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Volumn 26, Issue 1, 2015, Pages 36-45

Lung cancer chemotherapy agents increase procoagulant activity via protein disulfide isomerase-dependent tissue factor decryption

Author keywords

A549 cells; chemotherapy; endothelium; lung cancer; monocytes; thrombosis1

Indexed keywords

ANTINEOPLASTIC AGENT; BLOOD CLOTTING FACTOR 10A; CARBOPLATIN; CISPLATIN; CYSTEINE; DITHIOTHREITOL; GEMCITABINE; GLUTATHIONE; PACLITAXEL; PHOSPHATIDYLSERINE; PROCOAGULANT; PROTEIN DISULFIDE ISOMERASE; THIOL; THROMBOPLASTIN; PLATINUM COMPLEX;

EID: 84920806703     PISSN: 09575235     EISSN: 14735733     Source Type: Journal    
DOI: 10.1097/MBC.0000000000000145     Document Type: Article
Times cited : (27)

References (53)
  • 1
    • 13444256137 scopus 로고    scopus 로고
    • Malignancies, prothrombotic mutations, and the risk of venous thrombosis
    • Blom JW, Doggen CJ, Osanto S, Rosendaal FR. Malignancies, prothrombotic mutations, and the risk of venous thrombosis. JAMA 2005; 293:715-722.
    • (2005) JAMA , vol.293 , pp. 715-722
    • Blom, J.W.1    Doggen, C.J.2    Osanto, S.3    Rosendaal, F.R.4
  • 2
    • 0019223202 scopus 로고
    • Fatal pulmonary embolism in cancer patients: Is heparin prophylaxis justified?
    • Shen VS, Pollak EW. Fatal pulmonary embolism in cancer patients: is heparin prophylaxis justified? South Med J 1980; 73:841-843.
    • (1980) South Med J , vol.73 , pp. 841-843
    • Shen, V.S.1    Pollak, E.W.2
  • 4
    • 0020961939 scopus 로고
    • Activation of blood coagulation in cancer: Trousseau's syndrome revisited
    • Rickles FR, Edwards RL. Activation of blood coagulation in cancer: Trousseau's syndrome revisited. Blood 1983; 62:14-31.
    • (1983) Blood , vol.62 , pp. 14-31
    • Rickles, F.R.1    Edwards, R.L.2
  • 5
    • 0032956489 scopus 로고    scopus 로고
    • Expression of tissue factor in nonsmall-cell lung cancers and its relationship to metastasis
    • Sawada M, Miyake S, Ohdama S, Matsubara O, Masuda S, Yakumaru K, et al. Expression of tissue factor in nonsmall-cell lung cancers and its relationship to metastasis. Br J Cancer 1999; 79:472-477.
    • (1999) Br J Cancer , vol.79 , pp. 472-477
    • Sawada, M.1    Miyake, S.2    Ohdama, S.3    Matsubara, O.4    Masuda, S.5    Yakumaru, K.6
  • 6
    • 0035876016 scopus 로고    scopus 로고
    • Molecular basis for the relationship between thrombosis and cancer
    • Rickles FR, Falanga A. Molecular basis for the relationship between thrombosis and cancer. Thromb Res 2001; 102:V215-V224.
    • (2001) Thromb Res , vol.102 , pp. V215-V224
    • Rickles, F.R.1    Falanga, A.2
  • 7
    • 0032841392 scopus 로고    scopus 로고
    • Rates of initial and recurrent thromboembolic disease among patients with malignancy versus those without malignancy. Risk analysis using Medicare claims data
    • Levitan N, Dowlati A, Remick SC, Tahsildar HI, Sivinski LD, Beyth R, et al. Rates of initial and recurrent thromboembolic disease among patients with malignancy versus those without malignancy. Risk analysis using Medicare claims data. Medicine (Baltimore) 1999; 78:285-291.
    • (1999) Medicine (Baltimore) , vol.78 , pp. 285-291
    • Levitan, N.1    Dowlati, A.2    Remick, S.C.3    Tahsildar, H.I.4    Sivinski, L.D.5    Beyth, R.6
  • 9
    • 77749298319 scopus 로고    scopus 로고
    • American Society of Clinical Oncology Clinical Practice Guideline Update on Chemotherapy for Stage IV Non-Small-Cell Lung Cancer
    • Azzoli CG, Giaccone G, Temin S. American Society of Clinical Oncology Clinical Practice Guideline Update on Chemotherapy for Stage IV Non-Small-Cell Lung Cancer. J Oncol Pract 2010; 6:39-43.
