CCL5 promotes vascular endothelial growth factor expression and induces angiogenesis by down-regulating miR-199a in human chondrosarcoma cells

Cancer Letters

Volumn 357, Issue 2, 2015, Pages 476-487

  Liu, Guan Ting ^a   Huang, Yuan Li ^b   Tzeng, Huey En ^a,c   Tsai, Chun Hao ^a,d   Wang, Shih Wei ^e   Tang, Chih Hsin ^a,b,f  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b ASIA UNIVERSITY   (Taiwan)

^c TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e MACKAY MEDICAL COLLEGE   (Taiwan)

^f CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Angiogenesis; CCL5; Chondrosarcoma; MiR 199a; VEGF

Indexed keywords

MICRORNA; MICRORNA 199A; RANTES; UNCLASSIFIED DRUG; VASCULOTROPIN; 3' UNTRANSLATED REGION; MIRN199 MICRORNA, HUMAN; VASCULOTROPIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ARTICLE; CANCER STAGING; CHONDROSARCOMA; CHONDROSARCOMA CELL LINE; CHORIOALLANTOIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RNA ANALYSIS; TUMOR GROWTH; TUMOR XENOGRAFT; UPREGULATION; 3' UNTRANSLATED REGION; ANIMAL; BONE NEOPLASMS; CELL CULTURE; CHICK EMBRYO; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; ENDOTHELIAL PROGENITOR CELL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCID MOUSE; SEQUENCE HOMOLOGY; TUMOR CELL LINE; VASCULARIZATION; WESTERN BLOTTING;

MUS MUSCULUS;

3' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; BONE NEOPLASMS; CELL LINE, TUMOR; CELLS, CULTURED; CHEMOKINE CCL5; CHICK EMBRYO; CHONDROSARCOMA; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENDOTHELIAL PROGENITOR CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICE, SCID; MICRORNAS; NEOVASCULARIZATION, PATHOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, NUCLEIC ACID; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84920844343     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.11.015     Document Type: Article

References (37)

