메뉴 건너뛰기




Volumn 35, Issue 1, 2015, Pages 31-38

The anti-hypertensive drug prazosin induces apoptosis in the medullary thyroid carcinoma cell line TT

Author keywords

Apoptosis; Cell culture; Medullary thyroid carcinoma; Prazosin; Quinazolines; 1 adrenergic receptors

Indexed keywords

CASPASE 3; CASPASE 7; PRAZOSIN; ALPHA 1 ADRENERGIC RECEPTOR; ANTIHYPERTENSIVE AGENT; ANTINEOPLASTIC AGENT;

EID: 84920441963     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (17)

References (36)
  • 3
    • 0034163301 scopus 로고    scopus 로고
    • Medullary thyroid carcinoma: Clinical characteristics, treatment, prognostic factors, and a comparison of staging systems
    • Kebebew E, Ituarte PH, Siperstein AE, Duh QY and Clark OH: Medullary thyroid carcinoma: clinical characteristics, treatment, prognostic factors, and a comparison of staging systems. Cancer 88: 1139-1148, 2000.
    • (2000) Cancer , vol.88 , pp. 1139-1148
    • Kebebew, E.1    Ituarte, P.H.2    Siperstein, A.E.3    Duh, Q.Y.4    Clark, O.H.5
  • 4
    • 18344380647 scopus 로고    scopus 로고
    • Molecular genetics of multiple endocrine neoplasia types 1 and 2
    • Marx SJ: Molecular genetics of multiple endocrine neoplasia types 1 and 2. Nat Rev Cancer 5: 367-375, 2005.
    • (2005) Nat Rev Cancer , vol.5 , pp. 367-375
    • Marx, S.J.1
  • 5
    • 78650412305 scopus 로고    scopus 로고
    • Targeting RET receptor tyrosine kinase activation in cancer
    • Phay JE and Shah MH: Targeting RET receptor tyrosine kinase activation in cancer. Clin Cancer Res 16: 5936-5941, 2010.
    • (2010) Clin Cancer Res , vol.16 , pp. 5936-5941
    • Phay, J.E.1    Shah, M.H.2
  • 8
    • 84876244382 scopus 로고    scopus 로고
    • Christia vespertilionis plant extracts as novel antiproliferative agent against human neuroendocrine tumor cells
    • Hofer D, Schwach G, Ghaffari Tabrizi-Wizsy N, Sadjak A, Sturm S, Stuppner H and Pfragner R: Christia vespertilionis plant extracts as novel antiproliferative agent against human neuroendocrine tumor cells. Oncol Rep 29: 2219-2226, 2013.
    • (2013) Oncol Rep , vol.29 , pp. 2219-2226
    • Hofer, D.1    Schwach, G.2    Ghaffari Tabrizi-Wizsy, N.3    Sadjak, A.4    Sturm, S.5    Stuppner, H.6    Pfragner, R.7
  • 10
    • 0016767906 scopus 로고
    • Adrenergic and cholinergic receptors in the human prostate, prostatic capsule and bladder neck
    • Caine M, Raz S and Zeigler M: Adrenergic and cholinergic receptors in the human prostate, prostatic capsule and bladder neck. Brit J Urol 47: 193-202, 1975.
    • (1975) Brit J Urol , vol.47 , pp. 193-202
    • Caine, M.1    Raz, S.2    Zeigler, M.3
  • 11
    • 0018165637 scopus 로고
    • A placebo-controlled double-blind study of the effect of phenoxybenzamine in benign prostatic obstruction
    • Caine M, Perlberg S and Meretyk S: A placebo-controlled double-blind study of the effect of phenoxybenzamine in benign prostatic obstruction. Brit J Urol 50: 551-554, 1978.
    • (1978) Brit J Urol , vol.50 , pp. 551-554
    • Caine, M.1    Perlberg, S.2    Meretyk, S.3
  • 12
    • 0032426688 scopus 로고    scopus 로고
    • Induction of prostate apoptosis by doxazosin in benign prostatic hyperplasia
    • Kyprianou N, Litvak JP, Borkowski A, Alexander R and Jacobs SC: Induction of prostate apoptosis by doxazosin in benign prostatic hyperplasia. J Urology 159: 1810-1815, 1998.
    • (1998) J Urology , vol.159 , pp. 1810-1815
    • Kyprianou, N.1    Litvak, J.P.2    Borkowski, A.3    Alexander, R.4    Jacobs, S.C.5
  • 13
    • 0037079614 scopus 로고    scopus 로고
    • Quinazoline-derived alpha1-adrenoceptor antagonists induce prostate cancer cell apoptosis via an alpha1-adrenoceptor-independent action
