10.1097/QAI.0b013e31818cdef5
16. Marhefka, S., Tepper, V., Farley, J., Sleasman, J., & Mellins, C. (2006). Brief report: Assessing adherence to pediatric antiretroviral regimens using the 24-hour recall interview. Journal of Pediatric Psychology, 31(9), 989-994. doi:10.1093/jpepsy/jsj107
17. Marhefka, S. L., Tepper, V. J., Brown, J. L., & Farley, J. J. (2006). Caregiver psychosocial characteristics and children's adherence to antiretroviral therapy. AIDS Patient Care and STDs, 20(6), 429-437. doi:10.1089/apc.2006.20.429
18. Muller, A. D., Bode, S. D., Myer, L. P., Roux, P. M. M., & von Steinbuchel NPDRBH. (2008). Electronic measurement of adherence to pediatric antiretroviral therapy in South Africa. The Pediatric Infectious Disease Journal, 27(3), 257-262. doi:10.1097/INF.0b013e31815b1ad4
19. National AIDS and STD Control Programme MoH, Government of Kenya. (2005). Guidelines for antiretroviral drug therapy in Kenya. Nairobi: Ministry of Health.
20. Newell, M.-L., Coovadia, H., Cortina-Borja, M., Rollins, N., Gaillard, P., & Dabis, F. (2004). Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: A pooled analysis. Lancet, 364(9441), 1236-1243. doi:10.1016/S0140-6736(04)17140-7
21. Nyandiko, W. M., Ayaya, S., Nabakwe, E., Tenge, C., Sidle, J. E., Yiannoutsos, C. T., ... Tierney, W. M. (2006). Outcomes of HIV-infected orphaned and non-orphaned children on antiretroviral therapy in western Kenya. Journal of Acquired Immune Deficiency Syndromes, 43(4), 418-425. doi:10.1097/01.qai. 0000243122.52282.89
22. O'Brien, D. P., Sauvageot, D., Zachariah, R., & Humblet, P. (2006). In resource-limited settings good early outcomes can be achieved in children using adult fixed-dose combination antiretroviral therapy. AIDS, 20(15), 1955-1960. doi:10.1097/01.aids.0000247117.66585.ce
23. Polisset, J., Ametonou, F., Arrive, E., Aho, A., & Perez, F. (2009). Correlates of adherence to antiretroviral therapy in HIV-infected children in Lome, Togo, West Africa. AIDS Behavior, 13(1), 23-32. doi:10.1007/s10461-008- 9437-6
24. Reddi, A., Leeper, S. C., Grobler, A. C., Geddes, R., France, K. H., Dorse, G. L., ... Giddy, J. (2007). Preliminary outcomes of a paediatric highly active antiretroviral therapy cohort from KwaZulu-Natal, South Africa. BMC Pediatrics, 7(1), 13. doi:10.1186/1471-2431-7-13
25. Rouet, F., Fassinou, P., Inwoley, A., Anaky, M.-F., Kouakoussui, A., Rouzioux, C., ... Msellati, P. (2006). Long-term survival and immuno-virological response of African HIV-1-infected children to highly active antiretroviral therapy regimens. AIDS, 20(18), 2315-2319. doi:10.1097/QAD.0b013e328010943b
26. Simoni, J. M., Montgomery, A., Martin, E., New, M., Demas, P. A., & Rana, S. (2007). Adherence to antiretroviral therapy for pediatric HIV infection: A qualitative systematic review with recommendations for research and clinical management. Pediatrics, 119(6), e1371-1383. doi:10.1542/peds.2006-1232
27. Sivapalasingam, S., Wangechi, B., Marshed, F., Laverty, M., Essajee, S., Holzman, R. S., ... Diemert, D. J. (2009). Monitoring virologic responses to antiretroviral therapy in HIV-infected adults in Kenya: Evaluation of a low-cost viral load assay. PLoS ONE, 4(8), e6828. doi:10.1371/journal.pone.0006828
28. Song, R., Jelagat, J., Dzombo, D., Mwalimu, M., Mandaliya, K., Shikely, K., & Essajee, S. (2007). Efficacy of highly active antiretroviral therapy in HIV-1 infected children in Kenya. Pediatrics, 120(4), e856-861. doi:10.1542/peds.2006-1122
29. Steegen, K., Luchters, S., De Cabooter, N., Reynaerts, J., Mandaliya, K., Plum, J., ... Temmerman, M. (2007). Evaluation of two commercially available alternatives for HIV-1 viral load testing in resource-limited settings. Journal Virology Methods, 146(1-2), 178-187. doi:10.1016/j.jviromet.2007.06.019
30. Walker, A. S., Ford, D., Mulenga, V., Thomason, M. J., Nunn, A., Chintu, C., ... Bangsberg, D. R. (2009). Adherence to both cotrimoxazole and placebo is associated with improved survival among HIV-infected Zambian children. AIDS Behavior, 13(1), 33-41. doi:10.1007/s10461-008-9382-4
31. Wamalwa, D. C., Farquhar, C., Obimbo, E. M., Selig, S., Mbori-Ngacha, D. A., Richardson, B. A., ... John-Stewart, G. (2007). Early response to highly active antiretroviral therapy in HIV-1-infected Kenyan children. Journal of Acquired Immune Deficiency Syndromes, 45(3), 311-317.
32. Watson, D. C., & Farley, J. J. (1999). Efficacy of and adherence to highly active antiretroviral therapy in children infected with human immunodeficiency virus type 1. Pediatric Infectious Disease Journal, 18(8), 682-689. doi:10.1097/00006454-199908000-00006
33. Weidle, P. J., Wamai, N., Solberg, P., Liechty, C., Sendagala, S., Were, W., ... Ransom, R. L. (2006). Adherence to antiretroviral therapy in a home-based AIDS care programme in rural Uganda. The Lancet, 368(9547), 1587-1594. doi:10.1016/S0140-6736(06)69118-6
34. Williams, P. L., Storm, D., Montepiedra, G., Nichols, S., Kammerer, B., Sirois, P. A., ... PACTG 219C Team. (2006). Predictors of adherence to antiretroviral medications in children and adolescents with HIV infection. Pediatrics, 118(6), e1745-1757. doi:10.1542/peds. 2006-0493
35. World Health Organization. (2008). Towards universal access: Scaling up priority HIV/AIDS interventions in the health sector: Progress report 2008. Geneva: Author.
36. World Health Organization HAP. (2009). Priority interventions: HIV/AIDS prevention, treatment and care in the health sector. Geneva: Author.