Clearly defining pediatric massive transfusion: Cutting through the fog and friction with combat data

Journal of Trauma and Acute Care Surgery

Volumn 78, Issue 1, 2015, Pages 22-28

  Neff, Lucas P ^a,c   Cannon, Jeremy W ^b,c   Morrison, Jonathan J ^e   Edwards, Mary J ^b   Spinella, Philip C ^d   Borgman, Matthew A ^b  

^a DAVID GRANT MEDICAL CENTER   (United States)

^b SAN ANTONIO MILITARY MEDICAL CENTER   (United States)

^c Uniformed Services University of the Health Sciences   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

combat injury; damage control resuscitation; massive transfusion; Pediatric trauma

Indexed keywords

ADOLESCENT; AFGHANISTAN; ARTICLE; ARTIFICIAL VENTILATION; BATTLE INJURY; BLOOD CLOTTING DISORDER; BLOOD TRANSFUSION; CHILD; CHILDHOOD INJURY; CONTROLLED STUDY; FEMALE; HOSPITALIZATION; HUMAN; HYPOTHERMIA; INTENSIVE CARE UNIT; IRAQ; MAJOR CLINICAL STUDY; MALE; MASSIVE TRANSFUSION; MORTALITY; PREDICTION; PRIORITY JOURNAL; REGISTER; SENSITIVITY AND SPECIFICITY; SHOCK; THROMBOCYTOPENIA; TREATMENT OUTCOME; INJURY SCALE; PUBLIC HOSPITAL; RISK FACTOR; STATISTICS AND NUMERICAL DATA; UNITED STATES; WAR; WOUNDS AND INJURIES;

ADOLESCENT; AFGHAN CAMPAIGN 2001-; BLOOD TRANSFUSION; CHILD; FEMALE; HOSPITAL MORTALITY; HOSPITALS, MILITARY; HUMANS; INJURY SEVERITY SCORE; IRAQ WAR, 2003-2011; MALE; REGISTRIES; RISK FACTORS; SENSITIVITY AND SPECIFICITY; UNITED STATES; WOUNDS AND INJURIES;

EID: 84920815591     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0000000000000488     Document Type: Article

References (37)

