Supervised exercise improves cutaneous reinnervation capacity in metabolic syndrome patients

Annals of Neurology

Volumn 77, Issue 1, 2015, Pages 146-153

  Robinson Singleton, J ^a   Marcus, Robin L ^b   Lessard, Margaret K ^a   Jackson, Justin E ^b   Gordon Smith, A ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; CUTANEOUS REINNERVATION; DIABETIC PATIENT; DISEASE DURATION; EXERCISE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN TISSUE; INTRAEPIDERMAL NERVE FIBER DENSITY; LEG MOVEMENT; LIFESTYLE MODIFICATION; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MIDDLE AGED; NERVE FIBER REGENERATION; NERVE FIBER TRANSECTION; NERVOUS SYSTEM PARAMETERS; NEUROPATHY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PUNCH BIOPSY; REINNERVATION; SEX RATIO; SKIN BIOPSY; STATISTICAL SIGNIFICANCE; STUDY DESIGN; SYSTOLIC BLOOD PRESSURE; BIOPSY; COMPLICATION; CUTANEOUS DRUG ADMINISTRATION; DRUG EFFECTS; INNERVATION; KINESIOTHERAPY; METABOLIC DISEASES; NERVE REGENERATION; PATHOLOGY; PHYSIOLOGY; PROCEDURES; SKIN; SKIN DISEASES; TIME FACTOR;

ADMINISTRATION, CUTANEOUS; BIOPSY; CAPSAICIN; EXERCISE THERAPY; FEMALE; HUMANS; MALE; METABOLIC DISEASES; NERVE REGENERATION; SKIN; SKIN DISEASES; TIME FACTORS;

EID: 84920928478     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.24310     Document Type: Article

References (39)

