Clinical implication of urinary tubular markers in the early stage of nephropathy with type 2 diabetic patients

Diabetes Research and Clinical Practice

Volumn 97, Issue 2, 2012, Pages 251-257

  Kim, Sang Soo ^a   Song, Sang Heon ^a   Kim, In Joo ^a   Yang, Ji Young ^a   Lee, Jeong Gyu ^a   Kwak, Ihm Soo ^a   Kim, Yong Ki ^b  

^a Pusan National University Hospital   (South Korea)

^b Kim Yong Ki Internal Medicine Clinic   (South Korea)

Author keywords

Albuminuria; Diabetic nephropathy; Kidney tubule; Type 2 diabetes mellitus

Indexed keywords

ANGIOTENSINOGEN; BIOLOGICAL MARKER; FATTY ACID BINDING PROTEIN; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 18; KIDNEY INJURY MOLECULE 1; LIVER TYPE FATTY ACID BINDING PROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; AGE; ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETIC NEPHROPATHY; DIABETIC PATIENT; DIABETIC RETINOPATHY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE SEVERITY; FEMALE; GENDER; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY FUNCTION; MACROALBUMINURIA; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; NON INSULIN DEPENDENT DIABETES MELLITUS; PREDICTIVE VALUE; PROTEIN URINE LEVEL; SYSTOLIC BLOOD PRESSURE;

ACUTE-PHASE PROTEINS; ALBUMINURIA; ANGIOTENSINOGEN; BIOLOGICAL MARKERS; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; FATTY ACID-BINDING PROTEINS; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; INTERLEUKIN-18; KIDNEY TUBULES; LIPOCALINS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; PROTO-ONCOGENE PROTEINS; RECEPTORS, VIRUS; RISK FACTORS;

EID: 84865065019     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2012.02.019     Document Type: Article

References (34)

