Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer

British Journal of Pharmacology

Volumn 171, Issue 19, 2014, Pages 4478-4489

  Wang, Minghua ^a,b   Shim, Joong Sup ^b,c   Li, Ruo Jing ^b,d,e   Dang, Yongjun ^b   He, Qingli ^b   Das, Manisha ^b   Liu, Jun O ^b  

^a SOOCHOW UNIVERSITY   (China)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c University of Macau   (Macao)

^d BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^e FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; CLOFOCTOL; INOSITOL REQUIRING ENZYME 1; PROTEIN KINASE R; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; CRESOL; DNA BINDING PROTEIN; REGULATORY FACTOR X TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL PROLIFERATION; CELL VACUOLE; CONTROLLED STUDY; DRUG EFFICACY; ENDOPLASMIC RETICULUM STRESS; G1 PHASE CELL CYCLE CHECKPOINT; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; TOXICITY TESTING; TRANSLATION REGULATION; TUMOR GROWTH; UNFOLDED PROTEIN RESPONSE; ANIMAL; CELL CYCLE; CELL SURVIVAL; DRUG EFFECTS; DRUG SCREENING; GENETICS; HUMAN; METABOLISM; NUDE MOUSE; PATHOLOGY; PROSTATIC NEOPLASMS; TUMOR CELL LINE; TUMOR VOLUME;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; CRESOLS; DNA-BINDING PROTEINS; HUMANS; MALE; MICE, NUDE; PROSTATIC NEOPLASMS; TRANSCRIPTION FACTORS; TUMOR BURDEN; UNFOLDED PROTEIN RESPONSE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84920794090     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12800     Document Type: Article

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