Different protein expression associated with chemotherapy response in oropharyngeal cancer according to HPV status

BMC Cancer

Volumn 14, Issue 1, 2014, Pages

  Kim, Min Jee ^a   Ki, Myung Seo ^a   Kim, Karham ^a   Shim, Hyun Jeong ^a   Hwang, Jun Eul ^a   Bae, Woo Kyun ^a   Chung, Ik Joo ^a   Lee, Dong Hoon ^a   Lee, Joon Kyoo ^a   Yoon, Tae Mi ^a   Lim, Sang Chul ^a   Chung, Woong Ki ^a   Jeong, Jae Uk ^a   Lim, Hoi Soon ^a   Choi, Yoo Duk ^a   Cho, Sang Hee ^a  

^a Chonnam National University Research Institute of Medical Sciences   (South Korea)

Author keywords

bcl 2; Beta tubulin; Chemotherapy; HPV; Oropharyngeal cancer; p16; p53

Indexed keywords

BETA TUBULIN; CISPLATIN; DOCETAXEL; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; FLUOROURACIL; PROTEIN BCL 2; PROTEIN P16; PROTEIN P53; ANTINEOPLASTIC AGENT; DNA BINDING PROTEIN; ENDONUCLEASE; ERCC1 PROTEIN, HUMAN; TUBULIN; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INDUCTION CHEMOTHERAPY; MAJOR CLINICAL STUDY; MALE; OROPHARYNX CANCER; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PAPILLOMAVIRUS INFECTION; POLYMERASE CHAIN REACTION; PROGRESSION FREE SURVIVAL; PROTEIN EXPRESSION; CANCER GRADING; GENETICS; METABOLISM; MIDDLE AGED; MORTALITY; MULTIMODALITY CANCER THERAPY; OROPHARYNGEAL NEOPLASMS; PAPILLOMAVIRIDAE; PATHOLOGY; RISK FACTOR; TREATMENT OUTCOME; VERY ELDERLY; VIROLOGY;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COMBINED MODALITY THERAPY; DNA-BINDING PROTEINS; ENDONUCLEASES; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM STAGING; OROPHARYNGEAL NEOPLASMS; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PROTO-ONCOGENE PROTEINS C-BCL-2; RISK FACTORS; TREATMENT OUTCOME; TUBULIN; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84920759574     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-824     Document Type: Article

References (34)