1. American Diabetes association Standards of medical care in diabetes-2011. Diabetes Care 2011, 34(Suppl 1):S11-S61.
2. Narita T., Hosoba M., Kakei M., Ito S. Increased urinary excretions of immunoglobulin G, ceruloplasmin, and transferrin predict development of microalbuminuria in patients with type 2 diabetes. Diabetes Care 2006, 29:142-144.
3. Garg J.P., Bakris G.L. Microalbuminuria: marker of vascular dysfunction, risk factor for cardiovascular disease. Vasc Med 2002, 7:35-43.
4. Barratt J., Topham P. Urine proteomics: the present and future of measuring urinary protein components in disease. CMAJ 2007, 177:361-368.
5. Cohen M.P., Lautenslager G.T., Shearman C.W. Increased collagen IV excretion in diabetes. A marker of compromised filtration function. Diabetes Care 2001, 24:914-918.
6. Retnakaran R., Cull C.A., Thorne K.I., Adler A.I., Holman R.R. Risk factors for renal dysfunction in type 2 diabetes: U.K. Prospective Diabetes Study 74. Diabetes 2006, 55:1832-1839.
7. Bangstad H.J., Seljeflot I., Berg T.J., Hanssen K.F. Renal tubulointerstitial expansion is associated with endothelial dysfunction and inflammation in type 1 diabetes. Scand J Clin Lab Invest 2009, 69:138-144.
8. Phillips A.O., Steadman R. Diabetic nephropathy: the central role of renal proximal tubular cells in tubulointerstitial injury. Histol Histopathol 2002, 17:247-252.
9. Wolkow P.P., Niewczas M.A., Perkins B., Ficociello L.H., Lipinski B., Warram J.H., et al. Association of urinary inflammatory markers and renal decline in microalbuminuric type 1 diabetics. J Am Soc Nephrol 2008, 19:789-797.
10. Thomas M.C., Burns W.C., Cooper M.E. Tubular changes in early diabetic nephropathy. Adv Chronic Kidney Dis 2005, 12:177-186.
11. Han W.K., Wagener G., Zhu Y., Wang S., Lee H.T. Urinary biomarkers in the early detection of acute kidney injury after cardiac surgery. Clin J Am Soc Nephrol 2009, 4:873-882.
12. Haase M., Bellomo R., Devarajan P., Schlattmann P., Haase-Fielitz A. Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis 2009, 54:1012-1024.
13. Bagshaw S.M., Bellomo R. Early diagnosis of acute kidney injury. Curr Opin Crit Care 2007, 13:638-644.
14. Jeon Y.K., Kim M.R., Huh J.E., Mok J.Y., Song S.H., Kim S.S., et al. Cystatin C as an early biomarker of nephropathy in patients with type 2 diabetes. J Korean Med Sci 2001, 26:258-263.
15. Nielsen S.E., Schjoedt K.J., Astrup A.S., Tarnow L., Lajer M., Hansen P.R., et al. Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule 1 (KIM1) in patients with diabetic nephropathy: a cross-sectional study and the effects of lisinopril. Diabet Med 2010, 27:1144-1150.
16. Bolignano D., Lacquaniti A., Coppolino G., Donato V., Fazio M.R., Nicocia G., et al. Neutrophil gelatinase-associated lipocalin as an early biomarker of nephropathy in diabetic patients. Kidney Blood Press Res 2009, 32:91-98.
17. Nielsen S.E., Schjoedt K.J., Astrup A.S., Tarnow L., Lajer M., Hansen P.R., et al. Tubular markers do not predict the decline in glomerular filtration rate in type 1 diabetic patients with overt nephropathy. Kidney Int 2001, 79:1113-1118.
18. Vaidya V.S., Niewczas M.A., Ficociello L.H., Johnson A.C., Collings F.B., Warram J.H., et al. Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-beta-d-glucosaminidase. Kidney Int 2011, 79:464-470.
19. Nauta F.L., Boertien W.E., Bakker S.J., van Goor H., van Oeveren W., de Jong P.E., et al. Glomerular and tubular damage markers are elevated in patients with diabetes. Diabetes Care 2011, 34:975-981.
20. Nielsen S.E., Sugaya T., Hovind P., Baba T., Parving H.H., Rossing P. Urinary liver-type fatty acid-binding protein predicts progression to nephropathy in type 1 diabetic patients. Diabetes Care 2010, 33:1320-1324.
21. Kamijo-Ikemori A., Sugaya T., Yasuda T., Kawata T., Ota A., Tatsunami S., et al. Clinical significance of urinary liver-type fatty acid-binding protein in diabetic nephropathy of type 2 diabetic patients. Diabetes Care 2011, 34:691-696.
22. Myers G.L., Miller W.G., Coresh J., Fleming J., Greenberg N., Greene T., et al. Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program. Clin Chem 2006, 52:5-18.
23. Nakamura A., Shikata K., Hiramatsu M., Nakatou T., Kitamura T., Wada J., et al. Serum interleukin-18 levels are associated with nephropathy and atherosclerosis in Japanese patients with type 2 diabetes. Diabetes Care 2005, 28:2890-2895.
24. Miyauchi K., Takiyama Y., Honjyo J., Tateno M., Haneda M. Upregulated IL-18 expression in type 2 diabetic subjects with nephropathy: TGF-beta1 enhanced IL-18 expression in human renal proximal tubular epithelial cells. Diabetes Res Clin Pract 2009, 83:190-199.
25. Zhang H., Hile K.L., Asanuma H., Vanderbrink B., Franke E.I., Campbell M.T., et al. IL-18 mediates proapoptotic signaling in renal tubular cells through a Fas ligand-dependent mechanism. Am J Physiol Renal Physiol 2011, 301:F171-F178.
26. Leehey D.J., Singh A.K., Alavi N., Singh R. Role of angiotensin II in diabetic nephropathy. Kidney Int Suppl 2000, 77:S93-S98.
27. Saito T., Urushihara M., Kotani Y., Kagami S., Kobori H. Increased urinary angiotensinogen is precedent to increased urinary albumin in patients with type 1 diabetes. Am J Med Sci 2009, 338:478-480.
28. Liu F., Brezniceanu M.L., Wei C.C., Chenier I., Sachetelli S., Zhang S.L., et al. Overexpression of angiotensinogen increases tubular apoptosis in diabetes. J Am Soc Nephrol 2011, 19:269-280.
29. Visavadiya N.P., Li Y., Wang S. High glucose upregulates upstream stimulatory factor 2 in human renal proximal tubular cells through angiotensin II-dependent activation of CREB. Nephron Exp Nephrol 2011, 117:e62-e70.
30. Abbate M., Zoja C., Remuzzi G. How does proteinuria cause progressive renal damage?. J Am Soc Nephrol 2006, 17:2974-2984.
31. Zoja C., Garcia P.B., Remuzzi G. The role of chemokines in progressive renal disease. Front Biosci 2009, 14:1815-1822.
32. Nejat M., Hill J.V., Pickering J.W., Edelstein C.L., Devarajan P., Endre Z.H. Albuminuria increases cystatin C excretion: implications for urinary biomarkers. Nephrol Dial Transplant 2011, May 5 [Epub ahead of print].
33. Hvidberg V., Jacobsen C., Strong R.K., Cowland J.B., Moestrup S.K., Borregaard N. The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. FEBS Lett 2005, 579:773-777.
34. Oyama Y., Takeda T., Hama H., Tanuma A., Iino N., Sato K., et al. Evidence for megalin-mediated proximal tubular uptake of L-FABP, a carrier of potentially nephrotoxic molecules. Lab Invest 2005, 85:522-531.