1. Kennedy JM, Zochodne DW. The regenerative deficit of peripheral nerves in experimental diabetes: its extent, timing and possible mechanisms. Brain 2000;123:2118-2129.
2. Griffin JW, Thompson WJ. Biology and pathology of nonmyelinating Schwann cells. Glia 2008;56:1518-1531.
3. Callaghan B, Feldman E. The metabolic syndrome and neuropathy: therapeutic challenges and opportunities. Ann Neurol 2013;74:397-403.
4. Smith AG, Singleton JR. Obesity and hyperlipidemia are risk factors for early diabetic neuropathy. J Diabetes Complications 2013;27:436-442.
5. Smith AG, Rose K, Singleton JR. Idiopathic neuropathy patients are at high risk for metabolic syndrome. J Neurol Sci 2008;273:25-28.
6. Sumner CJ, Sheth S, Griffin JW, et al. The spectrum of neuropathy in diabetes and impaired glucose tolerance. Neurology 2003;60:108-111.
7. Guilford BL, Ryals JM, Wright DE. Phenotypic changes in diabetic neuropathy induced by a high-fat diet in diabetic C57BL/6 mice. Exp Diabetes Res 2011;2011:848307.
8. Stenkamp-Strahm CM, Kappmeyer AJ, Schmalz JT, et al. High-fat diet ingestion correlates with neuropathy in the duodenum myenteric plexus of obese mice with symptoms of type 2 diabetes. Cell Tissue Res 2013;354:381-394.
9. Lupachyk S, Watcho P, Hasanova N, et al. Triglyceride, nonesterified fatty acids, and prediabetic neuropathy: role for oxidative-nitrosative stress. Free Radic Biol Med 2012;52:1255-1263.
10. Vincent AM, Hayes JM, McLean LL, et al. Dyslipidemia-induced neuropathy in mice: the role of oxLDL/LOX-1. Diabetes 2009;58:2376-2385.
11. Malik RA, Tesfaye S, Newrick PG, et al. Sural nerve pathology in diabetic patients with minimal but progressive neuropathy. Diabetologia 2005;48:578-585.
12. Kennedy JM, Zochodne DW. Experimental diabetic neuropathy with spontaneous recovery: is there irreparable damage? Diabetes 2005;54:830-837.
13. Simone DA, Nolano M, Johnson T, et al. Intradermal injection of capsaicin in humans produces degeneration and subsequent reinnervation of epidermal nerve fibers: correlation with sensory function. J Neurosci 1998;18:8947-8959.
14. Polydefkis M, Hauer P, Sheth S, et al. The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy. Brain 2004;127:1606-1615.
15. Polydefkis M, Sirdofsky M, Hauer P, et al. Factors influencing nerve regeneration in a trial of timcodar dimesylate. Neurology 2006;66:259-261.
16. Schiffmann R, Hauer P, Freeman B, et al. Enzyme replacement therapy and intraepidermal innervation density in Fabry disease. Muscle Nerve 2006;34:53-56.
17. Third report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486-2497.
18. .Definition, diagnosis and classification of diabetes mellitus and it complications: report of a WHO consultation. Geneva, Switzerland: World Health Organization, 1999.
19. Grundy SM, Cleeman JI, Daniels SR, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005;112:2735-2752.
20. Feldman EL, Stevens MJ, Thomas PK, et al. A practical two-step quantitative clinical and electrophysiological assessment for the diagnosis and staging of diabetic neuropathy. Diabetes Care 1994;17:1281-1289.
21. Singleton JR, Bixby B, Russell JW, et al. The Utah Early Neuropathy Scale: a sensitive clinical scale for early sensory predominant neuropathy. J Peripher Nerv Syst 2008;13:218-227.
22. Lauria G, Bakkers M, Schmitz C, et al. Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study. J Peripher Nerv Syst 2010;15:202-207.
23. Tuomilehto J, Lindstrom J, Eriksson JG, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001;344:1343-1350.
24. Beriault K, Carpentier AC, Gagnon C, et al. Reproducibility of the 6-minute walk test in obese adults. Int J Sports Med 2009;30:725-727.
25. Bassey EJ, Short AH. A new method for measuring power output in a single leg extension: feasibility, reliability and validity. Eur J Appl Physiol Occup Physiol 1990;60:385-390.
26. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 1982;14:377-381.
27. American Diabetes Association. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 2003;26:S5-S20.
28. Straub RH, Thum M, Hollerbach C, et al. Impact of obesity on neuropathic late complications in NIDDM. Diabetes Care 1994;17:1290-1294.
29. Tesfaye S, Selvarajah D. The Eurodiab study: what has this taught us about diabetic peripheral neuropathy? Curr Diab Rep 2009;9:432-434.
30. Obrosova IG. Diabetic painful and insensate neuropathy: pathogenesis and potential treatments. Neurotherapeutics 2009;6:638-647.
31. Watcho P, Stavniichuk R, Ribnicky DM, et al. High-fat diet-induced neuropathy of prediabetes and obesity: effect of PMI-5011, an ethanolic extract of Artemisia dracunculus L. Mediators Inflamm 2010;2010:268547.
32. Davidson EP, Coppey LJ, Calcutt NA, et al. Diet-induced obesity in Sprague-Dawley rats causes microvascular and neural dysfunction. Diabetes Metab Res Rev 2010;26:306-318.
33. Groover AL, Ryals JM, Guilford BL, et al. Exercise-mediated improvements in painful neuropathy associated with prediabetes in mice. Pain 2013;154:2658-2667.
34. Smith AG, Russell J, Feldman EL, et al. Lifestyle intervention for pre-diabetic neuropathy. Diabetes Care 2006;29:1294-1299.
35. Kluding PM, Pasnoor M, Singh R, et al. The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy. J Diabetes Complications 2012;26:424-429.
36. Duncan GE, Perri MG, Theriaque DW, et al. Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults. Diabetes Care 2003;26:557-562.
37. Irwin ML, Yasui Y, Ulrich CM, et al. Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial. JAMA 2003;289:323-330.
38. Gan SK, Kriketos AD, Ellis BA, et al. Changes in aerobic capacity and visceral fat but not myocyte lipid levels predict increased insulin action after exercise in overweight and obese men. Diabetes Care 2003;26:1706-1713.
39. Smith AG, Howard JR, Kroll R, et al. The reliability of skin biopsy with measurement of intraepidermal nerve fiber density. J Neurol Sci 2005;228:65-69.