Highly viscous antibody solutions are a consequence of network formation caused by domain-domain electrostatic complementarities: Insights from coarse-grained simulations

Molecular Pharmaceutics

Volumn 12, Issue 1, 2015, Pages 127-139

  Buck, Patrick M ^a   Chaudhri, Anuj ^b   Kumar, Sandeep ^a   Singh, Satish K ^a  

^a PFIZER INC   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

coarse grained simulations; drug development; high concentration; mAb; v iscosity

Indexed keywords

MONOCLONAL ANTIBODY; ANTIBODY; IMMUNOGLOBULIN G; SOLUTION AND SOLUBILITY;

ANTIBODY STRUCTURE; ARTICLE; BIOPROCESS; CHEMICAL PARAMETERS; COARSE GRAINED SIMULATION; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTAL STRUCTURE; DENSITY; DIFFUSION COEFFICIENT; DRUG CONFORMATION; DRUG DELIVERY SYSTEM; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR SIZE; MOLECULAR WEIGHT; PARTICLE SIZE; PROTEIN DOMAIN; PROTEIN FUNCTION; SHEAR STRESS; STATIC ELECTRICITY; SURFACE CHARGE; SURFACE PROPERTY; VISCOSITY; CHEMISTRY; DIFFUSION; HUMAN; MATERIALS TESTING; PH; PROTEIN TERTIARY STRUCTURE; SOLUTION AND SOLUBILITY;

ANTIBODIES; ANTIBODIES, MONOCLONAL; DIFFUSION; DRUG DELIVERY SYSTEMS; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; MATERIALS TESTING; MOLECULAR DYNAMICS SIMULATION; PHARMACEUTICAL SOLUTIONS; PROTEIN STRUCTURE, TERTIARY; STATIC ELECTRICITY; SURFACE PROPERTIES; VISCOSITY;

EID: 84920502737     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500485w     Document Type: Article

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