Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis

Journal of Clinical Investigation

Volumn 125, Issue 1, 2015, Pages 208-221

  Menon, Madhav C ^a   Chuang, Peter Y ^a   Li, Zhengzhe ^a   Wei, Chengguo ^a   Zhang, Weijia ^a   Luan, Yi ^a   Yi, Zhengzi ^a   Xiong, Huabao ^b   Woytovich, Christopher ^a   Greene, Ilana ^a   Overbey, Jessica ^a   Rosales, Ivy ^c   Bagiella, Emilia ^a   Chen, Rong ^b   Ma, Meng ^b   Li, Li ^b   Ding, Wei ^b   Djamali, Arjang ^d   Saminego, Millagros ^e   O'Connell, Philip J ^f   Gallon, Lorenzo ^g   Colvin, Robert ^c   Schroppel, Bernd ^a   He, John Cijiang ^a,h   Murphy, Barbara ^a   more..

^a Division of Nephrology   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

^e UNIVERSITY OF MICHIGAN   (United States)

^f UNIVERSITY OF SYDNEY   (Australia)

^g NORTHWESTERN UNIVERSITY   (United States)

^h VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA1 COLLAGEN TYPE 1; BETA CATENIN; COLLAGEN; F ACTIN; PDZ PROTEIN; SHROOM3 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR 7 LIKE 2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; WNT PROTEIN; ACTIN BINDING PROTEIN; CTNNB1 PROTEIN, HUMAN; SHROOM3 PROTEIN, HUMAN; SMAD3 PROTEIN, HUMAN; TCF7L2 PROTEIN, HUMAN; TGFB1 PROTEIN, HUMAN;

ADULT; AGED; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC ALLOGRAFT NEPHROPATHY; COHORT ANALYSIS; CONTROLLED STUDY; ENHANCER REGION; GENE EXPRESSION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC TRANSCRIPTION; GLOMERULUS FILTRATION RATE; GRAFT RECIPIENT; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INTRON; KIDNEY FIBROSIS; KIDNEY TUBULE CELL; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; MOUSE; NONHUMAN; PROSPECTIVE STUDY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE TRAIT LOCUS; RENAL GRAFT DYSFUNCTION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION INITIATION; UPREGULATION; URETER OBSTRUCTION; WNT SIGNALING PATHWAY; ALLOGRAFT; ANIMAL; CLINICAL TRIAL; DISEASE PREDISPOSITION; FIBROSIS; GENETICS; HEK293 CELL LINE; KIDNEY; KIDNEY DISEASE; KIDNEY TRANSPLANTATION; METABOLISM; MULTICENTER STUDY; PATHOLOGY; PHYSIOLOGY; RISK;

ALLOGRAFTS; ANIMALS; BETA CATENIN; DISEASE SUSCEPTIBILITY; ENHANCER ELEMENTS, GENETIC; FIBROSIS; GENE EXPRESSION; GENETIC ASSOCIATION STUDIES; GENETIC LOCI; HEK293 CELLS; HUMANS; INTRONS; KIDNEY; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; MALE; MICE; MICROFILAMENT PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; RISK; SMAD3 PROTEIN; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN; TRANSCRIPTIONAL ACTIVATION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84920436425     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI76902     Document Type: Article

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