    • Benning CM and Kyprianou N: Quinazoline-derived alpha1-adrenoceptor antagonists induce prostate cancer cell apoptosis via an alpha1-adrenoceptor-independent action. Cancer Res 62: 597-602, 2002.
    • (2002) Cancer Res , vol.62 , pp. 597-602
    • Benning, C.M.1    Kyprianou, N.2
  • 14
    • 69249218041 scopus 로고    scopus 로고
    • The alpha1-adrenergic receptor antagonists, benoxathian and prazosin, induce apoptosis and a switch towards megakaryocytic differentiation in human erythroleukemia cells
    • Fuchs R, Stelzer I, Haas HS, Leitinger G, Schauenstein K and Sadjak A: The alpha1-adrenergic receptor antagonists, benoxathian and prazosin, induce apoptosis and a switch towards megakaryocytic differentiation in human erythroleukemia cells. Ann Hematol 88: 989-997, 2009.
    • (2009) Ann Hematol , vol.88 , pp. 989-997
    • Fuchs, R.1    Stelzer, I.2    Haas, H.S.3    Leitinger, G.4    Schauenstein, K.5    Sadjak, A.6
  • 15
    • 80051796256 scopus 로고    scopus 로고
    • Alpha1-Adrenergic drugs modulate differentiation and cell death of human erythroleukemia cells through non adrenergic mechanism
    • Fuchs R, Schraml E, Leitinger G, Stelzer I, Allard N, Haas HS, Schauenstein K and Sadjak A: alpha1-Adrenergic drugs modulate differentiation and cell death of human erythroleukemia cells through non adrenergic mechanism. Exp Cell Res 317: 2239-2251, 2011.
    • (2011) Exp Cell Res , vol.317 , pp. 2239-2251
    • Fuchs, R.1    Schraml, E.2    Leitinger, G.3    Stelzer, I.4    Allard, N.5    Haas, H.S.6    Schauenstein, K.7    Sadjak, A.8
  • 16
    • 82555190951 scopus 로고    scopus 로고
    • Alpha1-adrenergic drugs exhibit affinity to a thapsigargin-sensitive binding site and interfere with the intracellular Ca2+ homeostasis in human erythroleukemia cells
    • Fuchs R, Schraml E, Leitinger G, Letofsky-Papst I, Stelzer I, Haas HS, Schauenstein K and Sadjak A: alpha1-adrenergic drugs exhibit affinity to a thapsigargin-sensitive binding site and interfere with the intracellular Ca2+ homeostasis in human erythroleukemia cells. Exp Cell Res 317: 2969-2980, 2011.
    • (2011) Exp Cell Res , vol.317 , pp. 2969-2980
    • Fuchs, R.1    Schraml, E.2    Leitinger, G.3    Letofsky-Papst, I.4    Stelzer, I.5    Haas, H.S.6    Schauenstein, K.7    Sadjak, A.8
  • 17
    • 28144434596 scopus 로고    scopus 로고
    • Alpha1-adrenergic receptor antagonists: Novel therapy for pituitary adenomas
    • Fernando MA and Heaney AP: Alpha1-adrenergic receptor antagonists: novel therapy for pituitary adenomas. Mol Endocrinol 19: 3085-3096, 2005.
    • (2005) Mol Endocrinol , vol.19 , pp. 3085-3096
    • Fernando, M.A.1    Heaney, A.P.2
  • 18
    • 37149057007 scopus 로고    scopus 로고
    • The alpha1-adrenergic receptor antagonist doxazosin inhibits EGFR and NF-kappaB signalling to induce breast cancer cell apoptosis
    • Hui H, Fernando MA and Heaney AP: The alpha1-adrenergic receptor antagonist doxazosin inhibits EGFR and NF-kappaB signalling to induce breast cancer cell apoptosis. Eur J Cancer 44: 160-166, 2008.
    • (2008) Eur J Cancer , vol.44 , pp. 160-166
    • Hui, H.1    Fernando, M.A.2    Heaney, A.P.3
  • 19
    • 27944474670 scopus 로고    scopus 로고
    • Growth inhibitory effect of doxazosin on prostate and bladder cancer cells is the serotonin receptor pathway involved?
    • Siddiqui EJ, Shabbir M, Thompson CS, Mumtaz FH and Mikhailidis DP: Growth inhibitory effect of doxazosin on prostate and bladder cancer cells. Is the serotonin receptor pathway involved? Anticancer Res 25: 4281-4286, 2005.
    • (2005) Anticancer Res , vol.25 , pp. 4281-4286
    • Siddiqui, E.J.1    Shabbir, M.2    Thompson, C.S.3    Mumtaz, F.H.4    Mikhailidis, D.P.5
  • 20
