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Volumn 125, Issue 1, 2015, Pages 102-110

Upregulation of FγRIIb on monocytes is necessary to promote the superagonist activity of TGN1412

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR IIB; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; OKT 3; TGN 1412; TUMOR NECROSIS FACTOR ALPHA; CD28 ANTIGEN; CYTOKINE; FC RECEPTOR; MONOCLONAL ANTIBODY; TGN-1412 MONOCLONAL ANTIBODY;

EID: 84920569758     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-08-593061     Document Type: Article
Times cited : (48)

References (32)
  • 1
    • 33748416499 scopus 로고    scopus 로고
    • Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
    • Suntharalingam G, Perry MR, Ward S, et al. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med. 2006;355(10):1018-1028.
    • (2006) N Engl J Med. , vol.355 , Issue.10 , pp. 1018-1028
    • Suntharalingam, G.1    Perry, M.R.2    Ward, S.3
  • 2
    • 84897979659 scopus 로고    scopus 로고
    • Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412/TAB08
    • Tabares P, Berr S, Römer PS, et al. Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412/TAB08. Eur J Immunol. 2014;44(4): 1225-1236.
    • (2014) Eur J Immunol. , vol.44 , Issue.4 , pp. 1225-1236
    • Tabares, P.1    Berr, S.2    Römer, P.S.3
  • 3
    • 84864279250 scopus 로고    scopus 로고
    • Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice
    • Gogishvili T, Langenhorst D, Lühder F, et al. Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice. PLoS ONE. 2009;4(2):e4643.
    • (2009) PLoS ONE , vol.4 , Issue.2
    • Gogishvili, T.1    Langenhorst, D.2    Lühder, F.3
  • 4
    • 0042505740 scopus 로고    scopus 로고
    • Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists
    • Lühder F, Huang Y, Dennehy KM, et al. Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists. J Exp Med. 2003;197(8):955-966.
    • (2003) J Exp Med. , vol.197 , Issue.8 , pp. 955-966
    • Lühder, F.1    Huang, Y.2    Dennehy, K.M.3
  • 5
    • 77956304908 scopus 로고    scopus 로고
    • Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells
    • Eastwood D, Findlay L, Poole S, et al. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells. Br J Pharmacol. 2010; 161(3):512-526.
    • (2010) Br J Pharmacol. , vol.161 , Issue.3 , pp. 512-526
    • Eastwood, D.1    Findlay, L.2    Poole, S.3
  • 6
    • 37749032491 scopus 로고    scopus 로고
    • "Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: Better understanding the causes to improve preclinical testing of immunotherapeutics
    • Stebbings R, Findlay L, Edwards C, et al. "Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics. J Immunol. 2007;179(5): 3325-3331.
    • (2007) J Immunol. , vol.179 , Issue.5 , pp. 3325-3331
    • Stebbings, R.1    Findlay, L.2    Edwards, C.3
  • 7
    • 84880688741 scopus 로고    scopus 로고
    • Severity of the TGN1412 trial disaster cytokine storm correlated with IL-2 release
    • Eastwood D, Bird C, Dilger P, et al. Severity of the TGN1412 trial disaster cytokine storm correlated with IL-2 release. Br J Clin Pharmacol. 2013; 76(2):299-315.
    • (2013) Br J Clin Pharmacol. , vol.76 , Issue.2 , pp. 299-315
    • Eastwood, D.1    Bird, C.2    Dilger, P.3
  • 9
    • 84255160968 scopus 로고    scopus 로고
    • Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412
    • Römer PS, Berr S, Avota E, et al. Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412. Blood. 2011; 118(26):6772-6782.
    • (2011) Blood , vol.118 , Issue.26 , pp. 6772-6782
    • Römer, P.S.1    Berr, S.2    Avota, E.3
  • 10
    • 84896514032 scopus 로고    scopus 로고
    • Cell contact-dependent priming and fc interaction with CD32+ immune cells contribute to the TGN1412-triggered cytokine response
    • Bartholomaeus P, Semmler LY, Bukur T, et al. Cell contact-dependent priming and Fc interaction with CD32+ immune cells contribute to the TGN1412-triggered cytokine response. J Immunol. 2014;192(5):2091-2098.