    • (2010) J Oncol Pract , vol.6 , pp. 39-43
    • Azzoli, C.G.1    Giaccone, G.2    Temin, S.3
  • 10
    • 0036843105 scopus 로고    scopus 로고
    • Phase III randomized trial comparing three platinum-based doublets in advanced nonsmall-cell lung cancer
    • Scagliotti GV, De Marinis F, Rinaldi M, Crino L, Gridelli C, Ricci S, et al. Phase III randomized trial comparing three platinum-based doublets in advanced nonsmall-cell lung cancer. J Clin Oncol 2002; 20:4285-4291.
    • (2002) J Clin Oncol , vol.20 , pp. 4285-4291
    • Scagliotti, G.V.1    De Marinis, F.2    Rinaldi, M.3    Crino, L.4    Gridelli, C.5    Ricci, S.6
  • 11
    • 0033028673 scopus 로고    scopus 로고
    • Gemcitabine: Single-agent and combination therapy in nonsmall cell lung cancer
    • Sandler A, Ettinger DS. Gemcitabine: single-agent and combination therapy in nonsmall cell lung cancer. Oncologist 1999; 4:241-251.
    • (1999) Oncologist , vol.4 , pp. 241-251
    • Sandler, A.1    Ettinger, D.S.2
  • 12
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for nonsmall-cell lung cancer
    • Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A, et al. Paclitaxel-carboplatin alone or with bevacizumab for nonsmall-cell lung cancer. N Engl J Med 2006; 355:2542-2550.
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3    Brahmer, J.4    Schiller, J.H.5    Dowlati, A.6
  • 13
    • 34548400720 scopus 로고    scopus 로고
    • High risk of deep vein thrombosis in patients with nonsmall cell lung cancer: A cohort study of 493 patients
    • Tagalakis V, Levi D, Agulnik JS, Cohen V, Kasymjanova G, Small D. High risk of deep vein thrombosis in patients with nonsmall cell lung cancer: a cohort study of 493 patients. J Thorac Oncol 2007; 2:729-734.
    • (2007) J Thorac Oncol , vol.2 , pp. 729-734
    • Tagalakis, V.1    Levi, D.2    Agulnik, J.S.3    Cohen, V.4    Kasymjanova, G.5    Small, D.6
  • 14
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic nonsmall-cell lung cancer
    • Johnson DH, Fehrenbacher L, Novotny WF, Herbst RS, Nemunaitis JJ, Jablons DM, et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic nonsmall-cell lung cancer. J Clin Oncol 2004; 22:2184-2191.
    • (2004) J Clin Oncol , vol.22 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3    Herbst, R.S.4    Nemunaitis, J.J.5    Jablons, D.M.6
  • 15
    • 13944267884 scopus 로고    scopus 로고
    • Prospective evaluation of major vascular events in patients with nonsmall cell lung carcinoma treated with cisplatin and gemcitabine
    • Numico G, Garrone O, Dongiovanni V, Silvestris N, Colantonio I, Di Costanzo G, et al. Prospective evaluation of major vascular events in patients with nonsmall cell lung carcinoma treated with cisplatin and gemcitabine. Cancer 2005; 103:994-999.
    • (2005) Cancer , vol.103 , pp. 994-999
    • Numico, G.1    Garrone, O.2    Dongiovanni, V.3    Silvestris, N.4    Colantonio, I.5    Di Costanzo, G.6
  • 16
    • 20444433198 scopus 로고    scopus 로고
    • In vitro procoagulant activity induced in endothelial cells by chemotherapy and antiangiogenic drug combinations: Modulation by lower-dose chemotherapy
    • Ma L, Francia G, Viloria-Petit A, Hicklin DJ, du Manoir J, Rak J, et al. In vitro procoagulant activity induced in endothelial cells by chemotherapy and antiangiogenic drug combinations: modulation by lower-dose chemotherapy. Cancer Res 2005; 65:5365-5373.
