The combined effects of extracts containing carotenoids and vitamins E and C on growth and pigmentation of cultured human melanocytes

Skin Pharmacology and Physiology

Volumn 17, Issue 5, 2004, Pages 238-245

  Smit, N ^a   Vicanova, J ^b   Cramers, P ^a   Vrolijk, H ^a   Pavel, S ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Ferrosan AS   (Denmark)

Author keywords

Carotenoids; Lycopene; Melanin; Melanocytes; Vitamin C; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; CAROTENOID; LYCOPENE;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL GROWTH; CELL PROTECTION; COMET ASSAY; CONTROLLED STUDY; DNA STRAND BREAKAGE; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INCUBATION TIME; MELANOCYTE; MELANOGENESIS; MONOCULTURE; PRIORITY JOURNAL; SKIN PIGMENTATION; TOMATO;

ASCORBIC ACID; CAROTENOIDS; CELL COUNT; CELL PROLIFERATION; CELLS, CULTURED; DRUG COMBINATIONS; HUMANS; MELANOCYTES; PLANT EXTRACTS; SKIN PIGMENTATION; VITAMIN E;

EID: 5644298356     PISSN: 16605527     EISSN: None     Source Type: Journal    
DOI: 10.1159/000080217     Document Type: Article

References (36)

1. Anstey AV: Systemic photoprotection with alpha-tocopherol (vitamin E) and beta- carotene. Clin Exp Dermatol 2002;27:170-176.
2. Eberlein-Konig B, Placzek M, Przybilla B: Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-alphatocopherol (vitamin E). J Am Acad Dermatol 1998;38:45-48.
3. Alaluf S, Heinrich U, Stahl W, Tronnier H, Wiseman S: Dietary carotenoids contribute to normal human skin color and UV photosensitivity. J Nutr 2002;132:399-403.
4. Stahl W, Heinrich U, Jungmann H, von Laar J, Schietzel M, Sies H, Tronnier H: Increased dermal carotenoid levels assessed by noninvasive reflection spectrophotometry correlate with serum levels in women ingesting Betatene. J Nutr 1998;128:903-907.
5. Postaire E, Jungmann H, Béjot M, Heinrich U, Tronnier H: Evidence for antioxidant nutrients-induced pigmentation in skin: Results of a clinical trial. Biochem Mol Biol Int 1997;42:1023-1033.
6. Burke M, Edge R, Land EJ, McGarvey DJ, Truscott TG: One-electron reduction potentials of dietary carotenoid radical cations in aqueous micellar environments. FEBS Lett 2001;500:132-136.
7. Edge R, Truscott TG: Prooxidant and antioxidant reaction mechanisms of carotene and radical interactions with vitamins E and C. Nutrition 1997;13:992-994.
8. Mortensen A, Skibsted LH, Truscott TG: The interaction of dietary carotenoids with radical species. Arch Biochem Biophys 2001;385:13-19.
9. Bohm F, Edge R, McGarvey DJ, Truscott TG: Beta-carotene with vitamins E and C offers synergistic cell protection against NOx. FEBS Lett 1998;436:387-389.
10. Bohm F, Edge R, Foley S, Lange L, Truscott TG: Antioxidant inhibition of porphyrin-induced cellular phototoxicity. J Photochem Photobiol B 2001;65:177-183.
11. Bohm F, Edge R, Burke M, Truscott TG: Dietary uptake of lycopene protects human cells from singlet oxygen and nitrogen dioxide - ROS components from cigarette smoke. J Photochem Photobiol B 2001;64:176-178.
12. Di Mascio P, Kaiser S, Sies H: Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 1989;274:532-538.
13. Sies H, Stahl W: Lycopene: Antioxidant and biological effects and its bioavailability in the human. Proc Soc Exp Biol Med 1998;218:121-124.
14. Ribaya-Mercado JD, Garmyn M, Gilchrest BA, Russell RM: Skin lycopene is destroyed preferentially over beta-carotene during ultraviolet irradiation in humans. J Nutr 1995;125:1854-1859.
15. Andersson E, Vahlquist A, Rosdahl I: Betacarotene uptake and bioconversion to retinol differ between human melanocytes and keratinocytes. Nutr Cancer 2001;39:300-306.
16. Wenczl E, Van der Schans GP, Roza L, Kolb RM, Timmerman AJ, Smit NP, Pavel S, Schothorst AA: (Pheo)melanin photosensitizes UVA-induced DNA damage in cultured human melanocytes. J Invest Dermatol 1998;111:678-682.