1. Terek R.M., Schwartz G.K., Devaney K., Glantz L., Mak S., Healey J.H., et al. Chemotherapy and P-glycoprotein expression in chondrosarcoma. J. Orthop. Res 1998, 16:585-590.
2. Tang C.H. Molecular mechanisms of chondrosarcoma metastasis. Biomedicine 2012, 2:92-98.
3. Su C.M., Fong Y.C., Tang C.H. An overview of current and future treatment options for chondrosarcoma. Exp. Opin. Orph. Drugs 2014, 2:1-11.
4. Chen J.C., Fong Y.C., Tang C.H. Novel strategies for the treatment of chondrosarcomas: targeting integrins. Biomed. Res. Int 2013, 1-11.
5. Albini A., Tosetti F., Li V.W., Noonan D.M., Li W.W. Cancer prevention by targeting angiogenesis. Nat. Rev. Clin. Oncol 2012, 9:498-509.
6. Weis S.M., Cheresh D.A. Tumor angiogenesis: molecular pathways and therapeutic targets. Nat. Med 2011, 17:1359-1370.
7. Wu M.H., Huang C.Y., Lin J.A., Wang S.W., Peng C.Y., Cheng H.C., et al. Endothelin-1 promotes vascular endothelial growth factor-dependent angiogenesis in human chondrosarcoma cells. Oncogene 2014, 33:1725-1735.
8. Keating A.M., Jacobs D.S. Anti-VEGF treatment of corneal neovascularization. Ocul. Surf 2011, 9:227-237.
9. Liang X., Xu F., Ma C., Zhang Y., Xu W. VEGF signal system: the application of antiangiogenesis. Curr. Med. Chem 2013, 21:894-910.
10. Baltus T., von Hundelshausen P., Mause S.F., Buhre W., Rossaint R., Weber C. Differential and additive effects of platelet-derived chemokines on monocyte arrest on inflamed endothelium under flow conditions. J. Leukoc. Biol 2005, 78:435-441.
11. McCormack G., Moriarty D., O'Donoghue D.P., McCormick P.A., Sheahan K., Baird A.W. Tissue cytokine and chemokine expression in inflammatory bowel disease. Inflamm. Res 2001, 50:491-495.
12. Wang S.W., Wu H.H., Liu S.C., Wang P.C., Ou W.C., Chou W.Y., et al. CCL5 and CCR5 interaction promotes cell motility in human osteosarcoma. PLoS ONE 2012, 7. e35101.
13. Chuang J.Y., Yang W.H., Chen H.T., Huang C.Y., Tan T.W., Lin Y.T., et al. CCL5/CCR5 axis promotes the motility of human oral cancer cells. J. Cell. Physiol 2009, 220:418-426.
14. Velasco-Velazquez M., Pestell R.G. The CCL5/CCR5 axis promotes metastasis in basal breast cancer. Oncoimmunology 2013, 2. e23660.
15. Luboshits G., Shina S., Kaplan O., Engelberg S., Nass D., Lifshitz-Mercer B., et al. Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma. Cancer Res 1999, 59:4681-4687.
16. Velasco-Velazquez M., Jiao X., De La Fuente M., Pestell T.G., Ertel A., Lisanti M.P., et al. CCR5 antagonist blocks metastasis of basal breast cancer cells. Cancer Res 2012, 72:3839-3850.
17. Tang C.H., Yamamoto A., Lin Y.T., Fong Y.C., Tan T.W. Involvement of matrix metalloproteinase-3 in CCL5/CCR5 pathway of chondrosarcomas metastasis. Biochem. Pharmacol 2010, 79:209-217.
18. Ruan K., Fang X., Ouyang G. MicroRNAs: novel regulators in the hallmarks of human cancer. Cancer Lett 2009, 285:116-126.
19. Cheng Q., Yi B., Wang A., Jiang X. Exploring and exploiting the fundamental role of microRNAs in tumor pathogenesis. Onco Targets Ther 2013, 6:1675-1684.
20. Lim L.P., Lau N.C., Garrett-Engele P., Grimson A., Schelter J.M., Castle J., et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 2005, 433:769-773.
21. Huang C.Y., Chen S.Y., Tsai H.C., Hsu H.C., Tang C.H. Thrombin induces epidermal growth factor receptor transactivation and CCL2 expression in human osteoblasts. Arthritis Rheum 2012, 64:3344-3354.
22. Storgard C., Mikolon D., Stupack D.G. Angiogenesis assays in the chick CAM. Methods Mol. Biol 2005, 294:123-136.
23. Carmeliet P., Jain R.K. Angiogenesis in cancer and other diseases. Nature 2000, 407:249-257.
24. Sugasawa H., Ichikura T., Tsujimoto H., Kinoshita M., Morita D., Ono S., et al. Prognostic significance of expression of CCL5/RANTES receptors in patients with gastric cancer. J. Surg. Oncol 2008, 97:445-450.
25. Landskroner-Eiger S., Moneke I., Sessa W.C. miRNAs as modulators of angiogenesis. Cold Spring Harb. Perspect. Med 2013, 3. a006643.
26. Arcondeguy T., Lacazette E., Millevoi S., Prats H., Touriol C. VEGF-A mRNA processing, stability and translation: a paradigm for intricate regulation of gene expression at the post-transcriptional level. Nucleic Acids Res 2013, 41:7997-8010.
27. Bovee J.V., Hogendoorn P.C., Wunder J.S., Alman B.A. Cartilage tumours and bone development: molecular pathology and possible therapeutic targets. Nat. Rev. Cancer 2010, 10:481-488.
28. Lazennec G., Richmond A. Chemokines and chemokine receptors: new insights into cancer-related inflammation. Trends Mol. Med 2011, 16:133-144.
29. Borsig L., Wolf M.J., Roblek M., Lorentzen A., Heikenwalder M. Inflammatory chemokines and metastasis-tracing the accessory. Oncogene 2014, 33:3217-3224.
30. Martin L., Blanpain C., Garnier P., Wittamer V., Parmentier M., Vita C. Structural and functional analysis of the RANTES-glycosaminoglycans interactions. Biochemistry 2001, 40:6303-6318.
31. Suffee N., Hlawaty H., Meddahi-Pelle A., Maillard L., Louedec L., Haddad O., et al. RANTES/CCL5-induced pro-angiogenic effects depend on CCR1, CCR5 and glycosaminoglycans. Angiogenesis 2012, 15:727-744.
32. Huang C.Y., Fong Y.C., Lee C.Y., Chen M.Y., Tsai H.C., Hsu H.C., et al. CCL5 increases lung cancer migration via PI3K, Akt and NF-kappaB pathways. Biochem. Pharmacol 2009, 77:794-803.
33. Esquela-Kerscher A., Slack F.J. Oncomirs - microRNAs with a role in cancer. Nat. Rev. Cancer 2006, 6:259-269.
34. Zhang Q., Jeang K.T. Long noncoding RNAs and viral infections. Biomedicine 2013, 3:34-42.
35. Chen P.S., Su J.L., Hung M.C. Dysregulation of microRNAs in cancer. J. Biomed. Sci 2012, 19:90.
36. He J., Jing Y., Li W., Qian X., Xu Q., Li F.S., et al. Roles and mechanism of miR-199a and miR-125b in tumor angiogenesis. PLoS ONE 2013, 8. e56647.
37. Duan Z., Choy E., Harmon D., Liu X., Susa M., Mankin H., et al. MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration. Mol. Cancer Ther 2011, 10:1337-1345.