Detection of low prevalence somatic mutations in solid tumors with ultra-deep targeted sequencing

Genome Biology

Volumn 12, Issue 12, 2011, Pages

  Harismendy, Olivier ^a,b   Schwab, Richard B ^a   Bao, Lei ^a   Olson, Jeff ^c   Rozenzhak, Sophie ^a,b   Kotsopoulos, Steve K ^c   Pond, Stephanie ^d   Crain, Brian ^a   Chee, Mark S ^d   Messer, Karen ^a   Link, Darren R ^c   Frazer, Kelly A ^a,b,e  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b RADY CHILDREN'S HOSPITAL   (United States)

^c RainDance Technologies   (United States)

^d Prognosys Biosciences   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; ADULT; AGED; ARTICLE; BREAST CANCER; COLON CANCER; CONTROLLED STUDY; GENE IDENTIFICATION; GENE SEQUENCE; GENE TARGETING; GENETIC SCREENING; HUMAN; HUMAN TISSUE; MUTATIONAL ANALYSIS; ONCOGENE; OVARY CANCER; PERFORMANCE MEASUREMENT SYSTEM; PROCESS DESIGN; PROCESS DEVELOPMENT; SARCOMA; SENSITIVITY AND SPECIFICITY; SOLID TUMOR; SOMATIC MUTATION; ULTRA DEEP TARGETED SEQUENCING; VALIDATION STUDY; ANIMAL; CARCINOMA; DNA SEQUENCE; DRUG SCREENING; GENETIC DATABASE; GENETICS; HIGH THROUGHPUT SEQUENCING; LABORATORY AUTOMATION; METHODOLOGY; MIDDLE AGED; MOUSE; MUTATION; MUTATION RATE; TUMOR GENE;

AGED; ANIMALS; AUTOMATION, LABORATORY; CARCINOMA; DATABASES, GENETIC; GENES, NEOPLASM; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MICE; MIDDLE AGED; MUTATION; MUTATION RATE; SARCOMA; SENSITIVITY AND SPECIFICITY; SEQUENCE ANALYSIS, DNA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 83655211930     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/gb-2011-12-12-r124     Document Type: Article

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