Physical activity below the minimum international recommendations improves oxidative stress, ADMA levels, resting heart rate and small artery endothelial function

Clinica e Investigacion en Arteriosclerosis

Volumn 27, Issue 1, 2015, Pages 9-16

  Merino, J ^a,b   Ferre R ^a,b   Girona, J ^a,b   Aguas, D ^c   Cabre A ^a,b   Plana, N ^a,b   Vinuesa, A ^d,e   Ibarretxe, D ^a,b   Basora, J ^d,e   Buixadera, C ^a,b   Masana, L ^a,b  

^a HOSPITAL UNIVERSITARI SANT JOAN DE REUS   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c Ajuntament de Reus   (Spain)

^d INSTITUT CATALÀ DE LA SALUT   (Spain)

^e INSTITUT UNIVERSITARI D'INVESTIGACIÓ EN ATENCIÓ PRIMÀRIA JORDI GOL   (Spain)

Author keywords

ADMA; Oxidative stress; Physical activity; Small artery endothelial function

Indexed keywords

GLUTATHIONE PEROXIDASE; N(G),N(G) DIMETHYLARGININE; OXIDIZED LOW DENSITY LIPOPROTEIN; SUPEROXIDE DISMUTASE; ANTIOXIDANT; ARGININE; N,N-DIMETHYLARGININE;

ADULT; ARTICLE; AUGMENTATION INDEX; CARDIOVASCULAR PARAMETERS; CARDIOVASCULAR RISK; CLINICAL TRIAL; DIGITAL ARTERY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC EQUIVALENT; OBESITY; OXIDATIVE STRESS; PERIPHERAL ARTERY TONOMETRY; PHYSICAL ACTIVITY; PULSE WAVE; RESTING HEART RATE; SMALL ARTERY REACTIVE HYPEREMIA INDEX; TONOMETER; TONOMETRY; WEIGHT REDUCTION; AGED; ANALOGS AND DERIVATIVES; BLOOD; CARDIOVASCULAR DISEASES; COMPLICATION; HEART RATE; METABOLISM; MIDDLE AGED; MOTOR ACTIVITY; MULTIVARIATE ANALYSIS; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

AGED; ANTIOXIDANTS; ARGININE; CARDIOVASCULAR DISEASES; ENDOTHELIUM, VASCULAR; FEMALE; HEART RATE; HUMANS; MALE; MIDDLE AGED; MOTOR ACTIVITY; MULTIVARIATE ANALYSIS; OBESITY; OVERWEIGHT; OXIDATIVE STRESS;

EID: 84920741709     PISSN: 02149168     EISSN: 15781879     Source Type: Journal    
DOI: 10.1016/j.arteri.2014.04.004     Document Type: Article

References (30)

