Miropin, a novel bacterial serpin from the periodontopathogen Tannerella forsythia, inhibits a broad range of proteases by using different peptide bonds within the reactive center loop

Journal of Biological Chemistry

Volumn 290, Issue 1, 2015, Pages 658-670

  Ksiazek, Miroslaw ^a   Mizgalska, Danuta ^a   Enghild, Jan J ^b,c   Scavenius, Carsten ^b,c   Thogersen, Ida B ^b,c   Potempa, Jan ^a,d  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b AARHUS UNIVERSITY   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

^d UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BACTERIA; STOICHIOMETRY;

ASSOCIATION RATE CONSTANTS; BROAD SPECIFICITIES; HUMAN PATHOGENS; PRIMARY STRUCTURES; REACTIVE CENTER LOOPS; SERINE PROTEASE; STOICHIOMETRY OF INHIBITIONS; VIRULENCE FACTORS;

RATE CONSTANTS;

BACTERIAL PROTEIN; CATHEPSIN D; CATHEPSIN G; MIROPIN; PANCREATIC ELASTASE; PROTEINASE; SUBTILISIN; TRYPSIN; UNCLASSIFIED DRUG; CTSG PROTEIN, HUMAN; LEUKOCYTE ELASTASE; RECOMBINANT PROTEIN; SERINE PROTEINASE INHIBITOR;

ARTICLE; BINDING AFFINITY; CHEMICAL BOND; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SPECIFICITY; FEEDBACK SYSTEM; GINGIVA DISEASE; HUMAN; HUMAN CELL; INFLAMMATION; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PERIODONTITIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MICROARRAY; PROTEIN PURIFICATION; PROTEIN STRUCTURE; REACTIVE CENTER LOOP; STOICHIOMETRY; TANNERELLA FORSYTHIA; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; BACTEROIDETES; CHEMISTRY; ESCHERICHIA COLI; GENE EXPRESSION; GENETICS; KINETICS; METABOLISM; MICROBIOLOGY; MOLECULAR GENETICS; PERIODONTAL POCKET; SEQUENCE ALIGNMENT; THERMODYNAMICS;

BACTERIA (MICROORGANISMS); FORSYTHIA; PROKARYOTA; TANNERELLA FORSYTHENSIS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BACTEROIDETES; CATALYTIC DOMAIN; CATHEPSIN G; ESCHERICHIA COLI; GENE EXPRESSION; HUMANS; KINETICS; LEUKOCYTE ELASTASE; MOLECULAR SEQUENCE DATA; PERIODONTAL POCKET; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SERINE PROTEINASE INHIBITORS; SERPINS; SUBSTRATE SPECIFICITY; SUBTILISIN; THERMODYNAMICS; TRYPSIN;

EID: 84920520300     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.601716     Document Type: Article

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