    • (2014) J Immunol. , vol.192 , Issue.5 , pp. 2091-2098
    • Bartholomaeus, P.1    Semmler, L.Y.2    Bukur, T.3
  • 11
    • 84876385896 scopus 로고    scopus 로고
    • A human ICAM-1 antibody isolated by a function-first approach has potent macrophage-dependent antimyeloma activity in vivo
    • Veitonmaki N, Hansson M, Zhan F, et al. A human ICAM-1 antibody isolated by a function-first approach has potent macrophage-dependent antimyeloma activity in vivo. Cancer Cell. 2013; 23(4):502-515.
    • (2013) Cancer Cell. , vol.23 , Issue.4 , pp. 502-515
    • Veitonmaki, N.1    Hansson, M.2    Zhan, F.3
  • 12
    • 0023616796 scopus 로고
    • Preparation and performance of bispecific F(ab' gamma)2 antibody containing thioether-linked fab' gamma fragments
    • Glennie MJ, McBride HM, Worth AT, Stevenson GT. Preparation and performance of bispecific F(ab' gamma)2 antibody containing thioether-linked Fab' gamma fragments. J Immunol. 1987; 139(7):2367-2375.
    • (1987) J Immunol. , vol.139 , Issue.7 , pp. 2367-2375
    • Glennie, M.J.1    McBride, H.M.2    Worth, A.T.3    Stevenson, G.T.4
  • 13
    • 47749135829 scopus 로고    scopus 로고
    • Induction of cytosolic calcium flux by CD20 is dependent upon B cell antigen receptor signaling
    • Walshe CA, Beers SA, French RR, et al. Induction of cytosolic calcium flux by CD20 is dependent upon B Cell antigen receptor signaling. J Biol Chem. 2008;283(25):16971-16984.
    • (2008) J Biol Chem. , vol.283 , Issue.25 , pp. 16971-16984
    • Walshe, C.A.1    Beers, S.A.2    French, R.R.3
  • 14
    • 0033998434 scopus 로고    scopus 로고
    • Autonomous induction of proliferation, JNK and NF-alphaB activation in primary resting T cells by mobilized CD28
    • Bischof A, Hara T, Lin CH, Beyers AD, Hünig T. Autonomous induction of proliferation, JNK and NF-alphaB activation in primary resting T cells by mobilized CD28. Eur J Immunol. 2000;30(3): 876-882.
    • (2000) Eur J Immunol. , vol.30 , Issue.3 , pp. 876-882
    • Bischof, A.1    Hara, T.2    Lin, C.H.3    Beyers, A.D.4    Hünig, T.5
  • 15
    • 0031034123 scopus 로고    scopus 로고
    • CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: Evidence for functionally distinct forms of CD28
    • Tacke M, Hanke G, Hanke T, Hünig T. CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: evidence for functionally distinct forms of CD28. Eur J Immunol. 1997; 27(1):239-247.
    • (1997) Eur J Immunol. , vol.27 , Issue.1 , pp. 239-247
    • Tacke, M.1    Hanke, G.2    Hanke, T.3    Hünig, T.4
  • 16
    • 0026492077 scopus 로고
    • On the interaction of IgG subclasses with the low affinity fc gamma RIIa (CD32) on human monocytes, neutrophils, and platelets. Analysis of a functional polymorphism to human IgG2
    • Parren PW, Warmerdam PA, Boeije LC, et al. On the interaction of IgG subclasses with the low affinity Fc gamma RIIa (CD32) on human monocytes, neutrophils, and platelets. Analysis of a functional polymorphism to human IgG2. J Clin Invest. 1992;90(4):1537-1546.