1. Kones R. Primary prevention of coronary heart disease: integration of new data, evolving views, revised goals, and role of rosuvastatin in management. A comprehensive survey. Drug Des Devel Ther 2011, 5:325-380.
2. Mora S., Cook N., Buring J.E., Ridker P.M., Lee I.M. Physical activity and reduced risk of cardiovascular events: potential mediating mechanisms. Circulation 2007, 116:2110-2118.
3. Physical activity guidelines for Americans. Okla Nurse 2008, 53:25.
4. Physical Activity Guidelines Advisory Committee report, 2008 To the Secretary of Health and Human Services. Part A: executive summary. Nutr Rev 2009, 67:114-120.
5. Hambrecht R., Fiehn E., Weigl C., Gielen S., Hamann C., Kaiser R., et al. Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation 1998, 98:2709-2715.
6. DeSouza C.A., Shapiro L.F., Clevenger C.M., Dinenno F.A., Monahan K.D., Tanaka H., et al. Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation 2000, 102:1351-1357.
7. Newsholme P., Homem De Bittencourt P.I., O'Hagan C., De Vito G., Murphy C., Krause M.S. Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide. Clin Sci (Lond) 2009, 118:341-349.
8. Sibal L., Agarwal S.C., Home P.D., Boger R.H. The Role of Asymmetric Dimethylarginine (ADMA) in endothelial dysfunction and cardiovascular disease. Curr Cardiol Rev 2010, 6:82-90.
9. Pellegrin M., Alonso F., Aubert J.F., Bouzourene K., Braunersreuther V., Mach F., et al. Swimming prevents vulnerable atherosclerotic plaque development in hypertensive 2-kidney, 1-clip mice by modulating angiotensin II type 1 receptor expression independently from hemodynamic changes. Hypertension 2009, 53:782-789.
10. Gomes V.A., Casella-Filho A., Chagas A.C., Tanus-Santos J.E. Enhanced concentrations of relevant markers of nitric oxide formation after exercise training in patients with metabolic syndrome. Nitric Oxide 2008, 19:345-350.
11. Pierce G.L., Eskurza I., Walker A.E., Fay T.N., Seals D.R. Sex-specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults. Clin Sci (Lond) 2011, 120:13-23.
12. Goel R., Majeed F., Vogel R., Corretti M.C., Weir M., Mangano C., et al. Exercise-induced hypertension, endothelial dysfunction, and coronary artery disease in a marathon runner. Am J Cardiol 2007, 99:743-744.
13. Crouch R., Wilson A., Newbury J. A systematic review of the effectiveness of primary health education or intervention programs in improving rural women's knowledge of heart disease risk factors and changing lifestyle behaviours. Int J Evid Based Healthc 2011, 9:236-245.
14. Ferre R., Plana N., Merino J., Aragones G., Girona J., Heras M., et al. Effects of therapeutic lifestyle changes on peripheral artery tonometry in patients with abdominal obesity. Nutr Metab Cardiovasc Dis 2012, 22:95-102.
15. Elosua R., Garcia M., Aguilar A., Molina L., Covas M.I., Marrugar J., et al. Validation of the Minnesota leisure time physical activity questionnaire in Spanish women. Med Sci Sports Exerc 2000, 32:1431-1437.
16. Panagiotakos D.B., Pitsavos C., Arvaniti F., Stefanidis C. Adherence to the Mediterranean food pattern predicts the prevalence of hypertension, hypercholesterolemia, diabetes and obesity, among healthy adults; the accuracy of the MedDietScore. Prev Med 2007, 44:335-340.
17. DiClemente C.C., Prochaska J.O., Fairhurst S.K., Velicer W.F., Velasquez M.M., Rossi J.S. The process of smoking cessation: an analysis of precontemplation, contemplation, and preparation stages of change. J Consult Clin Psychol 1991, 59:295-304.
18. Hamburg N.M., Keyes M.J., Larson M.G., Vasan R.S., Schnabel R., Pryde M.M., et al. Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study. Circulation 2008, 117:2467-2474.
19. Vlachos I.S., Hatziioannou A., Perelas A., Perea D.N. Sonographic assessment of regional adiposity. Am J Roentgenol 2007, 189:1545-1553.
20. Pansini F., Cervellati C., Guariento A., Stacchini M.A., Castaldini C., Bernardi A., et al. Oxidative stress, body fat composition, and endocrine status in pre- and postmenopausal women. Menopause 2008, 15:112-118.
21. Wycherley T.P., Brinkworth G.D., Noakes M., Buckley J.D., Clifton P.M. Effect of caloric restriction with and without exercise training on oxidative stress and endothelial function in obese subjects with type 2 diabetes. Diabetes Obes Metab 2008, 10:1062-1073.
22. Earnest C.P., Lavie C.J., Blair S.N., Church T.S. Heart rate variability characteristics in sedentary postmenopausal women following six months of exercise training: the DREW study. PLoS ONE 2008, 3:e2288.
23. Bemelmans R.H., van der Graaf Y., Nathoe H.M., Wassink A.M., Vernooij J.W., Spiering W., et al. Increased visceral adipose tissue is associated with increased resting heart rate in patients with manifest vascular disease. Obesity (Silver Spring) 2012, 20:834-841.
24. Pou K.M., Massaro J.M., Hoffmann U., Vasan R.S., Maurovich-Horvat P., Larson M.G., et al. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation 2007, 116:1234-1241.
25. Lazaro I., Ferre R., Plana N., Aragones G., Girona J., Merino J., et al. Lifestyle changes lower FABP4 plasma concentration in patients with cardiovascular risk. Rev Esp Cardiol 2012, 65:152-157.
26. Schlager O., Giurgea A., Schuhfried O., Seidinger D., Hammer A., Groger M., et al. Exercise training increases endothelial progenitor cells and decreases asymmetric dimethylarginine in peripheral arterial disease: a randomized controlled trial. Atherosclerosis 2011, 217:240-248.
27. Custodis F., Baumhakel M., Schlimmer N., List F., Gensch C., Bohm M., et al. Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice. Circulation 2008, 117:2377-2387.
28. Drouin A., Gendron M.E., Thorin E., Gillis M.A., Mahlberg-Gaudin F., Tardif J.C., et al. Chronic heart rate reduction by ivabradine prevents endothelial dysfunction in dyslipidaemic mice. Br J Pharmacol 2008, 154:749-757.
29. Heusch G., Skyschally A., Gres P., van Caster P., Schilawa D., Schulz R. Improvement of regional myocardial blood flow and function and reduction of infarct size with ivabradine: protection beyond heart rate reduction. Eur Heart J 2008, 29:2265-2275.
30. Thorin E., Thorin-Trescases N. Vascular endothelial ageing, heartbeat after heartbeat. Cardiovasc Res 2009, 84:24-32.