Evaluation of an oral supplement containing Phyllanthus emblica fruit extracts, vitamin E, and carotenoids in vitiligo treatment

Dermatologic Therapy

Volumn 28, Issue 1, 2015, Pages 17-21

  Colucci, Roberta ^a   Dragoni, Federica ^a   Conti, Rossana ^a   Pisaneschi, Lisa ^a   Lazzeri, Linda ^a   Moretti, Silvia ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

antioxidants; vitiligo

Indexed keywords

ALPHA TOCOPHEROL; CALCINEURIN INHIBITOR; CAROTENOID; CORTICOSTEROID; EMBLICA OFFICINALIS EXTRACT; VITAMIN D DERIVATIVE; ANTIOXIDANT; DRUG COMBINATION;

ADULT; ARM; ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DERMATITIS; DISEASE COURSE; DISEASE EXACERBATION; DRUG EFFICACY; FEMALE; FOLLOW UP; FRUIT; HEAD; HUMAN; LEG; MAJOR CLINICAL STUDY; MALE; NECK; OUTCOME ASSESSMENT; PHOTOTHERAPY; SKIN PIGMENTATION; TOPICAL TREATMENT; TRUNK; VITILIGO; ADOLESCENT; CHEMISTRY; COMPARATIVE STUDY; DRUG COMBINATION; DRUG EFFECTS; EMBLICA OFFICINALIS; INTRADERMAL DRUG ADMINISTRATION; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; ORAL DRUG ADMINISTRATION; PATHOLOGY; PROCEDURES; TREATMENT OUTCOME; YOUNG ADULT;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ANTIOXIDANTS; CAROTENOIDS; COMBINED MODALITY THERAPY; DRUG COMBINATIONS; FEMALE; FOLLOW-UP STUDIES; FRUIT; HUMANS; MALE; MIDDLE AGED; PHOTOTHERAPY; PHYLLANTHUS EMBLICA; SKIN PIGMENTATION; TREATMENT OUTCOME; VITAMIN E; VITILIGO; YOUNG ADULT;

EID: 84920887564     PISSN: 13960296     EISSN: 15298019     Source Type: Journal    
DOI: 10.1111/dth.12172     Document Type: Article

References (19)

1. Alikhan A, Felsten LM, Daly M, Petronic-Rosic V,. Vitiligo: a comprehensive overview. Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. J Am Acad Dermatol 2011: 65: 473-491.
2. Shallreuter KU, Bahadoran P, Picardo M, et al. Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else? Exp Dermatol 2008: 17: 139-140, discussion 141-160.
3. Taieb A,. Vitiligo as an inflammatory skin disorder: a therapeutic perspective. Pigment Cell Melanoma Res 2012: 25: 9-13.
4. Colucci R, Böhm M, Moretti S,. Commentary from the Editorial Board to Vitiligo: interplay between oxidative stress and immune system (Laddha et al.). Exp Dermatol 2013: 22: 397-398.
5. Dell'Anna ML, Mastrofrancesco A, Sala R, et al. Antioxidants and narrow band-UVB in the treatment of vitiligo: a double-blind placebo controlled trial. Clin Exp Dermatol 2007: 32: 631-636.
6. Middelkamp-Hup MA, Pathak MA, Parrado C, et al. Orally administered Polypodium leucotomos extract decreases psoralen-UVA-induced phototoxicity, pigmentation, and damage of human skin. J Am Acad Dermatol 2004: 50: 41-49.
7. Dang GK, Parekar RR, Kamat SK, Scindia AM, Rege NN,. Antiinflammatory activity of Phyllanthus emblica, Plumbago zeylanica and Cyperus rotundus in acute models of inflammation. Phytother Res 2011: 25: 904-908.
8. Heinrich U, Gärtner C, Wiebusch M,. Supplement with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema. J Nutr 2003: 133: 98-101.
9. Akyol M, Celik VK, Ozcelik S, Polat M, Marufihah M, Atalay A,. The effects of vitamin E on the skin lipid peroxidation and the clinical improvement in vitiligo patients treated with PUVA. Eur J Dermatol 2002: 12: 24-26.
10. Taieb A,. Picardo on behalf of VETF members. The definition and assessment of vitiligo: a consensus report of the Vitiligo European Task Force. Pigment Cell Res 2007: 20: 27-35.
11. Moretti S, Arunachalam M, Colucci R, et al. Autoimmune markers in vitiligo patients appear correlated with obsession and phobia. J Eur Acad Dermatol Venereol 2012: 26: 861-867.
12. Singh MK, Yadav SS, Gupta V, Khattri S,. Immunomodulatory role of Emblica officinalis in arsenic induced oxidative damage and apoptosis in thymocytes of mice. BMC Complement Altern Med 2013: 27: 193.
13. Majeed M, Bhat B, Anand S, Sivakumar A, Paliwal P, Geetha KG,. Inhibition of UV-induced ROS and collagen damage by Phyllanthus emblica extract in normal human dermal fibroblasts. J Cosmet Sci 2011: 62: 49-56.
14. Jimbow K, Chen H, Park JS, Thomas PD,. Increased sensitivity of melanocytes to oxidative stress and abnormal expression of tyrosinase related protein in vitiligo. Br J Dermatol 2001: 144: 55-56.
15. Rao TP, Sakaguchi N, Juneja LR, Wada E, Yokozawa T,. Emblica (Emblica officinalis Gaertn.) extracts reduce oxidative stress in streptozotocin-induced diabetic rats. J Med Food 2005: 8: 362-368.
16. Wongpradabchai S, Chularojmontri L, Phornchirasilp S, Wattanapitayakul SK,. Protective effect of Phyllanthus emblica fruit extract against hydrogen peroxide-induced endothelial cell death. J Med Assoc Thai 2013: 96 (Suppl. 1): S40-S48.
17. Stahl W, Heinrich U, Jungmann H, Sies H, Tronnier H,. Carotenoids and carotenoïdes plus vitamin E protect against ultra-violet light-induced erythema in humans. Am J Clin Nutr 2000: 71: 795-798.
18. Alaluf S, Heinrich U, Stahl W, Tronnier H, Wiseman S,. Dietary carotenoids contribute to normal human skin colour and UV photosensitivity. J Nutr 2002: 132: 399-403.
19. Smit N, Vicanova J, Cramers P, Vrolijk H, Pavel S,. The combined effects of extracts containing carotenoids and vitamins E and C on growth and pigmentation of cultured human melanocytes. Skin Pharmacol Physiol 2004: 17: 238-245.