    • (1992) J Clin Invest. , vol.90 , Issue.4 , pp. 1537-1546
    • Parren, P.W.1    Warmerdam, P.A.2    Boeije, L.C.3
  • 17
    • 49649117477 scopus 로고    scopus 로고
    • Selective expansion of memory CD4(+) T cells by mitogenic human CD28 generates inflammatory cytokines and regulatory T cells
    • Singh M, Basu S, Camell C, et al. Selective expansion of memory CD4(+) T cells by mitogenic human CD28 generates inflammatory cytokines and regulatory T cells. Eur J Immunol. 2008;38(6):1522-1532.
    • (2008) Eur J Immunol. , vol.38 , Issue.6 , pp. 1522-1532
    • Singh, M.1    Basu, S.2    Camell, C.3
  • 18
    • 0026544070 scopus 로고
    • Characterization of IgG FcR-mediated proliferation of human T cells induced by mouse and human anti-CD3 monoclonal antibodies. Identification of a functional polymorphism to human IgG2 anti-CD3
    • Parren PW, Warmerdam PA, Boeije LC, Capel PJ, van de Winkel JG, Aarden LA. Characterization of IgG FcR-mediated proliferation of human T cells induced by mouse and human anti-CD3 monoclonal antibodies. Identification of a functional polymorphism to human IgG2 anti-CD3. J Immunol. 1992;148(3):695-701.
    • (1992) J Immunol. , vol.148 , Issue.3 , pp. 695-701
    • Parren, P.W.1    Warmerdam, P.A.2    Boeije, L.C.3    Capel, P.J.4    Van De Winkel, J.G.5    Aarden, L.A.6
  • 19
    • 34249341152 scopus 로고    scopus 로고
    • Monoclonal antibodies capable of discriminating the human inhibitory fcgamma-receptor IIB (CD32B) from the activating fcgamma-receptor IIA (CD32A): Biochemical, biological and functional characterization
    • Veri MC, Gorlatov S, Li H, et al. Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization. Immunology. 2007;121(3): 392-404.
    • (2007) Immunology. , vol.121 , Issue.3 , pp. 392-404
    • Veri, M.C.1    Gorlatov, S.2    Li, H.3
  • 20
    • 84888357068 scopus 로고    scopus 로고
    • Antitumor activities of agonistic anti-TNFR antibodies require differential FCγRIIB coengagement in vivo
    • Li F, Ravetch JV. Antitumor activities of agonistic anti-TNFR antibodies require differential FCγRIIB coengagement in vivo. Proc Natl Acad Sci USA. 2013;110(48):19501-19506.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.48 , pp. 19501-19506
    • Li, F.1    Ravetch, J.V.2
  • 21
    • 84958532861 scopus 로고    scopus 로고
    • FCγRIIB as a key determinant of agonistic antibody efficacy
    • White AL, Beers SA, Cragg MS. FCγRIIB as a key determinant of agonistic antibody efficacy. Curr Top Microbiol Immunol. 2014;382:355-372.
    • (2014) Curr Top Microbiol Immunol. , vol.382 , pp. 355-372
    • White, A.L.1    Beers, S.A.2    Cragg, M.S.3
  • 22
    • 84863594998 scopus 로고    scopus 로고
    • Apoptotic and antitumor activity of death receptor antibodies require inhibitory FCγ receptor engagement
    • Li F, Ravetch JV. Apoptotic and antitumor activity of death receptor antibodies require inhibitory FCγ receptor engagement. Proc Natl Acad Sci USA. 2012;109(27):10966-10971.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.27 , pp. 10966-10971
    • Li, F.1    Ravetch, J.V.2
  • 23
    • 80051925907 scopus 로고    scopus 로고
    • Interaction with FCγRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody
    • White AL, Chan HT, Roghanian A, et al. Interaction with FCγRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody. J Immunol. 2011;187(4):1754-1763.