    • 84875899823 scopus 로고    scopus 로고
    • Naftopidil induces apoptosis in malignant mesothelioma cell lines independently of alpha1-adrenoceptor blocking
    • Masachika E, Kanno T, Nakano T, Gotoh A and Nishizaki T: Naftopidil induces apoptosis in malignant mesothelioma cell lines independently of alpha1-adrenoceptor blocking. Anticancer Res 33: 887-894, 2013.
    • (2013) Anticancer Res , vol.33 , pp. 887-894
    • Masachika, E.1    Kanno, T.2    Nakano, T.3    Gotoh, A.4    Nishizaki, T.5
  • 21
    • 35448965498 scopus 로고    scopus 로고
    • Prazosin displays anticancer activity against human prostate cancers: Targeting DNA and cell cycle
    • Lin SC, Chueh SC, Hsiao CJ, Li TK, Chen TH, Liao CH, Lyu PC and Guh JH: Prazosin displays anticancer activity against human prostate cancers: targeting DNA and cell cycle. Neoplasia 9: 830-839, 2007.
    • (2007) Neoplasia , vol.9 , pp. 830-839
    • Lin, S.C.1    Chueh, S.C.2    Hsiao, C.J.3    Li, T.K.4    Chen, T.H.5    Liao, C.H.6    Lyu, P.C.7    Guh, J.H.8
  • 22
    • 34249017339 scopus 로고    scopus 로고
    • Biocompatibility of ultra-high molecular weight polyethylene (UHMW-PE) stabilized with alpha-tocopherol used for joint endoprostheses assessed in vitro
    • Wolf C, Lederer K, Pfragner R, Schauenstein K, Ingolic E and Siegl V: Biocompatibility of ultra-high molecular weight polyethylene (UHMW-PE) stabilized with alpha-tocopherol used for joint endoprostheses assessed in vitro. J Mater Sci 18: 1247-1252, 2007.
    • (2007) J Mater Sci , vol.18 , pp. 1247-1252
    • Wolf, C.1    Lederer, K.2    Pfragner, R.3    Schauenstein, K.4    Ingolic, E.5    Siegl, V.6
  • 23
    • 0000373736 scopus 로고
    • Techniques for the preservation of threedimensional structure in preparing specimens for the electron microscope
    • Anderson TF: Techniques for the preservation of threedimensional structure in preparing specimens for the electron microscope. Trans NY Acad Sci 13: 130-134, 1951.
    • (1951) Trans NY Acad Sci , vol.13 , pp. 130-134
    • Anderson, T.F.1
  • 25
    • 14444275786 scopus 로고    scopus 로고
    • Improved treatment of medullary thyroid cancer in a nude mouse model by combined radioimmunochemotherapy: Doxorubicin potentiates the therapeutic efficacy of radiolabeled antibodies in a radioresistant tumor type
    • Behr TM, Wulst E, Radetzky S, Blumenthal RD, Dunn RM, Gratz S, Rave-Frank M, Schmidberger H, Raue F and Becker W: Improved treatment of medullary thyroid cancer in a nude mouse model by combined radioimmunochemotherapy: doxorubicin potentiates the therapeutic efficacy of radiolabeled antibodies in a radioresistant tumor type. Cancer Res 57: 5309-5319, 1997.
    • (1997) Cancer Res , vol.57 , pp. 5309-5319
    • Behr, T.M.1    Wulst, E.2    Radetzky, S.3    Blumenthal, R.D.4    Dunn, R.M.5    Gratz, S.6    Rave-Frank, M.7    Schmidberger, H.8    Raue, F.9    Becker, W.10
  • 26
    • 0028216255 scopus 로고
    • Increased voltage-dependent calcium influx produced by alpha 1Badrenergic receptor activation in rat medullary thyroid carcinoma 6-23 cells
    • Esbenshade TA, Theroux TL and Minneman KP: Increased voltage-dependent calcium influx produced by alpha 1Badrenergic receptor activation in rat medullary thyroid carcinoma 6-23 cells. Mol Pharmacol 45: 591-598, 1994.
    • (1994) Mol Pharmacol , vol.45 , pp. 591-598
    • Esbenshade, T.A.1    Theroux, T.L.2    Minneman, K.P.3
  • 27
    • 0030022723 scopus 로고    scopus 로고
    • Norepinephrine induced calcitonin secretion in rat medullary thyroid carcinoma 6-23 cells: Interaction between intracellular calcium and cAMP