    • (2005) Cancer Res , vol.65 , pp. 5365-5373
    • Ma, L.1    Francia, G.2    Viloria-Petit, A.3    Hicklin, D.J.4    Du Manoir, J.5    Rak, J.6
  • 17
    • 84855168637 scopus 로고    scopus 로고
    • Evidence for acute vascular toxicity of cisplatin-based chemotherapy in patients with germ cell tumour
    • Ma L, Dieckmann KP, Struss WJ, Budde U. Evidence for acute vascular toxicity of cisplatin-based chemotherapy in patients with germ cell tumour. Anticancer Res 2011; 31:4501-4505.
    • (2011) Anticancer Res , vol.31 , pp. 4501-4505
    • Ma, L.1    Dieckmann, K.P.2    Struss, W.J.3    Budde, U.4
  • 18
    • 58149473467 scopus 로고    scopus 로고
    • Paclitaxel induces up-regulation of tissue factor in human aortic endothelial cells
    • Wang HJ, Huang H, Chuang YC, Huang HC. Paclitaxel induces up-regulation of tissue factor in human aortic endothelial cells. Int Immunopharmacol 2009; 9:144-147.
    • (2009) Int Immunopharmacol , vol.9 , pp. 144-147
    • Wang, H.J.1    Huang, H.2    Chuang, Y.C.3    Huang, H.C.4
  • 20
    • 33746888276 scopus 로고    scopus 로고
    • Modulation of monocyte function by activated protein C, a natural anticoagulant
    • Stephenson DA, Toltl LJ, Beaudin S, Liaw PC. Modulation of monocyte function by activated protein C, a natural anticoagulant. J Immunol 2006; 177:2115-2122.
    • (2006) J Immunol , vol.177 , pp. 2115-2122
    • Stephenson, D.A.1    Toltl, L.J.2    Beaudin, S.3    Liaw, P.C.4
  • 21
    • 0034744328 scopus 로고    scopus 로고
    • Carboplatin pharmacokinetics in patients receiving carboplatin and paclitaxel/docetaxel for advanced lung cancers: Impact of age and renal function on area under the curve
    • Kern W, Braess J, Friedrichsen S, Kaufmann CC, Schleyer E, Hiddemann W. Carboplatin pharmacokinetics in patients receiving carboplatin and paclitaxel/docetaxel for advanced lung cancers: impact of age and renal function on area under the curve. J Cancer Res Clin Oncol 2001; 127:64-68.
    • (2001) J Cancer Res Clin Oncol , vol.127 , pp. 64-68
    • Kern, W.1    Braess, J.2    Friedrichsen, S.3    Kaufmann, C.C.4    Schleyer, E.5    Hiddemann, W.6
  • 22
    • 33745726210 scopus 로고    scopus 로고
    • Pharmacology of the paclitaxel-cisplatin, gemcitabine-cisplatin, and paclitaxel-gemcitabine combinations in patients with advanced nonsmall cell lung cancer
    • Kroep JR, Smit EF, Giaccone G, Van der Born K, Beijnen JH, Van Groeningen CJ, et al. Pharmacology of the paclitaxel-cisplatin, gemcitabine-cisplatin, and paclitaxel-gemcitabine combinations in patients with advanced nonsmall cell lung cancer. Cancer Chemother Pharmacol 2006; 58:509-516.
    • (2006) Cancer Chemother Pharmacol , vol.58 , pp. 509-516
    • Kroep, J.R.1    Smit, E.F.2    Giaccone, G.3    Van Der Born, K.4    Beijnen, J.H.5    Van Groeningen, C.J.6
  • 23
    • 0035174972 scopus 로고    scopus 로고
    • Specificity, diversity, and convergence in VEGF and TNF-alpha signaling events leading to tissue factor up-regulation via EGR-1 in endothelial cells
    • Mechtcheriakova D, Schabbauer G, Lucerna M, Clauss M, De Martin R, Binder BR, et al. Specificity, diversity, and convergence in VEGF and TNF-alpha signaling events leading to tissue factor up-regulation via EGR-1 in endothelial cells. FASEB J 2001; 15:230-242.