17. Smit NP, Vink AA, Kolb RM, Steenwinkel MJ, van den Berg PT, van Nieuwpoort F, Roza L, Pavel S: Melanin offers protection against induction of cyclobutane pyrimidine dimers and 6-4 photoproducts by UVB in cultured human melanocytes. Photochem Photobiol 2001;74:424-430.
18. Marrot L, Belaidi JP, Meunier JR, Perez P, Agapakis-Causse C: The human melanocyte as a particular target for UVA radiation and an endpoint for photoprotection assessment. Photochem Photobiol 1999;69:686-693.
19. Smit NPM, Vandermeulen H, Koerten HK, Kolb RM, Mommaas AM, Lentjes EGWM, Pavel S: Melanogenesis in cultured melanocytes can be substantially influenced by l-tyrosine and l-cysteine. J Invest Dermatol 1997;109:796-800.
20. Smit NP, Westerhof W, Menko WJ, Verbeek NM, Pavel S: Stimulation of cultured melanocytes in medium containing a serum substitute: Ultroser-G. Pigment Cell Res 1995;8:19-27.
21. Lyons N, O'Brien N: Modulatory effects of an algal extract containing astaxanthin on UVAirradiated cells in culture. J Dermatol Sci 2002;30:73.
22. Noz KC, Bauwens M, van Buul PP, Vrolijk H, Schothorst AA, Pavel S, Tanke HJ, Vermeer BJ: Comet assay demonstrates a higher ultraviolet B sensitivity to DNA damage in dysplastic nevus cells than in common melanocytic nevus cells and foreskin melanocytes. J Invest Dermatol 1996;106:1198-1202.
23. de Leeuw SM, Smit NP, Van Veldhoven M, Pennings EM, Pavel S, Simons JW, Schothorst AA: Melanin content of cultured human melanocytes and UV-induced cytotoxicity. J Photochem Photobiol B 2001;61:106-113.
24. Ozeki H, Ito S, Wakamatsu K, Thody AJ: Spectrophotometric characterization of eumelanin and pheomelanin in hair. Pigment Cell Res 1996;9:265-270.
25. Ito S, Wakamatsu K: Chemical degradation of melanins: Application to identification of dopamine-melanin. Pigment Cell Res 1998;11:120-126.
26. Stevens LH, Davelaar E, Kolb RM, Pennings EJM, Smit NPM: Tyrosine and cysteine are substrates for blackspot synthesis in potato. Phytochemistry 1998;49:703-707.
27. Winder AJ, Harris H: New assays for the tyrosine hydroxylase and dopa oxidase activities of tyrosinase. Eur J Biochem 1991;198:317-326.
28. Lowry OH, Rosebrough DJ, Farr AL, Randall RJ: Protein measurements with the Folin phenol reagent. J Biol Chem 1951;193:265-275.
29. Eicker J, Kurten V, Wild S, Riss G, Goralczyk R, Krutmann J, Berneburg M: Betacarotene supplementation protects from photoaging-associated mitochondrial DNA mutation. Photochem Photobiol Sci 2003;2:655-659.
30. Briganti S, Camera E, Picardo M: Chemical and instrumental approaches to treat hyperpigmentation. Pigment Cell Res 2003;16:101-110.
31. Rosdahl I, Andersson E, Kagedal B, Torma H: Vitamin A metabolism and mRNA expression of retinoid-binding protein and receptor genes in human epidermal melanocytes and melanoma cells. Melanoma Res 1997;7:267-274.
32. Hoyos B, Imam A, Korichneva I, Levi E, Chua R, Hammerling U: Activation of c-Raf kinase by ultraviolet light. Regulation by retinoids. J Biol Chem 2002;277:23949-23957.
33. Welsh BM, Mason RS, Halliday GM: Topical all-trans retinoic acid augments ultraviolet radiation-induced increases in activated melanocyte numbers in mice. J Invest Dermatol 1999;112:271-278.
34. Offord EA, Gautier JC, Avanti O, Scaletta C, Runge F, Kramer K, Applegate LA: Photoprotective potential of lycopene, beta-carotene, vitamin E, vitamin C and carnosic acid in UVAirradiated human skin fibroblasts. Free Radic Biol Med 2002;32:1293-1303.
35. Césarini JP, Michel L, Maurette JM, Adhoute H, Béjot M: Immediate effects of UV radiation on the skin: Modification by an antioxidant complex containing carotenoids. Photodermatol Photoimmunol Photomed 2003;19:182-189.
36. Perluigi M, De Marco F, Foppoli C, Coccia R, Blarzino C, Marcante ML, Cini C: Tyrosinase protects human melanocytes from ROS-generating compounds. Biochem Biophys Res Commun 2003;305:250-256.