1. Stanworth SJ, Morris TP, Gaarder C, Goslings JC, Maegele M, Cohen MJ, König TC, Davenport RA, Pittet JF, Johansson PI, et al. Reappraising the concept of massive transfusion in trauma. Crit Care. 2010;14(6):R239.
2. Wilson RF, Mammen E, Walt AJ. Eight years of experience with massive blood transfusions. J Trauma. 1971;11(4):275-285.
3. Dehmer JJ, Adamson WT. Massive transfusion and blood product use in the pediatric trauma patient. Semin Pediatr Surg. 2010;19(4):286-291.
4. Nosanov L, Inaba K, Okoye O, Resnick S, Upperman J, Shulman I, Rhee P, Demetriades D. The impact of blood product ratios in massively transfused pediatric trauma patients. Am J Surg. 2013;206(5):655-660.
5. Brasel KJ, Vercruysse G, Spinella PC, Wade CE, Blackbourne LH, Borgman MA, Zarzabal LA, Du F, Perkins JG, Maegele M, et al. The association of blood component use ratios with the survival of massively transfused trauma patients with and without severe brain injury. J Trauma. 2011;71(2 Suppl 3): S343-S352.
6. Savage SA, Zarzaur BL, Croce MA, Fabian TC. Redefining massive transfusion when every second counts. J Trauma Acute Care Surg. 2013; 74(2):396-400; discussion 400-402.
7. Rahbar E, Fox EE, del Junco DJ, Harvin JA, Holcomb JB, Wade CE, Schreiber MA, Rahbar MH, Bulger EM, Phelan HA, et al.; PROMMT Study Group. Early resuscitation intensity as a surrogate for bleeding severity and early mortality in the PROMMTT study. J Trauma Acute Care Surg. 2013;75(1 Suppl 1):S16-S23.
8. Barcelona SL, Thompson AA, Coté CJ. Intraoperative pediatric blood transfusion therapy: a review of common issues. Part I: hematologic and physiologic differences from adults; metabolic and infectious risks. Paediatr Anaesth. 2005;15(9):716-726.
9. Paterson NA. Validation of a theoretically derived model for the management of massive blood loss in pediatric patients-a case report. Paediatr Anaesth. 2009;19(5):535-540.
10. Diab YA, Wong ECC, Luban NLC. Massive transfusion in children and neonates. Br J Haematol. 2013;161(1):15-26.
11. Chidester SJ, Williams N, Wang W, Groner JI. A pediatric massive transfusion protocol. J Trauma Acute Care Surg. 2012;73(5):1273-1277.
12. Hendrickson JE, Shaz BH, Pereira G, Parker PM, Jessup P, Atwell F, Polstra B, Atkins E, Johnson KK, Bao G, et al. Implementation of a pediatric trauma massive transfusion protocol: one institution's experience. Transfusion. 2012;52(6):1228-1236.
13. Pickett PM, Tripi PA. Massive transfusion protocol in pediatric trauma. Int Anesthesiol Clin. 2011;49(2):62-67.
14. Dressler AM, Finck CM, Carroll CL, Bonanni CC, Spinella PC. Use of a massive transfusion protocol with hemostatic resuscitation for severe intraoperative bleeding in a child. J Pediatr Surg. 2010;45(7):1530-1533.
15. Borgman MA, Maegele M, Wade CE, Blackbourne LH, Spinella PC. Pediatric trauma BIG score: predicting mortality in children after military and civilian trauma. Pediatrics. 2011;127(4):e892-e897.
16. Patregnani JT, Borgman MA, Maegele M, Wade CE, Blackbourne LH, Spinella PC. Coagulopathy and shock on admission is associated with mortality for children with traumatic injuries at combat support hospitals. Pediatr Crit Care Med. 2012;13(3):273-277.
17. WHO. Weight-for-age. WHO. Available at: http://www.who.int/childgrowth/standards/weight-for-age/en/. Accessed July 31, 2014.
18. Growth Charts-Data Table of Weight-for-Age Charts. Available at: http://www.cdc.gov/growthcharts/html-charts/wtage.htm. Accessed July 8, 2014.
19. Sihler KC, Napolitano LM. Massive transfusion: new insights. Chest. 2009;136(6):1654-1667.
20. Borgman MA, Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, Sebesta J, Jenkins D, Wade CE, Holcomb JB. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma. 2007;63(4): 805-813.
21. Hendrickson JE, Shaz BH, Pereira G, Atkins E, Johnson KK, Bao G, Easley KA, Josephson CD. Coagulopathy is prevalent and associated with adverse outcomes in transfused pediatric trauma patients. J Pediatr. 2012; 160(2):204-209.
22. Schuster KM, Davis KA, Lui FY, Maerz LL, Kaplan LJ. The status of massive transfusion protocols in United States trauma centers: massive transfusion or massive confusion? Transfusion. 2010;50(7):1545-1551.
23. Sihler KC, Napolitano LM. Complications of massive transfusion. Chest. 2010;137(1):209-220.
24. Lee AC, Reduque LL, Luban NLC, Ness PM, Anton B, Heitmiller ES. Transfusion-associated hyperkalemic cardiac arrest in pediatric patients receiving massive transfusion. Transfusion. 2014;54(1):244-254.
25. Borgman MA, Spinella PC, Holcomb JB, Blackbourne LH, Wade CE, Lefering R, Bouillon B, Maegele M. The effect of FFP:RBC ratio on morbidity and mortality in trauma patients based on transfusion prediction score. Vox Sang. 2011;101(1):44-54.
26. Nunez TC, Voskresensky IV, Dossett LA, Shinall R, Dutton WD, Cotton BA. Early prediction of massive transfusion in trauma: simple as ABC (assessment of blood consumption)? J Trauma. 2009;66(2):346-352.
27. Cap AP, Spinella PC, Borgman MA, Blackbourne LH, Perkins JG. Timing and location of blood product transfusion and outcomes in massively transfused combat casualties. J Trauma Acute Care Surg. 2012;73(2 Suppl 1): S89-S94.
28. Kashuk JL, Moore EE, Johnson JL, Haenel J, Wilson M, Moore JB, Cothren CC, Biffl WL, Banerjee A, Sauaia A. Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma:packed red blood cells the answer? J Trauma. 2008;65(2):261-270; discussion 270-271.
29. Del Junco DJ, Fox EE, Camp EA, Rahbar MH, Holcomb JB; PROMMTT Study Group. Seven deadly sins in trauma outcomes research: an epidemiologic post mortem for major causes of bias. J Trauma Acute Care Surg. 2013;75(1 Suppl 1):S97-S103.
30. Holcomb JB, Wade CE, Michalek JE, Chisholm GB, Zarzabal LA, Schreiber MA, Gonzalez EA, Pomper GJ, Perkins JG, Spinella PC, et al. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg. 2008;248(3): 447-458.
31. Zink KA, Sambasivan CN, Holcomb JB, Chisholm G, Schreiber MA. A high ratio of plasma and platelets to packed red blood cells in the first 6 hours of massive transfusion improves outcomes in a large multicenter study. Am J Surg. 2009;197(5):565-570; discussion 570.
32. Edwards MJ, Lustik M, Eichelberger MR, Elster E, Azarow K, Coppola C. Blast injury in children: an analysis from Afghanistan and Iraq, 2002-2010. J Trauma Acute Care Surg. 2012;73(5):1278-1283.
33. Eastridge BJ, Hardin M, Cantrell J, Oetjen-Gerdes L, Zubko T, Mallak C, Wade CE, Simmons J, Mace J, Mabry R, et al. Died of wounds on the battlefield: causation and implications for improving combat casualty care. J Trauma. 2011;71(1 Suppl):S4-S8.
34. Surrency AB, Graitcer PL, Henderson AK. Key factors for civilian injuries and deaths from exploding landmines and ordnance. Inj Prev. 2007; 13(3):197-201.
35. Schneidman D. Surgeons put planning, preparation, past experience to work in efforts to save Boston Marathon bombing victims. Bull Am Coll Surg. 2013;98(9):9-17.
36. Talving P, Lustenberger T, Lam L, Inaba K, Mohseni S, Plurad D, Green DJ, Demetriades D. Coagulopathy after isolated severe traumatic brain injury in children. J Trauma. 2011;71(5):1205-1210.
37. Levi M, Fries D, Gombotz H, van der Linden P, Nascimento B, Callum JL, Bélisle S, Rizoli S, Hardy JF, Johansson PI, et al. Prevention and treatment of coagulopathy in patients receiving massive transfusions. Vox Sang. 2011;101(2):154-174.