Investigation of known estimated glomerular filtration rate loci in patients with Type 2 diabetes

Diabetic Medicine

Volumn 30, Issue 10, 2013, Pages 1230-1235

  Deshmukh, H A ^a   Palmer, C N A ^a   Morris, A D ^a   Colhoun, H M ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALBUMINURIA; ALLELE; ARTICLE; CHRONIC KIDNEY DISEASE; DIABETIC PATIENT; FEMALE; GENETIC VARIABILITY; GLOMERULUS FILTRATION RATE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALBUMINURIA; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GLOMERULAR FILTRATION RATE; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RENAL INSUFFICIENCY, CHRONIC; REPRODUCIBILITY OF RESULTS; SCOTLAND; UROMODULIN;

EID: 84884726709     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/dme.12211     Document Type: Article

References (19)

1. Böger CA, Gorski M, Li M, Hoffmann MM, Huang C, Yang Q et al. Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD. PLoS Genet 2011; 7: e1002292.
2. O'Seaghdha CM, Fox CS. Genome-wide association studies of chronic kidney disease: what have we learned? Nat Rev Nephrol 2012; 8: 89-99.
3. Köttgen A, Glazer NL, Dehghan A, Hwang SJ, Katz R, Li M et al. Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet 2009; 41: 712-717.
4. Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Glazer NL et al. New loci associated with kidney function and chronic kidney disease. Nat Genet 2010; 42: 376-384.
5. Shriner D, Herbert A, Doumatey AP, Zhou J, Huang H, Erdos MR et al. Multiple loci associated with renal function in African Americans. PloS One 2012; 7: e45112.
6. MacIsaac RJ, Tsalamandris C, Panagiotopoulos S, Smith TJ, McNeil KJ, Jerums G. Nonalbuminuric renal insufficiency in type 2 diabetes. Diabetes Care 2004; 27: 195-200.
7. MacIsaac RJ, Panagiotopoulos S, McNeil KJ, Smith TJ, Tsalamandris C, Hao H. Is nonalbuminuric renal insufficiency in type 2 diabetes related to an increase in intrarenal vascular disease? Diabetes Care 2006; 29: 1560-1566.
8. Ellis JW, Chen MH, Foster MC, Liu CT, Larson MG, de Boer I et al. Validated SNPs for eGFR and their associations with albuminuria. Hum Mol Genet 2012; 21: 3293-3298.
9. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999; 130: 461-70.
10. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-575.
11. Bellenguez C, Strange A, Freeman C, Wellcome Trust Case Control Consortium, Donnelly P, Spencer CC. A robust clustering algorithm for identifying problematic samples in genome-wide association studies. Bioinformatics 2012; 28: 134-135.
12. Reznichenko A, Böger CA, Snieder H, van den Born J, de Borst MH, Damman J et al. UMOD as a susceptibility gene for end-stage renal disease. BMC Med Genet 2012; 13: 78.
13. Köttgen A, Yang Q, Shimmin LC, Tin A, Schaeffer C, Coresh J et al. Association of estimated glomerular filtration rate and urinary uromodulin concentrations with rare variants identified by UMOD gene region sequencing. PloS One 2012; 7: e38311.
14. Ahluwalia TS, Lindholm E, Groop L, Melander O. Uromodulin gene variant is associated with type 2 diabetic nephropathy. J Hypertens 2011; 29: 1731-1734.
15. Gudbjartsson DF, Holm H, Indridason OS, Thorleifsson G, Edvardsson V, Sulem P et al. Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseases. PLoS Genet 2010; 6: e1001039.
16. Liu CT, Garnaas MK, Tin A, Kottgen A, Franceschini N, Peralta CA et al. Genetic association for renal traits among participants of African ancestry reveals new loci for renal function. PLoS Genet 2011; 7: e1002264.
17. Bonetti S, Trombetta M, Boselli ML, Turrini F, Malerba G, Trabetti E. Variants of GCKR affect both beta-cell and kidney function in patients with newly diagnosed type 2 diabetes: the Verona newly diagnosed type 2 diabetes study 2. Diabetes Care 2011; 34: 1205-1210.
18. Coresh J, Astor BC, Greene T, Eknoyan G, Levey AS. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis 2003; 41: 1-12.
19. Ritz E, Zeng XX, Rychlík I. Clinical manifestation and natural history of diabetic nephropathy. Contrib Nephrol 2011; 170: 19-27.