    • (2011) J Immunol. , vol.187 , Issue.4 , pp. 1754-1763
    • White, A.L.1    Chan, H.T.2    Roghanian, A.3
  • 25
    • 0037191792 scopus 로고    scopus 로고
    • Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes
    • Stefanová I, Dorfman JR, Germain RN. Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature. 2002; 420(6914):429-434.
    • (2002) Nature , vol.420 , Issue.6914 , pp. 429-434
    • Stefanová, I.1    Dorfman, J.R.2    Germain, R.N.3
  • 26
    • 84871122818 scopus 로고    scopus 로고
    • Antibody C region influences TGN1412-like functional activity in vitro
    • Ball C, Fox B, Hufton S, et al. Antibody C region influences TGN1412-like functional activity in vitro. J Immunol. 2012;189(12):5831-5840.
    • (2012) J Immunol. , vol.189 , Issue.12 , pp. 5831-5840
    • Ball, C.1    Fox, B.2    Hufton, S.3
  • 28
    • 29144443587 scopus 로고    scopus 로고
    • Molecular analysis of expression and function of hFcgammaRIIbl and b2 isoforms in myeloid cells
    • Joshi T, Ganesan LP, Cao X, Tridandapani S. Molecular analysis of expression and function of hFcgammaRIIbl and b2 isoforms in myeloid cells. Mol Immunol. 2006;43(7):839-850.
    • (2006) Mol Immunol. , vol.43 , Issue.7 , pp. 839-850
    • Joshi, T.1    Ganesan, L.P.2    Cao, X.3    Tridandapani, S.4
  • 29
    • 65549114676 scopus 로고    scopus 로고
    • Specificity and affinity of human fcgamma receptors and their polymorphic variants for human IgG subclasses
    • Bruhns P, Iannascoli B, England P, et al. Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses. Blood. 2009;113(16): 3716-3725.
    • (2009) Blood , vol.113 , Issue.16 , pp. 3716-3725
    • Bruhns, P.1    Iannascoli, B.2    England, P.3
  • 30
    • 84905992571 scopus 로고    scopus 로고
    • FCγ receptor dependency of agonistic CD40 antibody in lymphoma therapy can be overcome through antibody multimerization
    • White AL, Dou L, Chan HT, et al. FCγ receptor dependency of agonistic CD40 antibody in lymphoma therapy can be overcome through antibody multimerization. J Immunol. 2014; 193(4):1828-1835.
    • (2014) J Immunol. , vol.193 , Issue.4 , pp. 1828-1835
    • White, A.L.1    Dou, L.2    Chan, H.T.3
  • 31
    • 0024380811 scopus 로고
    • Fc receptor isoforms exhibit distinct abilities for coated pit localization as a result of cytoplasmic domain heterogeneity
    • Prepublished on 1989/07/28 as DOI [pii]
    • Miettinen HM, Rose JK, Mellman I. Fc receptor isoforms exhibit distinct abilities for coated pit localization as a result of cytoplasmic domain heterogeneity. Cell. 1989;58(2):317-327. Prepublished on 1989/07/28 as DOI 0092-8674(89)90846-5 [pii].
    • (1989) Cell. , vol.58 , Issue.2 , pp. 317-327
    • Miettinen, H.M.1    Rose, J.K.2    Mellman, I.3
  • 32
    • 0028032257 scopus 로고
    • Tyrosine-containing sequence motifs of the human immunoglobulin G receptors FcRIIb1 and FcRIIb2 essential for endocytosis and regulation of calcium flux in B cells
    • Budde P, Bewarder N, Weinrich V, Schulzeck O, Frey J. Tyrosine-containing sequence motifs of the human immunoglobulin G receptors FcRIIb1 and FcRIIb2 essential for endocytosis and regulation of calcium flux in B cells. J Biol Chem. 1994;269(48):30636-30644.
    • (1994) J Biol Chem. , vol.269 , Issue.48 , pp. 30636-30644
    • Budde, P.1    Bewarder, N.2    Weinrich, V.3    Schulzeck, O.4    Frey, J.5


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