    • Zink-Lorenz A, Komitowska J and Raue F: Norepinephrine induced calcitonin secretion in rat medullary thyroid carcinoma 6-23 cells: interaction between intracellular calcium and cAMP. Exp Clin Endocrinol Diabetes 104: 43-49, 1996.
    • (1996) Exp Clin Endocrinol Diabetes , vol.104 , pp. 43-49
    • Zink-Lorenz, A.1    Komitowska, J.2    Raue, F.3
  • 28
    • 84859560882 scopus 로고    scopus 로고
    • Role of mitochondrial Ca2+ in the regulation of cellular energetics
    • Glancy B and Balaban RS: Role of mitochondrial Ca2+ in the regulation of cellular energetics. Biochemistry 51: 2959-2973, 2012.
    • (2012) Biochemistry , vol.51 , pp. 2959-2973
    • Glancy, B.1    Balaban, R.S.2
  • 29
    • 33749352630 scopus 로고    scopus 로고
    • Endoplasmic reticulum vacuolization and valosin-containing protein relocalization result from simultaneous hsp90 inhibition by geldanamycin and proteasome inhibition by velcade
    • Mimnaugh EG, Xu W, Vos M, Yuan X and Neckers L: Endoplasmic reticulum vacuolization and valosin-containing protein relocalization result from simultaneous hsp90 inhibition by geldanamycin and proteasome inhibition by velcade. Mol Cancer Res 4: 667-681, 2006.
    • (2006) Mol Cancer Res , vol.4 , pp. 667-681
    • Mimnaugh, E.G.1    Xu, W.2    Vos, M.3    Yuan, X.4    Neckers, L.5
  • 30
    • 3042544502 scopus 로고    scopus 로고
    • Massive cell vacuolization induced by organic amines such as procainamide
    • Morissette G, Moreau E, R CG and Marceau F: Massive cell vacuolization induced by organic amines such as procainamide. J Pharmacol Exp Ther 310: 395-406, 2004.
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 395-406
    • Morissette, G.1    Moreau, E.2    Cg, R.3    Marceau, F.4
  • 31
    • 79951909508 scopus 로고    scopus 로고
    • Design of tablets for the delayed and complete release of poorly water-soluble weak base drugs using SBE7M-beta-CD as a solubilizing agent
    • Rao VM, Zannou EA and Stella VJ: Design of tablets for the delayed and complete release of poorly water-soluble weak base drugs using SBE7M-beta-CD as a solubilizing agent. J Pharm Sci 100: 1576-1587, 2011.
    • (2011) J Pharm Sci , vol.100 , pp. 1576-1587
    • Rao, V.M.1    Zannou, E.A.2    Stella, V.J.3
  • 33
    • 0032461042 scopus 로고    scopus 로고
    • Effects of alprostadil and prazosin on motility, viability and membrane integrity of human sperm
    • Hellstrom WJ, Wang R, Peterson CA, Varady JC, Gesundheit N and Sikka SC: Effects of alprostadil and prazosin on motility, viability and membrane integrity of human sperm. J Urology 159: 1559-1562, 1998.
    • (1998) J Urology , vol.159 , pp. 1559-1562
    • Hellstrom, W.J.1    Wang, R.2    Peterson, C.A.3    Varady, J.C.4    Gesundheit, N.5    Sikka, S.C.6
  • 35
    • 0001667151 scopus 로고    scopus 로고
    • Coordinators for the ACRGTA and lipid-lowering treatment to prevent heart attack T: Major outcomes in highrisk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs. Diuretic: The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT)
    • Officers A, Coordinators for the ACRGTA and Lipid-Lowering Treatment to Prevent Heart Attack T: Major outcomes in highrisk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs. diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Jama 288: 2981-2997, 2002.
    • (2002) Jama , vol.288 , pp. 2981-2997
    • Officers, A.1
  • 36
    • 84891369678 scopus 로고    scopus 로고
    • Therapeutic value of quinazoline-based compounds in prostate cancer
    • Bilbro J, Mart M and Kyprianou N: Therapeutic value of quinazoline-based compounds in prostate cancer. Anticancer Res 33: 4695-4700, 2013.
    • (2013) Anticancer Res , vol.33 , pp. 4695-4700
    • Bilbro, J.1    Mart, M.2    Kyprianou, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.