1. Frisch M, Hjalgrim H, Jaeger AB, Biggar RJ: Changing patterns of tonsillar squamous cell carcinoma in the United States. Cancer Causes Control 2000, 11(6):489-495.
2. Nasman A, Attner P, Hammarstedt L, Du J, Eriksson M, Giraud G, Ahrlund-Richter S, Marklund L, Romanitan M, Lindquist D, Ramqvist T, Lindholm J, Sparén P, Ye W, Dahlstrand H, Munck-Wikland E, Dalianis T: Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma? Int J Cancer 2009, 125(2):362-366.
3. Shin A, Jung YS, Jung KW, Kim K, Ryu J, Won YJ: Trends of human papillomavirus-related head and neck cancers in Korea: national cancer registry data. Laryngoscope 2013, 123(11):E30-E37.
4. Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tan PF, Westra WH, Chung CH, Jordan RC, Lu C, Kim H, Axelrod R, Silverman CC, Redmond KP, Gillison ML: Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 2010, 363(1):24-35.
5. Fakhry C, Westra WH, Li S, Cmelak A, Ridge JA, Pinto H, Forastiere A, Gillison ML: Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 2008, 100(4):261-269.
6. Ragin CC, Taioli E: Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis. Int J Cancer 2007, 121(8):1813-1820.
7. Robinson M, Sloan P, Shaw R: Refining the diagnosis of oropharyngeal squamous cell carcinoma using human papillomavirus testing. Oral Oncol 2010, 46(7):492-496.
8. Westra TA, Parouty M, Brouwer WB, Beutels PH, Rogoza RM, Rozenbaum MH, Daemen T, Wilschut JC, Boersma C, Postma MJ: On discounting of health gains from human papillomavirus vaccination: effects of different approaches. Value Health 2012, 15(3):562-567.
9. Chung CH, Gillison ML: Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications. Clin Cancer Res 2009, 15(22):6758-6762.
10. Braakhuis BJ, Snijders PJ, Keune WJ, Meijer CJ, Ruijter-Schippers HJ, Leemans CR, Brakenhoff RH: Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus. J Natl Cancer Inst 2004, 96(13):998-1006.
11. Butz K, Geisen C, Ullmann A, Spitkovsky D, Hoppe-Seyler F: Cellular responses of HPV-positive cancer cells to genotoxic anti-cancer agents: repression of E6/E7-oncogene expression and induction of apoptosis. Int J Cancer 1996, 68(4):506-513.
12. Bristow RG, Benchimol S, Hill RP: The p53 gene as a modifier of intrinsic radiosensitivity: implications for radiotherapy. Radiother Oncol 1996, 40(3):197-223.
13. Olthof NC, Straetmans JM, Snoeck R, Ramaekers FC, Kremer B, Speel EJ: Next-generation treatment strategies for human papillomavirus-related head and neck squamous cell carcinoma: where do we go? Rev Med Virol 2012, 22(2):88-105.
14. Vermorken JB, Remenar E, Van Herpen C, Gorlia T, Mesia R, Degardin M, Stewart JS, Jelic S, Betka J, Preiss JH, van den Weyngaert D, Awada A, Cupissol D, Kienzer HR, Rey A, Desaunois I, Bernier J, Lefebvre JL, EORTC 24971/TAX 323 Study Group: Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer. N Engl J Med 2007, 357(17):1695-1704.
15. Posner MR, Hershock DM, Blajman CR, Mickiewicz E, Winquist E, Gorbounova V, Tjulandin S, Shin DM, Cullen K, Ervin TJ, Murphy BA, Raez LE, Cohen RB, Spaulding M, Tishler RB, Roth B, Viroglio Rdel C, Venkatesan V, Romanov I, Agarwala S, Harter KW, Dugan M, Cmelak A, Markoe AM, Read PW, Steinbrenner L, Colevas AD, Norris CM Jr, Haddad RI, TAX 324 Study Group: Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med 2007, 357(17):1705-1715.
16. Temam S, Flahault A, Perie S, Monceaux G, Coulet F, Callard P, Bernaudin JF, St Guily JL, Fouret P: p53 gene status as a predictor of tumor response to induction chemotherapy of patients with locoregionally advanced squamous cell carcinomas of the head and neck. J Clin Oncol 2000, 18(2):385-394.
17. Shinohara S, Kikuchi M, Tona R, Kanazawa Y, Kishimoto I, Harada H, Imai Y, Usami Y: Prognostic impact of p16 and p53 expression in oropharyngeal squamous cell carcinomas. Jpn J Clin Oncol 2014, 44(3):232-240.
18. Koh Y, Kim TM, Jeon YK, Kwon TK, Hah JH, Lee SH, Kim DW, Wu HG, Rhee CS, Sung MW, Kim CW, Kim KH, Heo DS: Class III beta-tubulin, but not ERCC1, is a strong predictive and prognostic marker in locally advanced head and neck squamous cell carcinoma. Ann Oncol 2009, 20(8):1414-1419.
19. Olaussen KA, Dunant A, Fouret P, Brambilla E, Andre F, Haddad V, Taranchon E, Filipits M, Pirker R, Popper HH, Stahel R, Sabatier L, Pignon JP, Tursz T, Le Chevalier T, Soria JC, IALT Bio Investigators: DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy. N Engl J Med 2006, 355(10):983-991.
20. Hwang JE, Hong JY, Kim K, Kim SH, Choi WY, Kim MJ, Jung SH, Shim HJ, Bae WK, Hwang EC, Lee KH, Lee JH, Cho SH, Chung IJ: Class III beta-tubulin is a predictive marker for taxane-based chemotherapy in recurrent and metastatic gastric cancer. BMC Cancer 2013, 13:431.
21. Pena JC, Thompson CB, Recant W, Vokes EE, Rudin CM: Bcl-xL and Bcl-2 expression in squamous cell carcinoma of the head and neck. Cancer 1999, 85(1):164-170.
22. Greene FL: The American joint committee on cancer: updating the strategies in cancer staging. Bull Am Coll Surg 2002, 87(7):13-15.
23. Romero-Pastrana F: Detection and typing of human papilloma virus by multiplex PCR with type-specific primers. ISRN Microbiol 2012, 2012:186915.
24. Begum S, Gillison ML, Ansari-Lari MA, Shah K, Westra WH: Detection of human papillomavirus in cervical lymph nodes: a highly effective strategy for localizing site of tumor origin. Clin Cancer Res 2003, 9(17):6469-6475.
25. Cullen KJ, Schumaker L, Nikitakis N, Goloubeva O, Tan M, Sarlis NJ, Haddad RI, Posner MR: Beta-Tubulin-II expression strongly predicts outcome in patients receiving induction chemotherapy for locally advanced squamous carcinoma of the head and neck: a companion analysis of the TAX 324 trial. J Clin Oncol 2009, 27(36):6222-6228.
26. Peltenburg LT: Radiosensitivity of tumor cells. Oncogenes and apoptosis. Q J Nucl Med 2000, 44(4):355-364.
27. Zhang HL, Ruan L, Zheng LM, Whyte D, Tzeng CM, Zhou XW: Association between class III beta-tubulin expression and response to paclitaxel/vinorebine-based chemotherapy for non-small cell lung cancer: a meta-analysis. Lung Cancer 2012, 77(1):9-15.
28. Real PJ, Sierra A, De Juan A, Segovia JC, Lopez-Vega JM, Fernandez-Luna JL: Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells. Oncogene 2002, 21(50):7611-7618.
29. Kamesaki S, Kamesaki H, Jorgensen TJ, Tanizawa A, Pommier Y, Cossman J: Bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced DNA strand breaks and their repair. Cancer Res 1993, 53(18):4251-4256.
30. Nix P, Cawkwell L, Patmore H, Greenman J, Stafford N: Bcl-2 expression predicts radiotherapy failure in laryngeal cancer. Br J Cancer 2005, 92(12):2185-2189.
31. Jeong SH, Jung JH, Han JH, Kim JH, Choi YW, Lee HW, Kang SY, Hwang YH, Ahn MS, Choi JH, Oh YT, Chun M, Kang S, Park KJ, Hwang SC, Sheen SS: Expression of Bcl-2 predicts outcome in locally advanced non-small cell lung cancer patients treated with cisplatin-based concurrent chemoradiotherapy. Lung Cancer 2010, 68(2):288-294.
32. Ritchie JM, Smith EM, Summersgill KF, Hoffman HT, Wang D, Klussmann JP, Turek LP, Haugen TH: Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx. Int J Cancer 2003, 104(3):336-344.
33. Gronhoj Larsen C, Gyldenlove M, Jensen DH, Therkildsen MH, Kiss K, Norrild B, Konge L, Von Buchwald C: Correlation between human papillomavirus and p16 overexpression in oropharyngeal tumours: a systematic review. Br J Cancer 2014, 110(6):1587-1594.
34. Marur S, D'Souza G, Westra WH, Forastiere AA: HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol 2010, 11(8):781-789.