    • (2001) FASEB J , vol.15 , pp. 230-242
    • Mechtcheriakova, D.1    Schabbauer, G.2    Lucerna, M.3    Clauss, M.4    De Martin, R.5    Binder, B.R.6
  • 24
    • 0028327099 scopus 로고
    • Monocyte tissue factor induction by lipopolysaccharide (LPS): Dependence on LPS-binding protein and CD14, and inhibition by a recombinant fragment of bactericidal/permeability-increasing protein
    • Meszaros K, Aberle S, Dedrick R, Machovich R, Horwitz A, Birr C, et al. Monocyte tissue factor induction by lipopolysaccharide (LPS): dependence on LPS-binding protein and CD14, and inhibition by a recombinant fragment of bactericidal/permeability-increasing protein. Blood 1994; 83:2516-2525.
    • (1994) Blood , vol.83 , pp. 2516-2525
    • Meszaros, K.1    Aberle, S.2    Dedrick, R.3    MacHovich, R.4    Horwitz, A.5    Birr, C.6
  • 26
    • 79953304684 scopus 로고    scopus 로고
    • The chemotherapy metabolite acrolein upregulates thrombin generation and impairs the protein C anticoagulant pathway in animal-based and cell-based models
    • Swystun LL, Mukherjee S, Levine M, Liaw PC. The chemotherapy metabolite acrolein upregulates thrombin generation and impairs the protein C anticoagulant pathway in animal-based and cell-based models. J Thromb Haemost 2011; 9:767-775.
    • (2011) J Thromb Haemost , vol.9 , pp. 767-775
    • Swystun, L.L.1    Mukherjee, S.2    Levine, M.3    Liaw, P.C.4
  • 28
    • 0031043059 scopus 로고    scopus 로고
    • Pathophysiologic implications of membrane phospholipid asymmetry in blood cells
    • Zwaal RF, Schroit AJ. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood 1997; 89:1121-1132.
    • (1997) Blood , vol.89 , pp. 1121-1132
    • Zwaal, R.F.1    Schroit, A.J.2
  • 29
    • 0037567421 scopus 로고    scopus 로고
    • Exposure of platelet membrane phosphatidylserine regulates blood coagulation
    • Lentz BR. Exposure of platelet membrane phosphatidylserine regulates blood coagulation. Prog Lipid Res 2003; 42:423-438.
    • (2003) Prog Lipid Res , vol.42 , pp. 423-438
    • Lentz, B.R.1
  • 30
    • 84859801846 scopus 로고    scopus 로고
    • Tissue factor encryption and decryption: Facts and controversies
    • Rao LV, Kothari H, Pendurthi UR. Tissue factor encryption and decryption: facts and controversies. Thromb Res 2012; 129 (Suppl 2):S13-S17.
    • (2012) Thromb Res , vol.129 , pp. S13-S17
    • Rao, L.V.1    Kothari, H.2    Pendurthi, U.R.3
  • 31
    • 37049001668 scopus 로고    scopus 로고
    • Tissue factor activation: Is disulfide bond switching a regulatory mechanism?
    • Pendurthi UR, Ghosh S, Mandal SK, Rao LV. Tissue factor activation: is disulfide bond switching a regulatory mechanism? Blood 2007; 110:3900-3908.
    • (2007) Blood , vol.110 , pp. 3900-3908
    • Pendurthi, U.R.1    Ghosh, S.2    Mandal, S.K.3    Rao, L.V.4
  • 32
    • 34548494139 scopus 로고    scopus 로고
    • Tissue factor coagulant function is enhanced by protein-disulfide isomerase independent of oxidoreductase activity
    • Versteeg HH, Ruf W. Tissue factor coagulant function is enhanced by protein-disulfide isomerase independent of oxidoreductase activity. J Biol Chem 2007; 282:25416-25424.
    • (2007) J Biol Chem , vol.282 , pp. 25416-25424
    • Versteeg, H.H.1    Ruf, W.2
  • 33
    • 0036335923 scopus 로고    scopus 로고
    • Chemotherapy-induced activation of hemostasis: Effect of a low molecular weight heparin (dalteparin sodium) on plasma markers of hemostatic activation
    • Weitz IC, Israel VK, Waisman JR, Presant CA, Rochanda L, Liebman HA. Chemotherapy-induced activation of hemostasis: effect of a low molecular weight heparin (dalteparin sodium) on plasma markers of hemostatic activation. Thromb Haemost 2002; 88:213-220.
