Neurotoxicity of silver nanoparticles in rat brain after intragastric exposure

Journal of Nanoscience and Nanotechnology

Volumn 15, Issue 6, 2015, Pages 4215-4223

  Xu, Liming ^a,b   Shao, Anliang ^a   Zhao, Yanhong ^a,c   Wang, Zhijie ^a,d   Zhang, Cuiping ^e   Sun, Yilin ^e   Deng, Jie ^c   Chou, Laisheng Lee ^f  

^a NATIONAL INSTITUTES FOR FOOD AND DRUG CONTROL   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

^c Center for Medical Device Evaluation/SFDA   (China)

^d Grandhope Biotech Co Ltd   (China)

^e CAPITAL MEDICAL UNIVERSITY   (China)

^f BOSTON UNIVERSITY   (United States)

Author keywords

Inflammatory effects; Neurotoxicity; Silver NPs; Tight junction proteins; Ultrastructural changes

Indexed keywords

BIOLOGICAL ORGANS; BLOOD; BRAIN; NANOPARTICLES; NEURONS; PROTEINS; RATS; TISSUE; TOXICITY; TRANSMISSION ELECTRON MICROSCOPY;

CENTRAL NERVOUS SYSTEMS; INFLAMMATORY EFFECTS; INTRAGASTRIC ADMINISTRATION; MRNA EXPRESSION LEVEL; NEUROTOXICITY; SILVER NANOPARTICLE (NPS); TIGHT JUNCTIONS; ULTRASTRUCTURAL CHANGES;

SILVER;

METAL NANOPARTICLE; SILVER; TIGHT JUNCTION PROTEIN;

ANIMAL; BLOOD; BRAIN; BRAIN CHEMISTRY; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; FEMALE; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; RAT; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; BRAIN; BRAIN CHEMISTRY; FEMALE; METAL NANOPARTICLES; RATS; RATS, SPRAGUE-DAWLEY; SILVER; TIGHT JUNCTION PROTEINS;

EID: 84920847630     PISSN: 15334880     EISSN: 15334899     Source Type: Journal    
DOI: 10.1166/jnn.2015.9612     Document Type: Article

References (27)

1. O. Bondarenko, K. Juganson, A. Ivask, K. Kasemets, M. Mortimer, and A. Kahru, Arch. Toxicol. 87, 1181 (2013).
2. X. Li, L. Xu, A. Shao, G. Wu, and N. Hanagata, J. Nanosci. Nanotech. 13, 161 (2013).
3. S. Hackenberg, A. Scherzed, M. Kessler, S. Hummel, A. Technau, K. Froelich, C. Ginzkey, C. Koehler, and R. Hagen, Toxicol. Lett. 201, 27 (2011).
4. L. Xu, T. Takemura, M. Xu, and N. Hanagata, Mater. Express 1, 74 (2011).
5. M. V. D. Zande, R. J. Vandebriel, E. V. Doren, E. Kramer, Z. H. Rivera, C. S. Serrano-Rojero, E. R. Gremmer, J. Mast, R. J. B. Peters, P. C. H. Hollman, P. J. M. Hendriksen, H. J. P.Marvin, A. A. C. M. Peijnenburg, H. Bouwmeester, ACS Nano 6, 7427 (2012).
6. K. Dziendzikowska, J. Gromadzka-Ostrowska, A. Lankoff, M. Oczkowski, A. Krawczyńska, J. Chwastowska, M. Sadowska-Bratek, E. Chajduk, M. Wojewódzka, M. Dušinská, and M. Kruszewski, J. Appl. Toxicol. 32, 920 (2012).
7. E. J. Park, E. Bae, J. Yi, Y. Kim, K. Choi, S. H. Lee, J. Yoon, B. C. Lee, and K. Park, Environ. Toxicol. Pharmacol. 30, 62 (2010).
8. M. B. Genter, N. C. Newman, H. G. Shertzer, S. F. Ali, and B. Bolon, Toxicol. Pathol. 40, 1004 (2012).
9. M. F. Rahman, J. Wang, T. A. Patterson, U. T. Saini, B. L. Robinson, G. D. Newport, R. C. Murdock, J. J. Schlager, S. M. Hussain, and S. F. Ali, Toxicol. Lett. 187, 15 (2009).
10. N. Hadrup, K. Loeschner, A. Mortensen, A. K. Sharma, K. Qvortrup, E. H. Larsen, and H. R. Lam, Neurotoxicology 33, 416 (2012).
11. J. Tang, L. Xiong, S. Wang, J. Wang, L. Liu, J. Li, F. Yuan, and T. Xi, J. Nanosci. Nanotechnol. 10, 1 (2010).
12. C. M. Powers, E. D. Levin, F. J. Seidler, and T. A. Slotkin, Neurotoxicol. Teratol. 33, 329 (2011).
13. P. Liu, Z. Huang, and N. Gu, Ecotoxicol. Environ. Safe. 87, 124 (2013).
14. Y. Liu, W. Guan, G. Ren, and Z. Yang, Toxicol. Lett. 209, 227 (2012).
15. H. S. Sharma, S. Hussain, J. Schlager, S. F. Ali, and A. Sharma, Acta Neurochir. Suppl. 106, 359 (2010).
16. L. Xu, X. Li, T. Takemura, N. Hanagata, G. Wu, and L. L. Chou, J. Nanobiotech. 1, 10 (2012).
17. Z. Yang, Z. W. Liu, R. P. Allaker, P. Reip, J. Oxford, Z. Ahmad, and G. Ren, J. R. Soc. Interface 7, S411(2010).
18. J. Tang, L. Xiong, G. Zhou, S. Wang, J. Wang, L. Liu, J. Li, F. Yuan, S. Lu, Z. Wan, L. Chou, and T. Xi, J. Nanosci. Nanotechnol. 10, 6313 (2010).
19. P. H. M. Hoet, I. Bruske-Hohlfeld, and O. V. Salata, J. Nanobiotechnol. 2, 12 (2004).
20. E. Oberdörster, Environ. Health Persp. 112, 1058 (2004).
21. J. Meng, Y. Ji, J. Liu, X. Cheng, H. Guo, W. Zhang, X. Wu, and H. Xu, Nanotoxicology Early Online, 8, 686 (2014).
22. D. P. Lankveld, A. G. Oomen, P. Krystek, A. Neigh, A. Troost-de Jong, C. W. Noorlander, J. C. H. Van Eijkeren, R. E. Geertsma, and W. H. De Jong, Biomaterials 31, 8350 (2010).
23. H. S. Sharma and A. Sharma, CNS Neurol Disord-Dr. 11, 65 (2012).
24. C. M. Powers, T. A. Slotkin, F. J. Seidler, A. R. Badireddy, and S. Padilla, Neurotoxicol. Teratol. 33, 708 (2011).
25. C. M. Powers, A. R. Badireddy, I. T. Ryde, F. J. Seidler, and T. A. Slotkin, Environ. Health Perspect. 119, 37 (2011).
26. W. J. Trickler, S. M. Lantz, R. C. Murdock, A. M. Schrand, B. L. Robinson, G. D. Newport, J. J. Schlager, S. J. Oldenburg, M. G. Paule, W. S. Jr, S. M. Hussain, and S. F. Ali, Toxicol. Sci. 118, 160 (2010).
27. N. Yin, Q. Liu, J. Liu, B. He, L. Cui, Z. Li, Z. Yun, G. Qu, S. Liu, Q. Zhou, and G. Jiang, Small 9, 1831 (2013).