    • (2002) Thromb Haemost , vol.88 , pp. 213-220
    • Weitz, I.C.1    Israel, V.K.2    Waisman, J.R.3    Presant, C.A.4    Rochanda, L.5    Liebman, H.A.6
  • 34
    • 0031033222 scopus 로고    scopus 로고
    • Monocytes upregulate endothelial cell expression of tissue factor: A role for cell-cell contact and cross-talk
    • Napoleone E, Di Santo A, Lorenzet R. Monocytes upregulate endothelial cell expression of tissue factor: a role for cell-cell contact and cross-talk. Blood 1997; 89:541-549.
    • (1997) Blood , vol.89 , pp. 541-549
    • Napoleone, E.1    Di Santo, A.2    Lorenzet, R.3
  • 35
    • 79952615903 scopus 로고    scopus 로고
    • Defibrotide prevents the activation of macrovascular and microvascular endothelia caused by soluble factors released to blood by autologous hematopoietic stem cell transplantation
    • Palomo M, Diaz-Ricart M, Rovira M, Escolar G, Carreras E. Defibrotide prevents the activation of macrovascular and microvascular endothelia caused by soluble factors released to blood by autologous hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2011; 17:497-506.
    • (2011) Biol Blood Marrow Transplant , vol.17 , pp. 497-506
    • Palomo, M.1    Diaz-Ricart, M.2    Rovira, M.3    Escolar, G.4    Carreras, E.5
  • 36
    • 15744377185 scopus 로고    scopus 로고
    • Deep vein thrombosis
    • Kyrle PA, Eichinger S. Deep vein thrombosis. Lancet 2005; 365:1163-1174.
    • (2005) Lancet , vol.365 , pp. 1163-1174
    • Kyrle, P.A.1    Eichinger, S.2
  • 39
    • 77956533379 scopus 로고    scopus 로고
    • Extracellular protein disulfide isomerase regulates coagulation on endothelial cells through modulation of phosphatidylserine exposure
    • Popescu NI, Lupu C, Lupu G. Extracellular protein disulfide isomerase regulates coagulation on endothelial cells through modulation of phosphatidylserine exposure. Blood 2010; 116:993-1001.
    • (2010) Blood , vol.116 , pp. 993-1001
    • Popescu, N.I.1    Lupu, C.2    Lupu, G.3
  • 40
    • 40549121595 scopus 로고    scopus 로고
    • Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation
    • Reinhardt C, von Bruhl ML, Manukyan D, Grahl L, Lorenz M, Altmann B, et al. Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation. J Clin Invest 2008; 118:1110-1122.
    • (2008) J Clin Invest , vol.118 , pp. 1110-1122
    • Reinhardt, C.1    Von Bruhl, M.L.2    Manukyan, D.3    Grahl, L.4    Lorenz, M.5    Altmann, B.6
  • 41
    • 0033769891 scopus 로고    scopus 로고
    • Apoptosis induced by dithiothreitol in HL-60 cells shows early activation of caspase 3 and isindependent ofmitochondria
    • Tartier L, McCarey YL, Biaglow JE, Kochevar IE, Held KD. Apoptosis induced by dithiothreitol in HL-60 cells shows early activation of caspase 3 and isindependent ofmitochondria. Cell Death Differ 2000; 7:1002-1010.
    • (2000) Cell Death Differ , vol.7 , pp. 1002-1010
    • Tartier, L.1    McCarey, Y.L.2    Biaglow, J.E.3    Kochevar, I.E.4    Held, K.D.5
  • 43
    • 0032169105 scopus 로고    scopus 로고
    • Cellular and molecular determinants of cisplatin resistance
    • Perez RP. Cellular and molecular determinants of cisplatin resistance. Eur J Cancer 1998; 34:1535-1542.
    • (1998) Eur J Cancer , vol.34 , pp. 1535-1542
    • Perez, R.P.1
  • 44
    • 0032947768 scopus 로고    scopus 로고
    • Review of the comparative pharmacology and clinical activity of cisplatin and carboplatin
    • Go RS, Adjei AA. Review of the comparative pharmacology and clinical activity of cisplatin and carboplatin. J Clin Oncol 1999; 17:409-422.
    • (1999) J Clin Oncol , vol.17 , pp. 409-422
    • Go, R.S.1    Adjei, A.A.2
  • 45
    • 0022504572 scopus 로고
    • The relationship between cisplatin sensitivity and drug uptake into mammalian cells in vitro
    • Eichholtz-Wirth H, Hietel B. The relationship between cisplatin sensitivity and drug uptake into mammalian cells in vitro. Br J Cancer 1986; 54:239-243.
    • (1986) Br J Cancer , vol.54 , pp. 239-243
    • Eichholtz-Wirth, H.1    Hietel, B.2
  • 46
    • 2542422438 scopus 로고    scopus 로고
    • Structure, recognition, and processing of cisplatin-DNA adducts
    • Jamieson ER, Lippard SJ. Structure, recognition, and processing of cisplatin-DNA adducts. Chem Rev 1999; 99:2467-2498.
    • (1999) Chem Rev , vol.99 , pp. 2467-2498
    • Jamieson, E.R.1    Lippard, S.J.2
  • 48
    • 0026516994 scopus 로고
    • Mechanism of action of taxol
    • Horwitz SB. Mechanism of action of taxol. Trends Pharmacol Sci 1992; 13:134-136.
    • (1992) Trends Pharmacol Sci , vol.13 , pp. 134-136
    • Horwitz, S.B.1
  • 49
    • 0034283773 scopus 로고    scopus 로고
    • Comparison of 2-methoxyestradiol-induced, docetaxel-induced, and paclitaxel-induced apoptosis in hepatoma cells and its correlation with reactive oxygen species
    • Lin HL, Liu TY, Chau GY, Lui WY, Chi CW. Comparison of 2-methoxyestradiol-induced, docetaxel-induced, and paclitaxel-induced apoptosis in hepatoma cells and its correlation with reactive oxygen species. Cancer 2000; 89:983-994.
    • (2000) Cancer , vol.89 , pp. 983-994
    • Lin, H.L.1    Liu, T.Y.2    Chau, G.Y.3    Lui, W.Y.4    Chi, C.W.5
  • 50
    • 79959956124 scopus 로고    scopus 로고
    • Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism
    • Donadelli M, Dando I, Zaniboni T, Costanzo C, Dalla Pozza E, Scupoli MT, et al. Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism. Cell Death Dis 2011; 2:e152.
    • (2011) Cell Death Dis , vol.2 , pp. e152
    • Donadelli, M.1    Dando, I.2    Zaniboni, T.3    Costanzo, C.4    Dalla Pozza, E.5    Scupoli, M.T.6
  • 51
    • 61349196954 scopus 로고    scopus 로고
    • Base excision repair of reactive oxygen species-initiated 7, 8-dihydro-8-oxo-2'-deoxyguanosine inhibits the cytotoxicity of platinum anticancer drugs
    • Preston TJ, Henderson JT, McCallum GP, Wells PG. Base excision repair of reactive oxygen species-initiated 7, 8-dihydro-8-oxo-2'-deoxyguanosine inhibits the cytotoxicity of platinum anticancer drugs. Mol Cancer Ther 2009; 8:2015-2026.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2015-2026
    • Preston, T.J.1    Henderson, J.T.2    McCallum, G.P.3    Wells, P.G.4
  • 52
    • 34249828179 scopus 로고    scopus 로고
    • Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs
    • Swanton C, Marani M, Pardo O, Warne PH, Kelly G, Sahai E, et al. Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs. Cancer Cell 2007; 11:498-512.
    • (2007) Cancer Cell , vol.11 , pp. 498-512
    • Swanton, C.1    Marani, M.2    Pardo, O.3    Warne, P.H.4    Kelly, G.5    Sahai, E.6
  • 53
    • 29244454269 scopus 로고    scopus 로고
    • Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis
    • Nawrocki ST, Carew JS, Pino MS, Highshaw RA, Dunner K Jr, Huang P, et al. Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis.Cancer Res 2005;65:11658-11666.
    • (2005) Cancer Res , vol.65 , pp. 11658-11666
    • Nawrocki, S.T.1    Carew, J.S.2    Pino, M.S.3    Highshaw, R.A.4    Dunner, Jr.K.5    Huang, P.6


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